https://www.bioworld.com/rss en-us STRC gene, which encodes stereocilin, a protein essential for the effective function of outer hair cells as cochlear amplifiers. Researchers from the Institut Pasteur and Sorbonne Université in Paris, France, have developed and evaluated the efficacy of an Strc gene therapy in a mouse model of DFNB16.]]> http://www.bioworld.com/articles/728436 Fri, 30 Jan 2026 08:00:00 -0500 https://www.bioworld.com/articles/728436-gene-therapy-restores-auditory-function-in-deaf-mice http://www.bioworld.com/articles/728527 Thu, 29 Jan 2026 09:00:00 -0500 https://www.bioworld.com/articles/728527-seamless-seals-112b-gene-editing-deal-with-lilly-on-hearing-loss Ear illustration http://www.bioworld.com/articles/728396 Wed, 28 Jan 2026 08:00:00 -0500 https://www.bioworld.com/articles/728396-sensorion-raises-funding-to-advance-sens-601-into-clinic Ear and sound waves illustration Cell Host & Microbe on Nov. 12, 2025, the database is expected to serve as a universal platform for academia and enable “precision microbiome medicine” for the industry, Lee told BioWorld.]]> http://www.bioworld.com/articles/726351 Tue, 18 Nov 2025 08:00:00 -0500 https://www.bioworld.com/articles/726351-most-complete-map-of-oral-microbiome-enables-links-to-systemic-disease Microbiome illustration Credit: Darryl Leja, NHGRI Cell Host & Microbe on Nov. 12, 2025, the database is expected to serve as a universal platform for academia and enable “precision microbiome medicine” for the industry, Lee told BioWorld.]]> http://www.bioworld.com/articles/726031 Thu, 13 Nov 2025 08:00:00 -0500 https://www.bioworld.com/articles/726031-most-complete-map-of-oral-microbiome-enables-links-to-systemic-disease Microbiome illustration Credit: Darryl Leja, NHGRI http://www.bioworld.com/articles/724002 Wed, 10 Sep 2025 09:00:00 -0400 https://www.bioworld.com/articles/724002-novel-antisense-oligonucleotide-therapy-for-dfna2-hearing-loss Illustration of ear next to DNA double helix http://www.bioworld.com/articles/723880 Thu, 04 Sep 2025 09:00:00 -0400 https://www.bioworld.com/articles/723880-gene-therapy-rescues-hearing-loss-in-murine-model-of-clic5-deafness http://www.bioworld.com/articles/723613 Wed, 27 Aug 2025 09:00:00 -0400 https://www.bioworld.com/articles/723613-lineage-enters-collaboration-for-anp-1-for-hearing-loss Illustration demonstrating parts of the ear http://www.bioworld.com/articles/722041 Tue, 08 Jul 2025 09:00:00 -0400 https://www.bioworld.com/articles/722041-turn-on-vitamin-a-pathway-and-regenerate-an-ear Aldh1a2 in rabbits vs. mice Aldh1a2 is highly expressed in rabbit blastema but not the mouse blastema. Credit: The Wei Wang Lab at National Institute of Biological Sciences, Beijing. http://www.bioworld.com/articles/721883 Wed, 02 Jul 2025 09:00:00 -0400 https://www.bioworld.com/articles/721883-turn-on-vitamin-a-pathway-and-regenerate-an-ear Aldh1a2 in rabbits vs. mice Aldh1a2 is highly expressed in rabbit blastema but not the mouse blastema. Credit: The Wei Wang Lab at National Institute of Biological Sciences, Beijing. http://www.bioworld.com/articles/721629 Tue, 01 Jul 2025 09:00:00 -0400 https://www.bioworld.com/articles/721629-turn-on-vitamin-a-pathway-and-regenerate-an-ear Aldh1a2 in rabbits vs. mice Aldh1a2 is highly expressed in rabbit blastema but not the mouse blastema. Credit: The Wei Wang Lab at National Institute of Biological Sciences, Beijing. GJB2 gene are the most common genetic cause of congenital sensorineural hearing loss and are mostly associated with an autosomal recessive non-syndromic deafness 1A (DFNB1A).]]> http://www.bioworld.com/articles/718165 Wed, 12 Mar 2025 09:00:00 -0400 https://www.bioworld.com/articles/718165-gjb2-gt-has-specific-targeting-and-efficacy-in-preclinical-models-of-deafness Hand cupping ear to illustration hearing loss http://www.bioworld.com/articles/718052 Mon, 10 Mar 2025 09:00:00 -0400 https://www.bioworld.com/articles/718052-new-animal-model-of-eosinophilic-otitis-media-developed Anatomical model of the ear next to an otoscope KDM6A gene is located in chromosome X and pathogenic variants in this gene are tied to Kabuki syndrome type 2. Even though progress in understanding the functions of KDM6A has been made, its role in cochlear development and auditory function remains poorly understood.]]> http://www.bioworld.com/articles/718028 Fri, 07 Mar 2025 09:00:00 -0500 https://www.bioworld.com/articles/718028-researchers-develop-novel-kabuki-syndrome-murine-model Mouse genome/DNA sequencing concept art. Credit: Darryl Leja, National Human Genome Research Institute, NIH http://www.bioworld.com/articles/717577 Wed, 05 Mar 2025 09:00:00 -0500 https://www.bioworld.com/articles/717577-ac-102-penetrates-rapidly-distributes-evenly-along-the-cochlea-after-intratympanic-delivery-in-pigs Illustration demonstrating parts of the ear http://www.bioworld.com/articles/717539 Mon, 03 Mar 2025 09:00:00 -0500 https://www.bioworld.com/articles/717539-gabarap-emerges-as-a-therapeutic-target-to-prevent-aminoglycoside-induced-hearing-loss Man holding hand up to ear http://www.bioworld.com/articles/717516 Fri, 28 Feb 2025 09:00:00 -0500 https://www.bioworld.com/articles/717516-ns-101-restores-synapse-function-in-hearing-loss-models Hearing ear icon GJB2 gene, which encodes the gap junction protein connexin 26. That regulates the transport of potassium and metabolites between inner ear cells. The coding sequence of this gene fits in an adenovirus-associated vector (AAV), making it an attractive approach for gene therapy.]]> http://www.bioworld.com/articles/717476 Wed, 26 Feb 2025 09:00:00 -0500 https://www.bioworld.com/articles/717476-restoring-gjb2-expression-rescues-hereditary-hearing-loss BioWorld.]]> http://www.bioworld.com/articles/717747 Tue, 25 Feb 2025 12:00:00 -0500 https://www.bioworld.com/articles/717747-regeneron-gene-therapy-improves-childrens-hearing Child cupping hand to ear http://www.bioworld.com/articles/715257 Wed, 11 Dec 2024 12:00:00 -0500 https://www.bioworld.com/articles/715257-loud-and-clear-sound-pharma-has-phase-iii-success-in-menieres Ear illustration http://www.bioworld.com/articles/713887 Mon, 28 Oct 2024 09:00:00 -0400 https://www.bioworld.com/articles/713887-riboxs-rxrg-001-cleared-to-enter-clinic-for-radiation-induced-xerostomia-and-hyposalivation RNA strand http://www.bioworld.com/articles/713473 Tue, 15 Oct 2024 09:00:00 -0400 https://www.bioworld.com/articles/713473-antioxidants-for-hearing-loss-and-menieres-disease-disclosed-in-primemupharma-patent MPZL2, is widely expressed in cochlear cells in the inner ear. Mutations in MPZL2 have been identified as the second most prevalent cause of mild to moderate hereditary hearing loss.]]> http://www.bioworld.com/articles/713462 Tue, 15 Oct 2024 09:00:00 -0400 https://www.bioworld.com/articles/713462-new-gene-therapy-for-hereditary-hearing-loss-described http://www.bioworld.com/articles/711468 Tue, 13 Aug 2024 09:00:00 -0400 https://www.bioworld.com/articles/711468-piplartine-counteracts-antibiotic-induced-hearing-loss Man holding hand up to ear Cdh23) gene in a line of laboratory mice gave rise to a new murine model with hereditary hearing loss and vestibular alterations.]]> http://www.bioworld.com/articles/711291 Wed, 07 Aug 2024 09:00:00 -0400 https://www.bioworld.com/articles/711291-mouse-model-of-profound-deafness-linked-to-a-emcdh23-em-variant Closeup of a mouse http://www.bioworld.com/articles/710539 Fri, 12 Jul 2024 12:00:00 -0400 https://www.bioworld.com/articles/710539-big-pharmas-ear-to-the-ground-as-hearing-loss-drum-beats-louder http://www.bioworld.com/articles/710529 Fri, 12 Jul 2024 09:00:00 -0400 https://www.bioworld.com/articles/710529-a-gene-therapy-could-restore-hearing-in-adults Illustration demonstrating parts of the ear http://www.bioworld.com/articles/710384 Thu, 11 Jul 2024 09:00:00 -0400 https://www.bioworld.com/articles/710384-a-gene-therapy-could-restore-hearing-in-adults Illustration demonstrating parts of the ear http://www.bioworld.com/articles/709416 Tue, 11 Jun 2024 09:00:00 -0400 https://www.bioworld.com/articles/709416-shionogi-enters-option-agreement-for-cilcares-hearing-loss-candidates Man holding hand up to ear 70% of the genes involved in pathogenic hearing loss are involved in autosomal recessive nonsyndromic hearing loss (ARNSHL), which accounts for 1 case for every 166 individuals in Iran due to the high rate of consanguineous marriage in the country.]]> http://www.bioworld.com/articles/709365 Tue, 11 Jun 2024 09:00:00 -0400 https://www.bioworld.com/articles/709365-dbx2-is-a-new-gene-tied-to-nonsyndromic-hearing-loss Ear and sound waves illustration