Login to Your Account

PERSISTence fails to prevail

Prospects for Durect Corp.’s Posimir (Saber-bupivacaine) dimmed dramatically with the late Thursday disclosure of a failed phase III study of the extended-release analgesic. more »

Our Habitat for All Things Science
BRCA1 function compromised in Alzheimer’s disease

The BRCA genes were first discovered for their roles in gynecological cancers, with the most deleterious mutations in BRCA1 and BRCA2 raising a woman’s lifetime risk of breast or ovarian cancer from 7 percent to somewhere between 45 and 65 percent.

But BRCA’s role is less sex-specific than its strong association with gynecological cancers would suggest. Both BRCA1 and BRCA2 play a role in repairing DNA damage, a function that is important in all cell types.



Partners in Focus