‘Encyclopedia’ of xenotransplantation reveals drivers of immune rejection
By transplanting a pig kidney into a brain-dead person, researchers have been able to conduct the first long-term study of the physiological processes occurring in both the transplant recipient and the pig organ for 61 days. The findings were published in the Nov. 14, 2025, issue of Nature in two papers – one focusing on physiological and immunological measurements, the other on multiomics.

‘Encyclopedia’ of xenotransplantation reveals drivers of immune rejection
By transplanting a pig kidney into a brain-dead person, researchers have been able to conduct the first long-term study of the physiological processes occurring in both the transplant recipient and the pig organ for 61 days. The findings were published in the Nov. 14, 2025, issue of Nature in two papers – one focusing on physiological and immunological measurements, the other on multiomics.
Tango’s first-in-class CoREST inhibitor overcomes anti-PD-1 resistance
Researchers from Tango Therapeutics Inc. presented preclinical efficacy data on TNG-260, an inhibitor of the co-repressor of repressor element-1 silencing transcription (CoREST) deacetylase complex, designed to treat immunotherapy-resistant STK11-mutant tumors.
Coave nominates lead gene therapy for retinal vascular diseases
Coave Therapeutics SA has nominated a lead gene therapy program, CoTx-101, for the treatment of retinal vascular diseases, such as wet age-related macular degeneration and diabetic macular edema.
Akeso’s AK-152 gains IND clearance in China for Alzheimer’s
Akeso Inc. has received clearance from China’s National Medical Products Administration (NMPA) to initiate clinical trials with AK-152 for Alzheimer’s disease.
Johns Hopkins reports work on gene therapy for ADPKD
Developing new gene therapies for autosomal dominant polycystic kidney disease (ADPKD) is still a challenge to date. A group of researchers from the Johns Hopkins Medicine in Baltimore has presented results from evaluation of a new gene therapy for treating ADPKD, AAV1-CBdelta27-264CFTR, where they focused on the surface receptors expressed in cystic epithelia.
Mitorx Therapeutics raises funds to advance Myo-004 for obesity
Mitorx Therapeutics Ltd. has raised £5.5 million (US$7.2 million) in a pre-series A round to advance its lead mitochondrial-targeted program, Myo-004, through clinical candidate selection.
Imhotex patents new NOD2 activators for Crohn’s disease
Imhotex Ltd. has disclosed desmuramylpeptide (DMP) analogues of muramyl dipeptide (MDP) acting as nucleotide-binding oligomerization domain-containing protein 2 (NOD2) activators reported to be useful for the treatment of Crohn’s disease.
CXCR3-activating peptide attenuates lung fibrosis in mice
A team of investigators at the University of Pittsburgh have found that a CXCR3-activating peptide (named CXCL10p) can prevent lung fibrosis and inflammation in the bleomycin mouse model.

Conferences

CDK2 degraders show activity in HR+/HER2- and CCNE1-amplified breast tumors
AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics
During the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, scientists from Plexium Inc. presented the identification of a new class of potent, selective, cereblon (CRBN)-based molecular glue degraders of CDK2 using its proprietary monovalent degrader platform.
Macrocyclic KIF18A inhibitors show preclinical promise
AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics
At the recent AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, researchers from Aurigene Oncology Ltd. presented the discovery and clinical characterization of novel macrocyclic KIF18A inhibitors.
HMPL-A251 combines HER2 targeting with precision payload
AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics
Hutchmed (China) Ltd. has developed HMPL-A251, a novel HER2 antibody-drug conjugate (ADC) designed to deliver a potent PI3K/PIKK inhibitor directly to tumor cells.
CGX-926 corrects MC4R deficiency-driven obesity
Endocrine/metabolic
Melanocortin-4-receptor MC4R is a crucial molecule involved in energy homeostasis, feeding behavior and metabolism, and loss-of-function mutations in this gene are the main monogenic cause of early-onset obesity. Congruence Therapeutics Inc. has developed a small molecule, CGX-926, that corrected...

Cancer

Charm nominates CHM-029 as development candidate for AML
Charm Therapeutics Ltd. has nominated CHM-029 as a development candidate for the treatment of acute myeloid leukemia (AML).

Infection

Anti-malarial targets P. falciparum phosphatidylinositol 4-kinase with reduced toxicity
In an effort to generate an effective and safer inhibitor, researchers at the University of Cape Town, University of Dundee and Massachusetts Institute of Technology used structure-guided rational design to improve on their previously reported 2,8-diaryl-1,5-naphthyridine inhibitor.

Dual-antigen mRNA vaccine protects against lethal DBV challenge
Immune
Investigators from the University of Science and Technology of China and RNAlfa Biotech have described a novel mRNA-based vaccine candidate against Dabie Banda virus (DBV), which has fatality rates of up to 30% in some East Asian countries.
‘Most complete’ map of oral microbiome enables links to systemic disease
Science
South Korean researchers led by Lee In-suk of Yonsei University have reported the most complete oral microbiome catalog to date, with more than 72,000 genomes. Detailed in Cell Host & Microbe on Nov. 12, 2025, the database is expected to serve as a universal platform for academia and enable...

Neurology/psychiatric

Adenosine surge is common thread in ketamine and ECT response
Science
Researchers from the Chinese Institute for Brain Research, the Chinese Academy of Medical Sciences, and their collaborators have identified adenosine as the driving force behind the rapid, fast-acting antidepressant effects of ketamine and electroconvulsive therapy (ECT). “Our journey into this...
Shanghai Innoxtal Therapeutics patents new Nav1.8 blockers
Patents
Shanghai Innoxtal Therapeutics Co. Ltd. has disclosed sodium channel protein type 10 subunit α (SCN10A; Nav1.8) blockers reported to be useful for the treatment of pain, arrhythmia and urinary incontinence.
Drosophila genetic screening reveals mechanisms behind AD pathology
Researchers from the Baylor College of Medicine have characterized 100 conserved Alzheimer’s disease (AD) risk orthologue genes in Drosophila and found several with unknown roles in brain structure, function and stress resilience. The implication of this finding is that new pathways of...
Transition Bio and Voyager Therapeutics partner in ALS and FTD
Collaboration
Transition Bio Inc. and Voyager Therapeutics Inc. have entered into a drug discovery collaboration and license option agreement for novel, selective small molecules for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) with TDP-43 pathology.
Sage Therapeutics discovers new GluN2A negative allosteric modulators
Patents
Sage Therapeutics Inc. has described sterol derivatives acting as glutamate receptor ionotropic, NMDA 2A (GRIN2A; GluN2A) negative allosteric modulators reported to be useful for the treatment of neurological disorders.

Endocrine/metabolic

Century Therapeutics unveils β islet program for type 1 diabetes
Century Therapeutics Inc. has announced its first program for type 1 diabetes, CNTY-813. The program comprises induced pluripotent stem cell (iPSC)-derived β islets engineered with the company’s proprietary Allo-Evasion 5.0 technology, designed to protect from T-cell, NK-cell and humoral immune...

Biomarkers

With transdiagnostic approach, smaller target groups aren’t inevitably smaller markets
Neurology/psychiatric
Despite the formidable challenges for developing precision psychiatry, the approach is notching its first successes in the preclinical and even some clinical settings. Many individual studies as well as large projects like the Psychiatric Ratings using Intermediate Markers (PRISM) studies and the...

Anchoring, and bootstrapping, psychiatry into the precision medicine era
Neurology/psychiatric
Psychiatry has struggled to enter the precision medicine era. But through a mix of innovations and bootstrapping, progress is coming to the field. Scientists are working on improving diagnoses by investigating potential biomarkers and collection methods.
Biomarker panel of three serum microRNAs predicts cervical cancer prognosis
Cancer
MicroRNAs (miRNAs) play key roles in cancer development by regulating genes involved in cell growth, differentiation, invasion, metastasis and angiogenesis. Because their expression patterns differ across tumor types and stages, miRNA profiles hold strong potential as noninvasive diagnostic and...

Gastrointestinal

Numab and Kaken sign agreement for NM-81 for IBD
Collaboration
Numab Therapeutics AG and Kaken Pharmaceutical Co. Ltd. have entered into a strategic licensing and co-development agreement for NM-81, a multi-specific antibody for the treatment of inflammatory bowel disease (IBD).
Genfit and Everzom form research collaboration in liver failure
Collaboration
Genfit SA has established a research collaboration with Everzom SAS to expand its acute-on-chronic liver failure (ACLF) research via exosome-based regenerative technology. The partners plan to conduct exploratory studies to assess efficacy of...
Eilean presents in vivo data on MALT1 degrader TE-205
Degradation inducer
Eilean Therapeutics LLC has presented in vivo data for its first-in-class MALT1 degrader, TE-205, as a disease-modifying therapy for ulcerative colitis.
Interline Therapeutics patent reports RIPK2 inhibitors for IBD
Patents
Interline Therapeutics Inc. has identified new compounds receptor-interacting serine/threonine-protein kinase 2 (RIPK2; RIP-2) inhibitors reported to be useful for the treatment of inflammatory bowel disease (IBD).
Daewon Pharm patent reveals new H+/K+-ATPase inhibitors
Patents
Daewon Pharmaceutical Co. Ltd. has reported new compounds acting as H+/K+-ATPase inhibitors useful for the treatment of reflux esophagitis.
Proqr’s AX-0810 gains European clinical trial clearance
Regulatory
Proqr Therapeutics NV has received clinical trial application (CTA) authorization under the EMA’s new centralized review process for a phase I study of AX-0810, which is being developed for the treatment of cholestatic diseases such as primary...

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