Published June 5 & 12 (EPO); May 30 & June 6 (WO)
Ajinomoto Antithrombotic WO 96/17078
Tokyo antibody
Antibody to human Von Willebrand factor; for use in antithrombotic therapy.
Akzo Nobel Terminal repeat WO 96/17079
Arnhem, the Netherlands amplification
Amplification method using terminal repeats, relatively constant temperature, and no serial reagent additions.
Astra PBP ligand WO 96/16082
Sodertlje, Sweden assay
Gene for variants of penicillin binding proteins (PBP), encoded proteins; for assaying PBP ligands.
Biotech. Biol. Sci. Res. Coun. Nisin variants WO 96/16180
Colney, U.K.
Genes for nisin variants, encoded proteins, transformed cells, nisin production methods.
Byk Gulden Helicobacter WO 96/17066
Konstanz, Germany inhibitor screen
Cells expressing Helicobacter P-type ATPase; for screening ulcer therapeutics.
California, Univ. of Cryptidin WO 96/16075
Oakland, Calif.
Genes for cryptidin, encoded proteins; for use in detecting and treating inflammation.
Cayla Hybrid suicide WO 96/16183
Toulouse, France genes
Hybrid suicide genes coding for activators of nucleotide base analogues; for cell destruction.
Chiron Viagene Alphavirus EPO 716 148 &
Emeryville, Calif. vectors WO 96/17072
Recombinant alphavirus vectors, methods of use; for gene therapy.
Cohen-Haguenauer, O. Retroviral WO 96/17071
Paris integration vector
Expression vector allowing genomic integration of retroviral vectors, cells, DNA sequences causing integration.
Columbia Univ. KS-specific WO 96/15779
New York herpesvirus
DNA from a Kaposi's sarcoma (KS)-specific herpesvirus, encoded proteins, antibodies; for vaccination.
CRC Biopharmaceutical Res. Cytotoxic WO 96/16176
Darlinghurst, Australia erbB3 binding protein
Fusion protein with erbB3 binding and toxin regions; for cytotoxic action against cells overexpressing erbB3.
Du Pont Compound WO 96/17082
Wilmington, Del. microsatellites
Compound microsatellites used to screen genomes for polymorphisms.
Duke Univ. Hemorrhagic WO 96/16975
Durham, N.C. telangiectasia diagnosis
Probes for gene mutations in the TGF receptor family; for diagnosing hereditary hemorrhagic telangiectasia.
Eisai Cell adhesion WO 96/16170
Tokyo proteins
Proteins involved in the regulation of cell-cell adhesion; for modifying cell adhesion.
French Assoc. Myopathy Calcium- WO 96/16175
Paris dependent protease
Gene for calcium-dependent protease, mutations by deletion or substitution, encoded proteins.
Genetic Therapy Tissue-specific WO 96/16676 &
Gaithersburg, Md. adenoviral vectors 17053
Adenoviral vector systems that are replication-deficient but specifically replicate in tumor cells.
Glaxo Cepaholsporin WO 96/16174
Greenford, U.K. conversion
Bacterial amidohydrolases; for one-step conversion of cephalosporin C and derivatives to 7-aminocephalosporin.
Grunenthal Fibrinolytic EPO 714 982
Aachen, Germany hybrid proteins
Hybrid proteins with fibrinolytic and thrombin inhibiting activity (in German).
Human Genome Sciences Choline WO 96/15806
Rockville, Md. acetyltransferase
Gene for human choline acetyltransferase polypeptide, encoded polypeptide; for treating neurodegeneration.
Human Genome Sciences G-coupled WO 96/16087
Rockville, Md. receptor
Gene for a human G-coupled receptor polypeptide, encoded polypeptide; for identifying agonists/antagonists.
Icos Calneurin WO 96/16172
Bothell, Wash.
Isolation of calneurin and calneurin inhibitors; for modulating anchoring protein function.
Imperial Coll. Polycationic gene WO 96/15811
London delivery
Polycationic peptides linked to integrin receptor ligands; for use as a gene therapy delivery vehicle.
Incyte Pharma Liver expressed WO 96/16979
Palo Alto, Calif. chemokines
Genes for chemokines expressed in livers and pituitaries, encoded proteins, antibodies; for treating inflammation.
Indiana Univ. Phenylalanine-free WO 96/17064
Bloomington, Ind. proteins
Natural proteins modified to remove phenylalanine residues, encoding genes; for treating phenylketonuria.
Inst. Plant Genetics Embryonal cardiac WO 96/16163
Gaitersieben, Germany muscle cells
Embryonal cardiac muscle cells transfected with marker genes; for cell-mediated gene transplants.
Inst. Psychiatry Assessing clozapine WO 96/17081
London treatment
Gene for serotonin 5-HT2A receptor with a specific polymorphism; for assessing responsiveness to neuroleptic agents.
Japanese Cancer Inst. Chromosome EPO 714 981
Tokyo 8 cancer gene
Chromosome 8 gene in deletion region common to lung, liver, and colorectal cancers, encoded protein.
Johns Hopkins Univ. Hedgehog WO 96/16668
Baltimore cleavage polypeptides
Polypeptides derived from hedgehog gene from specific cleavage by the autoproteolytic domain of the protein.
Krebs Res. Inst. Yeast secretion WO 96/16181
Heidelberg, Germany vector
Yeast expression plasmid coding for fusion peptides with signal peptide; for secretion.
La Jolla Cancer Res. Fdn. CD40- WO 96/16665
La Jolla, Calif. associated protein
Gene for CD40-associated protein, encoded protein; for identifying antagonists and agonists.
Lebens M.R. Stimulating WO 96/16178
Goteborg, Sweden mucosal immunity
Immunogens having mucosal membrane binding and mucosal immunity stimulating domains.
Leeds, Univ. of Modified WO 96/16173
Leeds, U.K. cystatins
Cystatins modified by site-directed methods or hybrid production; for inhibiting proteinases.
NIH (Natl. Inst. Hlth.) AAV vector WO 96/15777
Bethesda, Md. delivery
Adeno-associated viral (AAV) vector with coding sequences for rep protein in lipid vesicles; for gene therapy.
New England In vitro WO 96/16674
Deaconess Hosp. T-lymphopoiesis
Boston
In vitro T-lymphopoiesis system in which T cells are produced from precursors expressing CD34.
Nippon Chemiphar Denatured LDL WO 96/17058
Tokyo receptors
Gene for the denatured low-density lipoprotein (LDL) receptors of endothelial cells, encoded protein.
Novo Nordisk Less allergenic WO 96/16177
Bagsvaerd, Denmark proteins
Production of polypeptides with reduced allergenicity by using Zipper domains.
Oravax Immunoglobulin WO 96/16974
Cambridge, Mass. variable region antibodies
Genes for immunoglobulin variable regions, production hybridomas; for making chimeric antibodies.
Pasteur Inst. Hypermuta- EPO 714 980 &
Paris genesis WO 96/17056
Using biased concentrations of deoxynucleoside triphosphates to cause hypermutagenesis in reaction mixtures.
Queensland, Univ. of Bone disease WO 96/17057
St. Lucia, Australia marker
Chromosome 17 Sox-9 gene encoded protein; for diagnosing Campomelic Dysplasia and treatment of bone disease.
Rhone-Poulenc Rorer Calcium sensor WO 96/15801
Antony, France protein
Human calcium sensor protein, fragments, gene encoding the protein; for controlling calcium regulation.
Rhone-Poulenc Rorer GAP protein WO 96/16169
Antony, France ligands
Peptides capable of binding to the GAP protein SH3 domain, genes encoding these peptides.
Rockefeller Univ. SH3 kinase WO 96/17061
New York associated protein
SH3 kinase domain associated protein, signaling domain of this protein, encoding genes; for cell process control.
Salk Inst. Modified hormone EPO 716 145
La Jolla, Calif. receptor genes
Genes for hormone receptors with modified transcription activation domain position and/or copy number.
Schering T cell surface WO 96/17060
Kenilworth, N.J. antigens
Genes for T cell surface antigens, purified proteins, specific antibodies; for diagnostic kits.
Scofield, V.L. Contraceptive WO 96/15807
Pasadena, Calif. vaccine
Vaccines, contraceptives, and gene therapy delivery vectors in which sperm cells or components act as immunogens.
Scripps Res. Inst. Enzymatic DNA WO 96/17086
La Jolla, Calif. molecules
Catalytic or enzymatic DNA molecules capable of site-specific cleavage of nucleic acids.
Synaptic Pharma Antagonists for WO 96/16542
Paramus, N.J. eating disorders
Antagonists of neuropeptide Y/peptide YY receptor; for treating eating disorders.
Systemix Stem cell EPO 716 146
Palo Alto, Calif. marker protein
Gene for stem cell marker protein, encoded protein, antibodies, purification methods.
Takara Shuzo Transfection WO 96/17073
Kyoto, Japan by injection
Transfection by injection of foreign genes into cells in the presence of cell adhesion-active substances.
Takeda Tripeptide EPO 716 150
Osaka, Japan primers
DNA primers coding for specific tripeptides; for screening proteins for these tripeptide sequences.
Thomas Jefferson Univ. EGF receptor WO 96/16988
Philadelphia muteins
Overexpression of mutant Type III EGF receptor, encoding genes, antibodies to muteins; for tumor inhibition.
Transgene Vectors by WO 96/17070
Strasbourg, France recombination
Preparation of viral vectors within microorganisms by intermolecular homologous recombination; for gene therapy.
Vical IL-2 expression WO 96/17063
San Diego vector
Expression vectors with cytomegalovirus promoters; for expressing interleukin (IL)-2.
Washington Univ. Thrombospondin WO 96/17059
St. Louis domain receptor
Receptor for the cell-binding peptide sequences of the cell-binding domain of thrombospondins.
Wellcome Fdn. Extracellular WO 96/16179
Greenford, U.K. prodrug activation
Vector for expressing and secreting enzymes that activate prodrugs; for killing neighboring cells.
Wistar Inst. Mutated p53 WO 96/16989
Philadelphia proteins
Genes for mutated p53 proteins with altered tetramerization domains but unaltered activity; for modifying cell growth.
Yale Univ. Localizing WO 96/17074
New Haven, Conn. transcription sites
Peptides derived from the largest subunit of RNA polymerase II; for localizing sites of transcription for gene therapy.
Zymogenetics Low molecular WO 96/17062 &
Seattle weight thrombopoietin 17067
Genes for low molecular weight thrombopoietin, encoded proteins, vectors, cells, production/secretion methods.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.