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Prodrugs Matter

Idenix Tries to Convince FDA Not All Nucs Are Created Equal

By Brian Orelli
BioWorld Insight Contributing Writer

Monday, September 10, 2012

The demise of Bristol-Myers Squibb Co.'s hepatitis C drug BMS-986094, which BMS discontinued development of after patients in its Phase IIb study experienced heart and kidney toxicity, stretched further than just the big pharma. The FDA put a partial clinical hold on Idenix Pharmaceuticals Inc.'s related nuc IDX184 and then slapped a hold on its next-generation nuc, IDX19368, as well.

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