Published March 18 & 25 (EPO); March 12 & 19 (WO)

Amrad WO 98/10638, IL-13 modulators, Richmond, Australia, Genes for proteins that interact with interleukin (IL)-13, encoded proteins; for modulating IL-13 action.

Amrad WO 98/11225, Hematopoietin receptor, Richmond, Australia, Gene for a hematopoietin receptor, encoded protein; for developing , modulators, diagnostics, and therapeutics.

Beth Israel Deaconess Hosp. WO 98/09992, Hereditary atopy protein, Boston, Gene for HTm4 protein, encoded protein, expression system; for identifying modulators and treating hereditary atopy.

Biotechnology Inst. WO 98/10079, Lactic acid bacteria expression system, Hoersholm, Denmark, Lactic acid bacteria regulatable gene expression system; for producing mycobacterial proteins.

Boehringer Mannheim WO 98/10065, Breast cancer gene, Mannheim, Germany, Breast carcinoma-associated gene, encoded protein, antibodies; for cancer diagnosis, prevention, and therapy.

Brax Genomics WO 98/10095, DNA identification methodCambridge, U.K., Methods of identifying DNA sequences using predetermined length sticky end sequences.

California, Univ. of WO 98/10069

Hormone-refractory cancer gene, Oakland, Calif., Gene for E25a protein which is upregulated in hormone-refractory , cancers, encoded protein; for cancer treatment.

California, Univ. of WO 98/10085, Congestive heart failure vector, Oakland, Calif., Adenoviral vector for increasing the -adrenergic responsiveness of , the heart; for congestive heart failure.

Centocor WO 98/10292, Prostate-specific antigen antibodies, Malvern, Penn., Monoclonal antibodies for differentiating between bound and free , prostate-specific antigen; for cancer detection.

Chiron WO 98/09524, Liver gene therapy, Emeryville, Calif., Adeno-associated viral vectors for delivering antisense, ribozymes, , and other therapeutics to the liver.

Cold Sp. Harb. Labs WO 98/10067, Human latheo homolog, Cold Sp. Harb., N.Y., Human homolog of the latheo gene, encoded protein, modulators; , for controlling dopamine levels.

Columbia Univ. WO 98/11256, Beclin, New York, Beclin, a bcl-2 interacting gene near BRCA1 on chromosome , 17Q21, encoded protein; for diagnosing cancer.

CSIRO (Comm. Sci. Ind. Res. Org.) WO 98/10064, Immune response vector, Campbell, Australia, Vectors using an iron-regulated promoter; for expressing proteins , inducing an immune response.

Cornell Univ. WO 98/10072, Gamma-interferon inducer genes, Ithaca, N.Y., Genes for the gamma-interferon inducer factors interleukin (IL)-18 , and -18(, encoded proteins.

Dana-Farber Cancer Inst. WO 98/11221, Viral receptors, Boston, Genes for coxsackie virus and adenovirus receptors, encoded , proteins, antisense, antibodies, expression system.

Dana-Farber Cancer Inst. WO 98/11238, Protease M, Boston, Protease M, which is down-regulated in metastatic mammary , tumors, encoding gene, peptides, fusions, antibodies.

Duff, G., et al. WO 98/11237, Directed cleavage proteases, Sheffield, U.K., Incorporation of a target peptide sequence into a self-secreting , protease, encoding genes; for directed cleavage.

Eisai EPO 831 148, Tight junction occludin, Tokyo, Gene for the human adhesion molecule occludin found in cellular , tight junctions, encoded protein, antibodies.

Garvin, A. WO 98/11249, Peptide tagging sequences, Durmenach, France, Tagging genes with sequences that can be used, after PCR , amplification, to purify the resulting expressed proteins.

Geron WO 98/11204 & 11207, Telomere regulation, Menlo Park, Calif., Genes for telomerases, encoded proteins, reporter gene assay system , for modulators of telomere length and activity.

Hamada, H. WO 98/10084, Nuclear localization vector, Tokyo, Viral vectors having a nuclear localization signal joined to a , tetracycline activator gene, transfected cells.

Henry Jackson Fdn. WO 98/11229, Shiga toxins, Rockville, Md., Histidine-tagged Shiga toxins; for purifying other Shiga toxoids , useful in therapy.

Howard Florey Inst. WO 98/09510, Colon cancer model, Parkville, Australia, Transgenic animal model having a mutation in the Cdx2 Drosophila , caudal gene homolog; for studying colon cancer.

Human Genome Sciences WO 98/11138, Chemokine (-4, Rockville, Md., Gene for chemokine (-4, encoded protein, expression system; for , identifying modulators and treating immune diseases.

Hybridon WO 98/11211, Oligos for platelet depletion, Cambridge, Mass., Modified CpG-containing phosphorothioate oligonucleotides for , treating splenomegaly and platelet depletion.

Incyte WO 98/11219, Cancer-associated membrane protein, Palo Alto, Calif., Disease-associated membrane protein, encoding gene, antibodies, , expression system; for treating cancer.

Incyte WO 98/11220, Cell division cycle proteins, Palo Alto, Calif., Cell division cycle proteins, encoding genes, antisense, expression , systems; for affecting the cell cycle.

Incyte WO 98/11227, Granulocyte chemotactic protein, Palo Alto, Calif., Gene for granulocyte chemotactic protein 2 variant, encoded , protein, antibodies, expression system; for treating cancer.

Incyte WO 98/11232, Human nm23-like protein, Palo Alto, Calif., Human nm23-like protein, encoding gene, primers, expression , system.

Incyte WO 98/11233, Phosphorylase kinase gamma subunit

Palo Alto, Calif., Human phosphorylase kinase gamma subunit, encoding gene, , antisense, antibodies, expression system.

Incyte WO 98/11234, Protein kinases, Palo Alto, Calif., Human protein kinases, encoding genes, antisense, antibodies; for , identifying modulators.

Karaplis, A.C., et al. WO 98/10078, Phosphate metabolism gene, Kirkland, Que., Human PEX cDNA from tumors causing hyperphosphatemia , osteomalacia; for treating phosphate imbalances.

Laval Univ. EPO 829 540, Attenuated Leishmania strains, Sainte-Foy, Que., Attenuated Leishmania strains expressing granulocyte macrophage , colony stimulating factor (GM-CSF); for vaccines.

Leeds, Univ. of WO 98/10083, Herpesvirus vector, Leeds, U.K., Herpesvirus saimiri vector with deleted essential genes and inserted , foreign genes.

Li-Cor WO 98/11255, Cycled extension sequence analysis, Lincoln, Neb., Cycled primer extension of an internally labelled sequence with , thermostable polymerases; for DNA analysis.

London, Univ. Sch. Pharmacy WO 98/10748, Liposomes for DNA vaccines, London, Cationic liposomes containing genes capable of encoding an antigen , that elicits an immune response.

Mass. Gen. Hosp. WO 98/09649, Viral replication inhibition, Boston, Deficient encapsidation of viral nucleic acid using a protein capsid , assembly inhibitor; for viral inhibition.

Mass. Gen. Hosp. WO 98/11243, Baculoviral gene therapy vectors, Boston, Baculoviruses with an altered coat protein; for transducing cells , with exogenous genes to treat CNS disease and cancer.

Merck WO 98/11241, Antibody-cytokine fusions, Darmstadt, Germany, Antibody-cytokine fusion proteins produced in excellent yields using , a strong promoter and enhancer.

Molec. Biophotonics Lab WO 98/11210, Solid phase nucleic acid assay, Hamakita, Japan, Solid phase detection of nucleic acids in which ligation of samples , occurs while bound.

Monsanto WO 98/10062, Plant seed expression system, St. Louis, Rice glutellin-1 gene promoter linked to a foreign non-plant gene; , for expression in monocot plant seeds.

Mt. Sinai Sch. Med. WO 98/11222, Schizophrenia drug screen, New York, Schizophrenia drug screening assays using the human neuron-, specific glutamate transporter.

NIH (Natl. Inst. Hlth.) WO 98/11244, Adeno-associated viral vectors, Bethesda, Md., Adeno-associated virus 4 vectors, particles derived from this virus; , for gene therapy.

New York Blood Ctr. WO 98/11246, Blood cell antigen removal, New York, Gene for Flavobacterium keratolyticus endo- -galactosidase, , encoded protein; for removing blood cell antigens.

North American Vaccine WO 98/09648, Streptococcal vaccines, Rockville, Md., Mutant, non-IgA Fc binding C streptococcal antigens and , polysaccharide conjugates; for vaccines.

Novartis WO 98/11242, Agonist epilepsy drug, Basel, Switzerland, Agonist for the metabotropic glutamate receptor mGluR7, knock-out , transgenics; for treating epilepsy.

Novo Nordisk WO 98/11136, Weight loss protein, Bagsvaerd, Denmark, Gene for a cancer-related weight loss protein, encoded protein; for , treating weight-related disorders.

Novo Nordisk Biotech WO 98/11203, Altered protein production, Davis, Calif., Vectors for insertion into cell genomes; for producing altered , amounts of protein.

Onyx Pharma WO 98/10066, BRCA1 modulators, Richmond, Calif., Genes for proteins that modulate the gene product of BRCA1; for , breast cancer diagnosis and treatment.

Onyx Pharma WO 98/10076, Phospholipase D, Richmond, Calif., Gene for phospholipase D, encoded protein; for treating , inflammatory diseases and cancer.

Orlando, C., et al. WO 98/10094, Competitive PCR measurement, Firenze, Italy, Plasmids with two or more competitive sequences allowing , simultaneous gene measurement by competitive PCR.

Ortho Pharma WO 98/11224, Prostate cancer therapeutic, Raritan, N.J., Tumor necrosis factor-beta-like protein for treating androgen-, independent prostate cancer, conjugated toxin.

Pennsylvania, Univ. of WO 98/10086, Adeno-associated vector production, Philadelphia, Penn., Methods for efficient production of recombinant adeno-associated , viral vectors using a crelox recombinase system.

Pennsylvania, Univ. of WO 98/10087, Chimpanzee adenoviral vectors, Philadelphia, Penn., Recombinant chimpanzee adenoviral vector having heterologous , genes, infected cell lines.

Pennsylvania, Univ. of WO 98/10088, Adeno-associated vector production, Philadelphia, Penn., Inducible method for producing recombinant adeno-associated viral , vectors using a vector encoding T7 polymerase.

Protein Polymer Technol. WO 98/10063, Repetitive protein sequences, San Diego, Calif., Vectors having repetitive DNA sequences; for preparing large , repetitive sequence proteins.

Rhone-Poulenc Rorer WO 98/11213, Lou Gehrig's disease therapy, Antony, France, Systemic administration of expression systems for neurotrophic , factors; for treating amyotrophic lateral sclerosis.

Rockefeller Univ. WO 98/11231, Prokaryotic expression systems, New York, Promoters from L-arabinose pathway enzymes; for regulatable , prokaryotic expression of proteins.

Sagami Chemical Res. Ctr. WO 98/11215, Type-1 membrane proteins, Sagamihara, Japan, Human type-1 membrane proteins, encoding genes, recombinants, , expression system.

Sagami Chemical Res. Ctr. WO 98/11217, Secretory signal proteins, Sagamihara, Japan, Human proteins with secretory signal sequences, encoding genes, , expression systems.

Schering WO 98/11223, VEGF receptor antibodies, Berlin, Germany, Antibodies to a human vascular endothelial cell growth factor , (VEGF) receptor extracellular domain epitope.

Schering WO 98/11226, Human chemokines, Kenilworth, N.J., Genes for human CC and CXC chemokines, encoded proteins, , antibodies; for diagnostics and therapeutics.

Schraven, B., et al. WO 98/11209, Fyn kinase modulator, Ladenburg, Denmark, Gene for a protein that interacts with the protein tyrosine kinase , Fyn, encoding gene, antisense, modulator assays.

Siffert, W. WO 98/11212, PTX-sensitive G protein subunit, Essen, Germany, Beta-3 subunit of a PTX-sensitive human G protein, encoding gene, , production methods.

Signal Pharma WO 9810058, CNS progenitor cells, San Diego, Calif., Conditionally immortalized human CNS progenitor cells; for , identifying therapeutics for CNS-related diseases.

SmithKline Beecham WO 98/10692, Genes for trpS peptides, Philadelphia, Penn., Genes encoding trpS polypeptides, encoded proteins, production , methods; for screening antibacterials.

SmithKline Beecham WO 98/11236, Aspartic protease, Brentford, U.K., Gene for an aspartic protease, encoded protein; for identifying , inhibitors.

SS Pharma WO 98/10073, Fungi detection, Tokyo, Gene fragments for detecting the presence of Aspergillus fungi.

Sumitomo Chemical EPO 829 539, Male sterility factor, Osaka, Japan, Cytoplasmic male sterility factor genomic sequence; for confirming , cytoplasmic male sterility

Sumitomo Electric WO 98/10070, Humanized apoptosis-inhibiting antibody, Osaka, Japan, Humanized immunoglobulin that reacts with Fas ligand and its , apoptosis-inducing region; for inhibiting apoptosis.

Sumitomo Pharma WO 98/11216, Semaphorin Y, Osaka, Japan, Semaphorin Y, encoding gene, antisense, modulator assay; for , inhibiting nerve extension.

Takara Shuzo WO 98/09990

Fungal antigens, Kyoto, Japan, Fungal antigens, encoding genes; for diagnosis and stimulating , immune responses.

Takeda WO 98/11130, Nerve regeneration protein, Osaka, Japan, Ependymin-like protein, encoding gene, antibodies, vectors; for , inducing nerve regeneration.

Technion Res. & Develop. WO 98/10071, VEGF-based angiogenic factor, Haifa, Israel, Angiogenic factor based on fused exons of vascular endothelial , growth factor (VEGF); for cardiovascular disease.

Theodor Kocher Inst. WO 98/11218, Chemokine receptor 3, Bern, Switzerland, CXC chemokine receptor 3 which binds IP-10 or MIG, encoding , gene, expression system; for identifying modulators.

Thomas Jefferson Univ. WO 98/11214, Mammalian recombinases, Philadelphia, Penn., Mammalian recombinase genes and their promoters; for inducing , radiation sensitivity.

Transgene WO 98/11208, Therapy grade plasmids, Strasbourg, France, Method of preparing plasmid DNA, including gel chromatography, , for use in gene therapy.

Transkaryotic Therapies WO 98/11206, Fabry disease therapy, Cambridge, Mass., Therapy for the (-galactosidase A deficiency seen in Fabry disease , by overexpression or insertion of encoding gene.

Tularik WO 98/10059, Gene expression regulator assay, S. San Francisco, Cell-based assay using modified genes attached to a reporter gene; , for screening regulators of gene expression.

Varian WO 98/11433, DNA melting temperature assay, Mulgrave, Australia, Analyzing DNA by measuring differential optical densities of , single- and double-stranded sequences.

Visible Genetics WO 98/11259, Sexually transmitted disease detection, Toronto, Ont., Co-amplification and subsequent co-detection of several sexually , transmitted disease genes in patient samples.

Wako Chemical EPO 829 538, Peptidoglycan recognition protein, Osaka, Japan, Gene for peptidoglycan recognition protein, encoded protein, , expression system; for production.

Wakunaga Seiyaku EPO 829 535, Retroviral packaging cell, Osaka, Japan, Retroviral packaging cell with a vector having the polyoma virus , early region gene; for high titer viruses.

Wisconsin, Univ. of WO 98/10077, In vitro gene transposition, Madison, Wis., System for in vitro gene transposition using a modified bacterial , TN5 transposase.

Zymogenetics WO 98/09991, Enteric neural peptide, Seattle, Peptide from the distal ileum derived from somatostatin called , enteric neural peptide; for fat digestion control.