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      <title>TRX-319 silences autoreactive B and T cells in multiple sclerosis</title>
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        <![CDATA[Researchers from Tr1x Inc. presented the development of TRX-319, a novel allogeneic regulatory T-cell therapy designed for the treatment of autoimmune disorders.]]>
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      <guid>http://www.bioworld.com/articles/728788</guid>
      <pubDate>Wed, 11 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728788-trx-319-silences-autoreactive-b-and-t-cells-in-multiple-sclerosis</link>
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        <media:title type="plain">Illustration of lymphocytes</media:title>
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      <title>SUDO-550 demonstrates robust efficacy in MS models</title>
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        <![CDATA[TYK2, a Janus kinase family member, mediates signaling from pro-inflammatory cytokines such as type I interferons, IL-12 and IL-23. In multiple sclerosis (MS), chronic CNS inflammation involves glial activation and immune cell infiltration, making TYK2 inhibition a potential strategy to reduce neuroinflammation.]]>
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      <guid>http://www.bioworld.com/articles/728786</guid>
      <pubDate>Wed, 11 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728786-sudo-550-demonstrates-robust-efficacy-in-ms-models</link>
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        <media:title type="plain">Myelin sheath and neurons in the brain</media:title>
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      <title>Targeting TMEM97 alleviates MS symptoms and damage</title>
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        <![CDATA[TMEM97 regulates microglial activation and neuronal stress pathways linked to neuropathic pain and neuroinflammation in multiple sclerosis (MS). Pharmacological targeting of TMEM97 has shown neuroprotective effects in models of traumatic brain injury, Huntington’s disease and retinal ganglion cell degeneration, and may reduce pain while preserving neuronal function.]]>
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      <guid>http://www.bioworld.com/articles/728739</guid>
      <pubDate>Mon, 09 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728739-targeting-tmem97-alleviates-ms-symptoms-and-damage</link>
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      <title>Alumis’ brain-penetrant TYK2 inhibitor prevents neuroinflammation</title>
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        <![CDATA[Tyrosine kinase 2 (TYK2), expressed in astrocytes and microglia, is involved in the activation of pathways triggered by proinflammatory cytokines, such as IL-23, IL-12 and type I interferons (IFNs), within the central nervous system (CNS). Dysregulated activation of astrocytes and microglia may contribute to the neuroinflammation associated with progressive forms of multiple sclerosis (MS).]]>
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      <guid>http://www.bioworld.com/articles/717553</guid>
      <pubDate>Tue, 04 Mar 2025 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/717553-alumis-brain-penetrant-tyk2-inhibitor-prevents-neuroinflammation</link>
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        <media:title type="plain">Drug capsule spilling onto brain</media:title>
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