BioWorld
www.bioworld.com/articles/479723

European Patent Disclosures

Feb. 10, 2000

Published December 22 (EPO); December 16 (WO)

ACGT Medico WO 99/64628

Diagnostic detection

Toronto

Detection of DNA, RNA, and proteins in columns having snares; for diagnostics.

Adv. Res. & Technol. Inst. WO 99/64569

Recombinant AAV vectors

Indianapolis, Ind.

Generation of recombinant adeno-associated virus (AAV) vectors having reduced homologous recombination.

Amgen EPO 965 638

G-CSF analogs

Thousand Oaks, Calif.

G-CSF analogs, encoding gene sequences, computer programs for structural analysis and design; for therapeutics.

Axys Pharma WO 99/64630

Drug metabolism variation

S. San Francisco

Human phenol sulfotransferase gene polymorphisms; for diagnosing drug metabolism variation.

BASF WO 99/64572

Poly (ADP-ribose) polymerase gene

Ludwigshafen, Germany

Poly (ADP-ribose) polymerase gene, encoded protein, antibodies, homologs; for identifying modulators.

Bayer WO 99/64576

Human genes

Walpole, Mass.

Human genes, expression products, probes, antisense, antibodies; for cancer diagnostics and therapeutics.

Boston Univ. WO 99/64458

Anion transport modulators

Boston

Methods for identifying modulators of mitochondrial anion carrier activity using changes in membrane potential or pH.

California, Univ. of WO 99/64592

Green fluorescent proteins

Oakland, Calif.

Green fluorescent proteins, encoding gene sequences; for measuring pH in cellular compartments and other samples.

Celltech Therapeutics WO 99/64460

Divalent antibody fragments

Slough, U.K.

Divalent antibody fragments having synthetic or natural interchain bridges; for diagnostics and therapeutics.

Central Manchester Healthcare WO 99/64624

Mutation analysis

Manchester, U.K.

Hybrid nucleic acid primers; for PCR-based mutation analysis and diagnostics.

Chiron WO 99/64594

Prostate cancer genes

Emeryville, Calif.

Genes and gene expression products that are differentially regulated in prostate cancer, antisense, antibodies.

Clontech Labs WO 99/64438

Thermostable polymerase

Palo Alto, Calif.

Thermostable polymerase having no nuclease activity; for PCR-based analytical applications.

Devgen WO 99/64586

Phagocytosis modulators

Zwijnaarde, Belgium

Transfection of cells with genes influencing apoptotic cell phagocytosis; for finding phagocytosis modulators.

Discovery Technol. WO 99/64567

G-protein-coupled receptor modulators

Allschwil, Switzerland

Transformed cells expressing a heterologous G-protein-coupled receptor; for detecting modulators.

Fuso Pharma EPO 965 646

Ulcer bacteria probes

Osaka, Japan

Nucleic acid probes to Helicobacter pylori; for PCR-detection of inflammatory digestive tract infections.

Fuso Pharma WO 99/64591

Thyroid cancer therapy

Osaka, Japan

LAR phosphatase subunit antibodies; for thyroid cancer diagnostics and therapeutics.

Genentech WO 99/64461

Apo-2 ligand antibodies

S. San Francisco

Making monoclonal antibodies using a mixed antigen immunization protocol; for making Apo-2 ligand antibodies.

Genespan WO 99/64578

Hepatocarcinoma gene expression

Richmond, Wash.

Chemical agents for enhancing and stabilizing transient gene expression in cells in solid liver tumors.

Genostic Pharma WO 99/64626 & 64627

Genetic profiling probes

Cambridge, U.K.

Nucleic acid probes for the genetic profiling of mutations and polymorphisms.

Genset WO 99/64590

Prostate cancer antigen

Paris

Polymorphic markers of prostate carcinoma tumor antigen; for diagnosis of a disposition towards prostate cancer.

Georgetown Univ. WO 99/64057

Retinoic acid-inducible genes

Washington

Retinoic acid-inducible genes from lungs, encoded proteins; for identifying similarly inducible genes.

Georgia Tech. Univ. WO 99/64580

Microneedle devices

Atlanta

Microneedle devices, manufacturing methods; for transporting therapeutic and biological materials across tissue barriers.

Gilead Sciences WO 99/64459

Organic anion transporter gene

Foster City, Calif.

Organic anion transporter gene, encoded protein, transgenics; for identifying modulators.

Helix Res. Inst. WO 99/64454 & 64455

Nucleolar protein

Chiba, Japan

Nucleolar protein from a fetal human brain cDNA library, encoding gene sequences, peptides; for studying transport.

Henry Jackson Fdn. Military Med. WO 99/64603

B cell activation

Rockville, Md.

Epstein-Barr virus glycoprotein 350/220, naturally occurring variants; for enhanced B cell activation.

Hoechst Marion Roussel WO 99/64585

Angiotensin receptor

Frankfurt, Germany

Angiotensin receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.

Hoechst Marion Roussel WO 99/64598

Insulin analogs

Frankfurt, Germany

Insulin analogs with enhanced zinc binding capacity, stable complexes; for treating diabetes.

Immco Diagnostics WO 99/64447

Solution phase ELISA

Buffalo, N.Y.

Solution phase ELISA assays using target moieties linked to detector moieties; for insulin-dependent diabetes detection.

Immunoporation WO 99/64575

Enhancing transfection

Colchester, U.K.

Transfecting cells using osmotically active agents for enhancing the efficiency of cellular entry of materials.

Incyte Pharma WO 99/64593

Cell cycle regulators

Palo Alto, Calif.

Cell cycle regulatory proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 99/64596

Gene expression regulators

Palo Alto, Calif.

Proteins regulating gene expression, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Pharma WO 99/64609

Carboxypeptidase inhibitor

Palo Alto, Calif.

Human carboxypeptidase inhibitor, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Introgene WO 99/64582

Functional genomics assays

Leiden, Netherlands

High-throughput gene function screen using cell phenotype-altering gene expression; for functional genomics assays.

Krebs Res. Inst. WO 99/64584

Apoptosis-regulating protein

Heidelberg, Germany

Apoptosis-regulating protein, encoding gene, antibodies, production methods; for diagnostics and therapeutics.

La Jolla Pharma WO 99/64595

Detecting cardiolipin antibodies

San Diego

Domain 1 _2GPI polypeptides, encoding genes, mimetics; for detecting cardiolipin antibodies in thrombosis.

Leiden State Univ. EPO 965 648

Histocompatibility antigen genotyping

Leiden, Netherlands

Genomic typing of minor histocompatibility antigen HA-1 alleles; for diagnostic kits.

McMaster, C., et al. WO 99/64605

Choline-ethanolamine phosphotransferase

Halifax, Nova Scotia

Choline-ethanolamine phosphotransferase, encoding gene; for choline and platelet activating factor synthesis.

Memorec Med. Molec. Res. EPO 965 647 & WO 99/64623

DNA polymer identification

Cologne, Germany

Device for identification and quantification of nucleic acids and their transcription profiles [EPO in German].

Merck WO 99/64436

Motilin receptor

Rahway, N.J.

Motilin receptor, encoding gene, splice variants; for screening modulators to treat gastric motility disorders.

Merck WO 99/64577

Stable adenoviral vectors

Rahway, N.J.

Helper-dependent stable and less immunogenic adenoviral vectors; for gene therapy.

Mochida Pharma EPO 965 597

Cell membrane targeting

Tokyo

Materials with affinity for cell membranes including peptides, for targeting cell membranes.

Mochida Pharma EPO 965 637

Fas antigen derivatives

Tokyo

Fas antigen extracellular region derivatives, encoding gene sequences; for therapeutics.

Molecular Biophotonics Lab EPO 965 635

Transcription measurement

Hamakita, Japan

Fluorescence donor and acceptor RNA probes; for measuring transcription.

Mt. Sinai Sch. Med. WO 99/64571

Live, attenuated viruses

New York

Generation of live, attenuated viruses having down-regulated genes that still cause interferon induction.

Nantes Univ. WO 99/64568

Retroviral packaging

Nantes, France

Cell lines for packaging and producing recombinant retroviruses; for gene therapy.

NIH (Natl. Inst. Hlth.) WO 99/64073

HIV therapeutics

Bethesda, Md.

Recombinant immunotoxin with anti-gp120 antibody and cytotoxin moieties; for HIV therapeutics.

NIH (Natl. Inst. Hlth.) WO 99/64583

Modifying intracellular proteolysis

Bethesda, Md.

Phage-display libraries of recombinant binding proteins that modify proteolytic degradation; for intracellular delivery.

NIH (Natl. Inst. Hlth.) WO 99/64597

_2-microglobulin fusions

Bethesda, Md.

_2-microglobulin fusion proteins, high affinity variants; for vaccine adjuvants to enhance cytotoxic T cell responses.

New England Biolabs WO 99/64632

Restriction endonuclease discovery

Beverly, Mass.

Methods for efficiently identifying intact restriction endonuclease and DNA methyltransferase genes.

Nippon Suisan EPO 965 636

Vibrio infection detection

Tokyo

Nucleic acid probes for Vibrio parahaemolyticus; for PCR-based infection diagnostics.

Nippon Zoki Pharma EPO 965 594

AIDS treatment

Osaka, Japan

Nef-attachable protein, encoding gene sequences, antibodies; for treating AIDS.

Orchid Biocomputer WO 99/64437

Fluorescent nucleotide analogs

Princeton, N.J.

Nucleotide analogs with 3'-pro-fluorescent activity; for nucleic acid sequence analysis.

Pennsylvania, Univ. of WO 99/64074

Immunoresponse induction

Philadelphia

Regulatory sequences expressed in macrophages; for linkage to therapeutic genes to induce an immunoresponse.

Rhone-Poulenc Rorer WO 99/64587

_-secretase activity

Antony, France

Polypeptides having _-secretase activity, encoding gene sequences; for affecting _-amyloid deposition.

Rhone-Poulenc Rorer WO 99/64607

Heterologous protein production

Antony, France

Industrial methods for producing heterologous proteins in E. coli, production strains.

Ribotargets WO 99/64625

Identifying RNA binders

Cambridge, U.K.

Solution-based assay for identifying RNA-binding compounds using fluorescent reporter moieties.

Rockefeller Univ. WO 99/64606

Telomeric repeat binding factor

New York

Telomeric repeat binding factor tankyrase, encoding gene sequences; for modulator screens.

St. Jude Children's Hosp. WO 99/64610

Streptococcus vaccines

Memphis, Tenn.

Streptococcus pneumoniae zinc metalloprotease zmpB, encoding gene, analogs, variants, fragments; for vaccines.

Samyang Genex WO 99/64611

Antimicrobial production

Seoul, S. Korea

DNA constructs derived from the purF gene; for mass production of antimicrobial agents in microorganisms.

Schering WO 99/64608

Serine protease corin

Berlin

Serine protease corin, encoding gene sequences; for finding modulators, diagnostics, and therapeutics.

Sloan-Kettering Inst. EPO 965 640

Melanoma vaccines

New York

Peptide fragments of gp75, encoding gene sequences; for melanoma vaccines.

SmithKline Beecham WO 99/64021

hCEPR receptor peptides

Philadelphia

hCEPR receptor polypeptides, encoding gene sequences, recombinant production; for diagnostics and therapeutics.

SmithKline Beecham WO 99/64435

Kidney-specific gene

Philadelphia

Human kidney-specific gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 99/64452

GPR35A receptor

Philadelphia

GPR35A receptor, encoding gene sequences; recombinant production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 99/64602

Moraxella infection diagnostics

Rixensart, Belgium

Moraxella catarrahalis polypeptides, encoding genes, production methods; for diagnostics and therapeutics.

SmithKline Beecham WO 99/64629

Adipocyte protein homolog

Philadelphia

Homolog of the 30 kilodaton adipocyte complement-related protein, encoding gene; for diagnostics and therapeutics.

SmithKline Beecham WO 99/64633

Antiviral screens

Philadelphia

Herpes simplex virus origin protein N-terminal truncation, encoding gene sequences; for antiviral screens.

South Florida, Univ. of WO 99/64581

Cell electrofusion

Tampa, Fla.

Electrofusion of cells in a device where the cells to be fused are already in close contact.

Statens Serum Inst. WO 99/64462

IgG purification

Copenhagen

Chromatographic purification of immunoglobulin (Ig) G from crude plasma protein fractions; for intravenous therapy.

Switch Biotech EPO 965 642

Expression pattern analysis

Martinsreid, Germany

Cloning vector, methods of production; for analysis of mRNA expression patterns [in German].

Transgene EPO 965 583

Polyamine-mediated delivery

Strasbourg, France

Polyamines and their compositions; for transferring active substances into cells.

Transgene WO 99/64588

TGF RII receptor

Strasbourg, France

TGF_ RII receptor, encoding gene sequences; for gastric and colon cancer diagnostics and therapeutics.

Urocor WO 99/64631

Cancer gene probes

Oklahoma City, Okla.

Biomarkers and genetic probes for diagnosing prostate, breast, and bladder cancer.

Valentis WO 99/64615

Enhanced electroporation

The Woodlands, Texas

Electroporation of formulated nucleic acid complexes; for increased transfection efficiency.

Zeneca WO 99/64589

Receptor tyrosine kinase

London

Human receptor tyrosine kinase, encoding gene, antisense; for finding modulators, diagnostics, and therapeutics.

- Compiled By Chester A. Bisbee