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    <item>
      <title>Hematopoietic stem cell research points to leukemia’s early roots</title>
      <description>
        <![CDATA[Hematopoietic stem cell research over the past century has shown that leukemia may be driven by an invisible hand of inflammation. The bone marrow and inflammation, then, may hold the keys to preventing blood cancers, according to John E. Dick’s plenary session at the 2026 Korean Society of Hematology International Conference, held March 26, 2026.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730162</guid>
      <pubDate>Thu, 02 Apr 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730162-hematopoietic-stem-cell-research-points-to-leukemias-early-roots</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Cancer-cells.webp?t=1588880225" type="image/png" medium="image" fileSize="554020">
        <media:title type="plain">Cancer and blood cells</media:title>
      </media:content>
    </item>
    <item>
      <title>Small-molecule TREM2 agonist advances to treat Alzheimer’s</title>
      <description>
        <![CDATA[Microglia play a central role in the neuroinflammation associated with Alzheimer’s disease (AD). At the 20th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD), scientists focused on TREM2, a microglial receptor that regulates immune responses, exploring new ways to address neuroinflammation.&nbsp;]]>
      </description>
      <guid>http://www.bioworld.com/articles/730054</guid>
      <pubDate>Fri, 27 Mar 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730054-small-molecule-trem2-agonist-advances-to-treat-alzheimers</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Alzheimers-disease-vs-healthy-brain-neurons.webp?t=1774539087" type="image/jpeg" medium="image" fileSize="461468">
        <media:title type="plain">Comparison of neurons in a healthy brain and nerve cells in neurodegenerative disease with amyloid plaques</media:title>
      </media:content>
    </item>
    <item>
      <title>Somatic genomics pioneer Quotient signs $2.2B IBD deal with Merck</title>
      <description>
        <![CDATA[For a company founded only four years ago, Quotient Therapeutics Inc. entered its third major deal, this time with Merck & Co. Inc. to find novel drug targets for inflammatory bowel disease (IBD) using its somatic genomics platform technology.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729823</guid>
      <pubDate>Tue, 24 Mar 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729823-somatic-genomics-pioneer-quotient-signs-22b-ibd-deal-with-merck</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/GI-system-with-DNA-scientific-background.webp?t=1774388477" type="image/jpeg" medium="image" fileSize="500606">
        <media:title type="plain">Gastrointestinal system with DNA, scientific background</media:title>
      </media:content>
    </item>
    <item>
      <title>Emerging therapeutic strategies for Parkinson’s at ADPD 2026</title>
      <description>
        <![CDATA[Parkinson’s disease (PD) involves the progressive loss of dopaminergic neurons, particularly in the substantia nigra. This neurodegeneration is linked to the abnormal accumulation of α-synuclein, a protein that forms toxic aggregates and spreads between cells, damaging them. At the 20th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD), held from March 17 to 21, 2026, in Copenhagen, several strategies were presented that aim to modify the course of the disease and offer real alternatives to purely symptomatic treatments.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729789</guid>
      <pubDate>Mon, 23 Mar 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729789-emerging-therapeutic-strategies-for-parkinsons-at-adpd-2026</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Parkinsons-disease-PD-neuron-hands.webp?t=1774276432" type="image/jpeg" medium="image" fileSize="923725">
        <media:title type="plain">Art concept for Parkinson's disease</media:title>
      </media:content>
    </item>
    <item>
      <title>Lab-grown pig implant paves way to treat esophageal atresia </title>
      <description>
        <![CDATA[Scientists at Great Ormond Street Children’s Hospital in London have reported a new advance for tissue engineered grafts in a lab-grown esophagus that has sufficient muscle regeneration to coordinate peristalsis, enabling the recipient to swallow. The aim is to generate grafts that can be used to treat babies born with the rare congenital condition esophageal atresia, in which the esophagus fails to connect to the stomach, usually forming a close pouch instead.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729759</guid>
      <pubDate>Fri, 20 Mar 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729759-lab-grown-pig-implant-paves-way-to-treat-esophageal-atresia</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Pediatric/Infant-esophagus-and-stomach.webp?t=1774039148" type="image/jpeg" medium="image" fileSize="406415">
        <media:title type="plain">Infant esophagus and stomach</media:title>
      </media:content>
    </item>
    <item>
      <title>ADPD 2026: Three inflection points to target Alzheimer’s disease</title>
      <description>
        <![CDATA[A new way of understanding Alzheimer’s disease, based on biological inflection points that mark decisive moments in the progression of the disorder, could change how new drugs are developed to achieve more effective therapies. This new perspective could rethink strategies that depend not so much on the target itself, but on the precise moment at which it is addressed.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729852</guid>
      <pubDate>Fri, 20 Mar 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729852-adpd-2026-three-inflection-points-to-target-alzheimers-disease</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Alzheimers-disease-neurons-illustration.webp?t=1773932679" type="image/jpeg" medium="image" fileSize="319204">
        <media:title type="plain">Illustration of Alzheimer's disease in the brain</media:title>
      </media:content>
    </item>
    <item>
      <title>ADPD 2026: Can we prevent dementia? Scientists quantify it</title>
      <description>
        <![CDATA[Neurodegenerative disease and cognitive decline cannot be explained by a single process. Beta-amyloid plaques, hyperphosphorylated tau, alpha-synuclein, activated microglia and astrocytes, altered receptors such as TREM2, mitochondrial dysfunction, epigenetic changes and cerebrovascular alterations all seem to contribute to the development of dementia in Alzheimer’s disease (AD). While scientists attempt to address each of these elements, prevention is growing as a primary goal.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729688</guid>
      <pubDate>Wed, 18 Mar 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729688-adpd-2026-can-we-prevent-dementia-scientists-quantify-it</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Neurology-brain-MRI-imaging.webp?t=1773844698" type="image/jpeg" medium="image" fileSize="977275">
        <media:title type="plain">MRI image brain on black background</media:title>
      </media:content>
    </item>
    <item>
      <title>Digital model simulates the first fully functioning living cell</title>
      <description>
        <![CDATA[Entering a cell and watching its entire inner machinery at work, how DNA is copied, how proteins are assembled, or how it splits in two, has been, for decades, an impossible dream. Now, scientists at the University of Illinois have recreated everything that happens inside a cell at molecular scale in an unprecedented computational model. Syn3A is the first 4D digital cell, capable of combining time and space to simultaneously represent all the internal processes that drive the life cycle of a minimal prokaryotic organism.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729644</guid>
      <pubDate>Mon, 16 Mar 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729644-digital-model-simulates-the-first-fully-functioning-living-cell</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Digital-Cell-half-half-ribopart-dnabd-ptns-rnas-03-13-26.webp?t=1773672243" type="image/jpeg" medium="image" fileSize="1101579">
        <media:title type="plain">A simulated cell in the early stages of division.</media:title>
        <media:description type="plain">A simulated cell in the early stages of division. Left half shows membrane (green cubes) and ribosomes (yellow/purple) interwoven through in the cell’s chromosome (red). Right side shows all the proteins (grey) and RNA (orange) inside the cell with a small cutaway to show a second copy of the cell’s chromosome (blue). Credit: Graphic by Zane Thornburg. From Thornburg, Z.R. et al. Cell 2026, March 9. doi: 10.1016/j.cell.2026.02.009. Licensed under CC BY 4.0.</media:description>
      </media:content>
    </item>
    <item>
      <title>Precision psychiatry beyond, or before, biomarkers</title>
      <description>
        <![CDATA[There is broad agreement that psychiatric diagnoses in their current form are not reflective of any underlying biology, and that this is one of the things hampering psychiatric drug development. “We are still fully reliant on descriptive diagnoses that yield heterogeneous patient cohorts,” Steve Hyman told the audience at the European Congress of Neuropsychopharmacology (ECNP) Roadmap Meeting on Precision Psychiatry in Amsterdam in January.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729492</guid>
      <pubDate>Fri, 13 Mar 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729492-precision-psychiatry-beyond-or-before-biomarkers</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Neurology-brain-target-bullseye-precision-magnifying-glass.webp?t=1773432347" type="image/jpeg" medium="image" fileSize="305403">
        <media:title type="plain">Art concept for targeting the brain</media:title>
      </media:content>
    </item>
    <item>
      <title>Resident macrophages reveal the immune side of glaucoma</title>
      <description>
        <![CDATA[Scientists at Duke University have uncovered how macrophages help maintain intraocular pressure and have found that a specific type, resident macrophages, is essential for proper drainage of intraocular fluid. When these cells are removed, drainage becomes impaired and intraocular pressure rises, contributing to the development of glaucoma.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729662</guid>
      <pubDate>Thu, 12 Mar 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729662-resident-macrophages-reveal-the-immune-side-of-glaucoma</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Ocular/Aqueous-humor-drainage-from-the-eye.webp?t=1773240930" type="image/jpeg" medium="image" fileSize="611343">
        <media:title type="plain">Illustration showing aqueous humor drainage from the eye</media:title>
        <media:description type="plain">Aqueous humor drainage from the eye regulates intraocular pressure. It passes through the trabeculum and Schlemm’s canal, preventing glaucoma.</media:description>
      </media:content>
    </item>
    <item>
      <title>Three pediatric brain cancer types share a pineal gland origin</title>
      <description>
        <![CDATA[Similarities among three pediatric brain tumors that arise in different structures of the CNS – pineoblastoma, retinoblastoma and Group 3 medulloblastoma – have been linked to their shared origin during pineal gland development. Scientists at St. Jude Children’s Research Hospital have identified the molecular signatures that drive these tumors from pinealocyte progenitor cells that conserve a common differentiation program, providing a shared therapeutic target for these three cancer types.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729642</guid>
      <pubDate>Wed, 11 Mar 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729642-three-pediatric-brain-cancer-types-share-a-pineal-gland-origin</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Brain-Pineal-gland.webp?t=1773154224" type="image/jpeg" medium="image" fileSize="214692">
        <media:title type="plain">Illustration of brain cross-section showing the pineal gland</media:title>
      </media:content>
    </item>
    <item>
      <title>Uterus transplants show how immune cells shape pregnancy outcomes</title>
      <description>
        <![CDATA[A study involving a small cohort of women who have received womb transplants has cast fresh light on how the immune system shapes pregnancy outcomes, opening up new avenues of research into implantation failure, preeclampsia and preterm birth.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729466</guid>
      <pubDate>Wed, 11 Mar 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729466-uterus-transplants-show-how-immune-cells-shape-pregnancy-outcomes</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Sexual-health/Pregnancy.webp?t=1608060195" type="image/png" medium="image" fileSize="541206">
        <media:title type="plain">Pregnancy</media:title>
      </media:content>
    </item>
    <item>
      <title>Synthetic peptide and CAR-A each clear amyloid-β in Alzheimer’s</title>
      <description>
        <![CDATA[If one could sweep the brain clean and send the toxic substances that drive neurodegeneration to the recycling bin, perhaps one could treat Alzheimer’s disease. Researchers at the Chinese Academy of Sciences propose a new therapeutic strategy that uses synthetic peptides that bind to amyloid-β (Aβ) and direct it toward lysosomes. In addition, researchers at the Washington University School of Medicine in St. Louis have genetically modified astrocytes in vivo to express chimeric antigen receptors (CARs) that recognize and phagocytose Aβ plaques.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729577</guid>
      <pubDate>Tue, 10 Mar 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729577-synthetic-peptide-and-car-a-each-clear-amyloid-in-alzheimers</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Amyloid-plaques-nerve-cells-illustration.webp?t=1773070036" type="image/jpeg" medium="image" fileSize="879449">
        <media:title type="plain">Illustration of amyloid plaques on neurons</media:title>
      </media:content>
    </item>
    <item>
      <title>Study ties gut and saliva microbes to peanut allergy defense</title>
      <description>
        <![CDATA[In an article published in <em>Cell Host & Microbe</em> on March 3, 2026, researchers at McMaster University in Canada and at the Hospital Universitario de La Princesa in Spain have shed some light on the impact of microbiota on peanut-driven allergy and anaphylaxis.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729525</guid>
      <pubDate>Mon, 09 Mar 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729525-study-ties-gut-and-saliva-microbes-to-peanut-allergy-defense</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Immune/Peanut-allergy-illustration.webp?t=1654810785" type="image/png" medium="image" fileSize="564418">
        <media:title type="plain">Peanut allergy illustration</media:title>
      </media:content>
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    <item>
      <title>Brain’s hidden tau-clearing pathway uncovered</title>
      <description>
        <![CDATA[Researchers at INSERM and collaborators have identified hypothalamic tanycytes as mediators of tau clearance and shown that their structural and genetic disruption may drive Alzheimer’s disease pathology.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729506</guid>
      <pubDate>Fri, 06 Mar 2026 11:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729506-brains-hidden-tau-clearing-pathway-uncovered</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/INSERM-Tanycytes-capturing-Tau-protein-Vincent-Prevot-03-05-26.webp?t=1772729230" type="image/jpeg" medium="image" fileSize="528563">
        <media:title type="plain">Tanycytes in green capturing tau protein in red. </media:title>
        <media:description type="plain">Tanycytes in green capturing tau protein in red. Credit: Vincent Prévot, INSERM</media:description>
      </media:content>
    </item>
    <item>
      <title>Study: Weight regain after GLP-1s plateaus below starting weight  </title>
      <description>
        <![CDATA[A new study has reinforced that GLP-1 receptor agonists are unlikely to produce durable weight loss, but indicates that rather than returning to the starting weight, individual weight gain will plateau at 75.5% of the weight lost.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729342</guid>
      <pubDate>Thu, 05 Mar 2026 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729342-study-weight-regain-after-glp-1s-plateaus-below-starting-weight</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Obesity/Bathroom-scale-and-injector-pens.webp?t=1772744223" type="image/jpeg" medium="image" fileSize="929900">
        <media:title type="plain">Bathroom scale and injector pens</media:title>
      </media:content>
    </item>
    <item>
      <title>Alternative splicing strategy shows promise for Rett syndrome</title>
      <description>
        <![CDATA[A therapeutic strategy based on alternative splicing of the MECP2 gene could restore protein levels in Rett syndrome, a neurological disorder caused by mutations in that gene. Scientists at Baylor College of Medicine have successfully tested this approach both in vitro in neurons from Rett patients that produce some functional protein, correcting the altered gene expression and improving neuronal functions, and in vivo in mice.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729322</guid>
      <pubDate>Wed, 04 Mar 2026 07:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729322-alternative-splicing-strategy-shows-promise-for-rett-syndrome</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/X-Chromosomes-with-DNA-genetic-mutations.webp?t=1772654484" type="image/jpeg" medium="image" fileSize="473365">
        <media:title type="plain">Illustration of X chromosomes with DNA</media:title>
      </media:content>
    </item>
    <item>
      <title>Digital pathology speeds diagnostics, but tends to take shortcuts to do so</title>
      <description>
        <![CDATA[Computational pathology, which assesses molecular-level features of diseases directly from tissue images (rather than testing the tissue via methods such as staining or sequencing) is making rapid strides.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729148</guid>
      <pubDate>Tue, 03 Mar 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729148-digital-pathology-speeds-diagnostics-but-tends-to-take-shortcuts-to-do-so</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Computational-Pathology-Fayyaz-Minhas-University-of-Warwick.webp?t=1772555477" type="image/jpeg" medium="image" fileSize="857272">
        <media:title type="plain">Whole slide image illustrating the detection of key histological structures such as glands and cells. </media:title>
        <media:description type="plain">Whole slide image illustrating the detection of key histological structures such as glands and cells. Credit: Fayyaz Minhas/University of Warwick</media:description>
      </media:content>
    </item>
    <item>
      <title>HITting solid tumors with a closer look and a stronger CAR T cell</title>
      <description>
        <![CDATA[CAR T cells have been groundbreaking for the treatment of B-cell cancers. But 8 years after Kymriah (tisagenlecleucel, Novartis AG) became the first CAR T-cell therapy to be approved, there are no CAR Ts approved for solid tumors.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729130</guid>
      <pubDate>Mon, 02 Mar 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729130-hitting-solid-tumors-with-a-closer-look-and-a-stronger-car-t-cell</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/CAR-T-cell.webp?t=1671545711" type="image/png" medium="image" fileSize="497911">
        <media:title type="plain">CAR T cell attacking cancer cells</media:title>
        <media:description type="plain">Illustration of CAR T cell attacking cancer cells. 
Credit: La Jolla Institute
</media:description>
      </media:content>
    </item>
    <item>
      <title>CROI 2026: Science and funding cuts reverse decades of progress against HIV</title>
      <description>
        <![CDATA[The massive cuts to science, global health, and HIV programs that unfolded in 2025 triggered a crisis with worldwide repercussions. The dissolution of USAID, the shutdown of PEPFAR, and the suspension of thousands of NIH research projects led to an immediate collapse of essential services, from HIV prevention to access to treatment. At the 33rd Conference on Retroviruses and Opportunistic Infections (CROI) held Feb. 22-25, 2026, in Denver, scientists, activists, and health professionals presented data illustrating the scale of the damage and warned of a historic setback in the global HIV response.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729112</guid>
      <pubDate>Fri, 27 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729112-croi-2026-science-and-funding-cuts-reverse-decades-of-progress-against-hiv</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/HIV-with-graphs-numbers-and-map.webp?t=1772205424" type="image/jpeg" medium="image" fileSize="1068230">
        <media:title type="plain">HIV with graphs, numbers and map</media:title>
      </media:content>
    </item>
    <item>
      <title>CROI 2026 highlights depression and cognitive vulnerability in HIV</title>
      <description>
        <![CDATA[The effects of aging pose an additional challenge for people with HIV due to the neurological and psychological consequences that persist despite antiretroviral therapy. At the Conference on Retroviruses and Opportunistic Infections (CROI) held Feb. 22-25, 2026, in Denver, the scientific community examined how the virus affects the brain, how the reservoir is established in the CNS, and which genetic, immunological or treatment-related factors influence cognitive health.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729051</guid>
      <pubDate>Thu, 26 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729051-croi-2026-highlights-depression-and-cognitive-vulnerability-in-hiv</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Depression-concept-with-human-broken-brain-and-heavy-rain.webp?t=1772119734" type="image/jpeg" medium="image" fileSize="692951">
        <media:title type="plain">Depression concept with human, broken brain and heavy rain</media:title>
      </media:content>
    </item>
    <item>
      <title>CROI 2026: Neurodegeneration, the challenge of aging with HIV  </title>
      <description>
        <![CDATA[Antiretroviral therapies against HIV have been in use for more than 30 years and have enabled people living with HIV to maintain undetectable viral levels. Many of them are aging in good health. However, others present symptoms of cognitive decline. HIV can reach the brain and establish a reservoir there. Yet, it is still unknown what this reservoir is like, which cells are affected, and which comorbidities are typical of aging or are associated with the virus.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729031</guid>
      <pubDate>Wed, 25 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729031-croi-2026-neurodegeneration-the-challenge-of-aging-with-hiv</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Brain-and-virus-with-chromosome.webp?t=1772031510" type="image/jpeg" medium="image" fileSize="1307640">
        <media:title type="plain">Brain and virus with chromosome</media:title>
      </media:content>
    </item>
    <item>
      <title>SLAMF6 is suppressor of T-cell cancer immunity</title>
      <description>
        <![CDATA[SLAMF6 is an immune cell receptor whose function was not clear. Does it activate or inhibit cells? The results so far have been contradictory. Now, scientists at the Institut de Recherches Cliniques de Montréal have unveiled evidence that SLAMF6, a protein of the SLAM family that binds to copies of itself, is regulated by interactions between molecules of the same receptor within the same cell.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729174</guid>
      <pubDate>Thu, 19 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729174-slamf6-is-suppressor-of-t-cell-cancer-immunity</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/NIH-NIAID-T-Lymphocyte.webp?t=1715611906" type="image/png" medium="image" fileSize="958813">
        <media:title type="plain">Colorized scanning electron micrograph of a T lymphocyte.</media:title>
        <media:description type="plain">T lymphocyte. Credit: National Institute of Allergy and Infectious Diseases, NIH
</media:description>
      </media:content>
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    <item>
      <title>SCAN is core circuit affected in Parkinson’s disease</title>
      <description>
        <![CDATA[Parkinson’s disease is a neurodegenerative disorder that affects movement, and tremor is one of its signatures. But it is a much more wide-ranging disorder, and patients experience problems with cognitive and emotional processes as well. SCAN, the somato-cognitive action network identified in 2023, could reshape the definition of PD. Treating this circuit can improve outcomes.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729173</guid>
      <pubDate>Wed, 18 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729173-scan-is-core-circuit-affected-in-parkinsons-disease</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/WashU-Parkinsons-brain-SCAN-02-06-26.webp?t=1770392187" type="image/jpeg" medium="image" fileSize="299998">
        <media:title type="plain">Illustration of SCAN in Parkinson’s vs healthy subcortex</media:title>
        <media:description type="plain">The brain network that links thinking with movement, called SCAN, has been identified in a new study as the neurological basis of Parkinson’s disease. An experimental therapy that targeted this network more than doubled symptom improvement in a small group of patients with Parkinson’s, which is characterized by hyperconnectivity (left side of illustration) between SCAN and the brain’s subcortex. Credit: Sara Moser, WashU Medicine.</media:description>
      </media:content>
    </item>
    <item>
      <title>Human organoid mimics cancer-induced cachexia </title>
      <description>
        <![CDATA[The variety of organoids that can be developed in vitro is enabling major advances. Depending on the type of tissues and the research goals, these small 3D cell-based structures that mimic real tissue offer certain advantages over animal models. Scientists at the University of Padova in Italy have created human neuromuscular organoids to reproduce cancer-induced muscle cachexia, a condition that murine models do not accurately replicate.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728897</guid>
      <pubDate>Tue, 17 Feb 2026 11:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728897-human-organoid-mimics-cancer-induced-cachexia</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/organoids-petri-dish.webp?t=1709922088" type="image/jpeg" medium="image" fileSize="115495">
        <media:title type="plain">3D illustration of organoid models in a petri dish</media:title>
        <media:description type="plain">3D illustration of organoid models in a petri dish</media:description>
      </media:content>
    </item>
    <item>
      <title>Tumor, immune and neural cells are involved in cancer cachexia</title>
      <description>
        <![CDATA[A circuit formed by tumor, immune and nervous systems triggers cancer cachexia and anorexia, the excessive loss of weight, muscle and fat experienced in some cancer types. A new study is the first showing these three actors of a triangle interaction that initiates and feeds the process.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729009</guid>
      <pubDate>Fri, 13 Feb 2026 11:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729009-tumor-immune-and-neural-cells-are-involved-in-cancer-cachexia</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Cachexia-muscle-atrophy.webp?t=1770913107" type="image/jpeg" medium="image" fileSize="662505">
        <media:title type="plain">Illustration of normal muscle compared to muscle atrophy in cancer cachexia or anorexia</media:title>
      </media:content>
    </item>
    <item>
      <title>Targeting cholesterol deposition could treat lymphedema</title>
      <description>
        <![CDATA[The malfunction of lymphatic drainage that occurs in lymphedema leads to excessive cholesterol accumulation in the affected skin and lymphatic vessels, causing inflammation and fibrosis. However, surgery and the chemical reduction of accumulated cholesterol with cyclodextrin reduce inflammation and regenerate lymphatic vessels. Cholesterol is a potential therapeutic target for treating lymphedema, according to this study published on Feb. 11, 2026, in <em>Nature</em> by Veronique Angeli and her colleagues.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728782</guid>
      <pubDate>Wed, 11 Feb 2026 11:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728782-targeting-cholesterol-deposition-could-treat-lymphedema</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Lymphatic-system-human-body.webp?t=1770825974" type="image/jpeg" medium="image" fileSize="493389">
        <media:title type="plain">Illustration of human anatomy showing lymphatic system</media:title>
      </media:content>
    </item>
    <item>
      <title>ATF6 shapes liver cancer: from ER stress to inflammation</title>
      <description>
        <![CDATA[Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, representing approximately 75-85% of all cases. Often considered preventable, primary liver cancer ranks as the sixth most frequently diagnosed cancer and the third leading cause of cancer deaths worldwide. Through a multi-institutional effort, researchers have identified activated ATF6α as a driver of HCC that suppresses immune defenses, predicts response to immune checkpoint therapy, and represents a potential target for intervention.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728764</guid>
      <pubDate>Tue, 10 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728764-atf6-shapes-liver-cancer-from-er-stress-to-inflammation</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Cancer-hepatocellular-carcinoma-HCC-liver.webp?t=1754576483" type="image/png" medium="image" fileSize="1872447">
        <media:title type="plain">Photomicrograph of hepatocellular carcinoma</media:title>
        <media:description type="plain">Photomicrograph of hepatocellular carcinoma.</media:description>
      </media:content>
    </item>
    <item>
      <title>Three-stop loop is behind post-myocardial infarction responses</title>
      <description>
        <![CDATA[The neural and neuroimmune mechanisms behind myocardial infarction-triggered cardiac events, immune responses and activation of the nervous system remain largely unexplored. The heart and the brain talk to each other in what is known as cardioception. This communication between the two organs is orchestrated through neurons of the vagus nerve or the dorsal root ganglia, among others. Researchers from the University of California, San Diego have now shown that the dynamics of these interactions may play a crucial role in modulating inflammation, repair and cardiac functioning.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728738</guid>
      <pubDate>Mon, 09 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728738-three-stop-loop-is-behind-post-myocardial-infarction-responses</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/heart-brain-axis-talk.webp?t=1770651189" type="image/jpeg" medium="image" fileSize="182143">
        <media:title type="plain">Illustration of heart and brain communicating</media:title>
      </media:content>
    </item>
    <item>
      <title>New push to increase investor interest in UK life sciences research</title>
      <description>
        <![CDATA[The U.K.’s main research funding agency is looking to put more public money into proof of concept and pre-seed funding of putative university spinouts, to make them more investible and improve relations between academics and investors. The move by UK Research and Innovation, which in 2026 will allocate £9.22 billion (US$12.58 billion) of taxpayer money across all fields of research, is in response to a government edict that the agency prioritizes outputs over inputs.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728695</guid>
      <pubDate>Wed, 04 Feb 2026 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728695-new-push-to-increase-investor-interest-in-uk-life-sciences-research</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Purple-tinted-test-tubes-and-dropper.webp?t=1714427628" type="image/jpeg" medium="image" fileSize="148638">
        <media:title type="plain">Purple-tinted test tubes and dropper</media:title>
      </media:content>
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