Novel Path to iPSCs: Small Molecules Only
By Anette Breindl
Researchers have managed to create induced pluripotent stem cells (iPSCs) using only small molecules, obviating the need for transformation with oncogenes that has been one limit to such cells' clinical potential to date. The creation of iPSCs in 2007 opened new pathways toward regenerative medicine, at least in principle. By reprogramming adult cells into an embryonic stem cell-like state, researchers hoped to gain a source of cells for regenerative medicine.