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    <title>Nephrology</title>
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    <item>
      <title>Circulating sncRNA transcriptome in diabetic kidney disease and SGLT2 inhibitor treatment</title>
      <description>
        <![CDATA[Small noncoding RNAs (sncRNAs), including miRNAs, piRNAs and snoRNAs, can provide further biological insights into the mechanisms of chronic kidney disease (CKD) in diabetes. Researchers from Leiden University Medical Center and collaborating institutions previously discovered that various classes of circulating sncRNAs are associated with kidney function (eGFR, uACR) and prevalent diabetic CKD.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730930</guid>
      <pubDate>Thu, 07 May 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730930-circulating-sncrna-transcriptome-in-diabetic-kidney-disease-and-sglt2-inhibitor-treatment</link>
    </item>
    <item>
      <title>Ru@TiO2 protects kidneys from acute injury</title>
      <description>
        <![CDATA[Acute kidney injury (AKI), although sometimes reversible, is associated with an increased risk of chronic kidney disease (CKD) and progression to end-stage renal disease (ESRD). Reactive oxygen species (ROS) contribute to maladaptive repair and progression to CKD.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730348</guid>
      <pubDate>Tue, 14 Apr 2026 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730348-rutio2-protects-kidneys-from-acute-injury</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidney-dialysis-AI.webp?t=1589217904" type="image/png" medium="image" fileSize="203534">
        <media:title type="plain">Kidney illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Travere’s Filspari approved for rare kidney disease FSGS</title>
      <description>
        <![CDATA[Becoming the first and only fully FDA-approved treatment for focal segmental glomerulosclerosis (FSGS), Travere Therapeutics Inc.’s Filspari (sparsentan) has gained access to a second lucrative market with a regulatory package that validates proteinuria as a surrogate endpoint.]]>
      </description>
      <guid>http://www.bioworld.com/articles/730293</guid>
      <pubDate>Tue, 14 Apr 2026 08:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/730293-traveres-filspari-approved-for-rare-kidney-disease-fsgs</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidneys-pills-and-chart-line.webp?t=1762551836" type="image/jpeg" medium="image" fileSize="432770">
        <media:title type="plain">Kidneys, pills and chart line</media:title>
      </media:content>
    </item>
    <item>
      <title>PKU ballyhoo averting Street’s gaze from Maze phase II AMKD win?</title>
      <description>
        <![CDATA[Maze Therapeutics Inc. continues its journey toward a pivotal program after sharing positive top-line data from the phase II Horizon study with MZE-829, an oral, small-molecule, dual-mechanism APOL1 inhibitor, in patients with broad APOL1-mediated kidney disease (AMKD).]]>
      </description>
      <guid>http://www.bioworld.com/articles/729839</guid>
      <pubDate>Wed, 25 Mar 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729839-pku-ballyhoo-averting-streets-gaze-from-maze-phase-ii-amkd-win</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidney-disease-illustration.webp?t=1599165012" type="image/png" medium="image" fileSize="370906">
        <media:title type="plain">Kidney disease illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Vertex filing BLA for ‘best-in-class’ IgAN drug on Rainier win</title>
      <description>
        <![CDATA[Vertex Pharmaceuticals Inc. is on track to complete a BLA by the end of March seeking potential U.S. accelerated approval for povetacicept, its dual inhibitor of the BAFF and APRIL cytokines, to treat immunoglobulin A nephropathy (IgAN), following a successful phase III Rainier trial.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729449</guid>
      <pubDate>Tue, 10 Mar 2026 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/729449-vertex-filing-bla-for-best-in-class-igan-drug-on-rainier-win</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidneys.webp?t=1585681893" type="image/png" medium="image" fileSize="393213">
        <media:title type="plain">Kidneys</media:title>
      </media:content>
    </item>
    <item>
      <title>GSK licenses Frontier Biotechnologies’ siRNA therapeutics </title>
      <description>
        <![CDATA[Frontier Biotechnologies Inc. has entered into an exclusive licensing agreement with GSK plc whereby GSK will obtain exclusive worldwide rights to develop, manufacture and commercialize two of Frontier’s small interfering RNA (siRNA) pipeline products.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729033</guid>
      <pubDate>Wed, 25 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729033-gsk-licenses-frontier-biotechnologies-sirna-therapeutics</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/kidney-genetic-congenital.webp?t=1709655526" type="image/jpeg" medium="image" fileSize="168177">
        <media:title type="plain">Illustration of kidney with DNA structures</media:title>
      </media:content>
    </item>
    <item>
      <title>Asahi Kasei advances ETA receptor antagonist into clinic </title>
      <description>
        <![CDATA[Asahi Kasei Pharma Corp. has advanced its novel endothelin ETA receptor antagonist AK-1960 into phase I in Japan for the treatment of various refractory diseases, such as chronic kidney disease.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728935</guid>
      <pubDate>Thu, 19 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728935-asahi-kasei-advances-eta-receptor-antagonist-into-clinic</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Nephrology-Renal-Kidney.webp?t=1669825127" type="image/png" medium="image" fileSize="946164">
        <media:title type="plain">3D illustration of kidney cross section</media:title>
      </media:content>
    </item>
    <item>
      <title>NMPA clears Gensci-136 for trials in immunoglobulin A nephropathy</title>
      <description>
        <![CDATA[Changchun Genescience Pharmaceutical Co. Ltd. has received clearance from China’s National Medical Products Administration (NMPA) to start clinical trials with Gensci-136 for injection, a dual APRIL/BAFF antagonist in development for the treatment of immunoglobulin A nephropathy.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728881</guid>
      <pubDate>Mon, 16 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728881-nmpa-clears-gensci-136-for-trials-in-immunoglobulin-a-nephropathy</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Hands-holding-pink-paper-kidneys.webp?t=1724079521" type="image/jpeg" medium="image" fileSize="116046">
        <media:title type="plain">Hands holding pink paper kidneys</media:title>
      </media:content>
    </item>
    <item>
      <title>Salubris Pharma divulges new dual ETA/AT1 antagonists</title>
      <description>
        <![CDATA[Shenzhen Salubris Pharmaceuticals Co. Ltd. has discovered dual antagonists of endothelin ETA receptor (EDNRA; ETRA) and angiotensin AT1 receptor (AGTR1; AT1). They are reported to be useful for the treatment of chronic kidney disease, IgA nephropathy, focal segmental glomerulosclerosis and hypertension.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728844</guid>
      <pubDate>Fri, 13 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728844-salubris-pharma-divulges-new-dual-eta-at1-antagonists</link>
    </item>
    <item>
      <title>CD206+ macrophage-targeting peptide alleviates obstructive renal fibrosis in mice</title>
      <description>
        <![CDATA[Renal fibrosis originates from diverse etiologies, including diabetes, hypertension, glomerulonephritis and prolonged obstruction, which lead to persistent inflammation and altered repair processes that drive fibrogenesis. M2 macrophages, especially those expressing the macrophage mannose receptor (CD206), play a crucial role in driving fibrogenesis.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728833</guid>
      <pubDate>Fri, 13 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728833-cd206-macrophage-targeting-peptide-alleviates-obstructive-renal-fibrosis-in-mice</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidney-disease.webp?t=1722874886" type="image/jpeg" medium="image" fileSize="280482">
        <media:title type="plain">Illustration of diseased kidney</media:title>
      </media:content>
    </item>
    <item>
      <title>Chinese researchers discover new SLC22A12 inhibitors</title>
      <description>
        <![CDATA[Scientists from Shenzhen Medical Academy of Research and Translation and the Southern Medical University have synthesized solute carrier family 22 member 12 (SLC22A12; URAT1) inhibitors. They are reported to be useful for the treatment of kidney injury, hyperuricemia and gout.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728796</guid>
      <pubDate>Wed, 11 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728796-chinese-researchers-discover-new-slc22a12-inhibitors</link>
    </item>
    <item>
      <title>Paragonix’s Kidneyvault extends kidney preservation to 29 hours</title>
      <description>
        <![CDATA[Paragonix Technologies Inc.’s Kidneyvault portable renal perfusion system managed to preserve and enable the reallocation of a donor kidney for more than 29 hours, despite prolonged ischemic time, multiple handoffs and two commercial flights. Throughout the period, the Kidneyvault maintained stable hypothermic preservation, preventing the organ from being discarded and allowing it to be transplanted into a patient.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728660</guid>
      <pubDate>Fri, 06 Feb 2026 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728660-paragonixs-kidneyvault-extends-kidney-preservation-to-29-hours</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2026/Paragonix-KidneyVault-2-6.webp?t=1770412909" type="image/jpeg" medium="image" fileSize="218148">
        <media:title type="plain">Paragonix KidneyVault</media:title>
        <media:description type="plain">Paragonix Technologies’ Kidneyvault portable renal perfusion system. Credit: Paragonix Technologies Inc.</media:description>
      </media:content>
    </item>
    <item>
      <title>TGR5 as a target for acute kidney injury</title>
      <description>
        <![CDATA[Researchers from China hypothesized that Takeda G protein-coupled receptor 5 (TGR5), also known as G-protein coupled bile acid receptor 1, could have therapeutic potential in acute kidney injury by inhibiting ferroptosis.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728606</guid>
      <pubDate>Wed, 04 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728606-tgr5-as-a-target-for-acute-kidney-injury</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/kidney-nephrology.webp?t=1589217921" type="image/png" medium="image" fileSize="520589">
        <media:title type="plain">Kidneys</media:title>
      </media:content>
    </item>
    <item>
      <title>University of Antwerp patent divulges ferroptosis inhibitors</title>
      <description>
        <![CDATA[A group at the University of Antwerp has patented ferroptosis inhibitors. They are reported to be useful for the treatment of acute renal failure, sepsis, ischemia-reperfusion injury and more.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728518</guid>
      <pubDate>Tue, 03 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728518-university-of-antwerp-patent-divulges-ferroptosis-inhibitors</link>
    </item>
    <item>
      <title>PGC-1α gene delivery protects against kidney reperfusion injury</title>
      <description>
        <![CDATA[Renal ischemia-reperfusion injury (IRI) is a type of acute kidney injury commonly affecting hospitalized patients and associated with poor outcomes, including increased risk of death in severe cases. IRI is caused by a transient reduction in renal blood flow followed by blood reperfusion.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728299</guid>
      <pubDate>Fri, 23 Jan 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728299-pgc-1-gene-delivery-protects-against-kidney-reperfusion-injury</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidneys-renal-hand.webp?t=1747753189" type="image/jpeg" medium="image" fileSize="420668">
        <media:title type="plain">Illustration of kidneys floating over gloved hand</media:title>
      </media:content>
    </item>
    <item>
      <title>Chinese scientists patent new CYP11B2 inhibitors</title>
      <description>
        <![CDATA[Researchers from Jiangsu Hansoh Pharmaceutical Group Co. Ltd. and Shanghai Hansoh Biomedical Co. Ltd. have defined cytochrome P450 11B2, mitochondrial (CYP11B2; aldosterone synthase; ALDOS) inhibitors reported to be useful for the treatment of chronic kidney disease, diabetic nephropathy, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome as well as kidney and myocardial fibrosis.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728012</guid>
      <pubDate>Thu, 15 Jan 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728012-chinese-scientists-patent-new-cyp11b2-inhibitors</link>
    </item>
    <item>
      <title>Series B financing at Mediar Therapeutics</title>
      <description>
        <![CDATA[Mediar Therapeutics Inc. has announced an oversubscribed $76 million series B financing to support its novel anti-fibrotics through clinical studies. The funding will also be used to advance MTX-439 into phase I for the treatment of chronic kidney disease (CKD)-associated fibrosis.]]>
      </description>
      <guid>http://www.bioworld.com/articles/727743</guid>
      <pubDate>Thu, 08 Jan 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727743-series-b-financing-at-mediar-therapeutics</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Neprology-healthy-kidneys.webp?t=1745263173" type="image/jpeg" medium="image" fileSize="175840">
        <media:title type="plain">Doctor with illustration of kidneys</media:title>
      </media:content>
    </item>
    <item>
      <title>Huayao Jiyuan (Shenzhen) Pharmaceutical discovers new HIF-2α inhibitors</title>
      <description>
        <![CDATA[Huayao Jiyuan (Shenzhen) Pharmaceutical Co. Ltd. has described hypoxia inducible factor-2α (HIF-2α; EPAS1) inhibitors reported to be useful for the treatment of cancer, infections, cardiovascular disorders, anemia, chronic kidney disease, disorders of hematopoiesis, inflammatory disorders and acute respiratory distress syndrome (ARDS).]]>
      </description>
      <guid>http://www.bioworld.com/articles/727494</guid>
      <pubDate>Tue, 30 Dec 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727494-huayao-jiyuan-shenzhen-pharmaceutical-discovers-new-hif-2-inhibitors</link>
    </item>
    <item>
      <title>Rectify Pharmaceuticals and Boehringer Ingelheim partner in CKD</title>
      <description>
        <![CDATA[Rectify Pharmaceuticals Inc. has entered a strategic research and licensing agreement with Boehringer Ingelheim Pharma GmbH & Co. KG.]]>
      </description>
      <guid>http://www.bioworld.com/articles/727423</guid>
      <pubDate>Tue, 23 Dec 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727423-rectify-pharmaceuticals-and-boehringer-ingelheim-partner-in-ckd</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidneys2.webp?t=1637092651" type="image/png" medium="image" fileSize="254506">
        <media:title type="plain">Kidneys</media:title>
      </media:content>
    </item>
    <item>
      <title>Inhibition of PDE1A halts progression of renal fibrosis in mice</title>
      <description>
        <![CDATA[Renal fibrosis represents a key driver of the pathology of chronic kidney disease (CKD), marked by fibroblast activation, tubular damage and inflammation. Previous work found that cyclic guanosine monophosphate (cGMP) levels are markedly reduced in experimental models of renal fibrosis, but the reasons for this decline are not fully understood.]]>
      </description>
      <guid>http://www.bioworld.com/articles/727263</guid>
      <pubDate>Thu, 18 Dec 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727263-inhibition-of-pde1a-halts-progression-of-renal-fibrosis-in-mice</link>
    </item>
    <item>
      <title>Targeting WWP2 prevents progression of acute kidney injury</title>
      <description>
        <![CDATA[Researchers from the Children’s Hospital of Nanjing Medical University have identified WW domain-containing E3 ubiquitin protein ligase 2 (WWP2) as a key player in the progression from acute kidney injury (AKI) chronic kidney disease (CKD).]]>
      </description>
      <guid>http://www.bioworld.com/articles/727156</guid>
      <pubDate>Tue, 16 Dec 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727156-targeting-wwp2-prevents-progression-of-acute-kidney-injury</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidneys-renal-hand.webp?t=1747753189" type="image/jpeg" medium="image" fileSize="420668">
        <media:title type="plain">Illustration of kidneys floating over gloved hand</media:title>
      </media:content>
    </item>
    <item>
      <title>Otsuka’s IgAN therapy gets a thumbs-up from the FDA</title>
      <description>
        <![CDATA[The priority BLA from Otsuka Pharmaceutical Co. Ltd., of Tokyo, and its U.S. subsidiary, Otsuka Pharmaceutical Development & Commercialization Inc., for sibeprenlimab to treat immunoglobulin A nephropathy (IgAN) has received accelerated approved by the U.S. FDA.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726792</guid>
      <pubDate>Tue, 02 Dec 2025 00:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726792-otsukas-igan-therapy-gets-a-thumbs-up-from-the-fda</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidneys2.webp?t=1637092651" type="image/png" medium="image" fileSize="254506">
        <media:title type="plain">Kidneys</media:title>
      </media:content>
    </item>
    <item>
      <title>Q32 sells rare kidney disease drug to Akebia for $12M up front</title>
      <description>
        <![CDATA[Q32 Bio Inc. handed off rights to phase II-stage complement inhibitor ADX-097 in a deal with Akebia Therapeutics Inc. that helps the former extend its cash runway to focus on lead candidate bempikibart in alopecia areata and bolsters the latter’s efforts to build a rare kidney disease pipeline.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726603</guid>
      <pubDate>Mon, 01 Dec 2025 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726603-q32-sells-rare-kidney-disease-drug-to-akebia-for-12m-up-front</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidney-disease-illustration.webp?t=1599165012" type="image/png" medium="image" fileSize="370906">
        <media:title type="plain">Kidney disease illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Eli Lilly divulges new RXFP1 agonists </title>
      <description>
        <![CDATA[Eli Lilly & Co. has synthesized relaxin receptor 1 (RXFP1; LGR7) agonists reported to be useful for the treatment of pulmonary hypertension, chronic obstructive pulmonary disease, acute kidney disease, chronic kidney disease, diabetic nephropathy and cardiovascular disorders, among others.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726661</guid>
      <pubDate>Fri, 28 Nov 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726661-eli-lilly-divulges-new-rxfp1-agonists</link>
    </item>
    <item>
      <title>Otsuka’s IgAN therapy gets a thumbs-up from the FDA</title>
      <description>
        <![CDATA[The priority BLA from Otsuka Pharmaceutical Co. Ltd., of Tokyo, and its U.S. subsidiary, Otsuka Pharmaceutical Development & Commercialization Inc., for sibeprenlimab to treat immunoglobulin A nephropathy (IgAN) has received accelerated approved by the U.S. FDA.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726713</guid>
      <pubDate>Wed, 26 Nov 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726713-otsukas-igan-therapy-gets-a-thumbs-up-from-the-fda</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/Kidneys2.webp?t=1637092651" type="image/png" medium="image" fileSize="254506">
        <media:title type="plain">Kidneys</media:title>
      </media:content>
    </item>
    <item>
      <title>‘Encyclopedia’ of xenotransplantation reveals drivers of immune rejection</title>
      <description>
        <![CDATA[By transplanting a pig kidney into a brain-dead person, researchers have been able to conduct the first long-term study of the physiological processes occurring in both the transplant recipient and the pig organ for 61 days. The findings were published in the Nov. 14, 2025, issue of <em>Nature</em> in two papers – one focusing on physiological and immunological measurements, the other on multiomics.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726373</guid>
      <pubDate>Tue, 18 Nov 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726373-encyclopedia-of-xenotransplantation-reveals-drivers-of-immune-rejection</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Pig-organ-transplantation-xenotransplantation.webp?t=1743005066" type="image/jpeg" medium="image" fileSize="249011">
        <media:title type="plain">Abstract illustration of pig and human with medical motifs</media:title>
      </media:content>
    </item>
    <item>
      <title>‘Most complete’ map of oral microbiome enables links to systemic disease</title>
      <description>
        <![CDATA[South Korean researchers led by Lee In-suk of Yonsei University have reported the most complete oral microbiome catalog to date, with more than 72,000 genomes. Detailed in <em>Cell Host & Microbe</em> on Nov. 12, 2025, the database is expected to serve as a universal platform for academia and enable “precision microbiome medicine” for the industry, Lee told <em>BioWorld.</em>]]>
      </description>
      <guid>http://www.bioworld.com/articles/726351</guid>
      <pubDate>Tue, 18 Nov 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726351-most-complete-map-of-oral-microbiome-enables-links-to-systemic-disease</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2020/Nov-2020/Science-microbiome-11-5.webp?t=1604592414" type="image/png" medium="image" fileSize="553641">
        <media:title type="plain">Microbiome illustration</media:title>
        <media:description type="plain">Credit: Darryl Leja, NHGRI</media:description>
      </media:content>
    </item>
    <item>
      <title>Johns Hopkins reports work on gene therapy for ADPKD</title>
      <description>
        <![CDATA[Developing new gene therapies for autosomal dominant polycystic kidney disease (ADPKD) is still a challenge to date. A group of researchers from the Johns Hopkins Medicine in Baltimore has presented results from evaluation of a new gene therapy for treating ADPKD, AAV1-CBdelta27-264CFTR, where they focused on the surface receptors expressed in cystic epithelia.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726081</guid>
      <pubDate>Mon, 17 Nov 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726081-johns-hopkins-reports-work-on-gene-therapy-for-adpkd</link>
    </item>
    <item>
      <title>‘Encyclopedia’ of xenotransplantation reveals drivers of immune rejection</title>
      <description>
        <![CDATA[By transplanting a pig kidney into a brain-dead person, researchers have been able to conduct the first long-term study of the physiological processes occurring in both the transplant recipient and the pig organ for 61 days. The findings were published in the Nov. 14, 2025, issue of <em>Nature</em> in two papers – one focusing on physiological and immunological measurements, the other on multiomics.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726077</guid>
      <pubDate>Mon, 17 Nov 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726077-encyclopedia-of-xenotransplantation-reveals-drivers-of-immune-rejection</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Pig-organ-transplantation-xenotransplantation.webp?t=1743005066" type="image/jpeg" medium="image" fileSize="249011">
        <media:title type="plain">Abstract illustration of pig and human with medical motifs</media:title>
      </media:content>
    </item>
    <item>
      <title>Gentibio’s GNTI-823 promotes renal repair in AKI models </title>
      <description>
        <![CDATA[Gentibio Inc. has developed and presented data for GNTI-823, an allogeneic tissue Treg engineered from peripheral blood CD4+ T cells with CRISPR-based editing to induce FOXP3 expression, a rapamycin-inducible IL-2 signaling complex and an alarmin-responsive transgene.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726032</guid>
      <pubDate>Thu, 13 Nov 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726032-gentibios-gnti-823-promotes-renal-repair-in-aki-models</link>
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