Wednesday, March 30, 2011
Onyx Pharmaceuticals Inc., of Emeryville, Calif., is expanding its Phase III European FOCUS trial, which is evaluating the efficacy and tolerability of carfilzomib, a next-generation proteasome inhibitor, in patients with relapsed and refractory myeloma. Based on overall survival data from the Phase IIb 003-A1 study, the company is changing the primary endpoint of the FOCUS trial from progression-free survival to overall survival.
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