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Out, Damned SpoT

For Bacterial Infections, Getting Rid of Tolerance Is Good Thing

By Anette Breindl
Science Editor

Monday, November 21, 2011
Caloric restriction doesn't just extend the life span of people. Bacteria can become all-but-impervious to antibiotics when nutrients are limited – a phenomenon that is known as tolerance, to distinguish it from resistance, which is caused by mutations. Tolerance is particularly pronounced in biofilms, bacterial films, which are a problem on medical devices from catheters to hip implants.

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