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BioWorld - Tuesday, May 13, 2025
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Home » Astex gets $35M up front in expanded Merck deal targeting p53
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Astex gets $35M up front in expanded Merck deal targeting p53

Aug. 8, 2023
By Nuala Moran
Astex Pharmaceuticals Inc. is getting $35 million up front and up to $500 million per program as it extends its drug discovery collaboration with Merck & Co. Inc. to include small-molecule activators of the p53 tumor suppressor protein. The number of programs was not disclosed, but they will target forms of p53 that have lost their function as a result of cancer-induced mutations in the TP53 gene. The aim will be to override the mutation and restore the ability of the wild-type protein to bind DNA and perform its functions as a transcription factor.
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