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    <title>Antibiotic</title>
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    <item>
      <title>CARB-X supports antibiotic development at Harvard</title>
      <description>
        <![CDATA[CARB-X is awarding $1.2 million to the Andrew G. Myers research group at Harvard University to develop enhanced antibiotics that target multidrug-resistant gram-negative bacterial pathogens, including <em>Escherichia coli</em> and <em>Klebsiella pneumoniae</em>, to treat urinary tract infections, pneumonia and bloodstream infections.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729371</guid>
      <pubDate>Thu, 05 Mar 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729371-carb-x-supports-antibiotic-development-at-harvard</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Petri-dish.webp?t=1588874539" type="image/png" medium="image" fileSize="308576">
        <media:title type="plain">Petri dish</media:title>
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      <title>Bioversys tuberculosis combo targets drug resistance</title>
      <description>
        <![CDATA[Antibiotics specialist Bioversys AG has reported the first clinical proof-of-concept data for alpibectir (BVL-GSK098) in combination with ethionamide in pulmonary tuberculosis, with phase IIa early bactericidal activity data published in the <em>New England Journal of Medicine</em>.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729101</guid>
      <pubDate>Fri, 20 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729101-bioversys-tuberculosis-combo-targets-drug-resistance</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Infectious/Tuberculosis.webp?t=1589308574" type="image/png" medium="image" fileSize="431986">
        <media:title type="plain">Tuberculosis</media:title>
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      <title>Stoked Bio licenses rights to enterololin for Crohn’s disease</title>
      <description>
        <![CDATA[Stoked Bio Inc. has secured an exclusive global license from McMaster University for the patents covering enterololin, a promising narrow-spectrum antibiotic.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728937</guid>
      <pubDate>Thu, 19 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728937-stoked-bio-licenses-rights-to-enterololin-for-crohns-disease</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/NIH-NIAID-Scanning-electron-micrograph-of-Escherichia-coli.webp?t=1667837128" type="image/png" medium="image" fileSize="2031153">
        <media:title type="plain">Colorized scanning electron micrograph of E. coli bacteria.</media:title>
        <media:description type="plain">Escherichia coli bacteria. Credit: National Institute of Allergy and Infectious Diseases, NIH
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      <title>Nuzolvence, Blujepa win FDA nods for gonorrhea</title>
      <description>
        <![CDATA[Two new therapies are now FDA approved to treat the sexually transmitted infection gonorrhea, with Innoviva Inc.’s Nuzolvence (zoliflodacin) and GSK plc’s Blujepa (gepotidacin) offering additional antibiotic options comparable to standard of care. Both products had fast track, qualified infectious disease product and priority review designations.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726975</guid>
      <pubDate>Fri, 12 Dec 2025 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726975-nuzolvence-blujepa-win-fda-nods-for-gonorrhea</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Infectious/Neisseria-gonorrhoeae-gonorrhea.webp?t=1714662253" type="image/jpeg" medium="image" fileSize="336421">
        <media:title type="plain">Illustration of Neisseria gonorrhoeae</media:title>
      </media:content>
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    <item>
      <title>Subcutaneous biologics maker Bao Pharma prices $128M IPO</title>
      <description>
        <![CDATA[Bao Pharmaceuticals Co. Ltd., a developer of subcutaneous biologic drugs, priced its IPO at HK$26.38 on Dec. 2, aiming to raise about HK$1 billion (US$128 million). Bao expects net proceeds of HK$921.5 million after expenses, which will fund its “two-anti” strategy – developing both antibody and antibiotic drugs worldwide, mainly in China, the U.S. and Europe.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726622</guid>
      <pubDate>Tue, 02 Dec 2025 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726622-subcutaneous-biologics-maker-bao-pharma-prices-128m-ipo</link>
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    <item>
      <title>Novel antibiotic based on dimethylcysteamine pleuromutilin</title>
      <description>
        <![CDATA[As part of global efforts to develop next-generation antibiotics to overcome the growing problem of bacterial resistance to existing drugs, researchers at the Lanzhou Institute of Husbandry and Pharmaceutical Sciences prepared various derivatives of the dimethylcysteamine form of pleuromutilin, a naturally occurring diterpenoid.]]>
      </description>
      <guid>http://www.bioworld.com/articles/725248</guid>
      <pubDate>Thu, 16 Oct 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/725248-novel-antibiotic-based-on-dimethylcysteamine-pleuromutilin</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/NIH-NIAID-Methicillin-resistant-Staph-bacteria.webp?t=1682548628" type="image/jpeg" medium="image" fileSize="1483331">
        <media:title type="plain">Colorized scanning electron micrograph of MRSA.</media:title>
        <media:description type="plain">Methicillin-resistant Staphylococcus aureus bacteria (yellow) and a dead human white blood cell (colored red.) Credit: National Institute of Allergy and Infectious Diseases, NIH
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      <title>US drug security will come at a price</title>
      <description>
        <![CDATA[When it comes to the U.S. biopharma market, pricing seems to be the driving focus of most congressional conversations – and government contracts. Rep. Cliff Bentz, R-Ore., hit pause on that conversation at a June 11 House subcommittee hearing on the drug supply chain, when he asked if the U.S. is sacrificing security for price.]]>
      </description>
      <guid>http://www.bioworld.com/articles/721014</guid>
      <pubDate>Wed, 11 Jun 2025 11:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/721014-us-drug-security-will-come-at-a-price</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Drugs/Drug-supply-export.webp?t=1653338286" type="image/png" medium="image" fileSize="503763">
        <media:title type="plain">Blister drug pack atop globe</media:title>
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      <title>Arrepath’s antibiotic targeting Enterobacterales receives CARB-X funding</title>
      <description>
        <![CDATA[Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) will award Arrepath Inc. $3.7 million to execute a lead optimization workplan for its first-in-class antibiotic targeting a clinically novel target for the treatment of complicated urinary tract infections caused by multidrug-resistant <em>Enterobacterales</em>.]]>
      </description>
      <guid>http://www.bioworld.com/articles/718935</guid>
      <pubDate>Fri, 04 Apr 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/718935-arrepaths-antibiotic-targeting-enterobacterales-receives-carb-x-funding</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Infectious/Enterobacteriaceae.webp?t=1591046024" type="image/png" medium="image" fileSize="642930">
        <media:title type="plain">Enterobacteriaceae</media:title>
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      <title>FDA clears new class of antibiotic with nod for GSK’s Blujepa</title>
      <description>
        <![CDATA[Ushering in a new class of antibiotics, the U.S. FDA approved GSK plc’s gepotidacin for use in uncomplicated urinary tract infections. Branded Blujepa, the oral triazaacenaphthylene bacterial topoisomerase inhibitor is indicated for treating female adults and adolescents, 12 and older.]]>
      </description>
      <guid>http://www.bioworld.com/articles/718615</guid>
      <pubDate>Tue, 25 Mar 2025 15:15:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/718615-fda-clears-new-class-of-antibiotic-with-nod-for-gsks-blujepa</link>
    </item>
    <item>
      <title>Zai Lab, Pfizer team up to widen China access to antibacterial Xacduro</title>
      <description>
        <![CDATA[Zai Lab and Pfizer Inc. are teaming up in China to fight the deadly carbapenem-resistant <em>Acinetobacter baumannii</em> (CRAB) infection with novel antibacterial drug Xacduro (sulbactam-durlobactam). Through the collaboration, Zai Lab will leverage Pfizer’s commercial infrastructure in the anti-infective space to widen access to Xacduro in mainland China. Terms of the deal were not released.]]>
      </description>
      <guid>http://www.bioworld.com/articles/714901</guid>
      <pubDate>Tue, 26 Nov 2024 00:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/714901-zai-lab-pfizer-team-up-to-widen-china-access-to-antibacterial-xacduro</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Geographic-regions/Asia/china-us-deal.webp?t=1591119558" type="image/png" medium="image" fileSize="1457539">
        <media:title type="plain">China U.S. handshake</media:title>
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    </item>
    <item>
      <title>Zai Lab, Pfizer team up to widen China access to antibacterial Xacduro</title>
      <description>
        <![CDATA[Zai Lab and Pfizer Inc. are teaming up in China to fight the deadly carbapenem-resistant <em>Acinetobacter baumannii</em> (CRAB) infection with novel antibacterial drug Xacduro (sulbactam-durlobactam). Through the collaboration, Zai Lab will leverage Pfizer’s commercial infrastructure in the anti-infective space to widen access to Xacduro in mainland China. Terms of the deal were not released.]]>
      </description>
      <guid>http://www.bioworld.com/articles/714648</guid>
      <pubDate>Fri, 22 Nov 2024 00:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/714648-zai-lab-pfizer-team-up-to-widen-china-access-to-antibacterial-xacduro</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Geographic-regions/Asia/china-us-deal.webp?t=1591119558" type="image/png" medium="image" fileSize="1457539">
        <media:title type="plain">China U.S. handshake</media:title>
      </media:content>
    </item>
    <item>
      <title>With FDA approval, Iterum’s patience pays off</title>
      <description>
        <![CDATA[With the U.S. FDA’s approval of Orlynvah (sulopenem etzadroxil and probenecid) for uncomplicated urinary tract infections, Iterum Therapeutics plc can move on from regulatory delays and prepare to launch only the second FDA-approved treatment for the indication in the past 20 years.]]>
      </description>
      <guid>http://www.bioworld.com/articles/713932</guid>
      <pubDate>Fri, 25 Oct 2024 14:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/713932-with-fda-approval-iterums-patience-pays-off</link>
    </item>
    <item>
      <title>Avoiding losses results in insider trading settlement</title>
      <description>
        <![CDATA[Insider trading isn’t always about profits. Sometimes it’s avoiding losses. That’s the basis of the U.S. SEC’s complaint against Matthew Groom, an information technology consultant to Spero Therapeutics Inc. Groom agreed Sept. 15 to a $28,000 settlement to resolve the complaint stemming from a trade of Spero shares that enabled him to avoid $13,000 in losses when news of the company’s downsizing and issues with its lead product became public two years ago.]]>
      </description>
      <guid>http://www.bioworld.com/articles/713601</guid>
      <pubDate>Thu, 17 Oct 2024 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/713601-avoiding-losses-results-in-insider-trading-settlement</link>
    </item>
    <item>
      <title>New antibiotic smartly kills the bad guys but spares the good ones</title>
      <description>
        <![CDATA[A team led by Paul Hergenrother at the University of Illinois, Urbana Champaign (UIUC) has developed a novel antibiotic named lolamicin that was specific for gram-negative bacteria but did not harm the gut microbiome composition in mouse models.]]>
      </description>
      <guid>http://www.bioworld.com/articles/709102</guid>
      <pubDate>Mon, 03 Jun 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/709102-new-antibiotic-smartly-kills-the-bad-guys-but-spares-the-good-ones</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/gram-positive-negative-bacteria-cell-wall.webp?t=1717426090" type="image/jpeg" medium="image" fileSize="180577">
        <media:title type="plain">Illustration comparing cell walls of gram-positive and gram-negative bacteria</media:title>
      </media:content>
    </item>
    <item>
      <title>UK expands subscription model on antibiotic pilot program success</title>
      <description>
        <![CDATA[The U.K.’s world-first subscription model for antimicrobials is to be expanded following a successful pilot scheme in which companies are being paid a fixed annual fee for their drugs, regardless of the volume dispensed. ]]>
      </description>
      <guid>http://www.bioworld.com/articles/708477</guid>
      <pubDate>Fri, 10 May 2024 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/708477-uk-expands-subscription-model-on-antibiotic-pilot-program-success</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Drugs/Antibiotic-capsules-in-blister-packs.webp?t=1588278060" type="image/png" medium="image" fileSize="740755">
        <media:title type="plain">Capsules in blister packs</media:title>
      </media:content>
    </item>
    <item>
      <title>Preclinical characterization of new triaromatic pleuromutilin antibiotic candidate </title>
      <description>
        <![CDATA[A team from the University of Southern Denmark has reported the discovery of a novel triaromatic pleuromutilin antibiotic candidate for the treatment of gram-positive bacterial infections. Hit evaluation and optimization of previously reported drug-like pleuromutilin conjugates with broad antibacterial activity led to the identification of compound [I] as the most potent and easily synthesizable antibiotic lead.]]>
      </description>
      <guid>http://www.bioworld.com/articles/707554</guid>
      <pubDate>Mon, 15 Apr 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/707554-preclinical-characterization-of-new-triaromatic-pleuromutilin-antibiotic-candidate</link>
    </item>
    <item>
      <title>US FDA approves antibiotic Zevtera, Basilea seeks US partner</title>
      <description>
        <![CDATA[In a long and winding regulatory road that began with two complete response letters 15 years ago, Allschwil, Switzerland-based Basilea Pharmaceutica Ltd. finally gained U.S. FDA approval of its intravenous cephalosporin antibiotic, Zevtera (ceftobiprole medocaril sodium), to treat <em>Staphylococcus aureus</em> bacteremia, acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia.]]>
      </description>
      <guid>http://www.bioworld.com/articles/707281</guid>
      <pubDate>Thu, 04 Apr 2024 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/707281-us-fda-approves-antibiotic-zevtera-basilea-seeks-us-partner</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Infectious/Staphylococcus-aureus-staph-bacteria-infection.webp?t=1745260787" type="image/jpeg" medium="image" fileSize="394886">
        <media:title type="plain">Staphylococcus aureus</media:title>
      </media:content>
    </item>
    <item>
      <title>EMA’s CHMP backs new antibiotic, oral PNH drug in March meeting</title>
      <description>
        <![CDATA[The EMA’s Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion recommending approval of Pfizer Inc.’s Emblaveo (aztreonam-avibactam), an antibiotic combination that would offer a new option to patients with serious bacterial infections caused by multidrug-resistant gram-negative bacteria.]]>
      </description>
      <guid>http://www.bioworld.com/articles/707034</guid>
      <pubDate>Tue, 26 Mar 2024 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/707034-emas-chmp-backs-new-antibiotic-oral-pnh-drug-in-march-meeting</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Geographic-regions/Europe/Europe-pills-syringe-flag.webp?t=1588624886" type="image/png" medium="image" fileSize="617433">
        <media:title type="plain">EU flag, pills, syringe</media:title>
      </media:content>
    </item>
    <item>
      <title>EMA’s CHMP backs new antibiotic, oral PNH drug in March meeting</title>
      <description>
        <![CDATA[The EMA’s Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion recommending approval of Pfizer Inc.’s Emblaveo (aztreonam-avibactam), an antibiotic combination that would offer a new option to patients with serious bacterial infections caused by multidrug-resistant gram-negative bacteria. If approved, Emblaveo would be among the first beta-lactam/beta-lactamase inhibitor combos cleared for use in Europe.]]>
      </description>
      <guid>http://www.bioworld.com/articles/706953</guid>
      <pubDate>Fri, 22 Mar 2024 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/706953-emas-chmp-backs-new-antibiotic-oral-pnh-drug-in-march-meeting</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Geographic-regions/Europe/Europe-pills-syringe-flag.webp?t=1588624886" type="image/png" medium="image" fileSize="617433">
        <media:title type="plain">EU flag, pills, syringe</media:title>
      </media:content>
    </item>
    <item>
      <title>GSK’s oral antibiotic hits endpoints in gonorrhea study</title>
      <description>
        <![CDATA[With a regulatory filing expected later this year for gepotidacin based on positive data in uncomplicated urinary tract infections, GSK plc reported that the potentially first-in-class oral antibiotic hit its endpoints in a phase III trial in uncomplicated urogenital gonorrhea, the sexually transmitted disease facing a rise in incidence rate and increased antibiotic resistance.]]>
      </description>
      <guid>http://www.bioworld.com/articles/706101</guid>
      <pubDate>Mon, 26 Feb 2024 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/706101-gsks-oral-antibiotic-hits-endpoints-in-gonorrhea-study</link>
    </item>
    <item>
      <title>FDA issues CRL for Venatorx’s antibiotic combo in UTIs</title>
      <description>
        <![CDATA[The good news is that the U.S. FDA’s complete response letter (CRL) for Venatorx Pharmaceuticals Inc.’s intravenous antibiotic combination, cefepime-taniborbactam, in complicated urinary tract infections (cUTIs) requested no additional clinical testing. The bad news is the inevitable delay for a drug Venatorx and partner Melinta Therapeutics Inc. are aiming to position as a much-needed option for the fight against drug-resistant gram-negative infections.]]>
      </description>
      <guid>http://www.bioworld.com/articles/706029</guid>
      <pubDate>Fri, 23 Feb 2024 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/706029-fda-issues-crl-for-venatorxs-antibiotic-combo-in-utis</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Urology/Bladder-urinary-tract-illustration-with-bacteria.webp?t=1708719221" type="image/jpeg" medium="image" fileSize="402307">
        <media:title type="plain">Bladder, urinary tract illustration with bacteria</media:title>
      </media:content>
    </item>
    <item>
      <title>UK further restricts use of fluoroquinolones</title>
      <description>
        <![CDATA[Making them an antibiotic of last resort, the U.K.’s Medicines and Healthcare Products Regulatory Agency introduced new restrictions on the use of fluoroquinolones due to the risk of potentially long-term or irreversible side effects.]]>
      </description>
      <guid>http://www.bioworld.com/articles/704924</guid>
      <pubDate>Wed, 24 Jan 2024 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/704924-uk-further-restricts-use-of-fluoroquinolones</link>
    </item>
    <item>
      <title>Old-fashioned screening approach yields new antibiotic class</title>
      <description>
        <![CDATA[Researchers have identified a new class of antibiotics that works by blocking the transportation of lipopolysaccharide (LPS) to the outer membrane of the gram-negative bacterium <em>Acinetobacter baumannii</em>. The most advanced member of the class, zosurabalpin (RG-6006, Roche AG), was effective against multiple <em>A.</em><em> baumannii</em> strains, including carbapenem-resistant and multidrug-resistant strains.]]>
      </description>
      <guid>http://www.bioworld.com/articles/704312</guid>
      <pubDate>Thu, 04 Jan 2024 09:00:55 -0500</pubDate>
      <link>https://www.bioworld.com/articles/704312-old-fashioned-screening-approach-yields-new-antibiotic-class</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Multidrug-resistant-A-baumannii.webp?t=1704384396" type="image/jpeg" medium="image" fileSize="208867">
        <media:title type="plain">Acinetobacter spp.</media:title>
        <media:description type="plain">A 3D computer-generated image of a group of multidrug-resistant Acinetobacter spp. bacteria. The artistic recreation was based upon scanning electron microscopic imagery. Credit: CDC/Antibiotic Resistance Coordination and Strategy Unit; James Archer, medical illustrator</media:description>
      </media:content>
    </item>
    <item>
      <title>Explainable AI finds new class of antibiotics</title>
      <description>
        <![CDATA[Researchers have used explainable artificial intelligence (explainable AI) to find structurally new antibiotics with minimal toxicity. They reported their findings online in <em>Nature</em> on Dec. 20, 2023. In animal testing, compounds identified via the method showed that they had activity against drug-resistant gram-positive bacteria including methicillin-resistant <em>Staphylococcus aureus</em> (MRSA), one of the most serious bacterial public health threats.]]>
      </description>
      <guid>http://www.bioworld.com/articles/703901</guid>
      <pubDate>Wed, 20 Dec 2023 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/703901-explainable-ai-finds-new-class-of-antibiotics</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/MIT-Antibiotic-Predictions.webp?t=1703091717" type="image/jpeg" medium="image" fileSize="322721">
        <media:title type="plain">Bacteria targeted by technology concept art</media:title>
        <media:description type="plain">Using a type of artificial intelligence known as deep learning, MIT researchers have discovered a class of compounds that can kill a drug-resistant bacterium that causes more than 10,000 deaths in the U.S. every year. Credit: Christine Daniloff, MIT; Janice Haney Carr, CDC; iStock</media:description>
      </media:content>
    </item>
    <item>
      <title>New DAPG derivatives acting on bacterial cell membranes hold promise to treat MRSA infections</title>
      <description>
        <![CDATA[The emergence of <em>Staphylococcus aureus</em> strains resistant to almost all approved antibiotics in the clinic poses an urgent public health concern. Thus, new antibiotics exploiting alternative antibacterial mechanisms or molecular structures are critically needed to address the long-term threat of multidrug-resistant <em>S. aureus</em>, particularly methicillin-resistant <em>S. aureus</em> (MRSA).]]>
      </description>
      <guid>http://www.bioworld.com/articles/703702</guid>
      <pubDate>Wed, 13 Dec 2023 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/703702-new-dapg-derivatives-acting-on-bacterial-cell-membranes-hold-promise-to-treat-mrsa-infections</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/NIH-NIAID-Methicillin-resistant-Staph-bacteria.webp?t=1682548628" type="image/jpeg" medium="image" fileSize="1483331">
        <media:title type="plain">Colorized scanning electron micrograph of MRSA.</media:title>
        <media:description type="plain">Methicillin-resistant Staphylococcus aureus bacteria (yellow) and a dead human white blood cell (colored red.) Credit: National Institute of Allergy and Infectious Diseases, NIH
</media:description>
      </media:content>
    </item>
    <item>
      <title>Cage fight could make for resistance-resistant antibiotic</title>
      <description>
        <![CDATA[A newly discovered antibiotic has been shown to block the synthesis of bacterial cell walls via immutable targets, raising the prospect of a class of drugs that will not lose effect through the development of antimicrobial resistance. Clovibactin, isolated from soil bacteria, targets the cell wall precursor molecules lipid II, lipid III and undecaprenyl phosphate (C55PP), all of which have a pyrophosphate group in common.]]>
      </description>
      <guid>http://www.bioworld.com/articles/700277</guid>
      <pubDate>Wed, 23 Aug 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/700277-cage-fight-could-make-for-resistance-resistant-antibiotic</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-source/Clovibactin-hero.webp?t=1692800559" type="image/jpeg" medium="image" fileSize="133656">
        <media:title type="plain">Clovibactin art concept</media:title>
        <media:description type="plain">Clovibactin uses an unsual cage-like binding motif to tightly wrap around pyrophosphate-containing lipids in bacterial cell membranes. Credit: Markus Weingarth, Utrecht University</media:description>
      </media:content>
    </item>
    <item>
      <title>Improved LpxC inhibitor antibiotic ready for human trials</title>
      <description>
        <![CDATA[A different class of antibiotics could ease the increasing resistance triggered by some gram-negative bacteria. LpxC inhibitors are not new, but all attempts to develop them have failed due to cardiovascular toxicity or ineffectiveness. A modification of the structure of these compounds may have solved the problem. Duke University scientists demonstrated the preclinical safety and efficacy of an LpxC inhibitor candidate against a wide selection of these pathogens.]]>
      </description>
      <guid>http://www.bioworld.com/articles/699821</guid>
      <pubDate>Thu, 10 Aug 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/699821-improved-lpxc-inhibitor-antibiotic-ready-for-human-trials</link>
    </item>
    <item>
      <title>Synthetic antibiotics pack multiple punches against gram-positive bacteria </title>
      <description>
        <![CDATA[A chance discovery has led to a new class of antibiotics with multiple arms that interacted with the cell wall of gram-positive bacteria, inhibiting their assembly and disarming them. “It was an accidental discovery. We were using it to stain cells. We also were running evaluations of antibiotics. One of my former students came to me and said: ‘I think we have discovered something that is quite potent as an antibiotic,’” the senior author Xingyu Jiang told <em>BioWorld</em>.]]>
      </description>
      <guid>http://www.bioworld.com/articles/698894</guid>
      <pubDate>Thu, 13 Jul 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/698894-synthetic-antibiotics-pack-multiple-punches-against-gram-positive-bacteria</link>
    </item>
    <item>
      <title>Entasis’ bacterial infection drug receives FDA approval</title>
      <description>
        <![CDATA[A week ahead of its May 29 PDUFA date, the U.S. FDA has approved Xacduro (sulbactam for injection; durlobactam for injection) for treating one of the toughest and most deadly infections, carbapenem-resistant <em>Acinetobacter baumannii</em>, in adults.]]>
      </description>
      <guid>http://www.bioworld.com/articles/697353</guid>
      <pubDate>Wed, 24 May 2023 11:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/697353-entasis-bacterial-infection-drug-receives-fda-approval</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Drugs/Xacduro.webp?t=1684960544" type="image/jpeg" medium="image" fileSize="179219">
        <media:title type="plain">Xacduro</media:title>
      </media:content>
    </item>
    <item>
      <title>For fighting staph infections, multitasking fusion protein is perfect 10</title>
      <description>
        <![CDATA[Researchers at NYU Langone Health and Janssen Biotech Inc. have reported on mAbtyrins, bioengineered molecules composed of human monoclonal antibodies and centyrins that are a new way to fight <em>Staphylococcus aureus</em> infection on all fronts.In their experiments, which were published in <em>Cell Host & Microbe</em> on April 24, 2023, the team described mAbtyrin, as “a protein-based therapeutic that targets 10 disease-causing mechanisms employed by <em>S. aureus</em>,” senior author Victor Torres told<em> BioWorld. </em>]]>
      </description>
      <guid>http://www.bioworld.com/articles/696422</guid>
      <pubDate>Wed, 26 Apr 2023 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/696422-for-fighting-staph-infections-multitasking-fusion-protein-is-perfect-10</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/NIH-NIAID-Methicillin-resistant-Staph-bacteria.webp?t=1682548628" type="image/jpeg" medium="image" fileSize="1483331">
        <media:title type="plain">Colorized scanning electron micrograph of MRSA.</media:title>
        <media:description type="plain">Methicillin-resistant Staphylococcus aureus bacteria (yellow) and a dead human white blood cell (colored red.) Credit: National Institute of Allergy and Infectious Diseases, NIH
</media:description>
      </media:content>
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