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BioWorld - Tuesday, June 17, 2025
Home » Topics » Infection » Coronavirus

Coronavirus
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Infection

University of Minnesota presents new SARS-CoV-2 NSP14 methyltransferase inhibitors

Dec. 21, 2023
University of Minnesota has divulged nonstructural protein 14 (NSP14) (SARS-CoV-2) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection.
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SARS-CoV-2 virus particles
Infection

Aerosolized nanobodies broadly neutralize SARS-CoV-2 variants

Dec. 21, 2023
In a study published in Antiviral Research, researchers from the Max Planck Institute for Multidisciplinary Sciences and collaborators have presented optimized nanobodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 spike protein.
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Regulatory actions for Dec. 19, 2023

Dec. 19, 2023
Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Anheart, Arcutis, Avstera, Catalyst, Checkpoint, Cyclo, GC Pharma, Innovent, Irlab, Lexeo, Merck & Co., Novavax, Nrx, Pfizer, Santhera, Sirnaomics.
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In the clinic for Dec. 19, 2023

Dec. 19, 2023
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Akero, Aulos, Azura, BMS, Cara, CNS, Cyclacel, Daiichi, Ethris, GSK, Highfield, Innocare, Invivyd, Lantheus, Mirum, Mithra, Nectin, Neuren, Nicox, Oculis, Pepgen, Sensorion, Structure, Ultimovacs, Viridian, Windtree, Yoltech.
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Invivyd stock spikes as MAb shows strength against COVID

Dec. 18, 2023
By Lee Landenberger
Invivyd Inc.’s VYD-222 produced positive initial top-line results in the ongoing pivotal phase III Canopy study for preventing symptomatic COVID-19. The results could reach a vulnerable population of patients who are immunocompromised and don’t get the same protection as other patients, the company’s CEO, Dave Hering, told BioWorld.
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Regulatory actions for Dec. 12, 2023

Dec. 12, 2023
Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Alzamend, Ascendis, Astellas, Basilea, Erasca, Geneuro, GSK, Orchard, Revbio, Shuttle, Skye.
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Regulatory actions for Dec. 7, 2023

Dec. 7, 2023
Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Adaptimmune, Antengene, CG Oncology, Century, Zhejiang Jingxin, Mymd, Neurocrine, Novartis, Novavax, Optinose, Phathom, PTC, Ractigen, Systimmune.
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Coronavirus, mRNA and syringe
Infection

Off-target immune response from modified mRNA impacts future development

Dec. 7, 2023
By Nuala Moran
The Nobel Prize-winning modification that prevents the innate immune system from recognizing injected mRNA as foreign and blocking transcription of the protein it encodes has been found on some occasions to cause ribosomal frameshifting.
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Coronavirus, mRNA and syringe

Off-target immune response from modified mRNA impacts future development

Dec. 6, 2023
By Nuala Moran
The Nobel Prize-winning modification that prevents the innate immune system from recognizing injected mRNA as foreign and blocking transcription of the protein it encodes has been found on some occasions to cause ribosomal frameshifting.
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COVID-19 mRNA vaccine vials, syringe

Japan approves first self-amplifying mRNA COVID-19 vaccine from CSL, Arcturus

Dec. 5, 2023
By Tamra Sami
In a global first, Japan's Ministry of Health, Labor and Welfare has approved CSL Ltd.’s and Arcturus Therapeutics Inc.’s self-amplifying messenger RNA (sa-mRNA) vaccine (ARCT-154) for COVID-19 in adults. The approval marks the first milestone for a November 2022 licensing deal under which CSL subsidiary CSL Seqirus in-licensed Arcturus’ late-stage sa-mRNA vaccine platform technology.
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