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THE BIOWORLD BIOME: Our Habitat for All Things Science

Tomas Lindahl, of the British Francis Crick Institute, Paul Modrich, of Duke University School of Medicine, and Aziz Sancar, of the University of North Carolina School of Medicine, jointly won the 2015 Nobel prize in chemistry "for mechanistic studies of DNA repair."

The Nobel Assembly honored three scientists today for the drugs they have developed against tropical diseases, neglected and otherwise. One-half of the prize went to William Campbell, professor emeritus at Drew University and former research scientist at Merck, and Satoshi Omura, of the Japanese Kitasato University.

CCR5’s claim to fame in the clinical world is that it is a co-receptor that HIV uses to enter T cells, and that cells with two copies of a particular CCR5 variant, CCR5-delta32, are naturally resistant to HIV.
Scientists from Merck Research Laboratories have identified a synthetic molecule that was able to interfere with bacterial growth by interfering with a regulatory RNA sequence. The findings are a proof of principle that targeting regulatory RNA could lead to the development of new antibiotics, and possibly drugs targeting other types of diseases.
HONG KONG — For the first time, biologists have successfully developed functioning whole kidneys with a urinary excretion pathway from human stem cell-generated embryonic kidneys, Japanese researchers reported in the Proceedings of the National Academy of Sciences.
HONG KONG – A new multiethnic genomewide association study (GWAS) by an international research consortium has identified 12 new genetic loci influencing blood pressure and indicated a role for DNA methylation in blood pressure regulation, which could have important implications for the development of new antihypertensive treatments.

CRISPR Therapeutics co-founder Emmanuelle Charpentier was among those named as Thomson Reuters Citation Laureates this week, "researchers whose work has achieved quantifiable esteem and impact in the scientific community, at a level far beyond the norm. This attainment, demonstrated in the elevated quantity of highly cited papers written by these select researchers, signals that they are "of Nobel class" and "likely to earn the Nobel someday."

SAN DIEGO – Merck & Co Inc. reported data from two phase III trials of its antibody bezlotoxumab for the prevention of recurrent Clostridium difficile at the International Conference on Antimicrobials and Chemotherapy and the International Congress of Chemotherapy (ICAAC/ICC) 2015 annual meeting Sunday.
SAN DIEGO – The Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) kicks off in full swing Friday, but conference-goers got a primer on pandemic diseases Thursday as ICAAC held a joint symposium with the International Society of Infectious Disease.

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