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    <title>Microbiome</title>
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      <title>Microbiotica reports positive phase Ib data for live microbiome therapeutic</title>
      <description>
        <![CDATA[Microbiome specialist Microbiotica Ltd. announced positive data from a phase Ib study of MB-310, an orally administered live biotherapeutic product for treating ulcerative colitis, with 12 of 19 treated patients achieving clinical remission, compared to three of 10 patients in the placebo arm.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728728</guid>
      <pubDate>Wed, 11 Feb 2026 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728728-microbiotica-reports-positive-phase-ib-data-for-live-microbiome-therapeutic</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Gastrointestinal-vector-framework.webp?t=1739806991" type="image/jpeg" medium="image" fileSize="232822">
        <media:title type="plain">Illustration of intestinal track</media:title>
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    </item>
    <item>
      <title>Microbiotica entering clinic with live bacterial therapeutics</title>
      <description>
        <![CDATA[Microbiotica Ltd. is poised to advance two of its microbiome-derived products into the clinic after securing regulatory approval and fresh finance. The first live bacterial therapeutic, MB-097, will be tested in combination with Keytruda (pembrolizumab) in patients with advanced melanoma who have not responded to treatment with immune checkpoint inhibitors. The second product, MB-310, is a once-daily oral therapy for treating the inflammatory bowel disease, ulcerative colitis.]]>
      </description>
      <guid>http://www.bioworld.com/articles/712158</guid>
      <pubDate>Fri, 30 Aug 2024 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/712158-microbiotica-entering-clinic-with-live-bacterial-therapeutics</link>
    </item>
    <item>
      <title>Microbiotica entering clinic with live bacterial therapeutics</title>
      <description>
        <![CDATA[Microbiotica Ltd. is poised to advance two of its microbiome-derived products into the clinic after securing regulatory approval and fresh finance. The first live bacterial therapeutic, MB-097, will be tested in combination with Keytruda (pembrolizumab) in patients with advanced melanoma who have not responded to treatment with immune checkpoint inhibitors. The second product, MB-310, is a once-daily oral therapy for treating the inflammatory bowel disease, ulcerative colitis.]]>
      </description>
      <guid>http://www.bioworld.com/articles/711787</guid>
      <pubDate>Tue, 27 Aug 2024 00:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/711787-microbiotica-entering-clinic-with-live-bacterial-therapeutics</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Microbiome-pic.webp?t=1588872675" type="image/png" medium="image" fileSize="546434">
        <media:title type="plain">Microbiome illustration</media:title>
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    <item>
      <title>Gut microbiota degrade intestinal nicotine, alleviate smoking-related liver disease</title>
      <description>
        <![CDATA[Peking University researchers in collaboration with the NIH have discovered a new biochemical pathway related to a bacterium that eliminates nicotine in the intestine. The findings could lead to new ways to improve nonalcoholic fatty liver disease in smokers.]]>
      </description>
      <guid>http://www.bioworld.com/articles/690958</guid>
      <pubDate>Tue, 25 Oct 2022 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/690958-gut-microbiota-degrade-intestinal-nicotine-alleviate-smoking-related-liver-disease</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/NIH-NHGRI-Beneficial-Gut-Bacteria.webp?t=1666652080" type="image/png" medium="image" fileSize="504382">
        <media:title type="plain">Illustration of stomach, beneficial gut bacteria.</media:title>
        <media:description type="plain">Credit: Darryl Leja, National Human Genome Research Institute, NIH</media:description>
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    <item>
      <title>Gut microbiota degrade intestinal nicotine, alleviate smoking-related liver disease</title>
      <description>
        <![CDATA[Peking University researchers in collaboration with the NIH have discovered a new biochemical pathway related to a bacterium that eliminates nicotine in the intestine. The findings could lead to new ways to improve nonalcoholic fatty liver disease in smokers.]]>
      </description>
      <guid>http://www.bioworld.com/articles/690893</guid>
      <pubDate>Fri, 21 Oct 2022 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/690893-gut-microbiota-degrade-intestinal-nicotine-alleviate-smoking-related-liver-disease</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/NIH-NHGRI-Beneficial-Gut-Bacteria.webp?t=1666652080" type="image/png" medium="image" fileSize="504382">
        <media:title type="plain">Illustration of stomach, beneficial gut bacteria.</media:title>
        <media:description type="plain">Credit: Darryl Leja, National Human Genome Research Institute, NIH</media:description>
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    </item>
    <item>
      <title>Gut microbiota degrade intestinal nicotine, alleviate smoking-related liver disease</title>
      <description>
        <![CDATA[Peking University researchers in collaboration with the NIH have discovered a new biochemical pathway related to a bacterium that eliminates nicotine in the intestine. The findings could lead to new ways to improve nonalcoholic fatty liver disease (NAFLD) in smokers. In addition to the lung and the brain, nicotine can accumulate in the intestine, where the bacteria <em>Bacteroides xylanisolvens</em> could reduce its concentration and the severity of NAFLD. In their study, published in <em>Nature</em> Oct. 19, 2022, the researchers described the enzymes involved in this process and a new undiscovered pathway.]]>
      </description>
      <guid>http://www.bioworld.com/articles/690695</guid>
      <pubDate>Wed, 19 Oct 2022 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/690695-gut-microbiota-degrade-intestinal-nicotine-alleviate-smoking-related-liver-disease</link>
    </item>
    <item>
      <title>ADS-024 restores movement in mice with PD</title>
      <description>
        <![CDATA[Parkinson’s disease (PD) is one of those diseases in which bacteria may play a role in disease progression.]]>
      </description>
      <guid>http://www.bioworld.com/articles/689801</guid>
      <pubDate>Tue, 20 Sep 2022 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/689801-ads-024-restores-movement-in-mice-with-pd</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Parkinson's-disease-illustration.webp?t=1643408215" type="image/png" medium="image" fileSize="519828">
        <media:title type="plain">Parkinson's disease illustration showing neurons containing alpha-synuclein</media:title>
      </media:content>
    </item>
    <item>
      <title>Nestle banks on Enterome’s gut bacteria approach for IBD, food allergies</title>
      <description>
        <![CDATA[Microbiome specialist Enterome SA has out-licensed its lead human hormone mimetic, EM-1010, to Nestlé Health Sciences SA, in a deal that underlines the potential of its approach to generating novel drugs from proteins expressed by gut bacteria. EM-1010, the first program derived from Enterome’s Endomimics platform, is an orally available molecule that acts by promoting local release of interleukin 10 in the gut, with the aim of reducing inflammation. It is in development for the treatment of inflammatory bowel disease and food allergies and due to enter clinical trials in 2023.]]>
      </description>
      <guid>http://www.bioworld.com/articles/520790</guid>
      <pubDate>Mon, 18 Jul 2022 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/520790-nestle-banks-on-enteromes-gut-bacteria-approach-for-ibd-food-allergies</link>
    </item>
    <item>
      <title>Eurekare’s $60M series A to build, support microbiome and synthetic biology firms</title>
      <description>
        <![CDATA[LONDON – Technology commercialization specialist Eurekare SA has arrived on the scene after raising a $60 million series A, with which it plans to seed fund the formation of microbiome and synthetic biology startups and invest in later-stage rounds of companies specializing in those two fields.]]>
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      <guid>http://www.bioworld.com/articles/507222</guid>
      <pubDate>Tue, 18 May 2021 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/507222-eurekares-60m-series-a-to-build-support-microbiome-and-synthetic-biology-firms</link>
      <media:content url="https://www.bioworld.com/ext/resources/BW-source/2020/Nov-2020/Science-microbiome-11-5.webp?t=1604592414" type="image/png" medium="image" fileSize="553641">
        <media:title type="plain">Microbiome illustration</media:title>
        <media:description type="plain">Credit: Darryl Leja, NHGRI</media:description>
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    <item>
      <title>AI microbiome firm Xbiome raises $20M+ to push candidates into clinic</title>
      <description>
        <![CDATA[Shenzhen Xbiome Biotech Co. Ltd., an artificial intelligence (AI)-based microbiome drugmaker, raised more than $20 million in a series B+ round, Xbiome CEO Yan Tan told <em>BioWorld</em>, financing that will help the company launch its phase I trial next year. It has been a year since the drugmaker closed a $14 million series B round. During this period, Tan said Xbiome submitted an IND to the FDA in October for its fecal microbiota transplant (FMT) capsule candidate, a potential treatment for graft-vs.-host disease.]]>
      </description>
      <guid>http://www.bioworld.com/articles/500800</guid>
      <pubDate>Tue, 01 Dec 2020 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/500800-ai-microbiome-firm-xbiome-raises-20m-to-push-candidates-into-clinic</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/thumb/Gastrointestinal-microbiome.webp?t=1586206918" type="image/png" medium="image" fileSize="428343">
        <media:title type="plain">Gastrointestinal-microbiome</media:title>
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    </item>
    <item>
      <title>Trekkies delight: Federation launches with a $50M series A</title>
      <description>
        <![CDATA[Federation Bio Inc., which just closed a $50 million series A, had enough preclinical data in engineering bacteria to drive the immune system up or down that it actually could have become two separate companies, its new CEO told <em>BioWorld</em>.]]>
      </description>
      <guid>http://www.bioworld.com/articles/498631</guid>
      <pubDate>Tue, 06 Oct 2020 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/498631-trekkies-delight-federation-launches-with-a-50m-series-a</link>
    </item>
    <item>
      <title>Finch closes $90M series D round as microbiome therapies start to deliver</title>
      <description>
        <![CDATA[DUBLIN – Finch Therapeutics Inc. closed a $90 million series D round to take its oral microbiome therapy, CP-101, into late-stage clinical development and registration in chronic <em>Clostridioides difficile</em> infection and to move two additional programs, for chronic hepatitis B virus infection and autistic spectrum disorder, into the clinic.]]>
      </description>
      <guid>http://www.bioworld.com/articles/497903</guid>
      <pubDate>Thu, 17 Sep 2020 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/497903-finch-closes-90m-series-d-round-as-microbiome-therapies-start-to-deliver</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Microbiome-pic.webp?t=1588872675" type="image/png" medium="image" fileSize="546434">
        <media:title type="plain">Microbiome illustration</media:title>
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    <item>
      <title>CP-101 hits primary endpoint in phase II CDI trial, but will Finch take flight?</title>
      <description>
        <![CDATA[DUBLIN – Top-line data from a phase II pivotal trial of CP-101, Finch Therapeutics Group Inc.’s oral microbiome therapy for chronic Clostridioides difficile infection (CDI), are technically good, but how good is the big question.]]>
      </description>
      <guid>http://www.bioworld.com/articles/435930</guid>
      <pubDate>Tue, 23 Jun 2020 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/435930-cp-101-hits-primary-endpoint-in-phase-ii-cdi-trial-but-will-finch-take-flight</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Infectious/Clostridium-difficile-bacteria.webp?t=1592596059" type="image/png" medium="image" fileSize="341622">
        <media:title type="plain">Clostridium difficile bacteria</media:title>
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      <title>Rebiotix reports positive phase III efficacy data for its microbiome-based therapy</title>
      <description>
        <![CDATA[Rebiotix Inc. said RBX-2660, its standardized, non-antibiotic, microbiome-based therapy designed to reduce Clostridioides difficile (C. diff) infection recurrences, notched positive preliminary results on the primary efficacy endpoint of its ongoing pivotal phase III trial.]]>
      </description>
      <guid>http://www.bioworld.com/articles/434911</guid>
      <pubDate>Wed, 06 May 2020 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/434911-rebiotix-reports-positive-phase-iii-efficacy-data-for-its-microbiome-based-therapy</link>
    </item>
    <item>
      <title>Doubling down: Gilead counts on Second Genome in potential $1.5B+ pairing</title>
      <description>
        <![CDATA[Second Genome Inc. (SG) CEO Karim Dabbagh said his firm’s deal with Gilead Sciences Inc. is “pretty significant, given some of the other deals in the microbiome and inflammatory bowel disease [IBD] space,” telling <em>BioWorld</em> the potential $1.5 billion-plus agreement involves “biomarkers in multiple disease areas on five of Gilead’s portfolio programs in inflammation, fibrosis and oncology. Associated with that is a drug discovery collaboration around five targets in the context of IBD.”]]>
      </description>
      <guid>http://www.bioworld.com/articles/434215</guid>
      <pubDate>Mon, 06 Apr 2020 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/434215-doubling-down-gilead-counts-on-second-genome-in-potential-15b-pairing</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Gastrointestinal-microbiome.webp?t=1589217172" type="image/png" medium="image" fileSize="442923">
        <media:title type="plain">Intestine</media:title>
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    <item>
      <title>Seventure leads think-in on microbiome dealmaking</title>
      <description>
        <![CDATA[DUBLIN – Bio-Europe Spring’s virtual panel on the partnering dynamic between big pharma and microbiome-focused biotech firms was essentially an in-house webinar hosted by Seventure Partners, a Paris-based venture capital fund that has led the way in investing in microbiome-related therapeutics, diagnostics and other products.]]>
      </description>
      <guid>http://www.bioworld.com/articles/433981</guid>
      <pubDate>Thu, 26 Mar 2020 13:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/433981-seventure-leads-think-in-on-microbiome-dealmaking</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Microbiome-pic.webp?t=1588872675" type="image/png" medium="image" fileSize="546434">
        <media:title type="plain">Microbiome illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Seventure leads think-in on microbiome dealmaking</title>
      <description>
        <![CDATA[DUBLIN – Bio-Europe Spring’s virtual panel on the partnering dynamic between big pharma and microbiome-focused biotech firms was essentially an in-house webinar hosted by Seventure Partners, a Paris-based venture capital fund that has led the way in investing in microbiome-related therapeutics, diagnostics and other products.]]>
      </description>
      <guid>http://www.bioworld.com/articles/433912</guid>
      <pubDate>Tue, 24 Mar 2020 12:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/433912-seventure-leads-think-in-on-microbiome-dealmaking</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Microbiome-pic.webp?t=1588872675" type="image/png" medium="image" fileSize="546434">
        <media:title type="plain">Microbiome illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>South Korea's GI Innovation secures $31M in series B round for microbiome work</title>
      <description>
        <![CDATA[HONG KONG – GI Innovation Inc., a microbiome combination drug developer based in Seoul, South Korea, has recently issued fully paid convertible preferred stock (CPS) worth KRW37.5 billion (US$31 million) for a series B investment.]]>
      </description>
      <guid>http://www.bioworld.com/articles/429447</guid>
      <pubDate>Wed, 02 Oct 2019 00:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/429447-south-koreas-gi-innovation-secures-31m-in-series-b-round-for-microbiome-work</link>
    </item>
    <item>
      <title>Guts, glory: 'Seres' of tries in microbiome may yield success yet, experts insist</title>
      <description>
        <![CDATA[BOSTON – The gut microbiome and its prospects for drug development have been matters of debate for a while, sharpened by the high-profile phase II failure of Seres Therapeutics Inc.'s candidate, SER-109, in the summer of 2016. A panel at Biopharm America surveyed the space in light of developments since the stumble with that candidate, composed of about 50 species of firmicutes spores derived from stool specimens from healthy donors, against recurrent Clostridium difficile infection. ]]>
      </description>
      <guid>http://www.bioworld.com/articles/429362</guid>
      <pubDate>Fri, 13 Sep 2019 00:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/429362-guts-glory-seres-of-tries-in-microbiome-may-yield-success-yet-experts-insist</link>
    </item>
    <item>
      <title>PKU jujitsu: Firms vying for advantage, early bids weighed for likely merit</title>
      <description>
        <![CDATA[Findings disclosed from Synlogic Inc.'s phase Ib/IIa trial with SYNB-1020 in hyperammonemia surprised the company and Wall Street, dealing a blow to the compound but leaving in place the Synthetic Biotic platform, which genetically engineers probiotic microbes.]]>
      </description>
      <guid>http://www.bioworld.com/articles/429808</guid>
      <pubDate>Mon, 09 Sep 2019 00:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/429808-pku-jujitsu-firms-vying-for-advantage-early-bids-weighed-for-likely-merit</link>
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