Published April 19 (EPO); April 13 (WO); April 19 (GB)

Ajinomoto EPO 994 190

Homoserine resistance

Tokyo

Bacterial gene encoding a protein conferring resistance to L-homoserine.

Alabama, Univ. of WO 00/20436

Diabetes diagnostics

Birmingham, Ala.

Genomic DNA from chromosome 20 associated with diabetes, probes, polymorphisms; for diagnostics.

Chaux, P., et al. WO 00/20445

Anticancer T cells

Brussels, Belgium

Cytotoxic T cells isolated using MAGE tumor antigen stimulation.

Chemo-Serotherapeutic Res. Inst. WO 00/20570

Cancer metastasis inhibition

Kumamoto, Japan

Cathepsin D precursor-like enzyme fragment from plasma that inhibits cancer metastasis.

Children's Hosp. WO 00/20610

Full-length proteins

Boston

Disruption of Pichia yeast KEX1 gene; for preventing N-terminal residue cleavage and allowing protein production.

Cognetix WO 00/20018

KappaA conopeptides

Salt Lake City

Glycosylated and unglycosylated kappaA conopeptides; for modulating potassium transport in voltage-gated channels.

Connaught Labs WO 00/20609

Haemophilus therapeutics

Toronto

Protective recombinant Haemophilus influenzae high molecular weight proteins, encoding genes; for therapeutics.

Cornell Univ. WO 00/20568

Antifungal agent assay

Ithaca, N.Y.

Sugar transferases from fungal pathogens, encoding gene sequences; for developing antifungal agents.

Curagen WO 00/20447

Secreted proteins

New Haven, Conn.

Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.

Curagen WO 00/20448

NLK1-interacting proteins

New Haven, Conn.

NLK1-interacting proteins including vimentin, fragments, homologs; for treating cancer and viral infections.

Daikin WO 00/20558

RecA-based gene recombination

Osaka, Japan

Preparation of high performance RecA-like recombinase complex; for facilitating gene recombination.

Dartmouth College WO 00/20032

Cat allergy therapy

Hanover, N.H.

Recombinant cat allergen expressed in a baculovirus system; for diagnostics and therapeutics.

Eli Lilly WO 00/20593

IL-17 homolog

Indianapolis

Interleukin (IL)-17 homolog nucleic acids, encoded protein, transgenics, chimeras, antibodies.

Fluorescience GB 2 342 652

Coiled-coil proteins

Leeds, UK

Coiled-coil polypeptides and fragments with moieties involved in binding to the polypeptides.

Genotherapeutics WO 00/20608

Prostate cancer gene therapy

Memphis, Tenn.

Adenovirus vector having a _-lactamase gene controlled by the mouse mammary tumor promoter; for prostate cancer.

Genox Res. WO 00/20575

Cedar pollen allergy therapy

Ibaraki, Japan

Gene that is highly expressed in individuals having high cedar pollen-specific IgE levels; for treating allergies.

Genzyme WO 00/20029

Cancer vaccines

Framingham, Mass.

Genes differentially expressed in cancer cells; for designing antibody- and cell-based vaccines.

Genzyme WO 00/20457

Immunomodulatory therapeutics

Framingham, Mass.

Antigenic peptide epitopes related to IGF-II receptor having enhanced MHC binding; for immunomodulation.

Georgia, Med. College WO 00/20592

Osteotropic hormone

Augusta, Ga.

Glucose-dependent insulinotropic peptide for use as an osteotropic hormone.

Hall Inst. Med. Res. WO 00/20578

Modulating cell survival

Parkville, Australia

Modulation of cell survival using transfection of the p75 neurotrophin receptor gene and gene fragments.

Henkel WO 00/20566

Cytochrome mono-oxygenase

Gulph Mills, Penn.

Yeast cytochrome mono-oxygenase, encoding gene sequences; for producing dicarboxylic acids.

Incyte Genomics WO 00/20588

Bone marrow-derived proteins

Palo Alto, Calif.

Bone marrow-derived serum proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/20590

G-protein coupled receptors

Palo Alto, Calif.

G-protein coupled receptor proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/20604

Oxidoreductases

Palo Alto, Calif.

Oxidoreductases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.

Iowa, Univ. of WO 00/20582

Muscular dystrophy gene therapy

Iowa City, Iowa

Transfected gene expressing the sarcoglycan complex; for gene therapy for muscular dystrophy.

Isis Pharma WO 00/20432

Apoptosis-related therapeutics

Carlsbad, Calif.

Antisense oligonucleotides to bcl-x; for modulating gene expression and developing apoptosis-related therapeutics.

Isis Pharma WO 00/20435

TNF receptor antisense

Carlsbad, Calif.

Antisense oligos to TNF receptor-associated factors; for modulating gene expression and developing therapeutics.

Isis Pharma WO 00/20622

Selective DNA cleavage

Carlsbad, Calif.

Highly selective cleavage of single-stranded nucleic acids with a dimeric zinc finger peptide.

Isis Pharma WO 00/20635

Integrin a4 antisense

Carlsbad, Calif.

Modulation of integrin a4 expression using targeted antisense oligonucleotides; for therapeutics.

Kosan Biosciences WO 00/20601

Polyketide antibacterials

Hayward, Calif.

Polyketide synthase enzymes, recombinant DNA constructs for synthase modules; for making polyketide antibacterials.

Krebs Res. Ctr. WO 00/20617

Nuclear gene transfection

Heidelberg, Germany

Expression vector encoding a nuclear transport protein and a gene sequence to be transported; for nuclear transfection.

LeSaffre EPO 994 192

Protein production in yeast

Paris

Gene expression cassette for use in yeast cells to produce heterologous proteins. [in French].

Ludwig Inst. Cancer Res. WO 00/20460

Tumor antigen antibodies

New York

Isolation of T cell cDNAs encoding immunoglobulins that bind tumor antigens.

Ludwig Inst. Cancer Res. WO 00/20581

Tumor antigen peptides

New York

HLA class II binding peptides encoded by MAGE-A3 tumor-associated gene, antibodies; for stimulating CD4+ T cells.

Ludwig Inst. Cancer Res. WO 00/20586 & 20587

Renal cancer therapeutics

New York

Renal cancer-associated antigens, encoding gene sequences, fragments; for diagnostics and therapeutics.

Ludwig Inst. Cancer Res. WO 00/20594

TNF-inducible gene

New York

TNF-inducible gene encoding a CC chemokine; for finding ligands and modulators.

Massachusetts, Univ. of WO 00/20040

Inhibiting gene expression

Boston

5' untranslated region of RNAs ligated to a cell permeable molecule; for cell entry and gene expression inhibition.

Maxygen WO 00/20573

Mycotoxin detoxification

Redwood City, Calif.

DNA sequence shuffling for the production of nucleic acids that encode mycotoxin detoxification.

Mayo Clinic WO 00/20605

Hormone-dependent disease risk

Rochester, Minn.

Sulfotransferase sequence and flanking sequence variants; for determining the risk of hormone-dependent disease.

McMaster Univ. WO 00/20579

Oncogene-based therapeutics

Hamilton, Ont.

erbB-2/neu oncogene splice form encoding a constitutively expressed tyrosine kinase; for cancer therapy.

Merck WO 00/20438

Thrombin receptor-like receptor

Rahway, N.J.

G protein-coupled receptor resembling the thrombin receptor, encoding gene; for identifying modulators.

Millennium Pharma WO 00/19988

Th2-specific proteins

Cambridge, Mass.

Th2-specific proteins, encoding genes, fusions, antigenic peptides, antibodies; for diagnostics and therapeutics.

NIH (Natl. Inst. Hlth.) WO 00/20576

Apoptosis induction

Bethesda, Md.

Apoptosis-inducing antibodies that bind Notch protein on tumor cells; for therapeutics.

NIH (Natl. Inst. Hlth.) WO 00/20577

Angiogenesis inhibition

Bethesda, Md.

Inhibition of endothelial cell growth and angiogenesis associated with cancer using calreticulin and its fragments.

New Jersey, Med. & Dent. Univ. WO 00/20433

Cancer killing adenoviruses

Newark, N.J.

Identification of adenoviruses that are selectively cytotoxic for malignant lymphoid cells; for therapeutics.

Novo Nordisk WO 00/20596

Transcription activator

Bagsvaerd, Denmark

Fungal transcription activator, encoding gene sequences; for use in recombinant protein production systems.

Ortho-McNeil Pharma WO 00/20011

H3 histamine receptor

Raritan, N.J.

Human H3 histamine receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.

Pfizer GB 2 342 716

Antiviral agent assay

Sandwich, UK

Methods for identifying antiviral agents using interactions with serine-threonine phosphatase.

Reimann, H., et al. WO 00/20606

Protein production methods

Ulm, Germany

Methods for producing proteins using fusions of truncated variants of the SV40 large T antigen and antibodies.

Rigel Pharma WO 00/20574

Ligand binding screen

S. San Francisco

Fusions of random peptides with green fluorescent protein; for screening for ligand binding.

Rockefeller Univ. WO 00/20585

Timeless protein

New York

Gene encoding the mammalian timeless protein, antibodies; for diagnostics and therapeutics.

Rockefeller Univ. WO 00/20598

Septic shock therapy

New York

Staphylococcal and streptococcal toxin homolog peptides; for treating toxic shock syndrome and septic shock.

Rolleke, S. EPO 994 193

Organism identification

Vienna, Austria

Methods of identifying organisms using species-specific nucleic acid probes. [in German].

Rudolph, R. EPO 994 188

_-NGF production

Saale, Germany

Methods for obtaining _-nerve growth factor (NGF) from inclusion bodies in prokaryotes [in German].

Satoh, N., et al. WO 00/20442

Tumor-specific peptides

Ishikawa, Japan

Tumor-specific antigenic peptides; for developing cancer therapeutics.

Schrader, J. WO 00/20572

Tissue binding proteins

Dusseldorf, Germany

Tissue binding peptides, production methods; for diagnostics and therapeutics.

Southern California, Univ. of WO 00/20567

Learning-induced genes

Los Angeles

Learning-induced cerebellar genes, predicted encoded kinases; for studying mechanisms of learning and memory.

Stanford Univ. WO 00/20434

Modulating T cell signalling

Palo Alto, Calif.

Cadherin-like asymmetry protein-1; for modulating T and B cell surface-mediated cell signalling.

Stryker WO 00/20449, 20591, & 20607

Modified TGF-_ proteins

Kalamazoo, Mich.

Modified TGF-_ superfamily proteins including morphogenic proteins, fusions, heterodimers, chimeras; for therapeutics.

Takara Shuzo EPO 994 191

Hyperthermostable protease

Kyoto, Japan

Hyperthermostable protease resulting from amino acid residue changes, encoding gene, production methods.

Takeda Chemical WO 00/20439

Terminal methionine removal

Osaka, Japan

Chemical process for eliminating N-terminal methionine residues from proteins; for isolating mature proteins.

Takeda Chemical WO 00/20455 & 20456

G protein-coupled receptor

Osaka, Japan

G protein-coupled receptor from human hippocampus, encoding gene, fragments; for screening modulators.

Takeda Chemical WO 00/20580

G protein-coupled receptor

Osaka, Japan

G protein-coupled receptor from rat cerebellum, encoding gene, fragments; for screening inhibitors.

Tokiwa Chemical EPO 994 187

Pro-renin antibodies

Tokyo

Human pro-renin, antibodies; for controlling renin activity and developing therapeutics.

Urogenesys WO 00/20584

Cancer-associated gene

Santa Monica, Calif.

Human gene expressed in cancers of the prostate, bladder, pancreas, and colon; for diagnostics and therapeutics.

Urogenesys WO 00/20589

Prostate cancer proteins

Santa Monica, Calif.

Testis-specific proteins expressed in prostate cancer, encoding genes; for diagnostics and therapeutics.

Warner-Lambert WO 00/20450

Calcium channel subunits

Morris Plains, N.J.

Alpha-2/delta gene, encoded proteins that are calcium channel subunits; for diagnostics and therapeutics.

Yoon, T.-W. EPO 994 185

Diabetes cell therapy

Seodaemoon-Ku, S. Korea

Methods for culturing Langerhans islet cells; for transplantation and diabetes treatment.

YS New Technol. Inst. WO 00/20599

Capillary drug screens

Tochigi, Japan

Temperature-sensitive established capillary cell lines expressing SV40 large T antigen; for drug screens.

Zeneca GB 2 342 717

Allergy gene variations

London

LTC4 synthase gene single nucleotide polymorphisms and allelic variation; for allergy diagnostics and therapeutics.

Zymogenetics WO 00/20583

Ribonucleoprotein homolog

Seattle

Ribonucleoprotein homolog, encoding gene; for modulating mRNA processing.

Zymogenetics WO 00/20595

IL-1 homolog

Seattle

Interleukin (IL)-1 homolog, encoding gene, production methods; for treating inflammation.