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    <title>Clinical</title>
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    <item>
      <title>Xenon spikes, Theravance sinks after phase III readouts in March</title>
      <description>
        <![CDATA[<em>BioWorld</em> tracked 209 clinical trial readouts across phases I through III in March 2026, up from 152 in February and 144 in January. Among late-stage programs, 26 phase III trials reported positive results, two produced mixed results, and three failed to meet key endpoints. By phase, March updates included 62 from phase I, 74 from phase II and 73 phase III.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730620</guid>
      <pubDate>Fri, 24 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730620-xenon-spikes-theravance-sinks-after-phase-iii-readouts-in-march</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Clinics/Clinical-trial-icons.webp?t=1589393959" type="image/png" medium="image" fileSize="381982">
        <media:title type="plain">Health professional pointing stethoscope at Clinical Trial words, icons</media:title>
      </media:content>
    </item>
    <item>
      <title>Akeso sets durability bar as immuno-oncology 2.0 race heats up </title>
      <description>
        <![CDATA[Akeso Pharmaceuticals Inc. has raised the bar for next-generation immuno-oncology, reporting more than 23 months median overall survival in pancreatic cancer with its PD-1/CTLA-4 bispecific antibody cadonilimab, as emerging competitors begin to post earlier signals across solid tumors at the American Association for Cancer Research annual meeting in San Diego April 17 to 22.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730500</guid>
      <pubDate>Wed, 22 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730500-akeso-sets-durability-bar-as-immuno-oncology-20-race-heats-up</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Endocrine-metabolic-pancreas-anatomy-illustration.webp?t=1774020868" type="image/jpeg" medium="image" fileSize="655771">
        <media:title type="plain">Pancreas anatomy illustration</media:title>
      </media:content>
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    <item>
      <title>Netrin-1 inhibitor blocks chemo resistance in pancreatic cancer</title>
      <description>
        <![CDATA[Netris Pharma SA has delivered positive phase Ib data showing its first-in-class netrin-1 inhibitor NP-137 alleviates resistance to chemotherapy in pancreatic cancer. This could represent an important advance in treating these tumors, which are notoriously resistant to chemotherapy.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730499</guid>
      <pubDate>Wed, 22 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730499-netrin-1-inhibitor-blocks-chemo-resistance-in-pancreatic-cancer</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Clinics/IV-drip-infusion.webp?t=1776879592" type="image/jpeg" medium="image" fileSize="369450">
        <media:title type="plain">Health care worker with IV drip</media:title>
      </media:content>
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    <item>
      <title>Revolution rocks on with first-line PDAC data at AACR</title>
      <description>
        <![CDATA[And the positive news continues to flow for Revolution Medicines Inc. On the heels of a successful phase III trial for RAS inhibitor daraxonrasib in previously treated patients with metastatic pancreatic ductal adenocarcinoma (PDAC) – not to mention the firm pricing the largest follow-on offering in biopharma history – Revolution presented updated phase I/II data at the American Association for Cancer Research (AACR) meeting detailing impressive findings in first-line PDAC patients.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730496</guid>
      <pubDate>Wed, 22 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730496-revolution-rocks-on-with-first-line-pdac-data-at-aacr</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Targeted-cancer-cell.webp?t=1741213881" type="image/jpeg" medium="image" fileSize="269059">
        <media:title type="plain">Targeted cancer cell</media:title>
      </media:content>
    </item>
    <item>
      <title>Walking the talk, Kyverna phase II stiffens miv-cel CAR T case</title>
      <description>
        <![CDATA[Optimism rose for what could be the first CAR T therapy in autoimmune disease as Kyverna Therapeutics Inc. made public a positive primary analysis from its registrational trial, KYSA-8, of mivocabtagene autoleucel (miv-cel, KYV-101) in stiff-person syndrome. Kyverna plans to submit a BLA to the U.S. FDA in the first half of this year.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730495</guid>
      <pubDate>Wed, 22 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730495-walking-the-talk-kyverna-phase-ii-stiffens-miv-cel-car-t-case</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Musculoskeletal/Woman-stretching-her-arms-and-hands.webp?t=1776888974" type="image/jpeg" medium="image" fileSize="445659">
        <media:title type="plain">Woman stretching her arms and hands</media:title>
      </media:content>
    </item>
    <item>
      <title>Delta-Fly eyes NDA path despite AML phase III miss </title>
      <description>
        <![CDATA[Delta-Fly Pharma Inc. is pressing ahead with discussions with the FDA for its lead acute myeloid leukemia (AML) candidate, radgocitabine (DFP-10917), despite a phase III miss on its primary endpoint, instead leaning on earlier-stage efficacy signals and emerging combination data to support a potential path toward conditional approval.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730581</guid>
      <pubDate>Tue, 21 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730581-delta-fly-eyes-nda-path-despite-aml-phase-iii-miss</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Acute-myeloid-leukemia.webp?t=1588879994" type="image/png" medium="image" fileSize="485631">
        <media:title type="plain">Acute myeloid leukemia illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Xuanzhu shares dip despite phase III ALK inhibitor data</title>
      <description>
        <![CDATA[Xuanzhu Biopharmaceutical Co. Ltd. reported positive data from a local phase III study of dirozalkib (Xuan Fei Ning), an ALK inhibitor approved in China to treat patients with advanced non-small-cell lung cancer.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730579</guid>
      <pubDate>Tue, 21 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730579-xuanzhu-shares-dip-despite-phase-iii-alk-inhibitor-data</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Lung-cancer-illustration.webp?t=1621625770" type="image/png" medium="image" fileSize="543175">
        <media:title type="plain">Lung cancer illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Remedy pushes ‘cell-free’ secretome therapy for IPF into phase I </title>
      <description>
        <![CDATA[“Single drugs targeting single biological pathways are insufficient for complex diseases,” Remedy Cell Ltd. CEO Ayelet Dilion Mashiah told <em>BioWorld</em>. Remedy is taking a secretome-based approach to treat lung disorders, having moved its lead asset, RC-0315, into a first-in-human clinical trial for idiopathic pulmonary fibrosis (IPF) in January. ]]>
      </description>
      <guid>http://www.bioworld.com/articles/730576</guid>
      <pubDate>Tue, 21 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730576-remedy-pushes-cell-free-secretome-therapy-for-ipf-into-phase-i</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2026/Ayele-Dilion-Mashiah-CEO-Remedy-4-15.webp?t=1776282566" type="image/jpeg" medium="image" fileSize="469661">
        <media:title type="plain">Ayele Dilion Mashiah, CEO, Remedy</media:title>
        <media:description type="plain">Ayelet Dilion Mashiah, CEO, Remedy Cell Ltd.</media:description>
      </media:content>
    </item>
    <item>
      <title>Early data position Junshi in next-gen immuno-oncology race </title>
      <description>
        <![CDATA[Shanghai Junshi Biosciences Co. Ltd reported early clinical signals across its next-generation immuno-oncology pipeline, including response rates of up to 71% in metastatic colorectal cancer and 45.5% in hepatocellular carcinoma, at the American Association for Cancer Research meeting in San Diego.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730486</guid>
      <pubDate>Tue, 21 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730486-early-data-position-junshi-in-next-gen-immuno-oncology-race</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Cancer-cells-and-immunotherapy.webp?t=1623784162" type="image/png" medium="image" fileSize="495987">
        <media:title type="plain">Illustration of cancer cells and immunotherapy treatment</media:title>
      </media:content>
    </item>
    <item>
      <title>Xeltis secures CE mark for Axess, its hemodialysis conduit</title>
      <description>
        <![CDATA[Xeltis BV has secured CE mark approval for Axess, its restorative vascular access conduit for hemodialysis. The company also released 12-month data from its EU pivotal trial on the technology, which showed strong durability outcomes, including 79% secondary patency and a very low patency‑related reintervention rate of 1.3 per patient-year, as well as a substantial reduction in infection burden.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730483</guid>
      <pubDate>Tue, 21 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730483-xeltis-secures-ce-mark-for-axess-its-hemodialysis-conduit</link>
      <media:content url="https://www.bioworld.com/ext/resources/2025/Xeltis-Axess-vascular-access-conduit-8jan25jpg.webp?t=1776800189" type="image/jpeg" medium="image" fileSize="34193">
        <media:title type="plain">Xeltis-Axess-vascular-access-conduit-8jan25jpg.jpg</media:title>
        <media:description type="plain">Axess vascular access conduit. Credit: Xeltis BV</media:description>
      </media:content>
    </item>
    <item>
      <title>Nektar’s rezpeg more than worth its SALT in alopecia phase IIb</title>
      <description>
        <![CDATA[With rezpegaldesleukin (rezpeg) phase IIb data in alopecia areata holding strong over time, backers of Nektar Therapeutics Inc. are hopeful that the biologic can do for the hair loss market what Dupixent (dupilumab, Regeneron Pharmaceuticals Inc./Sanofi SA) did in atopic dermatitis.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730481</guid>
      <pubDate>Tue, 21 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730481-nektars-rezpeg-more-than-worth-its-salt-in-alopecia-phase-iib</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Dermatologic/Hair-loss-illustration2.webp?t=1776804334" type="image/jpeg" medium="image" fileSize="693160">
        <media:title type="plain">Hand showing bald patch of scalp</media:title>
      </media:content>
    </item>
    <item>
      <title>Xuanzhu shares dip despite phase III ALK inhibitor data</title>
      <description>
        <![CDATA[Xuanzhu Biopharmaceutical Co. Ltd. reported positive data from a local phase III study of dirozalkib (Xuan Fei Ning), an ALK inhibitor approved in China to treat patients with advanced non-small-cell lung cancer.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730470</guid>
      <pubDate>Mon, 20 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730470-xuanzhu-shares-dip-despite-phase-iii-alk-inhibitor-data</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Lung-cancer-illustration.webp?t=1621625770" type="image/png" medium="image" fileSize="543175">
        <media:title type="plain">Lung cancer illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Novo’s Forma acquisition pays off with mitapivat competitor</title>
      <description>
        <![CDATA[Novo Nordisk A/S reported top-line results from the phase III Hibiscus study of its pyruvate kinase-R activator, etavopivat, which was acquired through the 2022 buyout of Forma Therapeutics Holdings Inc. The results set up a potential competition for patients afflicted by sickle cell disease with fellow PKR activator mitapivat from Agios Pharmaceuticals Inc.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730468</guid>
      <pubDate>Mon, 20 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730468-novos-forma-acquisition-pays-off-with-mitapivat-competitor</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Hematologic/Sickle-cell-pic.webp?t=1589217567" type="image/png" medium="image" fileSize="558183">
        <media:title type="plain">Sickle cell illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Aiming to Jimi the regulatory lock in psychedelics</title>
      <description>
        <![CDATA[The quest by psychedelic drugs for full legitimacy in the pharmaceutical world has seen marked progress as well as (fewer) setbacks of late, and developers are hopeful that an important corner has been turned.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730466</guid>
      <pubDate>Mon, 20 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730466-aiming-to-jimi-the-regulatory-lock-in-psychedelics</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Drugs/Psychedelic-pills.webp?t=1652215818" type="image/png" medium="image" fileSize="256746">
        <media:title type="plain">Pills shaded in psychedelic colors</media:title>
      </media:content>
    </item>
    <item>
      <title>Delta-Fly eyes NDA path despite AML phase III miss </title>
      <description>
        <![CDATA[Delta-Fly Pharma Inc. is pressing ahead with discussions with the FDA for its lead acute myeloid leukemia (AML) candidate, radgocitabine (DFP-10917), despite a phase III miss on its primary endpoint, instead leaning on earlier-stage efficacy signals and emerging combination data to support a potential path toward conditional approval.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730406</guid>
      <pubDate>Fri, 17 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730406-delta-fly-eyes-nda-path-despite-aml-phase-iii-miss</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Acute-myeloid-leukemia.webp?t=1588879994" type="image/png" medium="image" fileSize="485631">
        <media:title type="plain">Acute myeloid leukemia illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Ebenbuild’s tech for predicting lung drug deposition validated</title>
      <description>
        <![CDATA[The ability of Ebenbuild GmbH’s digital twin technology to predict the deposition of inhaled drugs across the lungs has been validated in a study published in <em>Nature Communications Medicine</em>. The platform, which combines AI-driven image analysis and physics-based computational modeling, demonstrated strong agreement with in vivo imaging data across multiple inhalation scenarios. ]]>
      </description>
      <guid>http://www.bioworld.com/articles/730405</guid>
      <pubDate>Fri, 17 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730405-ebenbuilds-tech-for-predicting-lung-drug-deposition-validated</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2026/Ebenbuild-Lung-digital-twin-with-aerosol-particles-4-17.webp?t=1776455746" type="image/jpeg" medium="image" fileSize="720510">
        <media:title type="plain">Ebenbuild Lung digital twin with aerosol particles</media:title>
        <media:description type="plain"> Lung digital twin with aerosol particles. Credit: Ebenbuild GmbH</media:description>
      </media:content>
    </item>
    <item>
      <title>Lilly’s GLP-1 Foundayo aces MACE in DILI of a phase III </title>
      <description>
        <![CDATA[Wall Street met with satisfaction but not surprise Eli Lilly and Co.’s undeniably positive top-line results from the phase III Achieve-4 study testing the efficacy and safety of Foundayo (orforglipron) compared to insulin glargine in adults with type 2 diabetes and obesity or overweight at increased cardiovascular risk.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730389</guid>
      <pubDate>Thu, 16 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730389-lillys-glp-1-foundayo-aces-mace-in-dili-of-a-phase-iii</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Drugs/Foundayo.webp?t=1776371156" type="image/jpeg" medium="image" fileSize="145217">
        <media:title type="plain">Foundayo</media:title>
        <media:description type="plain">Credit: Eli Lilly and Co.</media:description>
      </media:content>
    </item>
    <item>
      <title>Remedy pushes ‘cell-free’ secretome therapy for IPF into phase I </title>
      <description>
        <![CDATA[“Single drugs targeting single biological pathways are insufficient for complex diseases,” Remedy Cell Ltd. CEO Ayelet Dilion Mashiah told <em>BioWorld</em>. Remedy is taking a secretome-based approach to treat lung disorders, having moved its lead asset, RC-0315, into a first-in-human clinical trial for idiopathic pulmonary fibrosis (IPF) in January. Secretomes refer to the collection of bioactive molecules secreted by cells in the extracellular space, including proteins, enzymes, growth factors and extracellular vesicles such as exosomes.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730310</guid>
      <pubDate>Wed, 15 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730310-remedy-pushes-cell-free-secretome-therapy-for-ipf-into-phase-i</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2026/Ayele-Dilion-Mashiah-CEO-Remedy-4-15.webp?t=1776282566" type="image/jpeg" medium="image" fileSize="469661">
        <media:title type="plain">Ayele Dilion Mashiah, CEO, Remedy</media:title>
        <media:description type="plain">Ayelet Dilion Mashiah, CEO, Remedy Cell Ltd.</media:description>
      </media:content>
    </item>
    <item>
      <title>‘Immune reset’ is ambition of Tr1x’s allogenic Tr1 cell therapy</title>
      <description>
        <![CDATA[Tr1x Inc. was founded with a simple but ambitious goal: to change how autoimmune and inflammatory diseases are treated,&nbsp;moving away from chronic treatment and toward durable cures. “We are trying to flip the script on regulatory T cells (Tregs),” Tr1x CEO David de Vries told <em>BioWorld</em>. “The goal is to reset the immune system rather than continuously suppress it, and we believe we have a unique technology to do that.”]]>
      </description>
      <guid>http://www.bioworld.com/articles/730296</guid>
      <pubDate>Tue, 14 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730296-immune-reset-is-ambition-of-tr1xs-allogenic-tr1-cell-therapy</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Cell-therapy-illustration.webp?t=1758833925" type="image/jpeg" medium="image" fileSize="857445">
        <media:title type="plain">Cell therapy illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Cortec prepares to implant BCI tech into third stroke patient</title>
      <description>
        <![CDATA[Cortec GmbH is preparing to implant its brain-computer interface (BCI) technology into a third stroke patient, with early clinical data showing that the device leads to significant improvement in hand and arm function. The company believes its Brain Interchange system could transform the lives of millions of patients.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730295</guid>
      <pubDate>Tue, 14 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730295-cortec-prepares-to-implant-bci-tech-into-third-stroke-patient</link>
      <media:content url="https://www.bioworld.com/ext/resources/BMT-source/2025/CorTec-BCI-Implant-system-30july25.webp?t=1776197788" type="image/jpeg" medium="image" fileSize="329461">
        <media:title type="plain">Cortec BCI Implant system</media:title>
        <media:description type="plain">Cortec Brain Interchange, brain-computer interface (BCI) system. Credit: Cortec GmbH</media:description>
      </media:content>
    </item>
    <item>
      <title>Synox en route to approval on positive phase III for TGCT</title>
      <description>
        <![CDATA[<p>Synox Therapeutics Ltd. is preparing to file for FDA approval of emactuzumab in treating tenosynovial giant cell tumor (TGCT), after announcing positive top-line phase III results.</p>]]>
      </description>
      <guid>http://www.bioworld.com/articles/730281</guid>
      <pubDate>Mon, 13 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730281-synox-en-route-to-approval-on-positive-phase-iii-for-tgct</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Knee-joint-giant-cell-tumor-of-bone.webp?t=1731436821" type="image/jpeg" medium="image" fileSize="188135">
        <media:title type="plain">Illustration of knee joint, giant cell tumor of bone</media:title>
      </media:content>
    </item>
    <item>
      <title>Spyre’s SPY-001 induces better outcomes in ulcerative colitis</title>
      <description>
        <![CDATA[Spyre Therapeutics Inc. is off to a good start in its goal to create the best combination therapy for inflammatory bowel disease, a group of chronic, relapsing autoimmune conditions of the digestive tract that encompasses Crohn’s disease and ulcerative colitis. The Waltham, Mass.-based company estimates the market for IBD is currently at approximately $25 billion but will jump to around $40 billion in 2030.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730280</guid>
      <pubDate>Mon, 13 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730280-spyres-spy-001-induces-better-outcomes-in-ulcerative-colitis</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Ulcerative-colitis-illustration.webp?t=1776115680" type="image/jpeg" medium="image" fileSize="312045">
        <media:title type="plain">Ulcerative colitis</media:title>
      </media:content>
    </item>
    <item>
      <title>MRD word heard loud, clear in Allogene LBCL cema-cel phase II</title>
      <description>
        <![CDATA[“Home-run” efficacy and what Cowen analyst Tyler Van Buren called “pristine” safety in the phase II Alpha3 study with CAR T therapy cemacabtagene ansegedleucel (cema-cel) sent shares of Allogene Therapeutics Inc. (NASDAQ:ALLO) skyward to a $4.46 high, up nearly 64%, on April 13. Shares eventually closed at $3.06, up 34 cents.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730278</guid>
      <pubDate>Mon, 13 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730278-mrd-word-heard-loud-clear-in-allogene-lbcl-cema-cel-phase-ii</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/leukemia-lymphoma-blood-cancer.webp?t=1724424490" type="image/jpeg" medium="image" fileSize="506006">
        <media:title type="plain">Art concept for hematologic cancer</media:title>
      </media:content>
    </item>
    <item>
      <title>Revolution’s daraxonrasib nails endpoints in pancreatic cancer trial </title>
      <description>
        <![CDATA[“Unprecedented,” “remarkable” and “transformative” were just a few of the descriptives tossed out by Wall Street analysts in response to Revolution Medicines Inc.’s phase III readout, showing RAS inhibitor daraxonrasib hit its overall survival and progression-free survival endpoints in previously treated patients with metastatic pancreatic ductal adenocarcinoma, setting up the company for potential regulatory filings this year and triggering another round of M&A speculation.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730277</guid>
      <pubDate>Mon, 13 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730277-revolutions-daraxonrasib-nails-endpoints-in-pancreatic-cancer-trial</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Endocrine/Pancreas-illustration.webp?t=1635186197" type="image/png" medium="image" fileSize="649346">
        <media:title type="plain">3D pancreas illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Amplia halts enrollment in phase II pancreatic cancer trial </title>
      <description>
        <![CDATA[Amplia Therapeutics Ltd. has halted recruitment in its phase II Amplicity trial in advanced pancreatic cancer due to three dose-limiting toxicities related to the chemotherapy regimen, modified FOLFIRINOX (mFOLFIRINOX), which is being administered in combination with lead compound narmafotinib (AMP-945), a focal adhesion kinase inhibitor.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730134</guid>
      <pubDate>Tue, 07 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730134-amplia-halts-enrollment-in-phase-ii-pancreatic-cancer-trial</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/pancreatic-cancer-pancreas-3D.webp?t=1729610305" type="image/jpeg" medium="image" fileSize="283423">
        <media:title type="plain">Illustration of cancer in the pancreas</media:title>
      </media:content>
    </item>
    <item>
      <title>Five-drug VIPOR regimen shows promise in aggressive blood cancer </title>
      <description>
        <![CDATA[Deep molecular advances are enabling precision medicine for the field of hematology, Wyndham Wilson said during a plenary session at the 2026 Korean Society of Hematology International Conference March 26.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730204</guid>
      <pubDate>Tue, 07 Apr 2026 11:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730204-five-drug-vipor-regimen-shows-promise-in-aggressive-blood-cancer</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2026/ICKSH_ViPOR-scans-4-1.webp?t=1775073716" type="image/jpeg" medium="image" fileSize="427849">
        <media:title type="plain">PET scans showing before and after treatment with VIPOR</media:title>
        <media:description type="plain">Before (top) and after (bottom) treatment with VIPOR. Full-body and cross-sectional PET scans of a patient show large lymphoma tumors (circled in red) that have disappeared with treatment. Credit: Center for Cancer Research/National Cancer Institute</media:description>
      </media:content>
    </item>
    <item>
      <title>Oral ‘roid void in PPD? Lipocine MINI bike may have wheels</title>
      <description>
        <![CDATA[Hopes in postpartum depression (PPD) with an oral version of brexanolone – a synthetic formulation of the endogenous neurosteroid allopregnanolone, approved by the U.S. FDA in 2019 when given intravenously for PPD – were dashed, at least near term, when Lipocine Inc. reported that the candidate failed in a phase III placebo-controlled trial.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730072</guid>
      <pubDate>Thu, 02 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730072-oral-roid-void-in-ppd-lipocine-mini-bike-may-have-wheels</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Postpartum-depression-mother-baby.webp?t=1745264208" type="image/jpeg" medium="image" fileSize="145014">
        <media:title type="plain">Tired mother holding newborn</media:title>
      </media:content>
    </item>
    <item>
      <title>Five-drug VIPOR regimen shows promise in aggressive blood cancer </title>
      <description>
        <![CDATA[Deep molecular advances are enabling precision medicine for the field of hematology, Wyndham Wilson said during a plenary session at the 2026 Korean Society of Hematology International Conference March 26.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729980</guid>
      <pubDate>Wed, 01 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729980-five-drug-vipor-regimen-shows-promise-in-aggressive-blood-cancer</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2026/ICKSH_ViPOR-scans-4-1.webp?t=1775073716" type="image/jpeg" medium="image" fileSize="427849">
        <media:title type="plain">PET scans showing before and after treatment with VIPOR</media:title>
        <media:description type="plain">Before (top) and after (bottom) treatment with VIPOR. Full-body and cross-sectional PET scans of a patient show large lymphoma tumors (circled in red) that have disappeared with treatment. Credit: Center for Cancer Research/National Cancer Institute</media:description>
      </media:content>
    </item>
    <item>
      <title>Assay what? Eyes on Pepgen’s DM1 phase II</title>
      <description>
        <![CDATA[Phase II data disclosed March 31 by Pepgen Inc. in myotonic dystrophy type 1 (DM1) hobbled the stock but might have been much different if not for one outlier in the 5-mg/kg multiple ascending dose cohort of the ongoing phase II Freedom2-DM1 trial – and Wall Street is pondering what the hitch means for the Boston-based firm as well as the competitive space.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729979</guid>
      <pubDate>Wed, 01 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729979-assay-what-eyes-on-pepgens-dm1-phase-ii</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Musculoskeletal/Limb-exam.webp?t=1613158518" type="image/png" medium="image" fileSize="400910">
        <media:title type="plain">Limb exam</media:title>
      </media:content>
    </item>
    <item>
      <title>Innovent’s IBI-302 meets phase III endpoints in neovascular AMD </title>
      <description>
        <![CDATA[Innovent Biologics Inc.’s efdamrofusp alfa (IBI-302) met the primary endpoint in the phase III Star trial in neovascular age-related macular degeneration (nAMD), and the Suzhou, China-based company will submit an NDA to China’s National Medical Products Administration.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730089</guid>
      <pubDate>Tue, 31 Mar 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730089-innovents-ibi-302-meets-phase-iii-endpoints-in-neovascular-amd</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Ocular/Amsler-grid-test.webp?t=1627064994" type="image/png" medium="image" fileSize="427571">
        <media:title type="plain">Woman taking Amsler grid eye exam</media:title>
      </media:content>
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