Published April 19 (EPO); April 13 (WO); April 19 (GB)
Ajinomoto EPO 994 190
Homoserine resistance
Tokyo
Bacterial gene encoding a protein conferring resistance to L-homoserine.
Alabama, Univ. of WO 00/20436
Diabetes diagnostics
Birmingham, Ala.
Genomic DNA from chromosome 20 associated with diabetes, probes, polymorphisms; for diagnostics.
Chaux, P., et al. WO 00/20445
Anticancer T cells
Brussels, Belgium
Cytotoxic T cells isolated using MAGE tumor antigen stimulation.
Chemo-Serotherapeutic Res. Inst. WO 00/20570
Cancer metastasis inhibition
Kumamoto, Japan
Cathepsin D precursor-like enzyme fragment from plasma that inhibits cancer metastasis.
Children's Hosp. WO 00/20610
Full-length proteins
Boston
Disruption of Pichia yeast KEX1 gene; for preventing N-terminal residue cleavage and allowing protein production.
Cognetix WO 00/20018
KappaA conopeptides
Salt Lake City
Glycosylated and unglycosylated kappaA conopeptides; for modulating potassium transport in voltage-gated channels.
Connaught Labs WO 00/20609
Haemophilus therapeutics
Toronto
Protective recombinant Haemophilus influenzae high molecular weight proteins, encoding genes; for therapeutics.
Cornell Univ. WO 00/20568
Antifungal agent assay
Ithaca, N.Y.
Sugar transferases from fungal pathogens, encoding gene sequences; for developing antifungal agents.
Curagen WO 00/20447
Secreted proteins
New Haven, Conn.
Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Curagen WO 00/20448
NLK1-interacting proteins
New Haven, Conn.
NLK1-interacting proteins including vimentin, fragments, homologs; for treating cancer and viral infections.
Daikin WO 00/20558
RecA-based gene recombination
Osaka, Japan
Preparation of high performance RecA-like recombinase complex; for facilitating gene recombination.
Dartmouth College WO 00/20032
Cat allergy therapy
Hanover, N.H.
Recombinant cat allergen expressed in a baculovirus system; for diagnostics and therapeutics.
Eli Lilly WO 00/20593
IL-17 homolog
Indianapolis
Interleukin (IL)-17 homolog nucleic acids, encoded protein, transgenics, chimeras, antibodies.
Fluorescience GB 2 342 652
Coiled-coil proteins
Leeds, UK
Coiled-coil polypeptides and fragments with moieties involved in binding to the polypeptides.
Genotherapeutics WO 00/20608
Prostate cancer gene therapy
Memphis, Tenn.
Adenovirus vector having a _-lactamase gene controlled by the mouse mammary tumor promoter; for prostate cancer.
Genox Res. WO 00/20575
Cedar pollen allergy therapy
Ibaraki, Japan
Gene that is highly expressed in individuals having high cedar pollen-specific IgE levels; for treating allergies.
Genzyme WO 00/20029
Cancer vaccines
Framingham, Mass.
Genes differentially expressed in cancer cells; for designing antibody- and cell-based vaccines.
Genzyme WO 00/20457
Immunomodulatory therapeutics
Framingham, Mass.
Antigenic peptide epitopes related to IGF-II receptor having enhanced MHC binding; for immunomodulation.
Georgia, Med. College WO 00/20592
Osteotropic hormone
Augusta, Ga.
Glucose-dependent insulinotropic peptide for use as an osteotropic hormone.
Hall Inst. Med. Res. WO 00/20578
Modulating cell survival
Parkville, Australia
Modulation of cell survival using transfection of the p75 neurotrophin receptor gene and gene fragments.
Henkel WO 00/20566
Cytochrome mono-oxygenase
Gulph Mills, Penn.
Yeast cytochrome mono-oxygenase, encoding gene sequences; for producing dicarboxylic acids.
Incyte Genomics WO 00/20588
Bone marrow-derived proteins
Palo Alto, Calif.
Bone marrow-derived serum proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/20590
G-protein coupled receptors
Palo Alto, Calif.
G-protein coupled receptor proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/20604
Oxidoreductases
Palo Alto, Calif.
Oxidoreductases, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Iowa, Univ. of WO 00/20582
Muscular dystrophy gene therapy
Iowa City, Iowa
Transfected gene expressing the sarcoglycan complex; for gene therapy for muscular dystrophy.
Isis Pharma WO 00/20432
Apoptosis-related therapeutics
Carlsbad, Calif.
Antisense oligonucleotides to bcl-x; for modulating gene expression and developing apoptosis-related therapeutics.
Isis Pharma WO 00/20435
TNF receptor antisense
Carlsbad, Calif.
Antisense oligos to TNF receptor-associated factors; for modulating gene expression and developing therapeutics.
Isis Pharma WO 00/20622
Selective DNA cleavage
Carlsbad, Calif.
Highly selective cleavage of single-stranded nucleic acids with a dimeric zinc finger peptide.
Isis Pharma WO 00/20635
Integrin a4 antisense
Carlsbad, Calif.
Modulation of integrin a4 expression using targeted antisense oligonucleotides; for therapeutics.
Kosan Biosciences WO 00/20601
Polyketide antibacterials
Hayward, Calif.
Polyketide synthase enzymes, recombinant DNA constructs for synthase modules; for making polyketide antibacterials.
Krebs Res. Ctr. WO 00/20617
Nuclear gene transfection
Heidelberg, Germany
Expression vector encoding a nuclear transport protein and a gene sequence to be transported; for nuclear transfection.
LeSaffre EPO 994 192
Protein production in yeast
Paris
Gene expression cassette for use in yeast cells to produce heterologous proteins. [in French].
Ludwig Inst. Cancer Res. WO 00/20460
Tumor antigen antibodies
New York
Isolation of T cell cDNAs encoding immunoglobulins that bind tumor antigens.
Ludwig Inst. Cancer Res. WO 00/20581
Tumor antigen peptides
New York
HLA class II binding peptides encoded by MAGE-A3 tumor-associated gene, antibodies; for stimulating CD4+ T cells.
Ludwig Inst. Cancer Res. WO 00/20586 & 20587
Renal cancer therapeutics
New York
Renal cancer-associated antigens, encoding gene sequences, fragments; for diagnostics and therapeutics.
Ludwig Inst. Cancer Res. WO 00/20594
TNF-inducible gene
New York
TNF-inducible gene encoding a CC chemokine; for finding ligands and modulators.
Massachusetts, Univ. of WO 00/20040
Inhibiting gene expression
Boston
5' untranslated region of RNAs ligated to a cell permeable molecule; for cell entry and gene expression inhibition.
Maxygen WO 00/20573
Mycotoxin detoxification
Redwood City, Calif.
DNA sequence shuffling for the production of nucleic acids that encode mycotoxin detoxification.
Mayo Clinic WO 00/20605
Hormone-dependent disease risk
Rochester, Minn.
Sulfotransferase sequence and flanking sequence variants; for determining the risk of hormone-dependent disease.
McMaster Univ. WO 00/20579
Oncogene-based therapeutics
Hamilton, Ont.
erbB-2/neu oncogene splice form encoding a constitutively expressed tyrosine kinase; for cancer therapy.
Merck WO 00/20438
Thrombin receptor-like receptor
Rahway, N.J.
G protein-coupled receptor resembling the thrombin receptor, encoding gene; for identifying modulators.
Millennium Pharma WO 00/19988
Th2-specific proteins
Cambridge, Mass.
Th2-specific proteins, encoding genes, fusions, antigenic peptides, antibodies; for diagnostics and therapeutics.
NIH (Natl. Inst. Hlth.) WO 00/20576
Apoptosis induction
Bethesda, Md.
Apoptosis-inducing antibodies that bind Notch protein on tumor cells; for therapeutics.
NIH (Natl. Inst. Hlth.) WO 00/20577
Angiogenesis inhibition
Bethesda, Md.
Inhibition of endothelial cell growth and angiogenesis associated with cancer using calreticulin and its fragments.
New Jersey, Med. & Dent. Univ. WO 00/20433
Cancer killing adenoviruses
Newark, N.J.
Identification of adenoviruses that are selectively cytotoxic for malignant lymphoid cells; for therapeutics.
Novo Nordisk WO 00/20596
Transcription activator
Bagsvaerd, Denmark
Fungal transcription activator, encoding gene sequences; for use in recombinant protein production systems.
Ortho-McNeil Pharma WO 00/20011
H3 histamine receptor
Raritan, N.J.
Human H3 histamine receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Pfizer GB 2 342 716
Antiviral agent assay
Sandwich, UK
Methods for identifying antiviral agents using interactions with serine-threonine phosphatase.
Reimann, H., et al. WO 00/20606
Protein production methods
Ulm, Germany
Methods for producing proteins using fusions of truncated variants of the SV40 large T antigen and antibodies.
Rigel Pharma WO 00/20574
Ligand binding screen
S. San Francisco
Fusions of random peptides with green fluorescent protein; for screening for ligand binding.
Rockefeller Univ. WO 00/20585
Timeless protein
New York
Gene encoding the mammalian timeless protein, antibodies; for diagnostics and therapeutics.
Rockefeller Univ. WO 00/20598
Septic shock therapy
New York
Staphylococcal and streptococcal toxin homolog peptides; for treating toxic shock syndrome and septic shock.
Rolleke, S. EPO 994 193
Organism identification
Vienna, Austria
Methods of identifying organisms using species-specific nucleic acid probes. [in German].
Rudolph, R. EPO 994 188
_-NGF production
Saale, Germany
Methods for obtaining _-nerve growth factor (NGF) from inclusion bodies in prokaryotes [in German].
Satoh, N., et al. WO 00/20442
Tumor-specific peptides
Ishikawa, Japan
Tumor-specific antigenic peptides; for developing cancer therapeutics.
Schrader, J. WO 00/20572
Tissue binding proteins
Dusseldorf, Germany
Tissue binding peptides, production methods; for diagnostics and therapeutics.
Southern California, Univ. of WO 00/20567
Learning-induced genes
Los Angeles
Learning-induced cerebellar genes, predicted encoded kinases; for studying mechanisms of learning and memory.
Stanford Univ. WO 00/20434
Modulating T cell signalling
Palo Alto, Calif.
Cadherin-like asymmetry protein-1; for modulating T and B cell surface-mediated cell signalling.
Stryker WO 00/20449, 20591, & 20607
Modified TGF-_ proteins
Kalamazoo, Mich.
Modified TGF-_ superfamily proteins including morphogenic proteins, fusions, heterodimers, chimeras; for therapeutics.
Takara Shuzo EPO 994 191
Hyperthermostable protease
Kyoto, Japan
Hyperthermostable protease resulting from amino acid residue changes, encoding gene, production methods.
Takeda Chemical WO 00/20439
Terminal methionine removal
Osaka, Japan
Chemical process for eliminating N-terminal methionine residues from proteins; for isolating mature proteins.
Takeda Chemical WO 00/20455 & 20456
G protein-coupled receptor
Osaka, Japan
G protein-coupled receptor from human hippocampus, encoding gene, fragments; for screening modulators.
Takeda Chemical WO 00/20580
G protein-coupled receptor
Osaka, Japan
G protein-coupled receptor from rat cerebellum, encoding gene, fragments; for screening inhibitors.
Tokiwa Chemical EPO 994 187
Pro-renin antibodies
Tokyo
Human pro-renin, antibodies; for controlling renin activity and developing therapeutics.
Urogenesys WO 00/20584
Cancer-associated gene
Santa Monica, Calif.
Human gene expressed in cancers of the prostate, bladder, pancreas, and colon; for diagnostics and therapeutics.
Urogenesys WO 00/20589
Prostate cancer proteins
Santa Monica, Calif.
Testis-specific proteins expressed in prostate cancer, encoding genes; for diagnostics and therapeutics.
Warner-Lambert WO 00/20450
Calcium channel subunits
Morris Plains, N.J.
Alpha-2/delta gene, encoded proteins that are calcium channel subunits; for diagnostics and therapeutics.
Yoon, T.-W. EPO 994 185
Diabetes cell therapy
Seodaemoon-Ku, S. Korea
Methods for culturing Langerhans islet cells; for transplantation and diabetes treatment.
YS New Technol. Inst. WO 00/20599
Capillary drug screens
Tochigi, Japan
Temperature-sensitive established capillary cell lines expressing SV40 large T antigen; for drug screens.
Zeneca GB 2 342 717
Allergy gene variations
London
LTC4 synthase gene single nucleotide polymorphisms and allelic variation; for allergy diagnostics and therapeutics.
Zymogenetics WO 00/20583
Ribonucleoprotein homolog
Seattle
Ribonucleoprotein homolog, encoding gene; for modulating mRNA processing.
Zymogenetics WO 00/20595
IL-1 homolog
Seattle
Interleukin (IL)-1 homolog, encoding gene, production methods; for treating inflammation.