I. COMMENCED TRADING IN JULY

Company (Symbol)

Date Filed

Date Comm.

Shares/Units (M)

Price

Shares Out(M)

Lead, Other Underwriters

Gross ($M)

Net ($M)

INITIAL OFFERINGS

BioMarin Pharmaceutical Inc. (BMRN)

5/4

7/22

4.5S

$13

34.1

U.S. Bancorp Piper Jaffray; Vontobel Securities Ltd.; Schroders Securities Co. Ltd.; Leerink Swann & Co.

$58.5

$54.4E

Biopure Corp. (BPUR)

5/19

7/30

3.5S

$12

22.1

J.P. Morgan & Co.; Adams, Harkness & Hill Inc.; Robert W. Baird & Co.

$42

$37.9E

Genentech Inc. (NYSE:DNA)

7/20

7/20

20S

$97

127.3

J.P. Morgan & Co.; Goldman, Sachs & Co.; Merrill Lynch & Co.; Warburg Dillon Read LLC; BancBoston Robertson Stephens

$1,940

­ **

FOLLOW-ON OFFERINGS

Alizyme plc (LSE:AZM)

6/28

7/5

1.6U

74p (US $1.19)

N/A

N/A

£5.2 (US $8.4)*

£4.9E (US $7.9E)

Angiotech Pharmaceuticals Inc. (TSE:ANP)

6/17

7/9

1.4S

$11.50

N/A

Levesque Beaubien Geoffrion Inc. and Loewen, Ondaatje, Mccutcheon Ltd.

C $16.3 (US $10.9)*

C $15.5E (US $10.4E)

Ribozyme Pharmaceuticals Inc. (RZYM)

3/26

7/7

1.8S

$3.50

11

Hambrecht & Quist LLC (Placement agent)

$6.3

$5.8

** Roche Holdings Inc., Genentech's major stockholder, is offering all the shares of common stock in this transaction and will receive the proceeds of the offering.

II. FILED AND PENDING

Company (Symbol)

Date Filed

Shares/Units (M)

Price Range

Shares Out (M)

Lead, Other UWs

Value (M)

INITIAL OFFERINGS

There were no initial public offerings filed in July.

FOLLOW-ON OFFERINGS

Advanced Tissue Sciences Inc. (ATIS)

7/12

5

$3.25

47.5

Shares directly offered by the company

$16.25

Aquila Biopharmaceuticals Inc.(AQLA)

6/4

0.75

$2

6.9

­

$1.5

NeoTherapeutics Inc.(NEOT)

6/18

3.5

$13

10.2

Joseph Charles & Associates

$45.5

Shaman Pharmaceuticals Inc.(OTC BB:SHMN)

5/7

1

$15

3.2

N/A

$15

Vion Pharmaceuticals Inc.(VION)

7/27

3.6

5.38

19.2

Brean Murray & Co. Inc.

$19.4

* Canadian dollars converted to U.S. dollars at a rate of C$1.00=U.S.$0.67.

* British pounds converted to U.S. dollars at a rate of GBP£1.00=U.S.$1.62.

1 Aquila registered 750,000 shares to be sold in a direct limited placement to be negotiated by the company.