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Battle of the T Cells

Metabolic Transcription Factor Regulates T-Cell Development

By Anette Breindl


Monday, August 29, 2011
In experiments that could ultimately bear practical fruit for the treatment of both cancer and autoimmune disorders, scientists have discovered that hypoxia inducible factor, or HIF-1, plays a major role in determining whether T cells develop into pro-inflammatory TH17 cells or regulatory T cells, which inhibit the actions of other T cells and prevent the immune response from going out of control.

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