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BioWorld - Sunday, March 26, 2023
Breaking News: A special invitation for new customers – 40% discount on any BioWorld subscriptionBreaking News: Pharming’s PI3K-delta inhibitor, Joenja, wins first FDA nod in APDSBreaking News: A special invitation for new customers – 40% discount on any BioWorld subscriptionBreaking News: A special invitation for new customers – 40% discount on any BioWorld subscription
  • Illustration of leg anatomy with target around knee

    Partially blocking inflammatory receptor could lead to treatment for osteoarthritis

    Partially blocking a receptor that helps regulate the activity of the inflammatory cytokine molecule interleukin-6 (IL-6) seems to promote tissue regeneration and block degeneration in a model of osteoarthritis. As reported in the March 22, 2023, issue of Science Translational Medicine, the receptor, called glycoprotein 130 (gp130), regulates both positive and negative inflammatory responses that can help regenerate tissue, but also cause degeneration.
  • RHOJ protein helps skin cancer resist chemotherapy

    RHOJ, a small GTPase, could hold the key to the survival of tumor cells during cancer treatments. When epithelial cells transformed into mesenchymal cells, the Rho-related GTP-binding protein RhoJ regulated their resistance to chemotherapy. The scientists observed this mechanism in mouse models of skin squamous cell carcinoma, but their results could go beyond just one type of cancer. When the team started its experiments, which were published March 23, 2023, in Nature, “I had never heard about RHOJ before,” the lead author Cédric Blanpain told BioWorld. Blanpain is the director of the Laboratory of Stem Cells and Cancer at the Université Libre de Bruxelles (ULB).
  • Partially blocking inflammatory receptor could lead to treatment for osteoarthritis

    Partially blocking a receptor that helps regulate the activity of the inflammatory cytokine molecule interleukin-6 (IL-6) seems to promote tissue regeneration and block degeneration in a model of osteoarthritis. As reported in the March 22, 2023, issue of Science Translational Medicine, the receptor, called glycoprotein 130 (gp130), regulates both positive and negative inflammatory responses that can help regenerate tissue, but also cause degeneration.
  • RHOJ protein helps skin cancer resist chemotherapy

    RHOJ, a small GTPase, could hold the key to the survival of tumor cells during cancer treatments. When epithelial cells transformed into mesenchymal cells, the Rho-related GTP-binding protein RhoJ regulated their resistance to chemotherapy. The scientists observed this mechanism in mouse models of skin squamous cell carcinoma, but their results could go beyond just one type of cancer. When the team started its experiments, which were published March 23, 2023, in Nature, “I had never heard about RHOJ before,” the lead author Cédric Blanpain told BioWorld. Blanpain is the director of the Laboratory of Stem Cells and Cancer at the Université Libre de Bruxelles (ULB).
  • A novel CAPN2-targeting ASO, AMX-0114, rescues neurite degeneration in vitro

    Calcium-dependent protease calpain-2 (CAPN2) has been previously proposed as a critical effector of axonal degeneration, which is a key early...
  • Lanzhou University researchers identify novel anti-TrxR curcumin analogue

    Uncontrolled growth, invasion and angiogenesis are malignant characteristics of cancer cells mediated by increased reactive oxygen species...
  • Stealth Biotherapeutics presents preclinical data for SBT-272 in neurodegeneration

    SBT-272 (Stealth Biotherapeutics Inc.) is a small molecule for treating mitochondrial dysfunction in neurodegenerative disorders, and the function...
  • Moderna and Generation Bio collaborate to develop nonviral genetic medicines

    Moderna Inc. and Generation Bio Co. have entered into a strategic collaboration to combine Moderna’s biological and technical expertise...
  • Targeting GPR10 as therapeutic strategy for obesity

    It has been previously demonstrated that disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals...
  • Kunshan Xinyunda Biotechnology patents new antibody-drug conjugates for cancer

    Kunshan Xinyunda Biotechnology Co. Ltd. has disclosed antibody-drug conjugates comprising an antibody linked to cytotoxic drug through a linker...
  • Evaxion’s AI technology leads to identification of new viral targets for cancer immunotherapy

    Artificial intelligence and digital health icons
  • Japanese researchers divulge new plasmalogen derivatives

  • S100A9 identified as a therapeutic target in paclitaxel-induced peripheral neuropathy

  • EPI-321 gene therapy leads phenotypic rescue in humanized murine model of FSHD

    Muscular dystrophy
  • Roche describes new GTPase KRAS mutant inhibitors for cancer

  • Nanjing Zhihe Pharmaceutical presents new cytidine derivatives for viral infections

  • SAPS3: a negative regulator of AMPK controlling metabolic homeostasis in mice under high-fat diet

    Obesity, fat cell research concept image
  • Northwest Agriculture & Forestry University discovers new NADH-ubiquinone oxidoreductase inhibitors

Listen to BioWorld Science

As James Peyer, the CEO of Cambrian Biopharma Inc., watched his grandfather fail every cancer treatment and pass away, he also saw the structure of his future company being born. Waiting until people became sick was the wrong way to treat disease, he found. Instead, Cambrian was created to develop anti-aging therapies, a unique business model that fits the new field of geroscience.
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Conferences

  • Acetaminophen pills

    JNJ-26366821 repairs acetaminophen-induced liver injury in mice

    Substance use and poisoning
    Acetaminophen (APAP) is a very common nonprescription analgesic, harmless at low doses, that can cause acute liver injury and even death from acute liver failure when overdosed. The temporal course of acetaminophen overdose-induced liver injury (AILI) can be depicted in two stages – injury and...
  • Illustration demonstrating muscle contraction in amyotrophic lateral sclerosis.

    Cav2 calcium channel modifier GV-58 shows beneficial effects in experimental ALS

    Neurology/Psychiatric
    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by failure of motor neurons that lead to paralysis. To date, no treatment exists for ALS that focuses on improving neuromuscular transmission, which would improve quality of life for ALS patients.
  • SLC6A19 inhibition as a strategy for PKU treatment

    Endocrine/Metabolic
    Phenylketonuria (PKU) is an autosomal recessive disorder where the primary catabolic pathway for phenylalanine (Phe) is disrupted due to mutations in the gene encoding PAH. Elevated Phe levels lie behind several neuropathologic anomalies that can lead to severe and irreversible mental retardation,...
  • Illustration of DNA, magnifying glass

    Identification of pathogenic GDF1 variant using molecular diagnosis in a patient with heterotaxy syndrome

    Biomarkers
    Researchers from Baylor College of Medicine presented data from postnatal testing with the aim of providing molecular diagnosis for a patient with prenatally diagnosed heterotaxy syndrome.
More in Conferences

Today's news in brief

  • Other news to note for March 23, 2023

  • Respiratory

  • Dermatologic

  • Cardiovascular

  • Hematologic

  • Nephrology

Patents

  • Chinese researchers discover new GTPase KRAS mutant inhibitors for cancer

  • UT-Battelle presents new SARS-CoV-2 PLpro inhibitors

  • Relay Therapeutics describes new JAK2 inhibitors for cancer

  • Courage Therapeutics and University of Michigan divulge new MC4R agonists and MC3R antagonists/partial agonists

  • Janssen Pharmaceutica patents new factor XIa and KLKB1 inhibitors

  • Shanghai Visonpharma discovers new TLR7 and TLR8 antagonists

  • Volastra Therapeutics presents new KIF18A inhibitors for cancer

  • Accellena Research and Development describes new TAAR1 agonists

  • Galixir divulges new JAK3 inhibitors

  • Shanghai Leadingtac Pharmaceutical patents new IRAK-4 degradation inducers

Cancer

  • Microscopic view of of high grade urothelial carcinoma of the ureter in a man.

    Flare Therapeutics announces financing to fund work targeting novel transcription factors

    Financings
    Flare Therapeutics Inc. has announced a US$123 million series B financing to support its work targeting novel transcription factors for cancer and other diseases.
  • Ono and Macomics enter macrophage-targeting antibody drug discovery collaboration

    Collaboration
  • KK-CL-1 identified as new therapeutic target in triple-negative breast cancer

  • Oxford Drug Design collaborates with Phoremost to accelerate targeted protein degradation discovery program

    Artificial intelligence
  • Georgetown University to study Shuttle's HDAC6 inhibitor SP-2-225 and radiation therapy in breast cancer model

    Collaboration
More in Cancer
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Infection

  • Colorized transmission electron micrograph of SARS-CoV-2 (UK B.1.1.7 variant).

    Researchers find mSWI/SNF complexes play role in SARS-CoV-2 infection

    Coronavirus
    Current prophylactic and therapeutic approaches for SARS-CoV-2 are effective, but the need for new approaches with broad activity makes virus-host interactions an essential piece to look at.
  • New STING agonists induce STING dimerization and show antiviral effects

    Stimulator of interferon genes protein (STING), an intracellular adaptor molecule that can detect...
  • Ocean Biomedical targets parasite protein PfGARP to tackle malaria

    Vaccines
    Ocean Biomedical Inc. has outlined details of its novel approach to treating malaria. Building on...
  • Arbutus Biopharma presents data on AB-343 for SARS-CoV-2 infection

    Conferences
  • Viral replication inhibitors described in recent Katholieke Universiteit Leuven patent

    Patents
  • Conjugates of NSAIDs and GS-441524 nucleotide analogue are efficacious against coronaviruses in vivo

    New compound
  • Middle Tennessee State University patent describes peptoids for fungal infections and tuberculosis

    Patents
More in Infection

Neurology/Psychiatric

  • Biohaven licenses ex-China rights to Highlightll’s TYK2/JAK1 inhibitor for neurological disorders

    License
    Biohaven Ltd. has acquired global rights, excluding China regions, from Hangzhou Highlightll Pharmaceutical Co. Ltd. for TLL-041, now designated BHV-8000, an oral, brain-penetrant, highly selective, dual TYK2/JAK1 inhibitor, for neurological disorders.
  • Hangzhou Healzen Therapeutics presents new KCNQ2/3 potassium channel activators

    Patents
    Hangzhou Healzen Therapeutics Co. Ltd. has divulged potassium voltage-gated channel subfamily KQT member 2/3 (KCNQ2/3) activators reported to be useful for the treatment of epilepsy, among others.
  • Artivila Therapeutics describes new SARM1 inhibitors

    Patents
    Artivila Therapeutics (Shenzhen) Co. Ltd. has identified NAD(+) hydrolase SARM1 (SAMD2; MyD88-5) inhibitors reported to be useful for the treatment of Alzheimer's and Parkinson's diseases, multiple sclerosis, amyotrophic lateral sclerosis and peripheral neuropathy.
  • Spinal cord

    Nurexone reports recovery of mice with spinal cord injuries after intranasal Exopten delivery

    Nurexone Biologic Inc. has released further results from a preclinical study of Exopten demonstrating effective treatment of 75% of paralyzed rats suffering from spinal cord injuries.
  • Neural network

    Small-molecule activators of KCC2 reduce neuronal excitability, show efficacy in benzodiazepine-resistant status epilepticus

    The neuron-specific K+/Cl- co-transporter KCC2 is involved in the shift from depolarizing to hyperpolarizing γ-aminobutyric acid receptor (GABAAR) currents and subsequent synaptic inhibition.
More in Neurology/Psychiatric

Immune

  • T cells initiate kidney inflammation in glomerulonephritis

  • Macrophages drive invasive breast cancer

  • Nervous system is unexpected player in anaphylactic shock

  • Study points to ways to increasing NK cell longevity

  • High-dose sucralose could fight autoimmune disease

  • Releasing T cells from neutrophil traps restores immunotherapy in pancreatic cancer

  • Modex Therapeutics enters license and collaboration with Merck & Co. for EBV vaccine candidate MDX-2201

  • Invivyd selects VYD-222 to advance as monoclonal antibody therapeutic option for COVID-19

  • Autoantibodies against chemokines are possible ally against long COVID

  • Bacterial meningitis invades the brain by repressing the immune system through pain receptors

Endocrine/Metabolic

  • Targeting YTHDF1 as new therapeutic strategy for obesity-associated metabolic disease

    Adipose tissue is categorized into white adipose tissue (WAT) and brown adipose tissue (BAT), depending on its morphology and function.
  • Novel BCKDHB variant and 6q14.1 deletion tied to double diagnosis of maple syrup urine disease and CHUJANS

    Conferences
  • Building a better, biological, BMI

    Omics
  • Plasma lyso-sphingomyelin as biomarker of response to olipudase alfa in patients with ASMD

    Conferences
  • Medshine Discovery reports GLP-1R agonists

    Patents
More in Endocrine/Metabolic
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Biomarkers

  • Breast cancer cells.

    IMMT shows theragnostic value in breast cancer

    Cancer
    The role that mitochondrial inner membrane protein (IMMT) has in regards to clinicopathology and tumor microenvironment in breast cancer in unclear. IMMT is part of the mitochondrial contact site and cristae organizing system (MICOS) and its function is to maintain mitochondrial integrity.
  • New pathogenic variant in NEB confirms diagnosis of nemaline myopathy 2

    Conferences
    Researchers from the University of Utah applied RNASeq analysis for an undiagnosed case of a critically ill newborn with a complex phenotype, with the aim of providing better diagnosis and improving treatment outcomes.
  • Investigators identify novel variants in the KIAA1109 gene related to Alkuraya-Kucinskas syndrome

    Conferences
    Investigators from the Thomas Jefferson University have presented a case report of a 27-year-old pregnant patient in whom cystic hygroma, extensive anasarca, bilateral pleural effusions, ascites, abnormally curved sacrum and hydrocephalus with parenchymal volume loss, among others were detected by...
  • Novel compound heterozygous variant in EFL1 found in Shwachman-Diamond syndrome 2

    Conferences
  • Novel mutation in SBDS tied to Shwachman-Diamond syndrome

    Conferences
  • Identifying mitokines as potential biomarkers in Rett syndrome

    Conferences
  • New missense variant in MCF2 gene identified in Aarskog-Scott syndrome-like phenotype

    Conferences
More in Biomarkers

Gastrointestinal

  • Condensates allow gut bacteria to adapt to the lean life

    Microbiome
    Gut bacteria used liquid-liquid phase separation (LLPS) to organize themselves into condensates, which allowed them to adapt to nutrient deprivation, enabling them to colonize the gut. In experiments reported in the March 17, 2023, issue of Science...
  • Silencing Timm13 reduces the expression of profibrogenic and apoptosis-related gene in mouse hepatocytes

    Researchers from the First Affiliated Hospital of Guangxi Medical University presented data from a study that aimed to assess the association between translocase of the inner mitochondrial membrane 13 (Timm13) and liver fibrosis.
  • Hepatocyte-specific SRSF1 knockout triggers NASH-like pathology in mice

    Endocrine/Metabolic
    Researchers from the University of Illinois Urbana-Champaign have published data from a study designed to assess the role of serine-arginine-rich splicing factor 1 (SRSF1) in hepatocyte function and survival.
  • I-FABP and sCD14, markers of GI permeability that are elevated in patients with idiopathic anaphylaxis

    Conferences
    Since episodes of idiopathic anaphylaxis (IA) are often accompanied by gastrointestinal (GI) manifestations, researchers from the National Institutes of Health aimed to investigate whether surrogate markers of GI permeability are aberrant in...
  • TREM-1 as a novel therapeutic target for the treatment of inflammatory bowel diseases

    Conferences
    Researchers from Celsius Therapeutics Inc...
  • Identification of new risk-associated loci in primary sclerosing cholangitis

    Biomarkers
    Primary sclerosing cholangitis (PSC) is a rare chronic and progressive autoimmune bile duct disease that is strongly associated with several immune-mediated disorders, the shared etiology and underlying characteristics of which is not completely...
More in Gastrointestinal

BioWorld Insider Podcast

One-on-one with medical innovators

podcast microphone, sound waves on purple backgroundBreakthrough medicines, billion-dollar deals, spectacular clinical successes and crushing failures all play a part in biopharma’s dynamic story. Developers make scientific advancements with the potential to change everything, only to face regulatory conundrums and ever-fluctuating markets. BioWorld tracks key events in the fast-moving sector every business day. Now, the BioWorld Insider podcast lets you hear directly from the movers and shakers whose collective work is changing how we all live. Join us each week for a new conversation.


Recent episodes:

  • Cambrian carves out a new niche as it works to keep people from getting sick
  • Rethinking obesity: Fitness may be more directly linked to health than weight
  • Looking ahead to 2023: CEOs contemplate the new normal
  • Psychedelic evolution: Mindset Pharma looks to change mental health treatment
  • $1B+ biopharma deals keep values afloat, even amid muted volume
  • Extending the human lifespan
  • New therapies vie to change fatal course of amyotrophic lateral sclerosis
  • Biopharma’s correction? 2022 1Q investments are both up and down
  • Who advises the CDC on big COVID decisions and how’s that working out?
  • Long COVID: Potentially the next public health crisis

View all

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