Vaccine

FDA’s VRBPAC faces complex COVID-19 landscape

Thu, 28 May 2026 12:00:00 -0400

Landing on the right COVID-19 vaccine formulation for the coming season is becoming more complicated against a backdrop of low vaccination rates, young children with little to no immunization, declining surveillance data and a new SARS-COV-2 lineage slowly emerging.

Work underway on vaccines, antivirals against rare Bundibugyo Ebola outbreak

Wed, 27 May 2026 09:00:00 -0400

Less than two weeks after the outbreak was officially declared, animal studies of a newly designed vaccine against the Bundibugyo Ebola virus are now underway in the U.S. and U.K., and the Serum Institute of India is standing ready to manufacture the vaccine for clinical trials. If the animal tests are positive, the vaccine will be ready for clinical trials in two to three months.

Eli Lilly offers to buy three vaccine makers

Wed, 27 May 2026 09:00:00 -0400

Eli Lilly and Co. has offered to buy three vaccine companies for up to $3.8 billion combined, including up to $1.55 billion for Vaccine Company Inc., whose in vivo nanoparticle (IVN) technologies are designed to enable antigens that elicit durable immune responses, much like virus-like particle (VLP) vaccines, but avoid the VLP manufacturing burden.

FDA adcom to consider next iteration of COVID-19 vaccines

Tue, 26 May 2026 12:00:00 -0400

What would normally be a routine meeting of the FDA’s Vaccines and Related Biological Products Advisory Committee May 28 may be more carefully watched given the overall turmoil surrounding vaccines in the U.S. The only task before the adcom is to recommend the COVID-19 vaccine formula for the upcoming season. That conversation will include looking at the effectiveness of the four FDA-approved vaccines currently in use in the U.S.

Work underway on vaccines, antivirals against rare Bundibugyo Ebola outbreak

Tue, 26 May 2026 12:00:00 -0400

Lilly buys three vaccine makers; PCSK9 base editor shows promise

Tue, 26 May 2026 12:00:00 -0400

As the most active biopharma acquirer of 2026, Eli Lilly and Co. offered to buy three vaccine companies for up to $3.8 billion combined, while it simultaneously released positive early clinical results of a gene editing medicine brought into the fold last year through its buyout of Verve Therapeutics Inc.

Dual adjuvant-HA stem nanoparticle vaccine generates protective immune response

Tue, 26 May 2026 09:00:00 -0400

Although influenza virus infection can be particularly life-threatening among young infants, approved vaccines are lacking for infants under 6 months. Aiming to overcome the required annual updates to the influenza vaccine, recent efforts have focused on generating vaccines that promote broadly reactive antibodies (Abs) targeting conserved regions of viral proteins, such as the stem domain of hemagglutinin (HA).

WHO declares Ebola outbreak a public health emergency of international concern

Tue, 19 May 2026 12:00:00 -0400

The threat posed by the Ebola outbreak in the Democratic Republic of Congo has intensified, with the confirmation that it is caused by the Bundibugyo species of the virus, for which there are no approved vaccines or antiviral therapies. At the same time, the high positivity rate, with eight laboratory confirmed cases out of 13 samples collected in various areas, and more reports of suspected cases and clusters of deaths, all point to a potentially much larger outbreak than currently is being detected and reported.

CDC vaccines panel to be ‘re-established’

Tue, 19 May 2026 12:00:00 -0400

It’s back to the drawing board for the U.S. CDC’s Advisory Committee on Immunization Practices (ACIP). After a year of Health and Human Services Secretary Robert Kennedy gutting the panel and restocking it mostly with people who share his views on vaccines, the CDC published a notice in the May 19 Federal Register saying it’s withdrawing the amended ACIP charter renewal issued April 6 and is instead “re-establishing” the committee.

Bundibugyo is harsh reminder of need for broad vaccine strategies

Tue, 19 May 2026 09:00:00 -0400

On Sunday, May 17th, 2026, the World Health Organization classified the ongoing Bundibugyo ebolavirus outbreak in the Democratic Republic of Congo (DRC) as a public health emergency of international concern (PHEIC). The rapid escalation to PHEIC is due to several factors. Given the high number of cases, the outbreak has likely been going undetected for some time, and may be a “much larger outbreak than what is currently being detected and reported, with significant local and regional risk of spread,” according to the WHO statement. The outbreak appears to already have crossed the border from the DRC into Uganda at least twice. And all this is happening with a virus for which there are no approved treatments or vaccines.

Bundibugyo is harsh reminder of need for broad vaccine strategies

Mon, 18 May 2026 12:00:00 -0400

WHO declares Ebola outbreak a public health emergency of international concern

Mon, 18 May 2026 00:00:00 -0400

Authorities work to quickly sequence Ebola species in latest outbreak

Fri, 15 May 2026 12:00:00 -0400

If the recent hantavirus outbreak wasn’t enough to keep public health officials busy, a new Ebola virus disease outbreak has been confirmed by authorities in the Democratic Republic of the Congo. While sequencing is ongoing to identify the Ebola species, experts have noted early results suggesting it appears to be different from the Zaire species that has caused previous outbreaks, including the deadliest outbreak in West Africa a decade ago, meaning existing vaccines and antibody treatments likely will not be effective.

APAC monitors hantavirus as Singapore isolates 2 from cruise ship

Tue, 12 May 2026 12:00:00 -0400

Singapore’s Communicable Diseases Agency on May 7 said that it isolated two residents for hantavirus testing after the individuals disembarked from an Atlantic cruise ship on May 2 and May 6, respectively. The measure comes in response to the cluster of cases from the cruise ship, MV Hondius, that has resulted in three deaths so far.

Two-step HIV vaccine induces broadly neutralizing antibodies

Tue, 12 May 2026 09:00:00 -0400

A designed chimeric virus induced broadly neutralizing antibodies against the macaque equivalent of HIV. The strategy works in two steps: first it uses an envelope protein with a mutation that reduces the glycan shield that makes it invisible to the immune system, and then it exposes the part of the protein most likely to generate these antibodies capable of blocking many variants of the virus. The macaques developed potent and diverse antibodies with this approach, which pave the way for the development of an HIV-1 vaccine.

APAC monitors hantavirus as Singapore isolates 2 from cruise ship

Fri, 08 May 2026 12:00:00 -0400

Hantavirus is ‘sentinel’ more than acute pandemic threat

Fri, 08 May 2026 09:00:00 -0400

News of eight infections and three deaths so far due to an emerging zoonotic virus has brought back unhappy memories of the early days of SARS-CoV-2. At a press conference on Thursday, officials from the WHO did their best to calm the public’s fears that the MV Hondius, the ship currently heading to the Canary Islands with its remaining passengers plus assorted medical, WHO and European Center for Disease Prevention and Control staff, is the 2026 version of the Diamond Princess.

Hepatitis A vaccine nonclinical efficacy can be tested in IFN receptor KO mice

Fri, 08 May 2026 09:00:00 -0400

Conventional mouse models are not susceptible to hepatitis A virus (HAV) because murine adaptor protein MAVS is not efficiently cleaved by HAV protease precursors, so intact type I interferon (IFN) signaling blocks productive infection. However, IFN receptor knockout (KO) mice are susceptible to HAV infection and show hallmark features of the infection, having recently been identified as a potential disease model. Researchers from Genematrix Inc. aimed to determine whether nonclinical efficacy studies can be performed in small animal models.

Two-step HIV vaccine induces broadly neutralizing antibodies

Fri, 08 May 2026 09:00:00 -0400

A designed chimeric virus induced broadly neutralizing antibodies (bNAbs) against the macaque equivalent of HIV. The strategy works in two steps: first it uses an envelope protein (Env) with a mutation that reduces the glycan shield that makes it invisible to the immune system, and then it exposes the part of the protein most likely to generate these antibodies capable of blocking many variants of the virus. The macaques developed potent and diverse antibodies with this approach, which pave the way for the development of an HIV-1 vaccine.

First measles treatment advances as vaccination rates drop

Thu, 07 May 2026 11:00:00 -0400

Scientists at the La Jolla Institute for Immunology have identified and characterized human antibodies that neutralize the measles virus by blocking its entry into the cell. This is the first time that antibodies have been shown to bind effectively to two essential viral proteins, creating a dual blockade that prevents infection. Unlike the current vaccine, which is based on an attenuated virus and is not recommended for immunocompromised individuals, these monoclonal antibodies could be used both as a new vaccine approach and as a treatment for the entire population.

Hantavirus is ‘sentinel’ more than acute pandemic threat

Thu, 07 May 2026 07:00:00 -0400

Liposomes displaying Env trimers drive HIV apex-focused responses

Mon, 04 May 2026 09:00:00 -0400

A new vaccination strategy designed to induce antibodies that recognize the apex of the HIV Env protein uses Env trimers displayed on liposomes to increase their density and orient them correctly. This presentation enhanced apex-focused antibody responses in macaques, and the monoclonal antibodies isolated after immunization showed binding modes and structural features resembling human broadly neutralizing antibodies (bNAbs), indicating that the vaccine can steer the antibody response toward this vulnerable site.

HHS appeals federal injunction ruling on vaccine changes

Thu, 30 Apr 2026 12:00:00 -0400

The U.S. Department of Health and Human Services (HHS) has appealed a recent federal ruling that put on hold several changes to the childhood vaccine schedule and the Advisory Committee on Immunization Practices as reconstituted by HHS Secretary Robert Kennedy.

CARB-X award supports Adjane’s gonorrhea vaccine

Tue, 28 Apr 2026 09:00:00 -0400

CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) is awarding US$2.6 million to Adjane Holding BV to advance the development of a vaccine candidate to prevent infections caused by Neisseria gonorrhoeae.

Kp-OMV4 elicits strong immunity against K. pneumoniae

Mon, 27 Apr 2026 09:00:00 -0400

Multidrug-resistant Klebsiella pneumoniae is a major health problem globally, with relevant infection-related mortality reported. Researchers from the Instituto de Salud Carlos III in Spain and their collaborators recently presented data regarding an outer membrane vesicle (OMV) vaccine for the management of K. pneumoniae infection, Kp-OMV4.

AI opens the way to systematic risk assessment of zoonotic potential of viruses

Wed, 22 Apr 2026 11:00:00 -0400

Researchers in the U.K. have developed an AI-driven method of identifying viruses in wild animals with the potential to spillover into humans. The technique makes it possible to use the genome sequences of the spike proteins by which viruses enter host cells to assess the potential to infect humans without having to isolate an individual virus and tests its infectivity in the lab.

K-Vax shows broad protection across circulating K. pneumoniae strains

Wed, 22 Apr 2026 09:00:00 -0400

Klebsiella pneumoniae and Acinetobacter baumannii are both major contributors to the global antimicrobial resistance crisis, causing rapidly progressive and often severe infections. Researchers from Vaxdyn SL and collaborators presented efficacy data for K-Vax, an inactivated, LPS-null whole-cell A. baumannii-based vaccine engineered to display conserved K. pneumoniae outer-membrane proteins on the bacterial cell surface.

New nominee may need a charm at the CDC

Fri, 17 Apr 2026 12:00:00 -0400

As U.S. President Donald Trump’s third nominee for CDC director, Erica Schwartz will soon find out if three times really is a charm. Trump announced the nomination on social media April 16, touting Schwartz’s credentials for the job. Calling her “incredibly talented,” Trump cited her “distinguished career” as a military doctor, in the Navy and Coast Guard, and her service as deputy surgeon general during his first term in office.

HHS budget hearing not so much about budget

Thu, 16 Apr 2026 12:00:00 -0400

U.S. Health and Human Services (HHS) Secretary Robert Kennedy made his first stop April 16 on a congressional tour in support of President Donald Trump’s proposed fiscal 2027 budget, which would reduce discretional spending for HHS and its agencies by about 12%.

KDTV-001: a trivalent HPV vaccine with broad and durable antitumor immunity

Wed, 15 Apr 2026 09:00:00 -0400

While most human papillomavirus (HPV) infections are cleared by the host immune system, persistent infection with high-risk HPV genotypes, particularly HPV16 and HPV18, can promote cervical cancer development. Researchers from Huazhong University of Science and Technology reported the development and preclinical characterization of KDTV-001, an HPV vaccine comprising a nonreplicating adenovirus type 5 vector encoding a codon-optimized fusion protein of the early antigens E6 and E7 derived from HPV genotypes 16, 18 and 52.