Published June 9 & 16 (EPO); June 10 (WO)

Akzo, NV Cancer monoclonals Arnhem, Netherlands B-cell lines from cancer patients' blood immunized with autologous tumor antigen; their monoclonal antibodies. For diagnosis, therapy.

Alabama, Univ. Res. Fn. Glial scar WO 93/10798 Birmingham, Ala. disruption Monoclonal antibody to glial cell adhesion molecule disrupts glial scars in damaged nerves.

American Cyanamid Co. Microbe over-produc- EPO 546 349 Stamford, Conn. ing PRP Haemophilus influenzae strain produces high quantities of capsular polysaccharide polyribosyl-ribitol-phosphate.

American Home Products Viral immunogens EPO 546 787 New York Chimeric DNA fragments encode influenza A virus surface protein; for vaccines, test kits, prevention, immunotherapy.

Australia Operations Plant-transform- WO 93/11243 Prop., Melbourne ing DNA Clones of gene encoding maize acetyl CoA carboxylase, flanked by heterologous DNA; to transform plants "with variety of useful effects."

BASF, AG Leech thrombin- WO 93/11239 Ludwigshafen, Germany inhibitors Recombinant, thrombin-inhibiting proteins, 57 amino-acids long, from Haemodypsa terrestrial leeches, for medicinal uses.

BioResearch Ireland Fish pathogen WO 93/11263 Dublin, Ireland probe DNA probe for detecting Afromonas salmonicida in water, bacterial culture, fish tissue or feces, etc.; for use in fish hatcheries.

Boehringer Ingelheim Transfecting eukaryotic EPO 545 016 Ingelheim, Germany cells Composition for nucleic acid complex transfection in higher eukaryotic cells, involving provision for endosomolysis. [Co- applicants; Genentech; U. of N. Carolina] (In German)

British Technology . Bi-cistronic WO 93/11250 Group, London poliovirus A eukaroyotic RNA virus, especially a poliovirus, bi-cistronic as to RNA function; to express foreign polypeptide in infected cells.

California, Univ. of Chromosomal DNA EPO 545 459 Berkeley, Calif. probes Microdissected chromosomal DNA fragments are digested, ligated to primers, amplified by PCR; to probe cDNA or genomic libraries.

California, Univ. of Variable-region WO 93/11252 Berkeley, Calif. expression Cloning vectors for expressing PCR-generated variable regions as complete heavy or light chains

Ciba-Geigy, AG 7B2 protein as WO 93/11248 Basel, Switzerland. chaperone Use of 7B2 protein as chaperone in vivo or in vitro; using recombinant cells that express 7B2.to produce desired protein in vivo.

Cor Therapeutics Inc. PDGF receptor WO 93/11223 S. San Francisco fragments Cell lines producing soluble peptides having platelet-derived growth factor (PDGF) ligand-binding activity.

Dartmouth University Lipocortin-1 WO 93/11222 Hanover, N.H. receptor A cellular protein involved in binding lipocortin-1; expressing its receptor; antibodies; diagnostic and therapeutic uses.

Du Pont Altering plant WO 93/11245 Wilmington, Del. lipids Nucleic acid fragments encoding fatty acid desaturase enzymes permit manipulating plant levels of unsaturated fatty acids.

Du Pont Identifyinhg micro- WO 93/11264 Wilmington, Del. organisms To identify a microorganism, isolate its genomic DNA, amplify variable sequences, to get polymorphs species-specific in size, number.

Dynal Asino/Nor Stem-cell virus- WO 93/11230 Oslo, Norway blocker Mammalian stem cell transduced with vectors carrying DNA encoding protein that blocks replication of virus that infects cell's progeny.

Enzon Inc. Multivalent WO 93/11161 Piscataway, N.J. proteins Gene sequences coding for hetero- and homo-bivalent single- chain, antigen-binding proteins.

Genentech Inc. Fixing misfolded WO 93/11240 S. San Francisco, Calif. IGF-1 Method for refolding into biologically active conformation insoluble, improperly folded IGF-1 precipitated from prokaryotic host cells.

Genentech Inc. Hormone synthesis WO 93/11247 S. San Francisco, Calif. Prohormone convertase, expressed in mammalian cells, for proper processing of active hormones, instead of adding them in cell culture.

Itoham Foods Inc. Sexing bovine EPO 546 762 Kobe, Hyogo, Japan embryos Male-specific and gender-neutral PCR primers permit amplifying specific DNA sequences to determine sex of bovine embryos.

Kyowa Hakko Kogyo DNA encoding EPO 545 688 Tokyo uricase DNA coding for uricase from genus Cellulomonas; expressing enzyme in host organism carrying the gene sequence.

Louvain, Cath. Univ. of Selecting micro- WO 93/11242 Louvain, Belgium organisms Recombinant microorganism fixed to solid support by a covalent inhibitor of active site of an enzymatic molecule on its surface.

Manitoba, Univ. of DNA-fragmenting WO 93/11246 Winnipeg, Canada enzymes DNA-fragmenting granule proteases, isolated from rat natural killer tumor cell line, cause apoptosis of targeted tumor cells.

Max Planck Institute Alzheimer diagnosis, EPO 544 942 Gttingen, Germany therapy WO 93/11231 Epitopes of phosphorylated tau protein from Alzheimer paired helical filaments; phosphorylating PK; antibodies to epitopes.

Max Planck Institute RFLP detection EPO 547 024 Gttingen, Germany Restriction fragment length polymorphism probe of eukaryotic genomes, using oligonucleotide hybridizing to tandem repeats.

Merck & Co. Platelet-collagen EPO 546 813 Rahway, N.J. adhesion Proteins isolated from extract of Ornithodoros moubata (relapsing-fever tick) inhibit platelet adhesion to collagen, but not fibrinogen; for prevention, treatment of thromboses.

Michigan, Univ. of Chromosome region WO 93/11265 Ann Arbor, Mich. probes Chromosome region-specific probes by direct in vitro enzymatic amplification of microdissected DNA, labelling for in situ hybridization.

Natl. Research Council Plant fungus WO 93/11241 Rome inhibitor Gene encoding fungal endopolygalacturonase is cloned from Phaseolus vulgaris (stringbeans). Transformed plants resist pathogens.

Nichirei Corp. Fibronectin gene EPO 546 333 Tokyo enhancer Recombinant vector comprises a cloned DNA having enhancer activity for fibronectin gene expression in mammalian cells.

NIH Pemphigus antigen WO 93/10813 Bethesda, Md. DNA encoding entire Pemphigus vulgaris antigen amino acid sequence, for diagnosis, treatment of this life-threatening skin disease.

Novo Nordisk AS Humicola insolens WO 93/11249 Bagsvaerd, Denmark proteins A recombinant enzyme isolated from Humicola insolens has endocellulase activity in presence of linear alkyl benzene sulfonate.

Novo Nordisk AS Protease-stable WO 93/11254 Bagsvaerd, Denmark proteins Substituting non-protease-labile amino-acid segments for labile ones provides protein with stability against proteolytic degradation.

Otsuka Pharm. Co. Human M-CSF EPO 547 026 Tokyo gene Gene encoding biologically active human macrophage-colony- stimulating factor; expression vector; transformant.

Pennsylvania, Univ. of Testicular tubule WO 93/11228 Philadelphia cells Colonizing host animal testes with foreign primitive germ cells to populate testicular seminiferous tubules of progeny.

Pioneer Hi-Bred Intl. Inhibiting plant EPO 545 730 Des Moines, Iowa fungi Gene for peptide tachyplesin, inserted into plant cells and expressed, confers antimicrobial activity against fungal pathogens.

Salk Institute Steroid/thyroid WO 93/11235 La Jolla, Calif. receptors Members of steroid/thyroid receptor superfamily can interact to form multimeric species.

Schering Corp. Interleukin-4 WO 93/11234 Kenilworth, N.J. antagonists Antagonists of human interleukin-4, based on critical region of its receptor's cytoplasmic domain; can inhibit IL-4 bioactivity.

Scripps Research Inst. Promoting cell WO 93/11229 La Jolla, Calif. attachment Receptor binding site on human fibronectin binds to platelet receptor glycoprotein; derived polypeptides can aid or inhibit cell attachment

Serono Laboratories, SA Calcium-regulated EPO 546 833 Madrid promoter Ca-regulated promoter increases production of extracellular foreign polypeptides, notably in Streptomyces expression systems.

Sloan-Kettering Inst. Mutation detection WO 93/11266 New York Detection of mutations and monoclonal lineages in a human subject by analysis of RNA conformation polymorphism.

Sumitomo Denki Kogyo DNA preparation EPO 546 176 Osaka, Japan process Prepare and anneal single-stranded nucleotide chain and primer; synthesize complementary chain to get double- stranded DNA; repeat steps.

Sumitomo Pharm. Co. Oncogenic IL-2 WO 93/11238 Osaka, Japan receptor Transplanting complementarity-determining region of mouse monoclonal to carcinoma-expressing IL-2 receptor; for immunotherapy.

Synaptic Pharm. Corp. Serotonin (5-HT1E) WO 93/11147 Paramus, N.J. receptor Newly discovered gene encodes human serotonin receptor; compounds to treat nervous-system disorders involving serotonin.

Taisho Pharm. Co. Tumor cell WO 93/11233 Tokyo proliferation DNA fragment encoding tumor cell proliferation inhibiting factor, prepared from mRNA of established cell line derived from 3T3 cells.

U. S. Biochemical Corp. Poly(A) polymerase WO 93/11227 Cleveland Nucleic acid encoding yeast, human or bovine poly(A) polymerase; methods of production and use.

Viagene Inc. Anti-cancer immuno- WO 93/10814 San Diego therapy Vector expressing immunogenic, non-tumorigenic altered cell normally associated with destruction-targeted tumor cells.

Wellcome Foundation Chimeric T-cell WO 93/11237 London antibodies Humanized mouse antibody in which complementarity- determining region sequence binds to T cells, inhibiting their proliferation.

Weyerhaeuser Co. Diguanylate enzymes WO 93/11244 Tacoma, Wash. Nucleotide sequences of Acetobacter operons; genes for cyclic diguanosine monophosphate; phosphodiesterase isozymes.

Whitehead Inst. Artificial cleavage WO 93/11251 Cambridge, Mass. site Replication-competent poliovirus carrying foreign DNA, and sequence encoding proteolytic cleavage site to free exogenous polypeptide.

Yeda R&D Co. Ligand-specific EPO 545 343 Rehovot, Israel FGFR Replacing ligand-binding site of one fibroblast growth-factor receptor (FGFR) with another confers latter's binding specificity.

(c) 1997 American Health Consultants. All rights reserved.