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    <title>Checkpoint blockers</title>
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      <title>B cells get in on the immune checkpoint fray</title>
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        <![CDATA[B cells that expressed a constellation of checkpoint inhibitors could be spurred into antitumor activity by deleting or blocking the checkpoint molecule T-cell immunoglobulin and mucin domain 1 (TIM-1). The findings, which were published online in <em>Nature</em> on June 21, 2023, suggest ways to bring B cells into the antitumor fight. More broadly, Lloyd Bod told <em>BioWorld</em>, his laboratory aims to “break the dogma that B cells only produce antibodies.”]]>
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      <guid>http://www.bioworld.com/articles/698431</guid>
      <pubDate>Wed, 28 Jun 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/698431-b-cells-get-in-on-the-immune-checkpoint-fray</link>
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      <title>Tissue-resident memory cells in lung may drive lung cancer in smokers</title>
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        <![CDATA[Differences in the immune reactions between smokers and nonsmokers may explain why only 20% of patients with lung cancer respond to immunotherapy treatment. Understanding these differences in the evolution of lung cancer between smokers and nonsmokers could be the key to unlocking new treatments.]]>
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      <guid>http://www.bioworld.com/articles/696287</guid>
      <pubDate>Fri, 21 Apr 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/696287-tissue-resident-memory-cells-in-lung-may-drive-lung-cancer-in-smokers</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/WEHI-TRM-Smoker-Lung-Tissue.webp?t=1706123739" type="image/png" medium="image" fileSize="1684771">
        <media:title type="plain">Tissue-resident memory T cells in the lung of smoker patients</media:title>
        <media:description type="plain">Immunofluorescence shows the presence of tissue-resident memory T cells (TRMs) in the lung of smoker patients. The TRM cells are represented in aqua and red, the lung airways are depicted in pink, and the cell nuclei are depicted in dark blue. Credit: WEHI researchers</media:description>
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      <title>For gliomas, hypermutated does not mean sensitive to checkpoint blockade</title>
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        <![CDATA[The largest study to date on hypermutated gliomas has delivered new insights into their origin, as well as their response to several different treatments. Specifically, even though they are hypermutated, such tumors are unlikely to respond to PD-1 blockers.]]>
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      <guid>http://www.bioworld.com/articles/434497</guid>
      <pubDate>Fri, 17 Apr 2020 13:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/434497-for-gliomas-hypermutated-does-not-mean-sensitive-to-checkpoint-blockade</link>
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        <media:title type="plain">Keith Ligon, chief of neuropathology, Brigham and Women's Hospital</media:title>
        <media:description type="plain">Keith Ligon, chief of neuropathology at Brigham
and Women’s Hospital. Credit: Dana-Farber Cancer Institute</media:description>
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    <item>
      <title>For gliomas, hypermutated does not mean sensitive to checkpoint blockade</title>
      <description>
        <![CDATA[The largest study to date on hypermutated gliomas has delivered new insights into their origin, as well as their response to several different treatments. Specifically, even though they are hypermutated, such tumors are unlikely to respond to PD-1 blockers.]]>
      </description>
      <guid>http://www.bioworld.com/articles/434436</guid>
      <pubDate>Wed, 15 Apr 2020 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/434436-for-gliomas-hypermutated-does-not-mean-sensitive-to-checkpoint-blockade</link>
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        <media:title type="plain">Keith Ligon, chief of neuropathology, Brigham and Women's Hospital</media:title>
        <media:description type="plain">Keith Ligon, chief of neuropathology at Brigham
and Women’s Hospital. Credit: Dana-Farber Cancer Institute</media:description>
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