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    <title>Stem cells</title>
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      <title>Regeneration in mammals is controlled by environmental conditions</title>
      <description>
        <![CDATA[The loss of regenerative capacity in mammals over the course of evolution may be linked to certain environmental conditions rather than to a genetic limitation. Tissue stiffness around an amputated area, oxygen availability, or epigenetic regulation could determine this ability, according to two simultaneously published but independent studies published in <em>Science</em>, as reported by <em>BioWorld</em> yesterday.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730344</guid>
      <pubDate>Fri, 10 Apr 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730344-regeneration-in-mammals-is-controlled-by-environmental-conditions</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Tsissios-regenerating-tadpole-limb-adw8526-hero.webp?t=1775828910" type="image/jpeg" medium="image" fileSize="1401255">
        <media:title type="plain">Confocal cross section of a regenerating tadpole limb. </media:title>
        <media:description type="plain">Confocal cross section of a regenerating tadpole limb, highlighting cellular boundaries (red) and nuclei (grey). Credit: Georgios Tsissios.</media:description>
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    </item>
    <item>
      <title>Regeneration in mammals is controlled by environmental conditions</title>
      <description>
        <![CDATA[The loss of regenerative capacity in mammals over the course of evolution may be linked to certain environmental conditions rather than to a genetic limitation. Tissue stiffness around an amputated area, oxygen availability, or epigenetic regulation could determine this ability, according to two simultaneously published but independent studies published in <em>Science</em> today.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730322</guid>
      <pubDate>Thu, 09 Apr 2026 14:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730322-regeneration-in-mammals-is-controlled-by-environmental-conditions</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Tsissios-regenerating-tadpole-limb-adw8526-hero.webp?t=1775828910" type="image/jpeg" medium="image" fileSize="1401255">
        <media:title type="plain">Confocal cross section of a regenerating tadpole limb. </media:title>
        <media:description type="plain">Confocal cross section of a regenerating tadpole limb, highlighting cellular boundaries (red) and nuclei (grey). Credit: Georgios Tsissios.</media:description>
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    </item>
    <item>
      <title>Optimized organoid model gives insights into celiac disease</title>
      <description>
        <![CDATA[Investigators at the Netherlands Hubrecht Institute have developed a novel gut organoid model, and used it to gain insight into the functions on human microfold (M) cells. Their experiments, which were published in the Dec. 10, 2025, issue of <em>Nature</em>, showed that M cells present gluten-derived antigens to T cells, which suggests a role for this cell type in the onset of celiac disease.]]>
      </description>
      <guid>http://www.bioworld.com/articles/727168</guid>
      <pubDate>Fri, 12 Dec 2025 00:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727168-optimized-organoid-model-gives-insights-into-celiac-disease</link>
    </item>
    <item>
      <title>Optimized organoid model gives insights into celiac disease</title>
      <description>
        <![CDATA[Investigators at the Netherlands Hubrecht Institute have developed a novel gut organoid model, and used it to gain insight into the functions on human microfold (M) cells. Their experiments, which were published in the Dec. 10, 2025, issue of <em>Nature</em>, showed that M cells present gluten-derived antigens to T cells, which suggests a role for this cell type in the onset of celiac disease.]]>
      </description>
      <guid>http://www.bioworld.com/articles/727036</guid>
      <pubDate>Thu, 11 Dec 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727036-optimized-organoid-model-gives-insights-into-celiac-disease</link>
    </item>
    <item>
      <title>Fertilizable egg-like cells generated with DNA from skin cells</title>
      <description>
        <![CDATA[Generating gametes from nonreproductive tissues could help overcome infertility. Previous studies have successfully transformed stem cells into viable oocytes through cellular reprogramming. Scientists at Oregon Health & Science University (OHSU) developed a method to derive them from skin cells via somatic cell nuclear transfer (SCNT), unlocking a mechanism that blends mitosis and meiosis. Now, the researchers have taken another step forward by generating fertilizable eggs from human skin cells.]]>
      </description>
      <guid>http://www.bioworld.com/articles/724671</guid>
      <pubDate>Wed, 01 Oct 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/724671-fertilizable-egg-like-cells-generated-with-dna-from-skin-cells</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Mitalipov-SCNT-oocyte-spindle-HERO.webp?t=1759331066" type="image/jpeg" medium="image" fileSize="601761">
        <media:title type="plain">Human SCNT oocyte with visible spindle before fertilization.</media:title>
        <media:description type="plain">Human SCNT oocyte with visible spindle (bright spot inside) before fertilization. Credit: Mitalipov laboratory, Oregon Health &amp;amp; Science University.</media:description>
      </media:content>
    </item>
    <item>
      <title>Stem cell therapies show safety in clinical trials in Parkinson's</title>
      <description>
        <![CDATA[Stem cell implantation is a step closer to becoming the next strategy against Parkinson's disease. Two clinical trials, one in phase I and the other in phase I/II, have demonstrated their safety and potential to restore dopamine production in the brains of patients with this currently incurable neurodegenerative condition. The number of participants in the study is still small, and further research is needed to demonstrate the clinical benefits of these cell therapies.]]>
      </description>
      <guid>http://www.bioworld.com/articles/719288</guid>
      <pubDate>Wed, 16 Apr 2025 11:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/719288-stem-cell-therapies-show-safety-in-clinical-trials-in-parkinsons</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Stem-cell-implantation-illustration.webp?t=1744835731" type="image/jpeg" medium="image" fileSize="250548">
        <media:title type="plain">Concept art for stem cell implantation</media:title>
      </media:content>
    </item>
    <item>
      <title>Quiescent, but not quiet, cancer stem cells in glioblastoma relapse</title>
      <description>
        <![CDATA[Six main cell types form glioblastomas, the most aggressive brain cancer due to its high rate of recurrence. Of these six, quiescent cancer stem cells are responsible for resistance to therapy and the reappearance of the tumor, according to a study that identified the six groups and highlighted the importance of these stem cells for the design of more effective therapies.]]>
      </description>
      <guid>http://www.bioworld.com/articles/714462</guid>
      <pubDate>Wed, 13 Nov 2024 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/714462-quiescent-but-not-quiet-cancer-stem-cells-in-glioblastoma-relapse</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/3d-medically-accurate-human-brain-tumor.webp?t=1731428528" type="image/jpeg" medium="image" fileSize="229906">
        <media:title type="plain">3D illustration of brain cancer</media:title>
      </media:content>
    </item>
    <item>
      <title>Quiescent, but not quiet, cancer stem cells in glioblastoma relapse</title>
      <description>
        <![CDATA[Six main cell types form glioblastomas (GBM), the most aggressive brain cancer due to its high rate of recurrence. Of these six, quiescent cancer stem cells are responsible for resistance to therapy and the reappearance of the tumor, according to a study that identified the six groups and highlighted the importance of these stem cells for the design of more effective therapies.]]>
      </description>
      <guid>http://www.bioworld.com/articles/714350</guid>
      <pubDate>Tue, 12 Nov 2024 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/714350-quiescent-but-not-quiet-cancer-stem-cells-in-glioblastoma-relapse</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/3d-medically-accurate-human-brain-tumor.webp?t=1731428528" type="image/jpeg" medium="image" fileSize="229906">
        <media:title type="plain">3D illustration of brain cancer</media:title>
      </media:content>
    </item>
    <item>
      <title>Stem cells eat dead cells to ensure tissue integrity</title>
      <description>
        <![CDATA[Phagocytosis – eliminating millions of dead cells every day – requires specialized cells such as macrophages, the true professionals, which migrate to engulf waste and dying cells.]]>
      </description>
      <guid>http://www.bioworld.com/articles/712104</guid>
      <pubDate>Wed, 28 Aug 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/712104-stem-cells-eat-dead-cells-to-ensure-tissue-integrity</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Fuchs-dead-cell-cleanup-Rockefeller-University-hero.webp?t=1724773092" type="image/jpeg" medium="image" fileSize="355069">
        <media:title type="plain">Hair follicle containing phagocytic stem cells</media:title>
        <media:description type="plain">A hair follicle containing phagocytic stem cells (single cells with two fluorescent colors) and non-phagocytic stem cells (a single color). Credit: Fuchs lab, Rockefeller University</media:description>
      </media:content>
    </item>
    <item>
      <title>Stem cells eat dead cells to ensure tissue integrity</title>
      <description>
        <![CDATA[Phagocytosis – eliminating millions of dead cells every day – requires specialized cells such as macrophages, the true professionals, which migrate to engulf waste and dying cells. But they are not the only ones that can perform this task, as scientists at Howard Hughes Medical Institute (HHMI) discovered when they investigated hair follicle stem cells (HFSCs), a tissue in constant regeneration, to clarify how dying cells are detected and cleared in the epithelium and the mesenchyme.]]>
      </description>
      <guid>http://www.bioworld.com/articles/711857</guid>
      <pubDate>Tue, 27 Aug 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/711857-stem-cells-eat-dead-cells-to-ensure-tissue-integrity</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Fuchs-dead-cell-cleanup-Rockefeller-University-hero.webp?t=1724773092" type="image/jpeg" medium="image" fileSize="355069">
        <media:title type="plain">Hair follicle containing phagocytic stem cells</media:title>
        <media:description type="plain">A hair follicle containing phagocytic stem cells (single cells with two fluorescent colors) and non-phagocytic stem cells (a single color). Credit: Fuchs lab, Rockefeller University</media:description>
      </media:content>
    </item>
    <item>
      <title>Jellyfish genes rejuvenate intestinal stem cells in fruit flies</title>
      <description>
        <![CDATA[Researchers in Japan were able to transfer genes from jellyfish into common fruit flies and discovered that the transferred gene suppressed an age-related intestinal issue in the flies. The findings suggest that studying genes specific to animals with high regenerative capability like jellyfish may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.]]>
      </description>
      <guid>http://www.bioworld.com/articles/711525</guid>
      <pubDate>Tue, 13 Aug 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/711525-jellyfish-genes-rejuvenate-intestinal-stem-cells-in-fruit-flies</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Blue-jelly-fish.webp?t=1723042732" type="image/jpeg" medium="image" fileSize="390030">
        <media:title type="plain">Photo of jellyfish in aquarium lit by blue light</media:title>
        <media:description type="plain">Many jellyfish species have robust regenerative capacities.</media:description>
      </media:content>
    </item>
    <item>
      <title>Jellyfish genes rejuvenate intestinal stem cells in fruit flies</title>
      <description>
        <![CDATA[Researchers in Japan were able to transfer genes from jellyfish into common fruit flies and discovered that the transferred gene suppressed an age-related intestinal issue in the flies. The findings suggest that studying genes specific to animals with high regenerative capability like jellyfish may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.]]>
      </description>
      <guid>http://www.bioworld.com/articles/711286</guid>
      <pubDate>Wed, 07 Aug 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/711286-jellyfish-genes-rejuvenate-intestinal-stem-cells-in-fruit-flies</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Blue-jelly-fish.webp?t=1723042732" type="image/jpeg" medium="image" fileSize="390030">
        <media:title type="plain">Photo of jellyfish in aquarium lit by blue light</media:title>
        <media:description type="plain">Many jellyfish species have robust regenerative capacities.</media:description>
      </media:content>
    </item>
    <item>
      <title>ISSCR 2024: Expanding niche definition gives insights into stem cells</title>
      <description>
        <![CDATA[The word “niche” implies a specialized environment. But to Fiona Doetsch, the stem cell niche is anything but. For brain stem cells, “the whole organism is the niche,” Doetsch told the audience at the third plenary session of the International Society for Stem Cell Research (ISSCR) annual meeting in Hamburg this week.]]>
      </description>
      <guid>http://www.bioworld.com/articles/710613</guid>
      <pubDate>Tue, 16 Jul 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/710613-isscr-2024-expanding-niche-definition-gives-insights-into-stem-cells</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/stem-cells.webp?t=1588878473" type="image/png" medium="image" fileSize="406148">
        <media:title type="plain">Stem cells</media:title>
      </media:content>
    </item>
    <item>
      <title>ISSCR 2024: Expanding niche definition gives insights into stem cells</title>
      <description>
        <![CDATA[The word “niche” implies a specialized environment. But to Fiona Doetsch, the stem cell niche is anything but. For brain stem cells, “the whole organism is the niche,” Doetsch told the audience at the third plenary session of the International Society for Stem Cell Research (ISSCR) annual meeting in Hamburg this week. It’s a surprising idea at first, given the brain’s protection from many circulating substances via a series of barriers, including the blood-brain barrier and the blood-cerebrospinal fluid barrier.]]>
      </description>
      <guid>http://www.bioworld.com/articles/710568</guid>
      <pubDate>Mon, 15 Jul 2024 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/710568-isscr-2024-expanding-niche-definition-gives-insights-into-stem-cells</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/stem-cells.webp?t=1588878473" type="image/png" medium="image" fileSize="406148">
        <media:title type="plain">Stem cells</media:title>
      </media:content>
    </item>
    <item>
      <title>ISSCR 2024: iPS cell line panels can be isogenic and diverse</title>
      <description>
        <![CDATA[The big advantage of cell culture to model diseases is its throughput. “You can play the disease over and over again in the dish,” Clive Svendsen told the audience at the International Society of Stem Cell Research (ISSCR) Annual Meeting held in Hamburg last week. That high throughput, however, is not particularly useful if the cell lines themselves do not accurately model the disease.  Cancer cell lines are used in many cell culture experiments far beyond cancer for their ability to grow. But they are “highly abnormal,” Bill Skarnes told the audience at an innovation showcase, as well as quite unstable. “I don’t think the [HEK-293] cell line is the same in your lab as it is in the lab next door,” Skarnes said.]]>
      </description>
      <guid>http://www.bioworld.com/articles/710509</guid>
      <pubDate>Mon, 15 Jul 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/710509-isscr-2024-ips-cell-line-panels-can-be-isogenic-and-diverse</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Cell-research-illustration.webp?t=1622054088" type="image/png" medium="image" fileSize="493368">
        <media:title type="plain">Cell research illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>ISSCR 2024: Expanding niche definition gives insights into stem cells</title>
      <description>
        <![CDATA[The word “niche” implies a specialized environment. But to Fiona Doetsch, the stem cell niche is anything but. For brain stem cells, “the whole organism is the niche,” Doetsch told the audience at the third plenary session of the International Society for Stem Cell Research (ISSCR) annual meeting in Hamburg this week. It’s a surprising idea at first, given the brain’s protection from many circulating substances via a series of barriers, including the blood-brain barrier and the blood-cerebrospinal fluid barrier.]]>
      </description>
      <guid>http://www.bioworld.com/articles/710469</guid>
      <pubDate>Fri, 12 Jul 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/710469-isscr-2024-expanding-niche-definition-gives-insights-into-stem-cells</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/stem-cells.webp?t=1588878473" type="image/png" medium="image" fileSize="406148">
        <media:title type="plain">Stem cells</media:title>
      </media:content>
    </item>
    <item>
      <title>A pan-approach against blood cancer preserving hematopoiesis</title>
      <description>
        <![CDATA[A group of scientists from Basel University Hospital have designed an antibody-drug conjugate (ADC) that eliminated blood cancer cells without attacking healthy hematopoietic stem cells (HSCs), which they modified by base editing and transplanted to renew an altered blood system. They achieved this by focusing on the panhematopoietic marker CD45.]]>
      </description>
      <guid>http://www.bioworld.com/articles/709013</guid>
      <pubDate>Wed, 29 May 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/709013-a-pan-approach-against-blood-cancer-preserving-hematopoiesis</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Blood-cancer-illustration.webp?t=1650579705" type="image/png" medium="image" fileSize="628557">
        <media:title type="plain">Blood cells and destruction of cancer cell</media:title>
      </media:content>
    </item>
    <item>
      <title>Human iPSCs restore muscle, function in monkeys with heart failure</title>
      <description>
        <![CDATA[Japanese researchers have transplanted human induced pluripotent stem cells (iPSCs) in a primate model of myocardial infarction and were able to restore heart muscle and function in monkeys. Developed by Tokyo-based Heartseed Inc., the grafted iPSCs consist of clusters of purified heart muscle cells (cardiomyocyte spheroids) that are injected into the myocardial layer of the heart. Published in <em>Circulation</em> on April 26, 2024, the study showed that the cardiomyocyte spheroids survived long term and showed improved contractile function with low occurrence of post-transplant arrhythmias.]]>
      </description>
      <guid>http://www.bioworld.com/articles/708362</guid>
      <pubDate>Tue, 07 May 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/708362-human-ipscs-restore-muscle-function-in-monkeys-with-heart-failure</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cardiovascular/cardiology-heart-illustration.webp?t=1601070099" type="image/png" medium="image" fileSize="948393">
        <media:title type="plain">Colorful illustration of the heart</media:title>
      </media:content>
    </item>
    <item>
      <title>Human iPSCs restore muscle, function in monkeys with heart failure</title>
      <description>
        <![CDATA[Japanese researchers have transplanted human induced pluripotent stem cells (iPSCs) in a primate model of myocardial infarction and were able to restore heart muscle and function in monkeys. Developed by Tokyo-based Heartseed Inc., the grafted iPSCs consist of clusters of purified heart muscle cells (cardiomyocyte spheroids) that are injected into the myocardial layer of the heart. Published in <em>Circulation</em> on April 26, 2024, the study showed that the cardiomyocyte spheroids survived long term and showed improved contractile function with low occurrence of post-transplant arrhythmias.]]>
      </description>
      <guid>http://www.bioworld.com/articles/708130</guid>
      <pubDate>Fri, 03 May 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/708130-human-ipscs-restore-muscle-function-in-monkeys-with-heart-failure</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cardiovascular/cardiology-heart-illustration.webp?t=1601070099" type="image/png" medium="image" fileSize="948393">
        <media:title type="plain">Colorful illustration of the heart</media:title>
      </media:content>
    </item>
    <item>
      <title>Iron rheostat turns on blood stem cells</title>
      <description>
        <![CDATA[Iron regulates the metabolism of hematopoietic stem cells (HSCs) and acts as a genetic control of their fate, preserving their identity and regenerative capacity during tissue maintenance and repair. A group of scientists at Albert Einstein College of Medicine has described the key components of a molecular pathway that iron regulates. “What we are proposing here with this mechanism is that iron serves like a switchboard and a sensor,” senior author Britta Will told <em>BioWorld</em>. Will is at the Department of Oncology, the Cell Biology Department, and the Ruth and David Gottesman Institute for Stem Cell Research and Regenerative Medicine at Albert Einstein College of Medicine.]]>
      </description>
      <guid>http://www.bioworld.com/articles/705763</guid>
      <pubDate>Tue, 27 Feb 2024 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/705763-iron-rheostat-turns-on-blood-stem-cells</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Blood-cells-in-a-bone-marrow-biopsy.webp?t=1709047477" type="image/jpeg" medium="image" fileSize="285814">
        <media:title type="plain">AI-generated image of blood cells in a bone marrow biopsy</media:title>
      </media:content>
    </item>
    <item>
      <title>Scientists find what prevents neuronal reprogramming in patients with mitochondrial deficiencies</title>
      <description>
        <![CDATA[Reprogramming techniques to generate functional neurons could improve neurodegeneration in the future. A group of researchers from the Institute for Stem Cell Research (ISF) in Germany have found the pathways that play a role in improving the conversion of astrocytes into neurons.]]>
      </description>
      <guid>http://www.bioworld.com/articles/704897</guid>
      <pubDate>Wed, 24 Jan 2024 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/704897-scientists-find-what-prevents-neuronal-reprogramming-in-patients-with-mitochondrial-deficiencies</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Neurology-neuron-pathways.webp?t=1685635688" type="image/jpeg" medium="image" fileSize="225697">
        <media:title type="plain">Concept art for "unlocking the secrets of the mind"</media:title>
      </media:content>
    </item>
    <item>
      <title>Targeting metalloproteinases can seal cerebral small vessel leaks</title>
      <description>
        <![CDATA[The generation of in vitro small blood vessels mimicking the alterations of cerebral small vessel disease (CSVD) allowed a British research group to identify a way to seal leaks to treat conditions such as stroke or vascular dementia. The inhibition of matrix metalloproteinases (MMPs), enzymes that participate in the formation of new vessels, restored the normal union of the cells, preventing the permeability of the system.]]>
      </description>
      <guid>http://www.bioworld.com/articles/702944</guid>
      <pubDate>Thu, 16 Nov 2023 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/702944-targeting-metalloproteinases-can-seal-cerebral-small-vessel-leaks</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/11-16-Cambridge-Disease-brain-endothelial-cells.webp?t=1700153897" type="image/jpeg" medium="image" fileSize="358177">
        <media:title type="plain">Disease brain endothelial cells stained for tight junction protein</media:title>
        <media:description type="plain">Disease brain endothelial cells stained for tight junction protein, occluding (red) and DAPI (nuclei, blue). Credit: Alessandra Granata/University of Cambridge.</media:description>
      </media:content>
    </item>
    <item>
      <title>1st chimeric monkey born with large embryonic stem cell contribution </title>
      <description>
        <![CDATA[Investigators at the Chinese Academy of Sciences have generated a chimeric monkey by injecting an embryonic stem cell into the morula, which is an extremely early embryo consisting of 16 to 32 cells. The animal survived for only 10 days, and it is not the first live birth of a chimeric primate. But it is the first such chimera with contributions from an embryonic stem cell, and that stem cell contributed a far higher proportion of cells in the newborn than have been achieved in previous attempts at creating chimeras.]]>
      </description>
      <guid>http://www.bioworld.com/articles/702838</guid>
      <pubDate>Tue, 14 Nov 2023 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/702838-1st-chimeric-monkey-born-with-large-embryonic-stem-cell-contribution</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/11-09-23-Cell-chimeric-monkey.webp?t=1699548527" type="image/jpeg" medium="image" fileSize="165932">
        <media:title type="plain">Images showing the green fluorescence signals in different body parts of the live-birth chimeric monkey.</media:title>
        <media:description type="plain">Images showing the green fluorescence signals in different body parts of the live-birth chimeric monkey at the age of 3 days Credit: Cao et al., Cell</media:description>
      </media:content>
    </item>
    <item>
      <title>1st chimeric monkey born with large embryonic stem cell contribution </title>
      <description>
        <![CDATA[Investigators at the Chinese Academy of Sciences have generated a chimeric monkey by injecting an embryonic stem cell into the morula, which is an extremely early embryo consisting of 16 to 32 cells. The animal survived for only 10 days, and it is not the first live birth of a chimeric primate. But it is the first such chimera with contributions from an embryonic stem cell, and that stem cell contributed a far higher proportion of cells in the newborn than have been achieved in previous attempts at creating chimeras.]]>
      </description>
      <guid>http://www.bioworld.com/articles/702714</guid>
      <pubDate>Thu, 09 Nov 2023 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/702714-1st-chimeric-monkey-born-with-large-embryonic-stem-cell-contribution</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/11-09-23-Cell-chimeric-monkey.webp?t=1699548527" type="image/jpeg" medium="image" fileSize="165932">
        <media:title type="plain">Images showing the green fluorescence signals in different body parts of the live-birth chimeric monkey.</media:title>
        <media:description type="plain">Images showing the green fluorescence signals in different body parts of the live-birth chimeric monkey at the age of 3 days Credit: Cao et al., Cell</media:description>
      </media:content>
    </item>
    <item>
      <title>First humanized mesonephros kidneys developed in pig embryos after implantation</title>
      <description>
        <![CDATA[Scientists at the Guangzhou Institutes of Biomedicine and Health have developed a humanized kidney at the mesonephros stage in pig embryos up to day 28 of gestation. It is the first time that this has been achieved in chimeric xenotransplants.]]>
      </description>
      <guid>http://www.bioworld.com/articles/701654</guid>
      <pubDate>Mon, 09 Oct 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/701654-first-humanized-mesonephros-kidneys-developed-in-pig-embryos-after-implantation</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidney-dialysis-AI.webp?t=1589217904" type="image/png" medium="image" fileSize="203534">
        <media:title type="plain">Kidney illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>The human thymus has multipotent stem cells with the capacity to maintain it</title>
      <description>
        <![CDATA[It was believed that they did not exist, but they are a reality. Scientists at the Francis Crick Institute in London have discovered stem cells in the thymus for the first time. The last organ to have its role described in humans still has properties that researchers could explore to prevent the decline of the immune system throughout life.]]>
      </description>
      <guid>http://www.bioworld.com/articles/700688</guid>
      <pubDate>Thu, 07 Sep 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/700688-the-human-thymus-has-multipotent-stem-cells-with-the-capacity-to-maintain-it</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Thymus.webp?t=1694098381" type="image/jpeg" medium="image" fileSize="711721">
        <media:title type="plain">Thymus</media:title>
        <media:description type="plain">A whole tissue section of a human thymus after birth, showing thymocytes (red), epithelial cells (cyan) and polykeratin stem cells next to fibronectin areas (green). Credit: Roberta Ragazzini, the Francis Crick Institute, Developmental Cell.</media:description>
      </media:content>
    </item>
    <item>
      <title>Mitochondrial modulator rejuvenates blood stem cells</title>
      <description>
        <![CDATA[Researchers have demonstrated that inhibiting mitophagy in ‘old’ hematopoietic stem cells (HSCs) completely restored their blood reconstitution capabilities, raising the prospect of addressing the age-related weakening of the immune system that stems from HSCs deteriorating over time.]]>
      </description>
      <guid>http://www.bioworld.com/articles/700594</guid>
      <pubDate>Mon, 04 Sep 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/700594-mitochondrial-modulator-rejuvenates-blood-stem-cells</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2021/Nov-2021/Science-mitochondria-11-4.webp?t=1636057227" type="image/png" medium="image" fileSize="313090">
        <media:title type="plain">Fluorescence microscopy image of mitochondria</media:title>
        <media:description type="plain">Fluorescence microscopy image of mitochondria. Credit: Nicola Roverato, University of Konstanz</media:description>
      </media:content>
    </item>
    <item>
      <title>Damaged lungs can be renewed by engrafting stem cells</title>
      <description>
        <![CDATA[One of the key advances in regenerative medicine has been the engraftment of external epithelial stem cells to supplement or replace damaged native cells. However, the difficulty in engrafting internal tissues has hindered the long-term rescue of diseased internal epithelia, such as those in the respiratory airways.]]>
      </description>
      <guid>http://www.bioworld.com/articles/700394</guid>
      <pubDate>Mon, 28 Aug 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/700394-damaged-lungs-can-be-renewed-by-engrafting-stem-cells</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Respiratory/Lung-respiratory-digital-AI-diagnostic.webp?t=1745267029" type="image/jpeg" medium="image" fileSize="296779">
        <media:title type="plain">Lung illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Damaged lungs can be renewed by engrafting stem cells</title>
      <description>
        <![CDATA[One of the key advances in regenerative medicine has been the engraftment of external epithelial stem cells to supplement or replace damaged native cells. However, the difficulty in engrafting internal tissues has hindered the long-term rescue of diseased internal epithelia, such as those in the respiratory airways.]]>
      </description>
      <guid>http://www.bioworld.com/articles/700372</guid>
      <pubDate>Mon, 28 Aug 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/700372-damaged-lungs-can-be-renewed-by-engrafting-stem-cells</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Respiratory/Lung-respiratory-digital-AI-diagnostic.webp?t=1745267029" type="image/jpeg" medium="image" fileSize="296779">
        <media:title type="plain">Lung illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Severe COVID-19 leaves epigenetic immune system memory </title>
      <description>
        <![CDATA[A study from Weill Cornell Medicine and The Jackson Laboratory has described the epigenetic mark SARS-CoV-2 left on immune system stem cells in the most severe cases of COVID-19 early in the pandemic, before the development of vaccines. In their work published in <em>Cell</em> on Aug. 18, 2023, the researchers presented a new methodology to analyze the epigenetic changes in monocytes and circulating hematopoietic stem and progenitor cells (HSPCs) that give rise to monocytes. That allowed corresponding author Steven Josefowicz and his colleagues to see if there were already changes induced by COVID-19 before HSPCs differentiated into monocytes.]]>
      </description>
      <guid>http://www.bioworld.com/articles/700241</guid>
      <pubDate>Tue, 22 Aug 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/700241-severe-covid-19-leaves-epigenetic-immune-system-memory</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Infectious/Coronavirus-Covid-19-DNA.webp?t=1589400106" type="image/png" medium="image" fileSize="653698">
        <media:title type="plain">Coronavirus and DNA</media:title>
      </media:content>
    </item>
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