Metabolex Inc., of Hayward, Calif., elected to its board of directors Pedro Cuatrecasas, retired vice president of Warner-Lambert Co.

Milkhaus Laboratory Inc., of Boxford, Mass., elected to its board of directors Richard McCloskey, vice president and chief medical officer of Malvern, Pa.-based Centocor Inc.

Ophidian Pharmaceuticals Inc., of Madison, Wis., named to its scientific advisory board Terrence Barrett, a gastroenterologist who is on the faculty of Northwestern University Medical School.

Orchid Biocomputer Inc., of Princeton, N.J., appointed Denis Grant senior director of pharmacogenetics.

Pangea Systems Inc., of Oakland, named Douglas Brutlag acting chief scientific officer.

Pharmacyclics Inc., of Sunnyvale, Calif., elected to its board of directors Phyllis Gardner, senior associate dean for education at Stanford University School of Medicine.

Pharsight Corp., of Mountain View, Calif., named Saeid Akhtari vice president of business development.

ProCyte Corp., of Redmond, Wash., elected to its board of directors Glenn Oclassen, founder of Oclassen Pharmaceuticals Inc.

Roche Molecular Systems Inc., of Pleasanton, Calif., named Martin Madaus, Joanne Spadoro and David Thomas as vice presidents.

The Immune Response Corp., of Carlsbad, Calif., named Howard Sampson vice president finance, chief financial officer and corporate treasurer, and Rand Mulford, senior vice president, corporate development and strategic planning, and corporate secretary.

Trega Biosciences Inc., of San Diego, appointed Mark Schwartz vice president of commercial operations and chief commercial officer.

Vivus Inc., of Mountain View, Calif., named to its board of directors Linda Shortliffe, a professor at Stanford University School of Medicine and chair of its urology department.