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      <title>China’s NMPA clears China Medical System’s CMS-D008 for clinic</title>
      <description>
        <![CDATA[China Medical System Holdings Ltd. has received clinical trial approval from China’s National Medical Products Administration (NMPA) for CMS-D008 injection for overweight or obese individuals.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729394</guid>
      <pubDate>Fri, 06 Mar 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729394-chinas-nmpa-clears-china-medical-systems-cms-d008-for-clinic</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/RNA-3D-illustration.webp?t=1725482193" type="image/jpeg" medium="image" fileSize="212050">
        <media:title type="plain">3D illustration of RNA</media:title>
      </media:content>
    </item>
    <item>
      <title>GSK nabs two Frontier Biotech siRNA assets in $1B deal </title>
      <description>
        <![CDATA[GSK plc will pay Frontier Biotechnologies Inc. $40 million up front and up to $963 million in milestone payments to license two of Frontier’s small interfering RNA-based assets in the field of immunology. ]]>
      </description>
      <guid>http://www.bioworld.com/articles/729316</guid>
      <pubDate>Tue, 03 Mar 2026 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729316-gsk-nabs-two-frontier-biotech-sirna-assets-in-1b-deal</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/siRNA-structure-model.webp?t=1732119622" type="image/jpeg" medium="image" fileSize="568771">
        <media:title type="plain">Illustration of siRNA structure</media:title>
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      <title>Atrium Tx launches with Avidity's RNA ticker and cardio assets </title>
      <description>
        <![CDATA[Targeting rare cardiomyopathy conditions with no approved disease-modifying therapies, Atrium Therapeutics Inc. started operations in San Diego, assuming the public listing and technology once held by Avidity Biosciences Inc., an RNA company acquired by Novartis AG for about $12 billion. Novartis closed the M&A, announced last October, as Atrium unveiled its pipeline and a $270 million cash position.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729314</guid>
      <pubDate>Mon, 02 Mar 2026 09:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729314-atrium-tx-launches-with-aviditys-rna-ticker-and-cardio-assets</link>
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        <media:title type="plain">Illustration of human heart with DNA structure background</media:title>
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    </item>
    <item>
      <title>Atrium Tx launches with Avidity's RNA ticker and cardio assets </title>
      <description>
        <![CDATA[Targeting rare cardiomyopathy conditions with no approved disease-modifying therapies, Atrium Therapeutics Inc. started operations in San Diego, assuming the public listing and technology once held by Avidity Biosciences Inc., an RNA company acquired by Novartis AG for about $12 billion. Novartis closed the M&A, announced last October, as Atrium unveiled its pipeline and a $270 million cash position.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729256</guid>
      <pubDate>Fri, 27 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729256-atrium-tx-launches-with-aviditys-rna-ticker-and-cardio-assets</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cardiovascular/heart-DNA-gene-therapy.webp?t=1721919232" type="image/png" medium="image" fileSize="381487">
        <media:title type="plain">Illustration of human heart with DNA structure background</media:title>
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    </item>
    <item>
      <title>GSK nabs two Frontier Biotech siRNA assets in $1B deal </title>
      <description>
        <![CDATA[GSK plc will pay Frontier Biotechnologies Inc. $40 million up front and up to $963 million in milestone payments to license two of Frontier’s small interfering RNA-based assets in the field of immunology. ]]>
      </description>
      <guid>http://www.bioworld.com/articles/729206</guid>
      <pubDate>Wed, 25 Feb 2026 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729206-gsk-nabs-two-frontier-biotech-sirna-assets-in-1b-deal</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/siRNA-structure-model.webp?t=1732119622" type="image/jpeg" medium="image" fileSize="568771">
        <media:title type="plain">Illustration of siRNA structure</media:title>
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    </item>
    <item>
      <title>GSK licenses Frontier Biotechnologies’ siRNA therapeutics </title>
      <description>
        <![CDATA[Frontier Biotechnologies Inc. has entered into an exclusive licensing agreement with GSK plc whereby GSK will obtain exclusive worldwide rights to develop, manufacture and commercialize two of Frontier’s small interfering RNA (siRNA) pipeline products.]]>
      </description>
      <guid>http://www.bioworld.com/articles/729033</guid>
      <pubDate>Wed, 25 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/729033-gsk-licenses-frontier-biotechnologies-sirna-therapeutics</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Nephrology/kidney-genetic-congenital.webp?t=1709655526" type="image/jpeg" medium="image" fileSize="168177">
        <media:title type="plain">Illustration of kidney with DNA structures</media:title>
      </media:content>
    </item>
    <item>
      <title>Madrigal licenses six Ribo siRNA programs</title>
      <description>
        <![CDATA[Madrigal Pharmaceuticals Inc. has signed an exclusive global license agreement with Suzhou Ribo Life Science Co. Ltd. and its subsidiary Ribocure Pharmaceuticals AB for six preclinical small interfering RNA (siRNA) programs.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728784</guid>
      <pubDate>Wed, 11 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728784-madrigal-licenses-six-ribo-sirna-programs</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/siRNA.webp?t=1590081687" type="image/png" medium="image" fileSize="147005">
        <media:title type="plain">siRNA bound to mRNA</media:title>
      </media:content>
    </item>
    <item>
      <title>Genentech licenses Sanegene’s RNAi asset in $1.7B deal</title>
      <description>
        <![CDATA[Genentech Inc. is paying $200 million up front and up to $1.5 billion in milestone payments to license one of Suzhou Sanegene Bio Inc.’s RNAi programs. Metabolic and autoimmune-focused Sanegene did not disclose specifics around the licensed candidate, except that it was derived from its LEAD (Ligand and Enhancer Assisted Delivery) platform.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728517</guid>
      <pubDate>Tue, 03 Feb 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728517-genentech-licenses-sanegenes-rnai-asset-in-17b-deal</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Interfering-RNA-(RNAi).webp?t=1750428815" type="image/jpeg" medium="image" fileSize="504763">
        <media:title type="plain">Interfering RNA (RNAi)</media:title>
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    <item>
      <title>Repertoire Decodes autoimmunity in $1.92B Eli Lilly deal</title>
      <description>
        <![CDATA[In its fourth major biopharma deal since its 2019 founding, Repertoire Immune Medicines signed a partnership with Eli Lilly and Co. to develop tolerizing therapies for several autoimmune diseases, gaining an up-front payment of $85 million, with a potential $1.84 billion in development and commercial milestone payments coming later, along with tiered royalties.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728474</guid>
      <pubDate>Thu, 29 Jan 2026 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728474-repertoire-decodes-autoimmunity-in-192b-eli-lilly-deal</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/T-cells2.webp?t=1588881096" type="image/png" medium="image" fileSize="517011">
        <media:title type="plain">T cells </media:title>
      </media:content>
    </item>
    <item>
      <title>Blocking TET3 disrupts OTX2 effects in group 3 medulloblastoma</title>
      <description>
        <![CDATA[Medulloblastoma is one of the most common pediatric brain malignancies. A deeper understanding of the mechanisms underlying tumor cell fate determination is crucial to develop novel, effective and safe therapeutic strategies. With this aim, researchers from the University of Chinese Academy of Sciences and collaborating institutions recently conducted a study integrating whole-genome bisulfite sequencing and bulk RNA sequencing (RNA-seq) data from 189 human medulloblastoma samples.]]>
      </description>
      <guid>http://www.bioworld.com/articles/728006</guid>
      <pubDate>Thu, 15 Jan 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/728006-blocking-tet3-disrupts-otx2-effects-in-group-3-medulloblastoma</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Cancer-research-microscope-pathology.webp?t=1669740694" type="image/png" medium="image" fileSize="1333240">
        <media:title type="plain">Microscope with laptop displaying histology image.</media:title>
      </media:content>
    </item>
    <item>
      <title>Sarepta Therapeutics seeks clinical trial clearance for SRP-1005</title>
      <description>
        <![CDATA[Sarepta Therapeutics Inc. has filed a clinical trial application (CTA) in New Zealand seeking clearance to initiate a first-in-human trial of SRP-1005 (formerly ARO-HTT). Pending approval, the INSIGHTT trial is anticipated to begin in the second quarter of this year.]]>
      </description>
      <guid>http://www.bioworld.com/articles/727748</guid>
      <pubDate>Thu, 08 Jan 2026 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727748-sarepta-therapeutics-seeks-clinical-trial-clearance-for-srp-1005</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/3D-illustration-of-RNA-and-proteins.webp?t=1738099271" type="image/jpeg" medium="image" fileSize="124015">
        <media:title type="plain">3D illustration of RNA and proteins</media:title>
      </media:content>
    </item>
    <item>
      <title>Obesity rings in New Year with Lilly-Nimbus $1.3B deal, RNAi data</title>
      <description>
        <![CDATA[Biopharma industry zeal for obesity therapeutics does not appear to be dying down any time soon, with Eli Lilly and Co. entering a $1.3 billion deal with Nimbus Therapeutics LLC for a new small molecule, and Arrowhead Pharmaceuticals Inc. rolling out phase I/IIa data of its RNAi therapeutics used in combination with Lilly’s GLP-1/GIP receptor agonist tirzepatide.]]>
      </description>
      <guid>http://www.bioworld.com/articles/727696</guid>
      <pubDate>Tue, 06 Jan 2026 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727696-obesity-rings-in-new-year-with-lilly-nimbus-13b-deal-rnai-data</link>
    </item>
    <item>
      <title>Rona Therapeutics seeks clinical trial clearance for RN-5681</title>
      <description>
        <![CDATA[Rona Therapeutics Co. Ltd. has announced the submission of RN-5681 to the Australian Human Research Ethics Committee (HREC), and anticipates dosing to begin in a phase I trial in the first quarter of next year.]]>
      </description>
      <guid>http://www.bioworld.com/articles/727265</guid>
      <pubDate>Thu, 18 Dec 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727265-rona-therapeutics-seeks-clinical-trial-clearance-for-rn-5681</link>
    </item>
    <item>
      <title>Bispecific siRNA knocks down YAP1, WWTR1 with single guide strand</title>
      <description>
        <![CDATA[Yes-associated protein (YAP), encoded by Yes1-associated transcriptional regulator (YAP1) and transcriptional coactivator with PDZ-binding motif (TAZ), encoded by WW domain containing transcription regulator 1 (WWTR1), are two crucial paralog transcriptional regulators of the Hippo pathway regulating organ size, tissue homeostasis and disease progression.]]>
      </description>
      <guid>http://www.bioworld.com/articles/727134</guid>
      <pubDate>Mon, 15 Dec 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727134-bispecific-sirna-knocks-down-yap1-wwtr1-with-single-guide-strand</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Liver-on-digital-lens.webp?t=1709588066" type="image/jpeg" medium="image" fileSize="175206">
        <media:title type="plain">Liver over digital lens background</media:title>
      </media:content>
    </item>
    <item>
      <title>Peptidream reveals milestone in Alnylam collaboration</title>
      <description>
        <![CDATA[Peptidream Inc. has announced a preclinical development milestone in its collaboration with Alnylam Pharmaceuticals Inc. under their siRNA conjugate discovery collaboration.]]>
      </description>
      <guid>http://www.bioworld.com/articles/727129</guid>
      <pubDate>Mon, 15 Dec 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/727129-peptidream-reveals-milestone-in-alnylam-collaboration</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/siRNA-structure-model.webp?t=1732119622" type="image/jpeg" medium="image" fileSize="568771">
        <media:title type="plain">Illustration of siRNA structure</media:title>
      </media:content>
    </item>
    <item>
      <title>Junevity raises funds to advance siRNA metabolism program</title>
      <description>
        <![CDATA[Junevity Inc. has raised $10 million in new funding, bringing its seed financing to a total of $20 million. The new funding will enable Junevity to advance JUN-01, its lead siRNA program for type 2 diabetes and obesity, through IND-enabling and initial clinical studies.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726804</guid>
      <pubDate>Thu, 04 Dec 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726804-junevity-raises-funds-to-advance-sirna-metabolism-program</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Endocrine-Metabolic-glucose-bloodstream.webp?t=1674056639" type="image/png" medium="image" fileSize="1313266">
        <media:title type="plain">Illustration of glucose molecules in a bloodstream</media:title>
      </media:content>
    </item>
    <item>
      <title>Tangram seeks clinical trial clearance for TGM-312 for MASH</title>
      <description>
        <![CDATA[Tangram Therapeutics plc has submitted a clinical trial application (CTA) to the U.K.’s Medicines and Healthcare products Regulatory Agency (MHRA) to initiate a phase I/II trial of TGM-312 for metabolic dysfunction-associated steatohepatitis (MASH).]]>
      </description>
      <guid>http://www.bioworld.com/articles/726567</guid>
      <pubDate>Wed, 26 Nov 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726567-tangram-seeks-clinical-trial-clearance-for-tgm-312-for-mash</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/fatty-liver-disease.webp?t=1589217291" type="image/png" medium="image" fileSize="932342">
        <media:title type="plain">Liver disease</media:title>
      </media:content>
    </item>
    <item>
      <title>Arrowhead’s plozasiran cleared for FCS; Ionis patent duel awaits</title>
      <description>
        <![CDATA[Arrowhead Pharmaceuticals Inc. won U.S. FDA approval of plozasiran in familial chylomicronemia syndrome (FCS), the second drug to gain clearance for use in the rare genetic disease following the late 2024 nod for Ionis Pharmaceuticals Inc.’s Tryngolza (olezarsen), setting up a battle in the marketplace even as the firms wage a patent dispute regarding the two RNA-based therapies.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726374</guid>
      <pubDate>Tue, 18 Nov 2025 15:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726374-arrowheads-plozasiran-cleared-for-fcs-ionis-patent-duel-awaits</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Drugs/Redemplo.webp?t=1763500052" type="image/jpeg" medium="image" fileSize="366924">
        <media:title type="plain">Redemplo packaging</media:title>
        <media:description type="plain">Credit: Arrowhead Pharmaceuticals Inc.</media:description>
      </media:content>
    </item>
    <item>
      <title>City Therapeutics seeks clinical trial clearance for CITY-FXI</title>
      <description>
        <![CDATA[City Therapeutics Inc. has submitted a clinical trial application (CTA) to the U.K. Medicines and Healthcare Products Regulatory Agency (MHRA) to initiate a phase I study of CITY-FXI, an investigational RNAi therapeutic targeting factor XI (FXI) for the treatment of thromboembolic diseases.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726059</guid>
      <pubDate>Tue, 11 Nov 2025 08:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726059-city-therapeutics-seeks-clinical-trial-clearance-for-city-fxi</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cardiovascular/Thrombosis-blood-clot.webp?t=1676651893" type="image/png" medium="image" fileSize="1702000">
        <media:title type="plain">Illustration of clot forming in blood vessel</media:title>
      </media:content>
    </item>
    <item>
      <title>Lilly moves deeper into RNAi with $1.2B Sanegene obesity deal</title>
      <description>
        <![CDATA[In a deal worth $1.2 billion, Suzhou Sanegene Bio Inc. and Eli Lilly and Co. are partnering to advance RNAi candidates for metabolic diseases based on Sanegene's tissue selective delivery technology.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726150</guid>
      <pubDate>Tue, 11 Nov 2025 00:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726150-lilly-moves-deeper-into-rnai-with-12b-sanegene-obesity-deal</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/RNA-strand.webp?t=1609964773" type="image/png" medium="image" fileSize="440899">
        <media:title type="plain">RNA strand</media:title>
      </media:content>
    </item>
    <item>
      <title>Lilly moves deeper into RNAi with $1.2B Sanegene obesity deal</title>
      <description>
        <![CDATA[In a deal worth $1.2 billion, Suzhou Sanegene Bio Inc. and Eli Lilly and Co. are partnering to advance RNAi candidates for metabolic diseases based on Sanegene's tissue selective delivery technology.]]>
      </description>
      <guid>http://www.bioworld.com/articles/726099</guid>
      <pubDate>Mon, 10 Nov 2025 12:00:00 -0500</pubDate>
      <link>https://www.bioworld.com/articles/726099-lilly-moves-deeper-into-rnai-with-12b-sanegene-obesity-deal</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/RNA-strand.webp?t=1609964773" type="image/png" medium="image" fileSize="440899">
        <media:title type="plain">RNA strand</media:title>
      </media:content>
    </item>
    <item>
      <title>Corsera Health seeks clinical trial clearance for COR-1004</title>
      <description>
        <![CDATA[Corsera Health Inc. has filed a clinical trial notification (CTN) seeking to initiate a phase I trial of COR-1004 in New Zealand. COR-1004 is a novel investigational subcutaneously administered siRNA targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) to reduce LDL cholesterol (LDL-C).]]>
      </description>
      <guid>http://www.bioworld.com/articles/725625</guid>
      <pubDate>Tue, 28 Oct 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/725625-corsera-health-seeks-clinical-trial-clearance-for-cor-1004</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Science-research-microscope.webp?t=1683923812" type="image/jpeg" medium="image" fileSize="168056">
        <media:title type="plain">Microscope with slide</media:title>
      </media:content>
    </item>
    <item>
      <title>Kalexo enters dyslipidemia fray with preclinical siRNA candidate </title>
      <description>
        <![CDATA[Mabwell Bioscience Co. Ltd. and Aditum Bio Management Co. LLC announced, in after-market hours Sept. 17, an agreement to forge a new company called Kalexo Bio Inc. and load the biotech with a preclinical dyslipidemia asset via a potential $1 billion global license deal.]]>
      </description>
      <guid>http://www.bioworld.com/articles/724563</guid>
      <pubDate>Tue, 23 Sep 2025 11:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/724563-kalexo-enters-dyslipidemia-fray-with-preclinical-sirna-candidate</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cardiovascular/Red-blood-cells-in-an-artery-with-cholesterol.webp?t=1749502465" type="image/jpeg" medium="image" fileSize="611671">
        <media:title type="plain">Red blood cells in an artery with cholesterol</media:title>
      </media:content>
    </item>
    <item>
      <title>Kalexo enters dyslipidemia fray with preclinical siRNA candidate </title>
      <description>
        <![CDATA[Mabwell Bioscience Co. Ltd. and Aditum Bio Management Co. LLC announced, in after-market hours Sept. 17, an agreement to forge a new company called Kalexo Bio Inc. and load the biotech with a preclinical dyslipidemia asset via a potential $1 billion global license deal.]]>
      </description>
      <guid>http://www.bioworld.com/articles/724302</guid>
      <pubDate>Thu, 18 Sep 2025 11:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/724302-kalexo-enters-dyslipidemia-fray-with-preclinical-sirna-candidate</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cardiovascular/Red-blood-cells-in-an-artery-with-cholesterol.webp?t=1749502465" type="image/jpeg" medium="image" fileSize="611671">
        <media:title type="plain">Red blood cells in an artery with cholesterol</media:title>
      </media:content>
    </item>
    <item>
      <title>Arrowhead files to begin clinical trials of ARO-MAPT</title>
      <description>
        <![CDATA[Arrowhead Pharmaceuticals Inc. has filed a request for regulatory clearance in New Zealand to initiate a phase I/IIa trial of ARO-MAPT, the company’s investigational RNA interference (RNAi) therapeutic being developed as a potential treatment for tauopathies, including Alzheimer’s disease.]]>
      </description>
      <guid>http://www.bioworld.com/articles/724043</guid>
      <pubDate>Fri, 12 Sep 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/724043-arrowhead-files-to-begin-clinical-trials-of-aro-mapt</link>
      <media:content url="https://www.bioworld.com/ext/resources/BWS/BWS-library/Alzheimer-disease-Tau-proteins.webp?t=1678376665" type="image/png" medium="image" fileSize="1787094">
        <media:title type="plain">Illustration of tau proteins in Alzheimer's disease</media:title>
      </media:content>
    </item>
    <item>
      <title>Novartis taps Argo again, inks potential $5.2B collaboration</title>
      <description>
        <![CDATA[Argo Biopharmaceutical Co. Ltd. and its RNAi work drew Novartis AG back to the table for a third time, as the companies entered a potential $5.2 billion deal involving cardiovascular-focused assets, including a right to first negotiation for BW-00112, an angiopoietin-like protein 3-targeting siRNA in phase II testing in severe hypertriglyceridemia.]]>
      </description>
      <guid>http://www.bioworld.com/articles/724035</guid>
      <pubDate>Tue, 09 Sep 2025 11:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/724035-novartis-taps-argo-again-inks-potential-52b-collaboration</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Deals-and-MAs/Collaboration-illustration.webp?t=1600375790" type="image/png" medium="image" fileSize="669559">
        <media:title type="plain">Deal illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Novartis taps Argo again, inks potential $5.2B collaboration</title>
      <description>
        <![CDATA[Argo Biopharmaceutical Co. Ltd. and its RNAi work drew Novartis AG back to the table for a third time, as the companies entered a potential $5.2 billion deal involving cardiovascular-focused assets, including a right to first negotiation for BW-00112, an angiopoietin-like protein 3-targeting siRNA in phase II testing in severe hypertriglyceridemia.]]>
      </description>
      <guid>http://www.bioworld.com/articles/723801</guid>
      <pubDate>Wed, 03 Sep 2025 11:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/723801-novartis-taps-argo-again-inks-potential-52b-collaboration</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Deals-and-MAs/Collaboration-illustration.webp?t=1600375790" type="image/png" medium="image" fileSize="669559">
        <media:title type="plain">Deal illustration</media:title>
      </media:content>
    </item>
    <item>
      <title>Arrowhead and Novartis sign agreement for ARO-SNCA</title>
      <description>
        <![CDATA[Arrowhead Pharmaceuticals Inc. has announced a global licensing and collaboration agreement with Novartis AG for ARO-SNCA, Arrowhead’s preclinical stage siRNA therapy for the treatment of synucleinopathies such as Parkinson’s disease, and for additional targets.]]>
      </description>
      <guid>http://www.bioworld.com/articles/723853</guid>
      <pubDate>Wed, 03 Sep 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/723853-arrowhead-and-novartis-sign-agreement-for-aro-snca</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Parkinson's-disease-illustration.webp?t=1643408215" type="image/png" medium="image" fileSize="519828">
        <media:title type="plain">Parkinson's disease illustration showing neurons containing alpha-synuclein</media:title>
      </media:content>
    </item>
    <item>
      <title>Axelyf emerges to tackle RNA delivery, advance autoimmune pipeline</title>
      <description>
        <![CDATA[Partly focused on delivery challenges that have limited the reach of RNA medicines, new biotech company Axelyf Inc. closed a $2.6 million seed round to support development of its AXL technology and to advance lead autoimmune candidate AXL-003.]]>
      </description>
      <guid>http://www.bioworld.com/articles/723626</guid>
      <pubDate>Tue, 26 Aug 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/723626-axelyf-emerges-to-tackle-rna-delivery-advance-autoimmune-pipeline</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/RNA-3D-illustration.webp?t=1725482193" type="image/jpeg" medium="image" fileSize="212050">
        <media:title type="plain">3D illustration of RNA</media:title>
      </media:content>
    </item>
    <item>
      <title>Regeneron's cemdisiran hits phase III endpoints in myasthenia gravis</title>
      <description>
        <![CDATA[Amid the increasingly competitive myasthenia gravis drug development space, siRNA candidate cemdisiran met phase III endpoints, with the monotherapy showing numerically higher results than a combination product. Regeneron Pharmaceuticals Inc., which has a worldwide license to cemdisiran from Alnylam Pharmaceuticals Inc., plans to file for U.S. approval in generalized myasthenia gravis, a rare and chronic autoimmune disease leading to life-threatening muscle weakness, in the first quarter of 2026.]]>
      </description>
      <guid>http://www.bioworld.com/articles/723314</guid>
      <pubDate>Tue, 26 Aug 2025 09:00:00 -0400</pubDate>
      <link>https://www.bioworld.com/articles/723314-regenerons-cemdisiran-hits-phase-iii-endpoints-in-myasthenia-gravis</link>
      <media:content url="https://www.bioworld.com/ext/resources/Stock-images/Clinics/Clinical-trial-virtual-display.webp?t=1623878058" type="image/png" medium="image" fileSize="404207">
        <media:title type="plain">Clinical trial virtual display</media:title>
      </media:content>
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