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BioWorld - Tuesday, June 6, 2023
Home » Topics » Infection » Coronavirus

Coronavirus
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Creative rendition of SARS-CoV-2 virus particles.
Biomarkers

Nasal anti-CD3 antibody targets T cells to reduce COVID-19-associated inflammation

March 28, 2023
No Comments
COVID-19 complications involve activated T cells that contribute to inflammation. Foralumab, a fully human anti-CD3 monoclonal antibody, targets the T-cell receptor and regulates T-cell function to suppress inflammation. In a pilot trial, foralumab reduced lung inflammation, serum IL-6 and C-reactive protein in cases of moderate COVID-19.
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China gives conditional nod to Zhongsheng’s COVID-19 oral pill

March 27, 2023
By Doris Yu
No Comments
China’s NMPA granted conditional approval for a COVID-19 oral pill to treat adult patients with mild to moderate cases of the virus to a unit of Guangdong Zhongsheng Pharmaceutical Co. Ltd. RAY-1216 is a peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro), which is also known as a 3C-like protease (3CLpro).
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Infection

Nanjing Zhihe Pharmaceutical presents new cytidine derivatives for viral infections

March 24, 2023
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Nanjing Zhihe Pharmaceutical Technology Co. Ltd. has divulged cytidine derivatives reported to be useful for the treatment of viral infections.
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China greenlights CSPC’s mRNA COVID-19 vaccine for emergency use

March 23, 2023
By Zhang Mengying
No Comments
CSPC Pharmaceutical Group Ltd.’s COVID-19 mRNA vaccine, SYS-6006, has been included for emergency use by the NMPA, the company said on March 22, marking the first domestically developed COVID-19 mRNA vaccine approved for use in China.
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Infection

UT-Battelle presents new SARS-CoV-2 PLpro inhibitors

March 23, 2023
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UT-Battelle LLC has divulged covalent nonstructural protein 3 (nsp3; PLpro) (SARS-CoV) inhibitors reported to be useful for the treatment of coronavirus acute respiratory syndrome.
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Colorized transmission electron micrograph of SARS-CoV-2 (UK B.1.1.7 variant).
Infection

Researchers find mSWI/SNF complexes play role in SARS-CoV-2 infection

March 23, 2023
No Comments
Current prophylactic and therapeutic approaches for SARS-CoV-2 are effective, but the need for new approaches with broad activity makes virus-host interactions an essential piece to look at.
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Other news to note for March 23, 2023

March 23, 2023
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Additional early-stage research and drug discovery news in brief, from: 280Bio, Evolveimmune Therapeutics, Imunon, Pepgen, Psycheceutical Bioscience.
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Moderna vaccine vial and syringe on tray

Not just Moderna on the HELP hot seat

March 22, 2023
By Mari Serebrov
No Comments
While Moderna Inc. CEO Stéphane Bancel was the one on the hot seat at a March 22 hearing before the U.S. Senate Health, Education, Labor and Pensions (HELP) Committee, biopharma profitability in general, and capitalism itself, came under fire as committee Chair Bernie Sanders (I-Vt.) railed about corporate greed in the sector.
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Regulatory actions for March 21, 2023

March 21, 2023
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Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Antengene, Aquavit, Arrowhead, Aviceda, Boan, Diamond, Enlivex, Fore, Ichnos, Intellia, Jiangsu Recbio, Luye, Mereo, Prestige, Sanofi, Sensei.
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Infection

Arbutus Biopharma presents data on AB-343 for SARS-CoV-2 infection

March 21, 2023
No Comments
For COVID-19, the limited durability of vaccines requires multiple injections, and their effectiveness is continuously challenged by emerging new spike variants of the virus. The SARS-CoV-2 main protease Mpro plays a role in major polyprotein processing events and is essential for viral replication.
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