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New findings may take the art of repurposing one level up. By combining PD-1 checkpoint inhibitors, which are the current stars of cancer immunotherapy, with Cox inhibitors, which have a more checkered history as successful painkillers that were later found to raise the risk of heart attacks, scientists were able to enable mice to overcome a third disease – chronic viral infection. more »

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Breaking mirror images for patients' good luck

Given the precision of chemical synthesis processes, small-molecule drugs can be a surprisingly mixed bag of molecules.

If a molecule has a chiral center, synthesis will give a mixture of two molecules that have the identical chemical composition but are mirror images of each other. Technically speaking, they are enantiomers. In the macrobiological world, a person's left and right hand are enantiomers of each other.

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