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BioWorld - Friday, March 5, 2021
Home » Authors » W. Todd Penberthy

W. Todd Penberthy

Articles

ARTICLES

Liver and DNA

Macrophages key to liver cells relaxin'

Jan. 29, 2021
By W. Todd Penberthy
No Comments
A packaged nanoparticle that delivered a relaxin-encoding gene therapy with microRNA reduced liver fibrosis, researchers in the laboratory of Leaf Huang at the University of North Carolina, Chapel Hill, Eshelman School of Pharmacy described in the Jan. 21, 2021, issue of Nature Nanotechnology.
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Cancer cell and DNA

BCL6 degrader works via combine and conquer strategy

Nov. 24, 2020
By W. Todd Penberthy
No Comments
The BCL6 degrader BI-3802 works by inducing polymerization of its target protein, which in turn triggers the addition of ubiquitin tags on the polymerized structure and degradation by the proteasome, scientists reported in the Nov. 18, 2020, issue of Nature.
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Adenovirus cells

"Foundational" research shows early gene therapy prevents Angelman syndrome

Oct. 30, 2020
By W. Todd Penberthy
No Comments
Scientists working at the University of North Carolina, Chapel Hill reported in the Oct. 21, 2020, issue of Nature on the successful development of a one-time specific sequence-directed gene therapy approach using the combination of AAV with CRISPR technology that successfully prevented the presentation of Angelman syndrome throughout the lifetime of a mouse model.
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Lung cancer illustration

Lipid metabolism controls lung cancer metastasis, not just diseases like atherosclerosis

Sep. 30, 2020
By W. Todd Penberthy
No Comments
Researchers working at the Jackson Laboratory Cancer Center reported in the September 21, 2020, issue of Nature Immunology that breast cancer cells induced neutrophils to accumulate lipids, which were transported to metastatic tumor cells through a macropinocytosis pathway, thus fueling the metastatic potential of tumor cells with lipids.
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Stroke illustration: brain, artery, neurons

Blood substitution therapy expands therapeutic time window for stroke

Aug. 31, 2020
By W. Todd Penberthy
No Comments
New research is set to expand the therapeutic time window for stroke treatment, while also contributing to the basic research understanding that stroke pathogenesis involves much more than acute disruption of blood flow.
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Man adding piece to brain
The long and short of it

Oncogene Ras affects memory consolidation

Jan. 21, 2020
By W. Todd Penberthy
No Comments
Remember how Ras is a frequently mutated oncogene in solid tumors? Well, it turns out Ras plays a role in those memories, too. In the Jan. 13, 2020, online issue of the Proceedings of the National Academy of Sciences, scientists at the Scripps Research Institute in Juniper, Fla., reported on the discovery that Ras signals through Raf and then Rho kinase to control whether memory is short- or long-term.
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Man adding piece to brain
The long and short of it

Oncogene Ras affects memory consolidation

Jan. 17, 2020
By W. Todd Penberthy
No Comments
Remember how Ras is a frequently mutated oncogene in solid tumors? Well, it turns out Ras plays a role in those memories, too. In the Jan. 13, 2020, online issue of the Proceedings of the National Academy of Sciences, scientists at the Scripps Research Institute in Juniper, Fla., reported on the discovery that Ras signals through Raf and then Rho kinase to control whether memory is short or long-term.
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Cells lining trachea

Targetable dopamine receptor influences childhood-onset asthma

Nov. 26, 2019
By W. Todd Penberthy
No Comments
Children are more susceptible to developing allergic asthma than adults. An estimated 6 million children have allergic asthma, making asthma one of the most common long-term diseases of childhood. Asthma is potentially life-threatening, yet there is no cure, rather only management of symptoms. Progress in understanding the disease was reported in the Dec 17, 2019, issue of Immunity.
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High oxygen levels may be issue in Leigh syndrome

Aug. 16, 2019
By W. Todd Penberthy
No Comments
Birth defects in mitochondrial genes can lead to devastating pediatric disorders with death within a year of birth, and when the dysfunction is milder it can lead to various types of degenerative conditions, including neurodegeneration.
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HMP delivers insights into microbiome changes, stability

June 6, 2019
By W. Todd Penberthy
No Comments
View All Articles by W. Todd Penberthy

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