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BioWorld - Monday, January 30, 2023
Home » Topics » Stem cells, BioWorld

Stem cells, BioWorld
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Comparison of senescent cells in regenerating muscle.
Musculoskeletal

Senescent cells are toxic to their neighbors, prevent muscle regeneration

Dec. 22, 2022
By Mar de Miguel
No Comments
The first in vivo cell atlas of senescent tissue in skeletal muscle has identified the damaging properties of these cells and explained why they block muscle regeneration. According to a study at Pompeu Fabra University led by scientists from Altos Labs Inc., cell damage caused the senescence of the cells, which secreted toxic substances into the surrounding microenvironment, causing fibrosis and preventing tissue regeneration.
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Stem cells

Kadimastem signals Nasdaq listing, lands $3.2M from Ilex Medical

Nov. 30, 2021
By Catherine Longworth
No Comments
Ilex Medical Ltd. has injected $3.2 million into cell therapy company Kadimastem Ltd., as it prepares to list on the Nasdaq.
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CD47 protein structure

ISSCR: Genome-edited stem cells can make immune-evading transplants

June 28, 2021
By Anette Breindl
No Comments
Multiple companies are pursuing CD47-blockade as a tumor immunotherapy approach. Sana Biotechnology Inc., too, is interested in the therapeutic potential of CD47 – but from a very different angle. By overexpressing CD47 on stem cells, researchers at Sana want to make transplanted cells invisible to the immune system.
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Stem cells

Back to the basics for new insights, with new technology

June 25, 2021
By Anette Breindl
No Comments
Sometimes, scientific progress comes from conceptual insights that arrive in a flash. More often, however, such progress arrives in a decidedly less glamorous, though no less important, manner – through the development of new technologies in what can be a very slow iterative cycle of getting a new method to work.
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Dopaminergic neurons

ISSCR 2020: In-brain direct reprogramming creates neurons, alleviates Parkinson’s

June 30, 2020
By Anette Breindl
No Comments
Two separate groups have recently shown that in mouse models, inactivation of a single gene was enough to directly convert other cell types in the brain into neurons.
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Stem cell-derived cerebral organoid
ISSCR 2020

‘Hope, hype and hubris’ of brain organoids on display at stem cell meeting

June 26, 2020
By Anette Breindl
No Comments
Technical challenges at the annual meeting of the International Society for Stem Cell Research (ISSCR) meeting led to at least one lively exchange of stem cell jokes in the chat box as the audience waited for talks to resume, including stem cell parental advice: “You can be anything you want when you grow up!”
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Human gastruloid
Important, and now visible

‘Gastruloids’ enable study of embryonic development

June 11, 2020
By Nuala Moran
No Comments
LONDON – After the human brain organoid, here comes the gastruloid – a 3D organized model of key elements of the human embryo at around 18 to 21 days old.
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Athersys researchers standing next to bioreactor in the lab

Pass the MUST-ARDS: Athersys starts pivotal study for stem cells to treat COVID-19-induced ARDS

May 6, 2020
By Stacy Lawrence
No Comments
Stem cells haven’t exactly panned out as hoped when it comes to approved therapeutics. There are only a couple that have received a nod from the FDA in very specific indications. But the ongoing COVID-19 pandemic could push stem cells back into the limelight and more firmly establish them as therapeutically relevant.
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‘Absolutely fascinating’

Stem cells, dead cells work equally well for heart repair

Nov. 27, 2019
By Anette Breindl
No Comments
A study published in the Nov. 27, 2019, advance online issue of Nature manages a rare feat. It is both a vindication of and egg in the face for cardiac stem cell research. The good news is that cardiac stem cell transplantation after a heart attack does improve heart function, although the effect is “mild,” Jeffery Molkentin told BioWorld.
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Australian researchers create kidney tissue from iPS cells

Nov. 25, 2019
By Tamra Sami
No Comments
MELBOURNE, Australia – Researchers at the Murdoch Children’s Research Institute in Melbourne are pushing the boundaries on creating kidney tissue from stem cells.
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