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BioWorld - Monday, May 16, 2022
Home » Authors » W. Todd Penberthy

W. Todd Penberthy

Articles

ARTICLES

Artery and plaque

Deleting protein switches macrophages to reduced-fat diet

March 31, 2022
By W. Todd Penberthy
No Comments
Scientists at the University of Connecticut have made progress in understanding the role of the targetable TRPM2 channel in the context of atherosclerosis, as they report in the March 28, 2022, issue of Nature Cardiovascular Research.
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Ebola virus

Persistent Ebolavirus in brain seeds relapses

Feb. 16, 2022
By W. Todd Penberthy
No Comments
In the Feb. 9, 2022, issue of Science Translational Medicine, investigators reported the anatomical location in which the Ebola virus was hiding and persisting in nonhuman primates had otherwise appeared to have been cured by monoclonal therapy prior to the relapse.
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Cross section of brain

Discovery of a familial intracranial aneurysm gene

Dec. 22, 2021
By W. Todd Penberthy
No Comments
Intracranial aneurysms, outwards bulges ballooning out of an artery, are surprisingly common in middle age, with an estimated prevalence of 2% in the general population. While only a small fraction of these common aneurysms actually go on to rupture, one-fourth of these ruptured aneurysms will lead to sudden death before hospitalization.
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Brain cancer illustration

BACE1 inhibition may find new target in glioblastoma

Nov. 15, 2021
By W. Todd Penberthy
No Comments
Researchers working at Lerner Research Institute, Cleveland Clinic reported in the November 8, 2021, issue of Nature Cancer that an inhibitor of the beta-amyloid producing enzyme, BACE1, could reprogram tumor-promoting M2 macrophages to exert M1 tumor-suppressing activities in animal models of glioblastoma multiforme.
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Elderly hands holding broken brain structure

Rare APOE variant gives insight into Alzheimer's pathogenesis

Oct. 8, 2021
By W. Todd Penberthy
No Comments
Despite the identification of the APOE gene as the strongest genetic link to late-onset Alzheimer's disease (AD) since 1993 and the subsequent advances in the understanding of AD pathogenesis, the development of effective consensus-directed treatment therapies has yet to be realized.
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Brain and encephalography

Targeting late inflammation via complement system ameliorates TBI-induced epilepsy

Sep. 15, 2021
By W. Todd Penberthy
No Comments
Investigators working at Gladstone Institutes reported new insights into sleep disturbances and seizures that can be a late consequence of even mild traumatic brain injuries (TBI), and how we may one day best treat these conditions by targeting the complement pathway.
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Colorful illustration of the heart

Stressed fat cells send mitochondria to teach heart cells self-defense

Aug. 27, 2021
By W. Todd Penberthy
No Comments
In Cell Metabolism, researchers working at the University of Texas Southwestern Medical Center reported that when fat cells (adipocytes) are chronically stressed, as is characteristic of obesity, they can release small vesicle exosomes that are respiration-competent and essentially portions of mitochondria.
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RNA

lncRNA HULC linked to phenylketonuria prevention, HULC-mimetics show therapeutic promise

Aug. 13, 2021
By W. Todd Penberthy
No Comments
Sometimes highly impactful serendipitous discoveries are made when performing genetic loss-of-function studies that were initially focused on putative tumor suppressors or other hypotheses.
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Cardiovascular.png

CXCL9 levels predict future cardiac aging and vascular dysfunction

July 20, 2021
By W. Todd Penberthy
No Comments
In the July 12, 2021, issue of Nature Aging, researchers working at the Buck Institute for Research on Aging describe analysis from 1,001 immunomes of generally healthy patients correlating soluble immune biomarkers against measures of multimorbidity, immunosenescence, frailty and cardiovascular disease over 11 years of longitudinal study.
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Tau neuron illustration

LDL receptor overexpression affects tauopathy in Alzheimer's model

June 29, 2021
By W. Todd Penberthy
No Comments
Researchers report in the June 21, 2021, online issue of Neuron that overexpression of the LDL receptor can reduce ApoE to prevent tauopathy-associated neurodegeneration in mouse models.
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View All Articles by W. Todd Penberthy

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