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    <title>Gastrointestinal</title>
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    <item>
      <title>Hanmi, Haisco win billion-dollar partnerships with Eli Lilly</title>
      <description>
        <![CDATA[Hanmi Pharmaceutical Co. Ltd. secured a $1.26 billion deal with Eli Lilly and Co. to out-license ex-Korea rights to sonefpeglutide (HM-15912), a Lapscovery-based glucagon-like peptide-2 analog in development for multiple indications, including an ongoing phase II study of short bowel syndrome. It was one of two billion-dollar Asian company deals signed by Lilly on June 1, with the second transaction involving Haisco Pharmaceutical Group Co. Ltd., of Beijing.]]>
      </description>
      <guid>http://www.bioworld.com/articles/731645</guid>
      <pubDate>Tue, 02 Jun 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731645-hanmi-haisco-win-billion-dollar-partnerships-with-eli-lilly</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2026/Hanmi-signage-6-1.webp?t=1780342948" type="image/jpeg" medium="image" fileSize="195343">
        <media:title type="plain">Hanmi signage</media:title>
        <media:description type="plain">Credit: Hanmi Pharmaceutical Co. Ltd.</media:description>
      </media:content>
    </item>
    <item>
      <title>Cancer specter looming, Abtect effect in UC wallops Abivax</title>
      <description>
        <![CDATA[Although analysts liked the data – calling them “truly amazing” and “transformational” – Wall Street apparently had qualms about three cancer cases that turned up in phase III top-line data from the Abtect maintenance trial with obefazimod. Paris-based Abivax SA’s oral, first-in-class miRNA-124 enhancer performed well in adults with moderately to severely active ulcerative colitis (UC), but shares of (NASDAQ:ABVX) closed June 2 at $72.50, down 44%, or $57.19.]]>
      </description>
      <guid>http://www.bioworld.com/articles/731525</guid>
      <pubDate>Tue, 02 Jun 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731525-cancer-specter-looming-abtect-effect-in-uc-wallops-abivax</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Stomach-pain.webp?t=1745258577" type="image/jpeg" medium="image" fileSize="208753">
        <media:title type="plain">Person holding stomach in pain </media:title>
      </media:content>
    </item>
    <item>
      <title>AX-2911 shows in vivo activity by correcting PNPLA3 in MASH</title>
      <description>
        <![CDATA[Alterations in PNPLA3, particularly the I148M variant, impair lipid metabolism in hepatocytes, leading to lipid accumulation and driving progression from steatosis to fibrosis and cirrhosis. Targeting this genetic driver may offer a strategy to reduce steatosis and limit disease progression.]]>
      </description>
      <guid>http://www.bioworld.com/articles/731582</guid>
      <pubDate>Tue, 02 Jun 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731582-ax-2911-shows-in-vivo-activity-by-correcting-pnpla3-in-mash</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Liver-illustration.webp?t=1613674462" type="image/png" medium="image" fileSize="432664">
        <media:title type="plain">Liver illustration</media:title>
        <media:description type="plain">Credit: Georgia State University</media:description>
      </media:content>
    </item>
    <item>
      <title>PRD-001 shows synergy with Rezdiffra for treating MASH</title>
      <description>
        <![CDATA[Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by lipid accumulation in the liver and inflammation. Sterol O-acyltransferase 2 (SOAT2) is a key enzyme in intestinal absorption and hepatic secretion of cholesterol. PRD Therapeutics Inc. has developed PRD-001, a selective SOAT2 inhibitor currently in phase I trials for MASH.]]>
      </description>
      <guid>http://www.bioworld.com/articles/731581</guid>
      <pubDate>Tue, 02 Jun 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731581-prd-001-shows-synergy-with-rezdiffra-for-treating-mash</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/fatty-liver-disease.webp?t=1589217291" type="image/png" medium="image" fileSize="932342">
        <media:title type="plain">Liver disease</media:title>
      </media:content>
    </item>
    <item>
      <title>EASL spotlight: TUNE-401 advances epigenetic silencing in HBV</title>
      <description>
        <![CDATA[Several presentations at EASL highlight a new generation of therapies coming into view, with the work from Tune Therapeutics Inc. standing out as one of the most relevant for the novelty it represents and the step forward it signals. The company is investigating the use of TUNE-401 as a potential treatment for hepatitis B.]]>
      </description>
      <guid>http://www.bioworld.com/articles/731576</guid>
      <pubDate>Tue, 02 Jun 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731576-easl-spotlight-tune-401-advances-epigenetic-silencing-in-hbv</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Hepatitis-B-virus-CC-by-2-0.webp?t=1780407811" type="image/jpeg" medium="image" fileSize="351561">
        <media:title type="plain">Hepatitis B virus rendering</media:title>
        <media:description type="plain">Hepatitis B virus. Credit: NIAID, CC BY 2.0.</media:description>
      </media:content>
    </item>
    <item>
      <title>CRISPR-based approach fights pathogenic &lt;em&gt;E. coli&lt;/em&gt; </title>
      <description>
        <![CDATA[Shiga toxin-producing <em>Escherichia coli</em> (STEC) represents a public health threat that can lead to serious problems, such as bloody diarrhea and hemolytic uremic syndrome in children in up to 10%-15% of cases. Antibiotics that normally combat diarrhea are not recommended for STEC infections and patients are usually treated only for symptomatology. Now, French researchers from Eligo Bioscience SA and their collaborators have published a paper on a CRISPR-based antimicrobial approach, EB-003.]]>
      </description>
      <guid>http://www.bioworld.com/articles/731575</guid>
      <pubDate>Tue, 02 Jun 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731575-crispr-based-approach-fights-pathogenic-eme-coli-em</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/E-coli-Thom-Leach.webp?t=1709224791" type="image/jpeg" medium="image" fileSize="391680">
        <media:title type="plain">Illustration of E. coli with window showing DNA</media:title>
        <media:description type="plain">E.coli. Credit: Thom Leach. License: CC by SA</media:description>
      </media:content>
    </item>
    <item>
      <title>Hanmi, Haisco win billion-dollar partnerships with Eli Lilly</title>
      <description>
        <![CDATA[Hanmi Pharmaceutical Co. Ltd. secured a $1.26 billion deal with Eli Lilly and Co. to out-license ex-Korea rights to sonefpeglutide (HM-15912), a Lapscovery-based glucagon-like peptide-2 analog in development for multiple indications, including an ongoing phase II study of short bowel syndrome. It was one of two billion-dollar Asian company deals signed by Lilly on June 1, with the second transaction involving Haisco Pharmaceutical Group Co. Ltd., of Beijing.]]>
      </description>
      <guid>http://www.bioworld.com/articles/731459</guid>
      <pubDate>Mon, 01 Jun 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731459-hanmi-haisco-win-billion-dollar-partnerships-with-eli-lilly</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2026/Hanmi-signage-6-1.webp?t=1780342948" type="image/jpeg" medium="image" fileSize="195343">
        <media:title type="plain">Hanmi signage</media:title>
        <media:description type="plain">Credit: Hanmi Pharmaceutical Co. Ltd.</media:description>
      </media:content>
    </item>
    <item>
      <title>PLT-012 shows efficacy across different MASH models</title>
      <description>
        <![CDATA[Researchers from Pilatus Biosciences SA recently presented preclinical efficacy data for PLT-012, a humanized IgG4 antibody targeting CD36, in metabolic dysfunction-associated steatohepatitis (MASH) models.]]>
      </description>
      <guid>http://www.bioworld.com/articles/731558</guid>
      <pubDate>Mon, 01 Jun 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731558-plt-012-shows-efficacy-across-different-mash-models</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Fatty-liver-steatosis-triglyceride.webp?t=1780322020" type="image/png" medium="image" fileSize="764301">
        <media:title type="plain">3D illustration of liver and photomicrograph showing triglyceride fat accumulated in liver cells.</media:title>
        <media:description type="plain">An estimated 444 million people worldwide are living with NASH/MASH.</media:description>
      </media:content>
    </item>
    <item>
      <title>EASL 2026: Emerging liver disease targets to watch</title>
      <description>
        <![CDATA[At the recently concluded European Association for the Study of the Liver meeting, presentations underscored how increasingly granular insights into liver pathobiology are driving the rapid identification of new druggable targets across diverse indications.]]>
      </description>
      <guid>http://www.bioworld.com/articles/731553</guid>
      <pubDate>Mon, 01 Jun 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731553-easl-2026-emerging-liver-disease-targets-to-watch</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Liver-on-digital-lens.webp?t=1709588066" type="image/jpeg" medium="image" fileSize="175206">
        <media:title type="plain">Liver over digital lens background</media:title>
      </media:content>
    </item>
    <item>
      <title>Pancreatic lesions show cancer traits but lack stromal support</title>
      <description>
        <![CDATA[The human pancreas often contains lesions that are common in the population and that, although they can become malignant, usually do not. To understand when this occurs and how these pancreatic cancer precursor lesions, known as pancreatic intraepithelial neoplasias (PanIN), evolve, scientists at the University of Michigan analyzed their gene expression patterns and their cellular microenvironment.]]>
      </description>
      <guid>http://www.bioworld.com/articles/731491</guid>
      <pubDate>Fri, 29 May 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731491-pancreatic-lesions-show-cancer-traits-but-lack-stromal-support</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Pasca-Lab-PanINmicroenvironment-hero-5-29-26.webp?t=1780066560" type="image/jpeg" medium="image" fileSize="1706525">
        <media:title type="plain">Immunofluorescence image of human donor pancreas with a precursor lesion lined by epithelial cells surrounded by fibroblasts. </media:title>
        <media:description type="plain">Immunofluorescence image of human donor pancreas with a precursor lesion lined by epithelial cells surrounded by fibroblasts. Credit: Pasca Lab</media:description>
      </media:content>
    </item>
    <item>
      <title>EASL 2026: Rebuilding the liver, from organoids to engineered ducts</title>
      <description>
        <![CDATA[With a historic WHO resolution adopted this week giving countries, for the first time, a mandate to address liver disease affecting 1.5 billion people worldwide, this momentum is strongly reflected at the ongoing European Association for the Study of the Liver 2026 congress in Barcelona. The mandate positions liver disease alongside cancer, cardiovascular disease and diabetes as a core global health priority.]]>
      </description>
      <guid>http://www.bioworld.com/articles/731472</guid>
      <pubDate>Thu, 28 May 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731472-easl-2026-rebuilding-the-liver-from-organoids-to-engineered-ducts</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Liver-illustration-purple.webp?t=1705415419" type="image/jpeg" medium="image" fileSize="218236">
        <media:title type="plain">Liver illustration </media:title>
      </media:content>
    </item>
    <item>
      <title>Daewoong nabs Innovo’s preclinical IBD asset in ₩663B deal</title>
      <description>
        <![CDATA[Daewoong Pharmaceutical Co. Ltd. secured an exclusive license to Innovo Therapeutics Inc.’s INV-008, a novel oral 15-hydroxyprostaglandin dehydrogenase inhibitor for inflammatory bowel disease (IBD), through a potential ₩662.5 billion (US$443.6 million) deal. ]]>
      </description>
      <guid>http://www.bioworld.com/articles/731364</guid>
      <pubDate>Tue, 19 May 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731364-daewoong-nabs-innovos-preclinical-ibd-asset-in-663b-deal</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2026/Daewoong-Innovo-CEOs-5-13.webp?t=1778686979" type="image/jpeg" medium="image" fileSize="116766">
        <media:title type="plain">Daewong CEO Park Sung-soo (left) with Innovo CEO Park Hee-dong</media:title>
        <media:description type="plain">Daewong Pharmaceutical CEO Park Sung-soo (left) with Innovo Therapeutics CEO Park Hee-dong.</media:description>
      </media:content>
    </item>
    <item>
      <title>Epirium’s 15-PGDH inhibitor IBD candidates improve disease outcomes in models</title>
      <description>
        <![CDATA[Epirium Bio Inc. has developed a series of small-molecule 15-PGDH inhibitors, the phase II-ready MF-300 and preclinical candidate MF-1305, as potential therapeutics for inflammatory bowel disease (IBD).]]>
      </description>
      <guid>http://www.bioworld.com/articles/731101</guid>
      <pubDate>Thu, 14 May 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731101-epiriums-15-pgdh-inhibitor-ibd-candidates-improve-disease-outcomes-in-models</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Gastrointestinal-microbiome.webp?t=1589217172" type="image/png" medium="image" fileSize="442923">
        <media:title type="plain">Intestine</media:title>
      </media:content>
    </item>
    <item>
      <title>Daewoong nabs Innovo’s preclinical IBD asset in ₩663B deal</title>
      <description>
        <![CDATA[Daewoong Pharmaceutical Co. Ltd. secured an exclusive license to Innovo Therapeutics Inc.’s INV-008, a novel oral 15-hydroxyprostaglandin dehydrogenase inhibitor for inflammatory bowel disease (IBD), through a potential ₩662.5 billion (US$443.6 million) deal. ]]>
      </description>
      <guid>http://www.bioworld.com/articles/731063</guid>
      <pubDate>Wed, 13 May 2026 11:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/731063-daewoong-nabs-innovos-preclinical-ibd-asset-in-663b-deal</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2026/Daewoong-Innovo-CEOs-5-13.webp?t=1778686979" type="image/jpeg" medium="image" fileSize="116766">
        <media:title type="plain">Daewong CEO Park Sung-soo (left) with Innovo CEO Park Hee-dong</media:title>
        <media:description type="plain">Daewong Pharmaceutical CEO Park Sung-soo (left) with Innovo Therapeutics CEO Park Hee-dong.</media:description>
      </media:content>
    </item>
    <item>
      <title>Mabwell’s 9MW5211 gains IND clearance for IBD </title>
      <description>
        <![CDATA[Mabwell (Shanghai) Bioscience Co. Ltd. has obtained IND clearance from the FDA for 9MW5211 for the treatment of inflammatory bowel disease (IBD). ]]>
      </description>
      <guid>http://www.bioworld.com/articles/730995</guid>
      <pubDate>Mon, 11 May 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730995-mabwells-9mw5211-gains-ind-clearance-for-ibd</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Holographic-intestine.webp?t=1683669912" type="image/jpeg" medium="image" fileSize="171482">
        <media:title type="plain">Hands holding holographic intestine</media:title>
      </media:content>
    </item>
    <item>
      <title>Kymera’s IRF5 degrader shows potential in IBD treatment</title>
      <description>
        <![CDATA[At the recently concluded Digestive Disease Week, researchers from Kymera Therapeutics Inc. presented preclinical efficacy data on KT-579, a selective oral IRF5 degrader, in models of IBD.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730907</guid>
      <pubDate>Wed, 06 May 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730907-kymeras-irf5-degrader-shows-potential-in-ibd-treatment</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Gastrointestinal-inflammatory-bowel-disease-IBD-Crohn.webp?t=1706553250" type="image/jpeg" medium="image" fileSize="247467">
        <media:title type="plain">Art concept for inflammation in the intestines</media:title>
      </media:content>
    </item>
    <item>
      <title>Enterobiotix raises $25.7M for phase IIb of microbiome pill in IBS</title>
      <description>
        <![CDATA[Microbiome specialist Enterobiotix Ltd. has raised £19 million (US$25.7 million) to fund phase IIb development of its lead program EBX-102-02 in the treatment of irritable bowel syndrome with constipation (IBS-C).]]>
      </description>
      <guid>http://www.bioworld.com/articles/730688</guid>
      <pubDate>Wed, 29 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730688-enterobiotix-raises-257m-for-phase-iib-of-microbiome-pill-in-ibs</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Money/Glass-pound-symbol1.webp?t=1637697971" type="image/png" medium="image" fileSize="286512">
        <media:title type="plain">British pound symbol</media:title>
      </media:content>
    </item>
    <item>
      <title>Montai’s MTAI-1025 demonstrates efficacy in ulcerative colitis</title>
      <description>
        <![CDATA[The combination of impaired epithelial barrier function, mucosal inflammation and elevated oxidative stress is determinant for the pathogenesis of ulcerative colitis (UC). NF-E2-related factor 2 (NRF2) is an important transcription factor for modulating antioxidant defenses, inhibiting inflammatory pathways and regenerating the epithelial barrier. Montai Therapeutics Inc. has developed a potent and selective NRF2 agonist compound, MTAI-1025, for the management of UC using its proprietary CONECTA platform.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730743</guid>
      <pubDate>Wed, 29 Apr 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730743-montais-mtai-1025-demonstrates-efficacy-in-ulcerative-colitis</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/IBD-inflammatory-bowel-disease-Crohns-Colitis.webp?t=1745258495" type="image/jpeg" medium="image" fileSize="193405">
        <media:title type="plain">Illustration of intestines with inflammation</media:title>
      </media:content>
    </item>
    <item>
      <title>Novel method BOOSTs organ growth after transplantation</title>
      <description>
        <![CDATA[A major challenge in tissue engineering is not only achieving the correct cellular organization of an engineered tissue, but also expanding it to a clinically useful size after implantation. Researchers from the Wyss Institute at Harvard University have developed a synthetic biology platform that genetically programs tissues to grow large organ implants on demand. Building on a 2017 study suggesting engineered liver tissues could respond to regenerative signals released after injury, the researchers set out to identify and harness those cues.
<br><br>
  “If we could figure out what those signals were, we could synthetically drive these factors locally in an implant to control its growth ourselves,” first author Amy Stoddard told <em>BioWorld</em>. Stoddard is a postdoctoral researcher at the Wyss Institute.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730717</guid>
      <pubDate>Tue, 28 Apr 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730717-novel-method-boosts-organ-growth-after-transplantation</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Misc/Neon-arrows.webp?t=1777389173" type="image/jpeg" medium="image" fileSize="548927">
        <media:title type="plain">Pink and blue neon arrows demonstrating acceleration</media:title>
      </media:content>
    </item>
    <item>
      <title>Elpiscience’s bispecific antibody ES-302 reduces disease activity in IBD model</title>
      <description>
        <![CDATA[Researchers from Elpiscience Biopharmaceuticals Inc. hypothesized that dual targeting of the TL1A/DR3 and IL-23 signaling pathways with a single bispecific antibody would exert superior efficacy by reshaping the immune landscape in disorders such as inflammatory bowel disease (IBD). The company has developed a bispecific antibody targeting both TL1A/DR3 and IL-23p19 – ES-302 – for the treatment of IBD.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730557</guid>
      <pubDate>Wed, 22 Apr 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730557-elpisciences-bispecific-antibody-es-302-reduces-disease-activity-in-ibd-model</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Gastrointestinal-vector-framework.webp?t=1739806991" type="image/jpeg" medium="image" fileSize="232822">
        <media:title type="plain">Illustration of intestinal track</media:title>
      </media:content>
    </item>
    <item>
      <title>Daiichi to divest consumer health unit to Suntory for $1.5B</title>
      <description>
        <![CDATA[Daiichi Sankyo. Co. Ltd. will begin a phased sale of its consumer health subsidiary, Daiichi Sankyo Healthcare Co. Ltd., to Suntory Holdings Ltd., as the Tokyo-based drugmaker sharpens its focus on oncology.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730574</guid>
      <pubDate>Tue, 21 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730574-daiichi-to-divest-consumer-health-unit-to-suntory-for-15b</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Deals-and-MAs/Arrows-opposite-directions.webp?t=1588276411" type="image/png" medium="image" fileSize="20890">
        <media:title type="plain">Two arrows in opposite directions</media:title>
      </media:content>
    </item>
    <item>
      <title>Daiichi to divest consumer health unit to Suntory for $1.5B</title>
      <description>
        <![CDATA[Daiichi Sankyo. Co. Ltd. will begin a phased sale of its consumer health subsidiary, Daiichi Sankyo Healthcare Co. Ltd., to Suntory Holdings Ltd., as the Tokyo-based drugmaker sharpens its focus on oncology.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730407</guid>
      <pubDate>Fri, 17 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730407-daiichi-to-divest-consumer-health-unit-to-suntory-for-15b</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Deals-and-MAs/Arrows-opposite-directions.webp?t=1588276411" type="image/png" medium="image" fileSize="20890">
        <media:title type="plain">Two arrows in opposite directions</media:title>
      </media:content>
    </item>
    <item>
      <title>Mayinglong Pharmaceutical presents new 5-HT4 receptor agonists</title>
      <description>
        <![CDATA[Mayinglong Pharmaceutical Group Co. Ltd. has reported new 5-HT4 receptor agonists that are potentially useful for the treatment of gastroesophageal reflux disease, constipation, irritable bowel syndrome, dyspepsia, delayed gastric emptying (gastroparesis), intestinal pseudo-obstruction, diabetic gastroparesis and postoperative Ileus.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730360</guid>
      <pubDate>Tue, 14 Apr 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730360-mayinglong-pharmaceutical-presents-new-5-ht4-receptor-agonists</link>
    </item>
    <item>
      <title>Hubei Bio-Pharmaceutical Industrial Technological Institute divulges new VAV1 degraders</title>
      <description>
        <![CDATA[Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. has identified new molecular glue degrader compounds acting as proto-oncogene Vav (VAV1)/protein cereblon (CRBN) interaction inducers for degradation of VAV1 reported to be useful for the treatment of inflammatory bowel disease.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730359</guid>
      <pubDate>Tue, 14 Apr 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730359-hubei-bio-pharmaceutical-industrial-technological-institute-divulges-new-vav1-degraders</link>
    </item>
    <item>
      <title>Spyre’s SPY-001 induces better outcomes in ulcerative colitis</title>
      <description>
        <![CDATA[Spyre Therapeutics Inc. is off to a good start in its goal to create the best combination therapy for inflammatory bowel disease, a group of chronic, relapsing autoimmune conditions of the digestive tract that encompasses Crohn’s disease and ulcerative colitis. The Waltham, Mass.-based company estimates the market for IBD is currently at approximately $25 billion but will jump to around $40 billion in 2030.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730280</guid>
      <pubDate>Mon, 13 Apr 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730280-spyres-spy-001-induces-better-outcomes-in-ulcerative-colitis</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Ulcerative-colitis-illustration.webp?t=1776115680" type="image/jpeg" medium="image" fileSize="312045">
        <media:title type="plain">Ulcerative colitis</media:title>
      </media:content>
    </item>
    <item>
      <title>GLP-1R drug response tied to variants in target genes</title>
      <description>
        <![CDATA[The development of glucagon-like peptide 1 receptor (GLP-1R) agonists, such as semaglutide and tirzepatide, has been a game changer in the clinical management of overweight and obesity, but there is interpersonal variability in efficacy of these medications for weight loss, as well as in the incidence of undesired side effects. Investigators from the 23andMe Research Institute have shed some light on how variations in the GLP-1R and GIP receptor (GIPR) genes impact their effectiveness and the occurrence of side effects.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730325</guid>
      <pubDate>Mon, 13 Apr 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730325-glp-1r-drug-response-tied-to-variants-in-target-genes</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Omics-genetics-DNA-human-body-illustration.webp?t=1776093243" type="image/jpeg" medium="image" fileSize="864177">
        <media:title type="plain">Illustration of the human body next to a DNA double helix</media:title>
      </media:content>
    </item>
    <item>
      <title>TIPE2 silencing attenuates colitis</title>
      <description>
        <![CDATA[The tumor necrosis factor (TNF)-α-induced protein 8-like 2 (TIPE2), predominantly expressed in bone marrow-derived cells or lymphoid tissues, is an essential regulator of immune homeostasis. TIPE2 acts as a key negative modulator of inflammatory signaling through the suppression of toll-like receptor (TLR) activity, with TIPE2-deficient mice exhibiting spontaneous systemic inflammation and premature death.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730262</guid>
      <pubDate>Fri, 10 Apr 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730262-tipe2-silencing-attenuates-colitis</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Gastrointestinal-system-illustration.webp?t=1769098607" type="image/jpeg" medium="image" fileSize="679694">
        <media:title type="plain">Gastrointestinal system</media:title>
      </media:content>
    </item>
    <item>
      <title>Proqr Therapeutics expands early-stage pipeline</title>
      <description>
        <![CDATA[Proqr Therapeutics NV has highlighted the continued progression and expansion of its early-stage pipeline of RNA editing therapies, including programs in cholestatic diseases, Hurler syndrome, metabolic dysfunction-associated steatohepatitis and Rett syndrome.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730238</guid>
      <pubDate>Thu, 09 Apr 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730238-proqr-therapeutics-expands-early-stage-pipeline</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/RNA-strand.webp?t=1609964773" type="image/png" medium="image" fileSize="440899">
        <media:title type="plain">RNA strand</media:title>
      </media:content>
    </item>
    <item>
      <title>Korea roundup: Alteogen, Celltrion lead biotech deals</title>
      <description>
        <![CDATA[Subcutaneous formulation technology, microbiomes and oncological assets drove dealmaking in South Korea’s biotech sector this week.&nbsp;]]>
      </description>
      <guid>http://www.bioworld.com/articles/730087</guid>
      <pubDate>Tue, 31 Mar 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730087-korea-roundup-alteogen-celltrion-lead-biotech-deals</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2026/Celltrion-Kobiolabs-3-26.webp?t=1774632497" type="image/jpeg" medium="image" fileSize="738862">
        <media:title type="plain">Seo Jin-seok of Celltrion (right) with Ko Kwang-pyo of Kobiolabs (left)</media:title>
        <media:description type="plain">Seo Jin-seok, CEO, Celltrion (right) with Ko Kwang-pyo, founder and CEO, Kobiolabs (left).</media:description>
      </media:content>
    </item>
    <item>
      <title>US FDA says no, again, to Vanda’s tradipitant in gastroparesis</title>
      <description>
        <![CDATA[The U.S. path forward is narrowing for Vanda Pharmaceuticals Inc.’s tradipitant as a treatment for gastroparesis, a serious disorder for which there’s been no new treatment in several decades.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729966</guid>
      <pubDate>Tue, 31 Mar 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729966-us-fda-says-no-again-to-vandas-tradipitant-in-gastroparesis</link>
    </item>
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