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    <title>Omics</title>
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    <item>
      <title>New E3 ligase atlas aims to expand degrader drug discovery</title>
      <description>
        <![CDATA[An international team led by Australia’s Walter and Eliza Hall Institute (WEHI) has created the first authoritative atlas for a class of enzymes that regulate almost every cellular process in the human body. The new atlas identifies 672 high-confidence E3 ligases and provides a new reference framework for disease biology and targeted protein degradation research.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729853</guid>
      <pubDate>Tue, 24 Mar 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729853-new-e3-ligase-atlas-aims-to-expand-degrader-drug-discovery</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/WEHI-E3ome-Atlas-03-24-2026.webp?t=1774367730" type="image/jpeg" medium="image" fileSize="297208">
        <media:title type="plain">Illustration of the E3-ome atlas</media:title>
        <media:description type="plain">The organization and distribution of the landmark “E3-ome” atlas. The new compendium has resolved more than 18 years of inconsistencies within the scientific community. Credit: WEHI</media:description>
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    </item>
    <item>
      <title>‘Most complete’ map of oral microbiome enables links to systemic disease</title>
      <description>
        <![CDATA[South Korean researchers led by Lee In-suk of Yonsei University have reported the most complete oral microbiome catalog to date, with more than 72,000 genomes. Detailed in <em>Cell Host & Microbe</em> on Nov. 12, 2025, the database is expected to serve as a universal platform for academia and enable “precision microbiome medicine” for the industry, Lee told <em>BioWorld.</em>]]>
      </description>
      <guid>http://www.bioworld.com/articles/726351</guid>
      <pubDate>Tue, 18 Nov 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726351-most-complete-map-of-oral-microbiome-enables-links-to-systemic-disease</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2020/Nov-2020/Science-microbiome-11-5.webp?t=1604592414" type="image/png" medium="image" fileSize="553641">
        <media:title type="plain">Microbiome illustration</media:title>
        <media:description type="plain">Credit: Darryl Leja, NHGRI</media:description>
      </media:content>
    </item>
    <item>
      <title>‘Most complete’ map of oral microbiome enables links to systemic disease</title>
      <description>
        <![CDATA[South Korean researchers led by Lee In-suk of Yonsei University have reported the most complete oral microbiome catalog to date, with more than 72,000 genomes. Detailed in <em>Cell Host & Microbe</em> on Nov. 12, 2025, the database is expected to serve as a universal platform for academia and enable “precision microbiome medicine” for the industry, Lee told <em>BioWorld.</em>]]>
      </description>
      <guid>http://www.bioworld.com/articles/726031</guid>
      <pubDate>Thu, 13 Nov 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726031-most-complete-map-of-oral-microbiome-enables-links-to-systemic-disease</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2020/Nov-2020/Science-microbiome-11-5.webp?t=1604592414" type="image/png" medium="image" fileSize="553641">
        <media:title type="plain">Microbiome illustration</media:title>
        <media:description type="plain">Credit: Darryl Leja, NHGRI</media:description>
      </media:content>
    </item>
    <item>
      <title>Genetic code governing how mutations affect mRNA uncovered</title>
      <description>
        <![CDATA[Researchers at Monash University in Melbourne, Australia, have uncovered the hidden code governing how genetic mutations affect RNA splicing and result in disease. The researchers were able to identify the specific mutations that cause changes in RNA splicing, Sureshkumar Balasubramanian, the lead researcher at Monash University’s School of Biological Sciences, told <em>BioWorld</em>.]]>
      </description>
      <guid>http://www.bioworld.com/articles/725770</guid>
      <pubDate>Thu, 30 Oct 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/725770-genetic-code-governing-how-mutations-affect-mrna-uncovered</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Rna-protein-3D-illustration.webp?t=1733934965" type="image/jpeg" medium="image" fileSize="350273">
        <media:title type="plain">Art concept for RNA and protein</media:title>
      </media:content>
    </item>
    <item>
      <title>Genetic code governing how mutations affect mRNA uncovered</title>
      <description>
        <![CDATA[Researchers at Monash University in Melbourne, Australia, have uncovered the hidden code governing how genetic mutations affect RNA splicing and result in disease. The researchers were able to identify the specific mutations that cause changes in RNA splicing, Sureshkumar Balasubramanian, the lead researcher at Monash University’s School of Biological Sciences, told <em>BioWorld</em>.]]>
      </description>
      <guid>http://www.bioworld.com/articles/725624</guid>
      <pubDate>Tue, 28 Oct 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/725624-genetic-code-governing-how-mutations-affect-mrna-uncovered</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Rna-protein-3D-illustration.webp?t=1733934965" type="image/jpeg" medium="image" fileSize="350273">
        <media:title type="plain">Art concept for RNA and protein</media:title>
      </media:content>
    </item>
    <item>
      <title>Multiomics study identifies 18 potential MS targets, opening paths to drug discovery and repurposing</title>
      <description>
        <![CDATA[Multiple sclerosis (MS) is an immune-mediated inflammatory disease characterized by demyelination and degeneration in the central nervous system. ]]>
      </description>
      <guid>http://www.bioworld.com/articles/721992</guid>
      <pubDate>Wed, 09 Jul 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/721992-multiomics-study-identifies-18-potential-ms-targets-opening-paths-to-drug-discovery-and-repurposing</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Demyelination-of-a-neuron.webp?t=1687357719" type="image/jpeg" medium="image" fileSize="237601">
        <media:title type="plain">Demyelination of a neuron</media:title>
      </media:content>
    </item>
    <item>
      <title>From maps to gene therapies, who’s who in cardiovascular disease</title>
      <description>
        <![CDATA[Cellular atlases and omics studies, such as genomics, transcriptomics and proteomics, have become key tools for identifying the diversity of all the elements that make up the cardiovascular system. These approaches help scientists understand how cells, genes and molecules function and interact in both healthy and diseased conditions, revealing critical points where targeted interventions could not only relieve symptoms but potentially reverse the underlying pathology at its origin.]]>
      </description>
      <guid>http://www.bioworld.com/articles/721861</guid>
      <pubDate>Tue, 08 Jul 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/721861-from-maps-to-gene-therapies-whos-who-in-cardiovascular-disease</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Cardiology-genomics-genetics-illustration.webp?t=1751985662" type="image/jpeg" medium="image" fileSize="693008">
        <media:title type="plain">Illustration of heart analysis for DNA and drug impacts</media:title>
      </media:content>
    </item>
    <item>
      <title>Germline variants’ impact on pan-cancer proteome</title>
      <description>
        <![CDATA[A large-scale study has revealed the impact of germline variants on proteins in 10 cancer types. Scientists from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) conducted a precision proteogenomic analysis in a pan-cancer study with data from 1,064 patients, identifying tumor heterogeneity and tumorigenesis associated with heritable genetic alterations.]]>
      </description>
      <guid>http://www.bioworld.com/articles/719726</guid>
      <pubDate>Fri, 25 Apr 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/719726-germline-variants-impact-on-pan-cancer-proteome</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Biology-cell-division-illustration.webp?t=1745335410" type="image/jpeg" medium="image" fileSize="344793">
        <media:title type="plain">Illustration of cell dividing</media:title>
      </media:content>
    </item>
    <item>
      <title>Germline variants’ impact on pan-cancer proteome</title>
      <description>
        <![CDATA[A large-scale study has revealed the impact of germline variants on proteins in 10 cancer types. Scientists from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) conducted a precision proteogenomic analysis in a pan-cancer study with data from 1,064 patients, identifying tumor heterogeneity and tumorigenesis associated with heritable genetic alterations. The results provide a broad view of cancer risk that could be useful for patient stratification and the design of prevention strategies.]]>
      </description>
      <guid>http://www.bioworld.com/articles/719433</guid>
      <pubDate>Tue, 22 Apr 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/719433-germline-variants-impact-on-pan-cancer-proteome</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Biology-cell-division-illustration.webp?t=1745335410" type="image/jpeg" medium="image" fileSize="344793">
        <media:title type="plain">Illustration of cell dividing</media:title>
      </media:content>
    </item>
    <item>
      <title>First atlas of the endometrium with polycystic ovary syndrome</title>
      <description>
        <![CDATA[Although the causes of polycystic ovary syndrome (PCOS) are unclear, researchers know this condition leads to endometrial dysfunction in women who have hormonal imbalances, and insulin resistance. Now, a study led by scientists at the Karolinska Institutet in Sweden has revealed the cellular and genetic differences that distinguish this disorder in the first atlas of the human endometrium during the proliferative phase of the menstrual cycle.]]>
      </description>
      <guid>http://www.bioworld.com/articles/718932</guid>
      <pubDate>Fri, 04 Apr 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/718932-first-atlas-of-the-endometrium-with-polycystic-ovary-syndrome</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-structure/Gynecology-PCOS-Polycystic-ovary-syndrome.webp?t=1743779083" type="image/jpeg" medium="image" fileSize="190345">
        <media:title type="plain">Illustration of female reproductive system with polycystic ovary</media:title>
      </media:content>
    </item>
    <item>
      <title>AI-based spatial omics unveils molecular talks in tumors</title>
      <description>
        <![CDATA[The three-dimensional analysis of cell types and their locations by spatial transcriptomics provides key information of their interactions within tissues or organs. Based on this technology, scientists at the Wellcome Sanger Institute have developed an AI tool called Nichecompass, which shows a comprehensive view of the cancer microenvironments, the different cells, their locations, and how they communicate with each other through different molecules inside the tumor.]]>
      </description>
      <guid>http://www.bioworld.com/articles/718668</guid>
      <pubDate>Wed, 26 Mar 2025 10:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/718668-ai-based-spatial-omics-unveils-molecular-talks-in-tumors</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/TME-tumor-microenvironment-3D.webp?t=1699370810" type="image/jpeg" medium="image" fileSize="457538">
        <media:title type="plain">3D Rendering of tumor microenvironment</media:title>
      </media:content>
    </item>
    <item>
      <title>AI-based spatial omics unveils molecular talks in tumors</title>
      <description>
        <![CDATA[The three-dimensional analysis of cell types and their locations by spatial transcriptomics provides key information of their interactions within tissues or organs. Based on this technology, scientists at the Wellcome Sanger Institute have developed an AI tool called Nichecompass, which shows a comprehensive view of the cancer microenvironments, the different cells, their locations, and how they communicate with each other through different molecules inside the tumor. This AI could process data in an hour and compare samples before and after a treatment.]]>
      </description>
      <guid>http://www.bioworld.com/articles/718529</guid>
      <pubDate>Tue, 25 Mar 2025 10:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/718529-ai-based-spatial-omics-unveils-molecular-talks-in-tumors</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/TME-tumor-microenvironment-3D.webp?t=1699370810" type="image/jpeg" medium="image" fileSize="457538">
        <media:title type="plain">3D Rendering of tumor microenvironment</media:title>
      </media:content>
    </item>
    <item>
      <title>AI reads cancer cells’ 3D shape to predict their drug response</title>
      <description>
        <![CDATA[Scientists at the Institute of Cancer Research (ICR) in the U.K. are developing a technology that analyzes, in vitro, how the 3D morphology of cancer cells changes when exposed to a compound, using AI to predict their response to new treatments. The researchers estimate that their methodology could accelerate drug development by 6 years, by ruling out unsuccessful drugs and thus reducing the number of preclinical trials.]]>
      </description>
      <guid>http://www.bioworld.com/articles/718482</guid>
      <pubDate>Mon, 24 Mar 2025 10:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/718482-ai-reads-cancer-cells-3d-shape-to-predict-their-drug-response</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Cancer-cells-pic.webp?t=1591653278" type="image/png" medium="image" fileSize="432362">
        <media:title type="plain">Digital cancer cells illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>In HIV, draining the reservoir means understanding the brain</title>
      <description>
        <![CDATA[The availability of effective antiretroviral therapy has lowered the risk, and the severity, of neural sequelae of HIV infection. “Early in the HIV pandemic, approximately 15% of people with HIV had dementia and or encephalitis,” Howard Fox told his audience. “Fortunately, with treatment, the prevalence of these severe disorders has been greatly lowered. But there is persistence of what are called more minor disorders – which are not minor if you have them.”]]>
      </description>
      <guid>http://www.bioworld.com/articles/718291</guid>
      <pubDate>Fri, 14 Mar 2025 10:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/718291-in-hiv-draining-the-reservoir-means-understanding-the-brain</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Neurology-brain-magnifying-glass.webp?t=1741964843" type="image/jpeg" medium="image" fileSize="91475">
        <media:title type="plain">Illustration of magnifying glass inspecting brain</media:title>
      </media:content>
    </item>
    <item>
      <title>Study looks to noncoding gene variants for new drug targets</title>
      <description>
        <![CDATA[A new multi-omics approach to unpicking how noncoding gene variants influence the development of common chronic diseases has identified tens of thousands of instances where variants have an impact on gene expression levels and gene splicing, the post-transcriptional modification that allows one gene to code for multiple proteins.]]>
      </description>
      <guid>http://www.bioworld.com/articles/718260</guid>
      <pubDate>Wed, 12 Mar 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/718260-study-looks-to-noncoding-gene-variants-for-new-drug-targets</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/NIH-NHGRI-Genome-in-3D.webp?t=1741296509" type="image/png" medium="image" fileSize="1388583">
        <media:title type="plain">Genome concept art.</media:title>
        <media:description type="plain">Credit: Darryl Leja and Ernesto del Aguila III, National Human Genome Research Institute, NIH
</media:description>
      </media:content>
    </item>
    <item>
      <title>Inflammation appears to cause mutations linked to MS progression</title>
      <description>
        <![CDATA[For the first time, researchers have identified that inflammation – long associated with multiple sclerosis (MS) – appears to cause increased mutations that damage neurons linked to MS progression. Researchers at the Florey Institute and the University of Melbourne studied MS brain lesions, which are areas of past or ongoing brain inflammation that are visible as spots on MRI scans.]]>
      </description>
      <guid>http://www.bioworld.com/articles/718190</guid>
      <pubDate>Tue, 11 Mar 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/718190-inflammation-appears-to-cause-mutations-linked-to-ms-progression</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Florey-Inst-Justin-Rubio-hero-3-10.webp?t=1741616070" type="image/jpeg" medium="image" fileSize="172789">
        <media:title type="plain">Justin Rubio working in the lab</media:title>
        <media:description type="plain">Justin Rubio, head of The Florey Institute’s Neurogenetics Group</media:description>
      </media:content>
    </item>
    <item>
      <title>Inflammation appears to cause mutations linked to MS progression</title>
      <description>
        <![CDATA[For the first time, researchers have identified that inflammation – long associated with multiple sclerosis (MS) – appears to cause increased mutations that damage neurons linked to MS progression. Researchers at the Florey Institute and the University of Melbourne studied MS brain lesions, which are areas of past or ongoing brain inflammation that are visible as spots on MRI scans.]]>
      </description>
      <guid>http://www.bioworld.com/articles/718045</guid>
      <pubDate>Mon, 10 Mar 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/718045-inflammation-appears-to-cause-mutations-linked-to-ms-progression</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Florey-Inst-Justin-Rubio-hero-3-10.webp?t=1741616070" type="image/jpeg" medium="image" fileSize="172789">
        <media:title type="plain">Justin Rubio working in the lab</media:title>
        <media:description type="plain">Justin Rubio, head of The Florey Institute’s Neurogenetics Group</media:description>
      </media:content>
    </item>
    <item>
      <title>More than 100M cells included in the human cell atlas</title>
      <description>
        <![CDATA[An international consortium of thousands of scientists is creating the Human Cell Atlas, a three-dimensional map of all the cells in the body. The goal is to understand all the cells that make up human tissues, organs and systems, which will enable multiple medical applications. This collection of cell maps is openly available for navigation at single-cell resolution, identified through omics analyses that reveal the tridimensional distribution of each cell.]]>
      </description>
      <guid>http://www.bioworld.com/articles/714904</guid>
      <pubDate>Tue, 26 Nov 2024 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/714904-more-than-100m-cells-included-in-the-human-cell-atlas</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Embryonic-skeletal-development-hero-11-21.webp?t=1732207101" type="image/jpeg" medium="image" fileSize="471182">
        <media:title type="plain">D-rendered image showing atlas of human embryonic skeletal development</media:title>
        <media:description type="plain">Atlas of human embryonic skeletal development. A 3D-rendered image showing where the skeleton has cartilage (purple), which acts as a ‘scaffold’ before bone (purple) is formed in the majority of the skeleton. It also shows the cellular make-up in a developing cranium, where the top of the skull does not have any cartilage (blue), showing it forms bone uniquely without needing cartilage preceding. Credit: A. Chédotal &amp;amp; R. Blain, Institut de la Vision, Paris &amp;amp; MeLiS/UCBL/ HCL, Lyon.</media:description>
      </media:content>
    </item>
    <item>
      <title>More than 100M cells included in the human cell atlas</title>
      <description>
        <![CDATA[An international consortium of thousands of scientists is creating the Human Cell Atlas, a three-dimensional map of all the cells in the body. The goal is to understand all the cells that make up human tissues, organs and systems, which will enable multiple medical applications. This collection of cell maps is openly available for navigation at single-cell resolution, identified through omics analyses that reveal the tridimensional distribution of each cell.]]>
      </description>
      <guid>http://www.bioworld.com/articles/714679</guid>
      <pubDate>Thu, 21 Nov 2024 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/714679-more-than-100m-cells-included-in-the-human-cell-atlas</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Embryonic-skeletal-development-hero-11-21.webp?t=1732207101" type="image/jpeg" medium="image" fileSize="471182">
        <media:title type="plain">D-rendered image showing atlas of human embryonic skeletal development</media:title>
        <media:description type="plain">Atlas of human embryonic skeletal development. A 3D-rendered image showing where the skeleton has cartilage (purple), which acts as a ‘scaffold’ before bone (purple) is formed in the majority of the skeleton. It also shows the cellular make-up in a developing cranium, where the top of the skull does not have any cartilage (blue), showing it forms bone uniquely without needing cartilage preceding. Credit: A. Chédotal &amp;amp; R. Blain, Institut de la Vision, Paris &amp;amp; MeLiS/UCBL/ HCL, Lyon.</media:description>
      </media:content>
    </item>
    <item>
      <title>Alternative splicing study reveals genetic variants across Indonesian archipelago </title>
      <description>
        <![CDATA[A new study helps explain the role of genetic variation in shaping gene regulation in the Indonesian archipelago, one of the most diverse regions in the world. “This study is the only study of splicing from Southeast Asian populations. There is basically no data from this part of the world,” study author Irene Gallego Romero told <em>BioWorld</em>. For drug discovery, most of the people that have historically participated in clinical trials are of European ancestry, and scientists are just beginning to study African populations to better understand genetic differences in these populations, said Romero, a population geneticist and biological anthropologist at the University of Melbourne.]]>
      </description>
      <guid>http://www.bioworld.com/articles/713706</guid>
      <pubDate>Tue, 22 Oct 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/713706-alternative-splicing-study-reveals-genetic-variants-across-indonesian-archipelago</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Geographic-regions/Asia/Indonesia-map.webp?t=1729090934" type="image/jpeg" medium="image" fileSize="238401">
        <media:title type="plain">Illustrated map of Indonesia showing connected dots</media:title>
      </media:content>
    </item>
    <item>
      <title>Alternative splicing study reveals genetic variants across Indonesian archipelago </title>
      <description>
        <![CDATA[A new study helps explain the role of genetic variation in shaping gene regulation in the Indonesian archipelago, one of the most diverse regions in the world. “This study is the only study of splicing from Southeast Asian populations. There is basically no data from this part of the world,” study author Irene Gallego Romero told <em>BioWorld</em>. For drug discovery, most of the people that have historically participated in clinical trials are of European ancestry, and scientists are just beginning to study African populations to better understand genetic differences in these populations, said Romero, a population geneticist and biological anthropologist at the University of Melbourne.]]>
      </description>
      <guid>http://www.bioworld.com/articles/713492</guid>
      <pubDate>Wed, 16 Oct 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/713492-alternative-splicing-study-reveals-genetic-variants-across-indonesian-archipelago</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Geographic-regions/Asia/Indonesia-map.webp?t=1729090934" type="image/jpeg" medium="image" fileSize="238401">
        <media:title type="plain">Illustrated map of Indonesia showing connected dots</media:title>
      </media:content>
    </item>
    <item>
      <title>Neuregulin variant predicts gabapentin efficacy in chronic pelvic pain</title>
      <description>
        <![CDATA[Investigators at the University of Edinburgh have identified a genomic location linked to sensitivity to gabapentin in individuals with idiopathic chronic pelvic pain.]]>
      </description>
      <guid>http://www.bioworld.com/articles/711057</guid>
      <pubDate>Wed, 31 Jul 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/711057-neuregulin-variant-predicts-gabapentin-efficacy-in-chronic-pelvic-pain</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Misc/pelvis-gynecology-prolapse.webp?t=1745262121" type="image/jpeg" medium="image" fileSize="165084">
        <media:title type="plain">Female doctor with 3D medical model of pelvis</media:title>
      </media:content>
    </item>
    <item>
      <title>ISSCR 2024: iPS cell line panels can be isogenic and diverse</title>
      <description>
        <![CDATA[The big advantage of cell culture to model diseases is its throughput. “You can play the disease over and over again in the dish,” Clive Svendsen told the audience at the International Society of Stem Cell Research (ISSCR) Annual Meeting held in Hamburg last week. That high throughput, however, is not particularly useful if the cell lines themselves do not accurately model the disease.  Cancer cell lines are used in many cell culture experiments far beyond cancer for their ability to grow. But they are “highly abnormal,” Bill Skarnes told the audience at an innovation showcase, as well as quite unstable. “I don’t think the [HEK-293] cell line is the same in your lab as it is in the lab next door,” Skarnes said.]]>
      </description>
      <guid>http://www.bioworld.com/articles/710509</guid>
      <pubDate>Mon, 15 Jul 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/710509-isscr-2024-ips-cell-line-panels-can-be-isogenic-and-diverse</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Cell-research-illustration.webp?t=1622054088" type="image/png" medium="image" fileSize="493368">
        <media:title type="plain">Cell research illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Finely slicing T cells yields rare, disease-associated subtypes</title>
      <description>
        <![CDATA[A new methodology based on the regulation of genetic enhancers has made it possible to develop a cellular map that reveals new types of helper T cells related to immunological disorders that could be explored for the development of new therapies. “I am very interested in the function of rare T cells, and I am trying to analyze their function by eliminating certain rare T cells with antibodies with ADCC [antibody-dependent cell-mediated cytotoxicity] activity or by disrupting genes that characterize rare T cells in animal models,” senior author Yasuhiro Murakawa told <em>BioWorld</em>.]]>
      </description>
      <guid>http://www.bioworld.com/articles/710178</guid>
      <pubDate>Tue, 09 Jul 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/710178-finely-slicing-t-cells-yields-rare-disease-associated-subtypes</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Helper-t-cell.webp?t=1720538295" type="image/jpeg" medium="image" fileSize="161183">
        <media:title type="plain">Illustration of a helper t cell in the bloodstream</media:title>
      </media:content>
    </item>
    <item>
      <title>DNA damage and open chromatin are epigenetic twins in Alzheimer’s disease </title>
      <description>
        <![CDATA[Alzheimer’s disease (AD) is a neurodegenerative condition in which amyloid plaques and neurofibrillary tangles accumulate in the brain. In addition to genetic factors, DNA damage and epigenetic alterations also play a key role in the pathogenesis and progression of this disease, altering gene expression, the functioning and maintenance of brain cells. DNA double-strand breaks (DSBs) and chromatin accessibility are two hallmarks of AD whose study could reveal new ways of approaching this disease.]]>
      </description>
      <guid>http://www.bioworld.com/articles/710083</guid>
      <pubDate>Wed, 03 Jul 2024 07:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/710083-dna-damage-and-open-chromatin-are-epigenetic-twins-in-alzheimers-disease</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/DNA-damage-mutation.webp?t=1729781875" type="image/jpeg" medium="image" fileSize="155438">
        <media:title type="plain">Concept art for damaged DNA structure</media:title>
      </media:content>
    </item>
    <item>
      <title>Dissecting post-traumatic stress disorder and depression</title>
      <description>
        <![CDATA[Scientists from the PsychENCODE Consortium have analyzed the brain transcriptome in a coordinated series of studies to map all the cell types, genes, epigenetic factors, and molecular pathways involved in different psychiatric disorders. After a first set of projects based on bulk analysis, the second phase of this project included 14 simultaneous publications that revealed the cellular atlas of post-traumatic stress disorder and major depressive disorder, among others.]]>
      </description>
      <guid>http://www.bioworld.com/articles/709127</guid>
      <pubDate>Fri, 31 May 2024 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/709127-dissecting-post-traumatic-stress-disorder-and-depression</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Psychiatry-illustration.webp?t=1710887261" type="image/jpeg" medium="image" fileSize="103707">
        <media:title type="plain">Two silhouettes with tangle, gear, spiral</media:title>
      </media:content>
    </item>
    <item>
      <title>Dissecting post-traumatic stress disorder and depression</title>
      <description>
        <![CDATA[Scientists from the PsychENCODE Consortium have analyzed the brain transcriptome in a coordinated series of studies to map all the cell types, genes, epigenetic factors, and molecular pathways involved in different psychiatric disorders. After a first set of projects based on bulk analysis, the second phase of this project included 14 simultaneous publications that revealed the cellular atlas of post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), among others.]]>
      </description>
      <guid>http://www.bioworld.com/articles/708971</guid>
      <pubDate>Tue, 28 May 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/708971-dissecting-post-traumatic-stress-disorder-and-depression</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Psychiatry-illustration.webp?t=1710887261" type="image/jpeg" medium="image" fileSize="103707">
        <media:title type="plain">Two silhouettes with tangle, gear, spiral</media:title>
      </media:content>
    </item>
    <item>
      <title>Preserving autophagy protects from muscle aging</title>
      <description>
        <![CDATA[A protein whose expression decreases during aging could be key to preserving cellular maintenance mechanisms and preventing the progressive loss of muscle mass that occurs during aging. Scientists from the Institute for Research in Biomedicine (IRB) and the University of Barcelona (UB) have revealed the role of the TP53INP2 protein in autophagy and the effects of its reduction on skeletal muscle during aging.]]>
      </description>
      <guid>http://www.bioworld.com/articles/707957</guid>
      <pubDate>Fri, 26 Apr 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/707957-preserving-autophagy-protects-from-muscle-aging</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Musculoskeletal/Musculoskeletal-cross-section-bone-muscle.webp?t=1690901154" type="image/jpeg" medium="image" fileSize="230462">
        <media:title type="plain">3D cross-section illustration of muscle anatomy</media:title>
      </media:content>
    </item>
    <item>
      <title>In 2023, big projects create ‘satellite maps’ of cell biology</title>
      <description>
        <![CDATA[If we unraveled the DNA of the 46 chromosomes of a single human cell, it would barely measure 2 meters. If we did the same with the rest of the body, if we aligned the 3 billion base pairs of its 5 trillion cells, we could travel the distance from the Earth to the Sun more than 100 times. It seems unreachable. However, that is the unit of knowledge of the large sequencing projects achieved in 2023.]]>
      </description>
      <guid>http://www.bioworld.com/articles/704456</guid>
      <pubDate>Tue, 09 Jan 2024 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/704456-in-2023-big-projects-create-satellite-maps-of-cell-biology</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Pangenome-reference-hero.webp?t=1703866149" type="image/jpeg" medium="image" fileSize="323844">
        <media:title type="plain">Art concept for pangenome wrapping around the globe</media:title>
        <media:description type="plain">The pangenome reference is a collection of different genomes from which to compare an individual genome sequence. Like a map of the subway system, the pangenome graph has many possible routes for a sequence to take. Credit: Darryl Leja, NHGRI</media:description>
      </media:content>
    </item>
    <item>
      <title>In 2023, big projects create ‘satellite maps’ of cell biology</title>
      <description>
        <![CDATA[If we unraveled the DNA of the 46 chromosomes of a single human cell, it would barely measure 2 meters. If we did the same with the rest of the body, if we aligned the 3 billion base pairs of its 5 trillion cells, we could travel the distance from the Earth to the Sun more than 100 times. It seems unreachable. However, that is the unit of knowledge of the large sequencing projects achieved in 2023. From the generation of the human pangenome to cell-by-cell maps of the brain and kidneys, scientists this year have completed several omics collaborative projects stored in large international databases. Now, what’s the plan?]]>
      </description>
      <guid>http://www.bioworld.com/articles/704380</guid>
      <pubDate>Fri, 05 Jan 2024 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/704380-in-2023-big-projects-create-satellite-maps-of-cell-biology</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Pangenome-reference-hero.webp?t=1703866149" type="image/jpeg" medium="image" fileSize="323844">
        <media:title type="plain">Art concept for pangenome wrapping around the globe</media:title>
        <media:description type="plain">The pangenome reference is a collection of different genomes from which to compare an individual genome sequence. Like a map of the subway system, the pangenome graph has many possible routes for a sequence to take. Credit: Darryl Leja, NHGRI</media:description>
      </media:content>
    </item>
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