Radiopharm Theranostics Ltd. announced that the U.S. FDA has cleared the IND application for betabart (RV-01), its Lu177-B7H3 monoclonal antibody designed with strong affinity for the 4Ig isoform of B7-H3 that is highly expressed in tumors and not in healthy tissues.
People with the subtype of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) associated with fusion of MEF2D with other genes show quite poor prognosis. Most patients fail to respond to hematopoietic stem cell transplantation or other conventional treatments. Researchers at Shanghai Jiao Tong University School of Medicine have reported a lead compound that could treat BCP-ALL.
Serine/threonine-protein kinase WNK1 inhibitors have been described in a Dania Therapeutics ApS patent as potentially useful for the treatment of cancer and hypertension.
Pelemed Co. Ltd. has prepared pyrrolotriazine derivatives acting as tyrosine-protein kinase Yes (YES1) inhibitors reported to be useful for the treatment of cancer.
The sialyltransferase ST6GAL1 is upregulated in several types of cancer and its expression is particularly elevated in triple-negative breast cancer, which is extremely aggressive and associated with very poor prognosis.
The chaperone protein Hsp90 is overexpressed in many cancers, where it helps protect and drive cell proliferation by stabilizing growth factor receptors and promoting their downstream signaling. Hsp90 inhibitors show anticancer potential, but many induce substantial adverse effects.
Activating apoptosis of tumor cells by binding a soluble form of the membrane protein TRAIL to its surface receptors DR4 and DR5 on the tumor surface shows promise as a cancer therapy, but the ligand on its own has only a minutes-long half-life and does not strongly activate the receptors.
The U.S. FDA has cleared Zymeworks Inc.’s IND application for ZW-251, a novel glypican-3 (GPC3)-targeted antibody-drug conjugate (ADC) incorporating the company’s proprietary topoisomerase 1 (TOPO1) inhibitor payload, ZD-06519, for the treatment of hepatocellular carcinoma (HCC).
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