European Patent Disclosures
Published December 22 (EPO); December 16 (WO)
ACGT Medico WO 99/64628
Diagnostic detection
Toronto
Detection of DNA, RNA, and proteins in columns having snares; for diagnostics.
Adv. Res. & Technol. Inst. WO 99/64569
Recombinant AAV vectors
Indianapolis, Ind.
Generation of recombinant adeno-associated virus (AAV) vectors having reduced homologous recombination.
Amgen EPO 965 638
G-CSF analogs
Thousand Oaks, Calif.
G-CSF analogs, encoding gene sequences, computer programs for structural analysis and design; for therapeutics.
Axys Pharma WO 99/64630
Drug metabolism variation
S. San Francisco
Human phenol sulfotransferase gene polymorphisms; for diagnosing drug metabolism variation.
BASF WO 99/64572
Poly (ADP-ribose) polymerase gene
Ludwigshafen, Germany
Poly (ADP-ribose) polymerase gene, encoded protein, antibodies, homologs; for identifying modulators.
Bayer WO 99/64576
Human genes
Walpole, Mass.
Human genes, expression products, probes, antisense, antibodies; for cancer diagnostics and therapeutics.
Boston Univ. WO 99/64458
Anion transport modulators
Boston
Methods for identifying modulators of mitochondrial anion carrier activity using changes in membrane potential or pH.
California, Univ. of WO 99/64592
Green fluorescent proteins
Oakland, Calif.
Green fluorescent proteins, encoding gene sequences; for measuring pH in cellular compartments and other samples.
Celltech Therapeutics WO 99/64460
Divalent antibody fragments
Slough, U.K.
Divalent antibody fragments having synthetic or natural interchain bridges; for diagnostics and therapeutics.
Central Manchester Healthcare WO 99/64624
Mutation analysis
Manchester, U.K.
Hybrid nucleic acid primers; for PCR-based mutation analysis and diagnostics.
Chiron WO 99/64594
Prostate cancer genes
Emeryville, Calif.
Genes and gene expression products that are differentially regulated in prostate cancer, antisense, antibodies.
Clontech Labs WO 99/64438
Thermostable polymerase
Palo Alto, Calif.
Thermostable polymerase having no nuclease activity; for PCR-based analytical applications.
Devgen WO 99/64586
Phagocytosis modulators
Zwijnaarde, Belgium
Transfection of cells with genes influencing apoptotic cell phagocytosis; for finding phagocytosis modulators.
Discovery Technol. WO 99/64567
G-protein-coupled receptor modulators
Allschwil, Switzerland
Transformed cells expressing a heterologous G-protein-coupled receptor; for detecting modulators.
Fuso Pharma EPO 965 646
Ulcer bacteria probes
Osaka, Japan
Nucleic acid probes to Helicobacter pylori; for PCR-detection of inflammatory digestive tract infections.
Fuso Pharma WO 99/64591
Thyroid cancer therapy
Osaka, Japan
LAR phosphatase subunit antibodies; for thyroid cancer diagnostics and therapeutics.
Genentech WO 99/64461
Apo-2 ligand antibodies
S. San Francisco
Making monoclonal antibodies using a mixed antigen immunization protocol; for making Apo-2 ligand antibodies.
Genespan WO 99/64578
Hepatocarcinoma gene expression
Richmond, Wash.
Chemical agents for enhancing and stabilizing transient gene expression in cells in solid liver tumors.
Genostic Pharma WO 99/64626 & 64627
Genetic profiling probes
Cambridge, U.K.
Nucleic acid probes for the genetic profiling of mutations and polymorphisms.
Genset WO 99/64590
Prostate cancer antigen
Paris
Polymorphic markers of prostate carcinoma tumor antigen; for diagnosis of a disposition towards prostate cancer.
Georgetown Univ. WO 99/64057
Retinoic acid-inducible genes
Washington
Retinoic acid-inducible genes from lungs, encoded proteins; for identifying similarly inducible genes.
Georgia Tech. Univ. WO 99/64580
Microneedle devices
Atlanta
Microneedle devices, manufacturing methods; for transporting therapeutic and biological materials across tissue barriers.
Gilead Sciences WO 99/64459
Organic anion transporter gene
Foster City, Calif.
Organic anion transporter gene, encoded protein, transgenics; for identifying modulators.
Helix Res. Inst. WO 99/64454 & 64455
Nucleolar protein
Chiba, Japan
Nucleolar protein from a fetal human brain cDNA library, encoding gene sequences, peptides; for studying transport.
Henry Jackson Fdn. Military Med. WO 99/64603
B cell activation
Rockville, Md.
Epstein-Barr virus glycoprotein 350/220, naturally occurring variants; for enhanced B cell activation.
Hoechst Marion Roussel WO 99/64585
Angiotensin receptor
Frankfurt, Germany
Angiotensin receptor, encoding gene sequences, production methods; for diagnostics and therapeutics.
Hoechst Marion Roussel WO 99/64598
Insulin analogs
Frankfurt, Germany
Insulin analogs with enhanced zinc binding capacity, stable complexes; for treating diabetes.
Immco Diagnostics WO 99/64447
Solution phase ELISA
Buffalo, N.Y.
Solution phase ELISA assays using target moieties linked to detector moieties; for insulin-dependent diabetes detection.
Immunoporation WO 99/64575
Enhancing transfection
Colchester, U.K.
Transfecting cells using osmotically active agents for enhancing the efficiency of cellular entry of materials.
Incyte Pharma WO 99/64593
Cell cycle regulators
Palo Alto, Calif.
Cell cycle regulatory proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/64596
Gene expression regulators
Palo Alto, Calif.
Proteins regulating gene expression, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/64609
Carboxypeptidase inhibitor
Palo Alto, Calif.
Human carboxypeptidase inhibitor, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Introgene WO 99/64582
Functional genomics assays
Leiden, Netherlands
High-throughput gene function screen using cell phenotype-altering gene expression; for functional genomics assays.
Krebs Res. Inst. WO 99/64584
Apoptosis-regulating protein
Heidelberg, Germany
Apoptosis-regulating protein, encoding gene, antibodies, production methods; for diagnostics and therapeutics.
La Jolla Pharma WO 99/64595
Detecting cardiolipin antibodies
San Diego
Domain 1 _2GPI polypeptides, encoding genes, mimetics; for detecting cardiolipin antibodies in thrombosis.
Leiden State Univ. EPO 965 648
Histocompatibility antigen genotyping
Leiden, Netherlands
Genomic typing of minor histocompatibility antigen HA-1 alleles; for diagnostic kits.
McMaster, C., et al. WO 99/64605
Choline-ethanolamine phosphotransferase
Halifax, Nova Scotia
Choline-ethanolamine phosphotransferase, encoding gene; for choline and platelet activating factor synthesis.
Memorec Med. Molec. Res. EPO 965 647 & WO 99/64623
DNA polymer identification
Cologne, Germany
Device for identification and quantification of nucleic acids and their transcription profiles [EPO in German].
Merck WO 99/64436
Motilin receptor
Rahway, N.J.
Motilin receptor, encoding gene, splice variants; for screening modulators to treat gastric motility disorders.
Merck WO 99/64577
Stable adenoviral vectors
Rahway, N.J.
Helper-dependent stable and less immunogenic adenoviral vectors; for gene therapy.
Mochida Pharma EPO 965 597
Cell membrane targeting
Tokyo
Materials with affinity for cell membranes including peptides, for targeting cell membranes.
Mochida Pharma EPO 965 637
Fas antigen derivatives
Tokyo
Fas antigen extracellular region derivatives, encoding gene sequences; for therapeutics.
Molecular Biophotonics Lab EPO 965 635
Transcription measurement
Hamakita, Japan
Fluorescence donor and acceptor RNA probes; for measuring transcription.
Mt. Sinai Sch. Med. WO 99/64571
Live, attenuated viruses
New York
Generation of live, attenuated viruses having down-regulated genes that still cause interferon induction.
Nantes Univ. WO 99/64568
Retroviral packaging
Nantes, France
Cell lines for packaging and producing recombinant retroviruses; for gene therapy.
NIH (Natl. Inst. Hlth.) WO 99/64073
HIV therapeutics
Bethesda, Md.
Recombinant immunotoxin with anti-gp120 antibody and cytotoxin moieties; for HIV therapeutics.
NIH (Natl. Inst. Hlth.) WO 99/64583
Modifying intracellular proteolysis
Bethesda, Md.
Phage-display libraries of recombinant binding proteins that modify proteolytic degradation; for intracellular delivery.
NIH (Natl. Inst. Hlth.) WO 99/64597
_2-microglobulin fusions
Bethesda, Md.
_2-microglobulin fusion proteins, high affinity variants; for vaccine adjuvants to enhance cytotoxic T cell responses.
New England Biolabs WO 99/64632
Restriction endonuclease discovery
Beverly, Mass.
Methods for efficiently identifying intact restriction endonuclease and DNA methyltransferase genes.
Nippon Suisan EPO 965 636
Vibrio infection detection
Tokyo
Nucleic acid probes for Vibrio parahaemolyticus; for PCR-based infection diagnostics.
Nippon Zoki Pharma EPO 965 594
AIDS treatment
Osaka, Japan
Nef-attachable protein, encoding gene sequences, antibodies; for treating AIDS.
Orchid Biocomputer WO 99/64437
Fluorescent nucleotide analogs
Princeton, N.J.
Nucleotide analogs with 3'-pro-fluorescent activity; for nucleic acid sequence analysis.
Pennsylvania, Univ. of WO 99/64074
Immunoresponse induction
Philadelphia
Regulatory sequences expressed in macrophages; for linkage to therapeutic genes to induce an immunoresponse.
Rhone-Poulenc Rorer WO 99/64587
_-secretase activity
Antony, France
Polypeptides having _-secretase activity, encoding gene sequences; for affecting _-amyloid deposition.
Rhone-Poulenc Rorer WO 99/64607
Heterologous protein production
Antony, France
Industrial methods for producing heterologous proteins in E. coli, production strains.
Ribotargets WO 99/64625
Identifying RNA binders
Cambridge, U.K.
Solution-based assay for identifying RNA-binding compounds using fluorescent reporter moieties.
Rockefeller Univ. WO 99/64606
Telomeric repeat binding factor
New York
Telomeric repeat binding factor tankyrase, encoding gene sequences; for modulator screens.
St. Jude Children's Hosp. WO 99/64610
Streptococcus vaccines
Memphis, Tenn.
Streptococcus pneumoniae zinc metalloprotease zmpB, encoding gene, analogs, variants, fragments; for vaccines.
Samyang Genex WO 99/64611
Antimicrobial production
Seoul, S. Korea
DNA constructs derived from the purF gene; for mass production of antimicrobial agents in microorganisms.
Schering WO 99/64608
Serine protease corin
Berlin
Serine protease corin, encoding gene sequences; for finding modulators, diagnostics, and therapeutics.
Sloan-Kettering Inst. EPO 965 640
Melanoma vaccines
New York
Peptide fragments of gp75, encoding gene sequences; for melanoma vaccines.
SmithKline Beecham WO 99/64021
hCEPR receptor peptides
Philadelphia
hCEPR receptor polypeptides, encoding gene sequences, recombinant production; for diagnostics and therapeutics.
SmithKline Beecham WO 99/64435
Kidney-specific gene
Philadelphia
Human kidney-specific gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/64452
GPR35A receptor
Philadelphia
GPR35A receptor, encoding gene sequences; recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/64602
Moraxella infection diagnostics
Rixensart, Belgium
Moraxella catarrahalis polypeptides, encoding genes, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/64629
Adipocyte protein homolog
Philadelphia
Homolog of the 30 kilodaton adipocyte complement-related protein, encoding gene; for diagnostics and therapeutics.
SmithKline Beecham WO 99/64633
Antiviral screens
Philadelphia
Herpes simplex virus origin protein N-terminal truncation, encoding gene sequences; for antiviral screens.
South Florida, Univ. of WO 99/64581
Cell electrofusion
Tampa, Fla.
Electrofusion of cells in a device where the cells to be fused are already in close contact.
Statens Serum Inst. WO 99/64462
IgG purification
Copenhagen
Chromatographic purification of immunoglobulin (Ig) G from crude plasma protein fractions; for intravenous therapy.
Switch Biotech EPO 965 642
Expression pattern analysis
Martinsreid, Germany
Cloning vector, methods of production; for analysis of mRNA expression patterns [in German].
Transgene EPO 965 583
Polyamine-mediated delivery
Strasbourg, France
Polyamines and their compositions; for transferring active substances into cells.
Transgene WO 99/64588
TGF RII receptor
Strasbourg, France
TGF_ RII receptor, encoding gene sequences; for gastric and colon cancer diagnostics and therapeutics.
Urocor WO 99/64631
Cancer gene probes
Oklahoma City, Okla.
Biomarkers and genetic probes for diagnosing prostate, breast, and bladder cancer.
Valentis WO 99/64615
Enhanced electroporation
The Woodlands, Texas
Electroporation of formulated nucleic acid complexes; for increased transfection efficiency.
Zeneca WO 99/64589
Receptor tyrosine kinase
London
Human receptor tyrosine kinase, encoding gene, antisense; for finding modulators, diagnostics, and therapeutics.
- Compiled By Chester A. Bisbee