https://www.bioworld.com/rss en-us http://www.bioworld.com/articles/729823 Tue, 24 Mar 2026 12:00:00 -0400 https://www.bioworld.com/articles/729823-somatic-genomics-pioneer-quotient-signs-22b-ibd-deal-with-merck Gastrointestinal system with DNA, scientific background Nature on July 23, 2025. Both studies re-sequenced probands from the open-access 1000 Genomes Project, which was one of the first projects to sequence individuals from diverse populations.]]> http://www.bioworld.com/articles/722504 Thu, 24 Jul 2025 11:00:00 -0400 https://www.bioworld.com/articles/722504-a-fresh-look-at-1000-genomes-is-more-detailed-and-more-panoramic Illustration of group of people with chromosomes floating above Nature on July 23, 2025. Both studies re-sequenced probands from the open-access 1000 Genomes Project, which was one of the first projects to sequence individuals from diverse populations. While one paper “goes very deep and tries to reconstruct a few genomes to basically near completion,” the other specifically looked at structural variants in a larger number of genomes. Together, they give new insights into genome variation.]]> http://www.bioworld.com/articles/722402 Wed, 23 Jul 2025 11:00:00 -0400 https://www.bioworld.com/articles/722402-a-fresh-look-at-1000-genomes-is-more-detailed-and-more-panoramic Illustration of group of people with chromosomes floating above http://www.bioworld.com/articles/718040 Wed, 05 Mar 2025 09:00:00 -0500 https://www.bioworld.com/articles/718040-uk-releases-three-decades-of-childrens-genomic-data Group of kids, faces huddled together http://www.bioworld.com/articles/717206 Mon, 10 Feb 2025 09:00:00 -0500 https://www.bioworld.com/articles/717206-genomic-study-paves-way-for-multimorbidity-treatments DNA, RNA concept art. Credit: Darryl Leja, National Human Genome Research Institute, NIH http://www.bioworld.com/articles/715001 Tue, 03 Dec 2024 09:00:00 -0500 https://www.bioworld.com/articles/715001-study-finds-genetic-factors-behind-early-onset-type-2-diabetes-in-south-asians The DNA double helix overlays a field of ACGTs and binary numbers. Credit: Jonathan Bailey, National Human Genome Research Institute, NIH BioWorld. Zehnder is co-founder and CEO of Fauna Bio Inc., which uses comparative genomics to identify gene networks that underlie disease resistance in different animal species.]]> http://www.bioworld.com/articles/705167 Tue, 30 Jan 2024 12:00:00 -0500 https://www.bioworld.com/articles/705167-through-comparative-genomics-becoming-tough-as-nails-or-squirrels 13-lined-ground-squirrel.jpg http://www.bioworld.com/articles/704456 Tue, 09 Jan 2024 09:00:00 -0500 https://www.bioworld.com/articles/704456-in-2023-big-projects-create-satellite-maps-of-cell-biology Art concept for pangenome wrapping around the globe The pangenome reference is a collection of different genomes from which to compare an individual genome sequence. Like a map of the subway system, the pangenome graph has many possible routes for a sequence to take. Credit: Darryl Leja, NHGRI http://www.bioworld.com/articles/704380 Fri, 05 Jan 2024 09:00:00 -0500 https://www.bioworld.com/articles/704380-in-2023-big-projects-create-satellite-maps-of-cell-biology Art concept for pangenome wrapping around the globe The pangenome reference is a collection of different genomes from which to compare an individual genome sequence. Like a map of the subway system, the pangenome graph has many possible routes for a sequence to take. Credit: Darryl Leja, NHGRI http://www.bioworld.com/articles/704127 Fri, 29 Dec 2023 09:00:00 -0500 https://www.bioworld.com/articles/704127-in-2023-big-projects-create-satellite-maps-of-cell-biology Art concept for pangenome wrapping around the globe The pangenome reference is a collection of different genomes from which to compare an individual genome sequence. Like a map of the subway system, the pangenome graph has many possible routes for a sequence to take. Credit: Darryl Leja, NHGRI http://www.bioworld.com/articles/703281 Wed, 29 Nov 2023 09:00:00 -0500 https://www.bioworld.com/articles/703281-a-trillion-in-each-of-us-flagship-backed-quotient-takes-on-somatic-genomics Cells and DNA helix http://www.bioworld.com/articles/703218 Wed, 22 Nov 2023 12:00:00 -0500 https://www.bioworld.com/articles/703218-a-trillion-in-each-of-us-flagship-backed-quotient-takes-on-somatic-genomics Cells and DNA helix http://www.bioworld.com/articles/696850 Wed, 10 May 2023 11:00:00 -0400 https://www.bioworld.com/articles/696850-pangenome-gives-more-panoramic-view-of-human-diversity Illustration showing pangenome graph The new pangenome reference is a collection of different genomes from which to compare an individual genome sequence. Like a map of the subway system, the pangenome graph has many possible routes for a sequence to take, represented by the different colors. The detouring paths at the top of the image represent single nucleotide variants (SNVs), which are single letter differences. The yellow path that loops around itself and repeats the same nucleotides represents a duplication variant. The pink path that loops counterclockwise and follows the nucleotide sequence backwards represents an inversion variant. At the bottom, the green and dark blue paths miss the C nucleotide in its route and represent a deletion variant. The light blue path, which has extra nucleotides in its route, represents an insertion variant. Credit: Darryl Leja, National Human Genome Research Institute, NIH Nature Genetics on May 8, 2023. Circular DNAs are present in at least a third of cancer cells, and their presence correlates with poor prognosis in many cases. They can carry driver genes that have separated themselves from their chromosome of origin, and some research suggests that they serve as “reserve copies” of driver genes. Boundless Bio Inc. is in phase I trials targeting ecDNAs.]]> http://www.bioworld.com/articles/696756 Mon, 08 May 2023 09:00:00 -0400 https://www.bioworld.com/articles/696756-parallel-sequencing-yields-genomic-secrets-of-extrachromosomal-dna Nuclei and chromosomes of neuroblastoma cells Nuclei and chromosomes of neuroblastoma cells. DNA rings are colored yellow, turquoise, or magenta. Each color is associated with different cancer genes. Credit: Charité/ Rocío Chamorro González http://www.bioworld.com/articles/693828 Wed, 01 Feb 2023 11:00:00 -0500 https://www.bioworld.com/articles/693828-tracking-metastases-by-gene-expression-unveils-four-subtypes-of-cancer Cell Genomics, the scientists observed the genetic overlap between common NPDs and 29 BCTs, including functional genes, regulatory elements and new genetic correlations linked to hematological data and for these diseases.]]> http://www.bioworld.com/articles/693599 Wed, 25 Jan 2023 11:00:00 -0500 https://www.bioworld.com/articles/693599-blood-cells-can-tell-tales-about-risk-of-neurological-and-psychiatric-disorders http://www.bioworld.com/articles/693241 Thu, 12 Jan 2023 09:00:00 -0500 https://www.bioworld.com/articles/693241-ucla-biobank-takes-advantage-of-las-diversity
“We found that a small percentage of male cancers are expressing XIST, which normally is expressed in female cancers. And the percentage of male cancers that express XIST is variable depending on the cancer type,” Srinivas Viswanathan, researcher in the Department of Medical Oncology at the Dana-Farber Cancer Institute at Harvard and assistant professor of Medicine at Harvard Medical School, told BioWorld.]]> http://www.bioworld.com/articles/691484 Fri, 11 Nov 2022 09:00:00 -0500 https://www.bioworld.com/articles/691484-some-male-cancer-cells-inactivate-the-x-chromosome A still from an X inactivation animation A still from an X Inactivation animation. Credit: Walter and Eliza Hall Institute http://www.bioworld.com/articles/667491 Thu, 01 Sep 2022 09:00:00 -0400 https://www.bioworld.com/articles/667491-ten-new-variants-linked-to-crohns-disease Illustration of DNA, digestive system http://www.bioworld.com/articles/517527 Fri, 01 Apr 2022 10:00:00 -0400 https://www.bioworld.com/articles/517527-telomere-to-telomere-the-human-genome-is-done DNA NGS genome sequencing MDFIC pathogenic variants underlying the severe lymphatic disorder, central conducting lymphatic anomaly (CCLA), in seven people from six separate families.]]> http://www.bioworld.com/articles/516699 Mon, 07 Mar 2022 10:05:00 -0500 https://www.bioworld.com/articles/516699-genetic-findings-pave-way-to-treatment-of-lymph-disorder Lymph nodes Genome Medicine demonstrated. The full process from blood sample to shortlist of causative variants and likely diseases takes just a matter of hours and the time to interpret whole genomes is condensed to about 15 minutes.]]> http://www.bioworld.com/articles/512394 Thu, 14 Oct 2021 13:00:00 -0400 https://www.bioworld.com/articles/512394-fabric-genomics-ai-quickly-identifies-90-of-rare-disease-genomic-variants DNA data illustration http://www.bioworld.com/articles/511144 Tue, 07 Sep 2021 10:00:00 -0400 https://www.bioworld.com/articles/511144-analysis-boosts-genomics-driven-precision-medicine DNA data illustration http://www.bioworld.com/articles/507789 Thu, 03 Jun 2021 13:00:00 -0400 https://www.bioworld.com/articles/507789-diverse-cohort-expands-diabetes-genomics Child, DNA, genomics illustration http://www.bioworld.com/articles/507693 Tue, 01 Jun 2021 12:00:00 -0400 https://www.bioworld.com/articles/507693-diverse-cohort-expands-diabetes-genomics Child, DNA, genomics illustration http://www.bioworld.com/articles/500124 Thu, 12 Nov 2020 12:00:00 -0500 https://www.bioworld.com/articles/500124-quick-ish-cleanup-can-preserve-privacy-in-functional-genomics-datasets Data privacy illustration Credit: Wendolyn Hill Science and Cell family of journals, as well as in Genome Biology.]]> http://www.bioworld.com/articles/497617 Thu, 10 Sep 2020 12:00:00 -0400 https://www.bioworld.com/articles/497617-gtex-explores-variation-in-genome-bureaucracy Expression quantitative trait loci Sections of the genome, known as expression Quantitative Trait Loci (eQTL), work to control how genes are turned off and on. Variants in eQTLs affect how much of a protein a cell will produce. Credit: Darryl Leja, National Human Genome Research Institute, NIH Nature and its sister journals on July 29, 2020, consisted of 6,000 experiments performed on around 1,300 samples.]]> http://www.bioworld.com/articles/496333 Wed, 29 Jul 2020 12:00:00 -0400 https://www.bioworld.com/articles/496333-data-reported-from-encode-phase-iii ENCODE project illustration Image credit, above: ENCODE Animation credit, below: Ernesto Del Aguila III, NHGRI http://www.bioworld.com/articles/435442 Fri, 29 May 2020 13:00:00 -0400 https://www.bioworld.com/articles/435442-gnomad-identifies-rare-loss-of-function-variants Genome illustration Credit: Susanna M. Hamilton, Broad Communications http://www.bioworld.com/articles/435375 Wed, 27 May 2020 12:00:00 -0400 https://www.bioworld.com/articles/435375-gnomad-identifies-rare-loss-of-function-variants Genome illustration Credit: Susanna M. Hamilton, Broad Communications