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BioWorld - Thursday, May 22, 2025
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Home » Most-edited-ever donor genomes lead to 2-year survival in porcine-to-primate kidney transplants
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Immune

Most-edited-ever donor genomes lead to 2-year survival in porcine-to-primate kidney transplants

Oct. 11, 2023
By Anette Breindl and Mar de Miguel
Scientists at Egenesis Inc. have transplanted kidneys from genome-edited pigs into cynomolgus monkeys that remained functional for long periods after transplantation. The monkeys, whose own kidneys were removed during the surgery, survived for a median of 176 days after receiving one pig kidney. Maximal survival was just over 2 years. The data were published today in Nature. Egenesis CEO Mike Curtis told reporters that the study has achieved the longest survival to date “using clinically translatable immunosuppression … longer survival has been achieved using really aggressive immunosuppression that really isn’t clinically translatable.”
BioWorld BioWorld Science Science Transplantation Immune Nephrology

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