Published July 19 & 26 (EPO & GB); July 13 & 20 (WO)
Agricult., Fisheries &Equine arteritisWO95/19438
Food Ministry viral peptides
London
Equine arteritis virus peptides, antibodies; foridentification assays to prevent spontaneous abortion inhorses.
Akzo NobelBovine herpes virus EPO 663 403
Arnhem, Netherlandsvector
Mutant bovine herpes virus vector for introducingheterologous proteins into a host; for response topathogen.
Alexion PharmaNon-prolifer-WO 95/19368, 428
New Haven, Conn. ating cell transduction
Retroviral vector particles with nuclear localizationsequence; for transduction of non-proliferating cells.
Baylor Coll. Med.Fluid spaceWO 95/19182
Houstongene therapy
Expression vectors for delivering genes to cells in bodyfluid spaces; for somatic gene therapy.
BehringwerkeYeast infectionsEPO 664 336
Marburg, Germany
Saccharomyces-specific antigens and antibodies to them;for identifying and quantifying infection [in German].
Biotech. & GeneticFructosyltrans-EPO 663442
Engin. Inst. ferase
Havana
Coding sequence of extracellular Acetobacterfructosyltransferase; for producing low-caloriesweeteners.
Biotech. & GeneticDextranase sugarEPO 663443
Engin. Inst. production
Havana
Coding sequence of fungal dextranase; for dextranhydrolysis in sugar cane juice for increased sugarproduction.
California, Univ. ofSyphilis therapyWO95/18632
Oakland, Calif.
Amino acid sequences of antigenic rare outer membraneproteins from spirochaetes; for syphilisdetection/treatment.
California, Univ. ofMCP receptorsWO95/19436
Oakland, Calif.
Coding sequences for monocyte chemoattractant protein(MCP) receptors, encoded proteins; for antagonistidentification.
CalydonProstate cancer WO 95/19434
Menlo Park, Calif.therapy
Prostate-specific transcriptional regulatory sequencecontrolling toxin gene expression; for cancer therapy.
CNRS (Natl. Ctr. Hematopoietic EPO 663444
Hlth. Res.) stem cells
Paris
Bipotent immature mammalian hematopoietic precursorcells, pure stem cell culture, maturation factors.
Children's Hosp.p53 gene WO 95/18818
Philadelphiapolymorphism
Identification of a p53 gene polymorphism; fordetermining lineage, linkage and inheritance.
Ciba-GeigySynergistic WO 95/18859, 9443
Basel, Switzerlandantifungal proteins
Plant proteins that are synergistic with antifungalantibiotics; for treating Candida infections.
CSIRO (Comm. Sci.Enzyme-based WO95/19440
Ind. Res. Org.) bioremediation
Campbell, Australia
Coding sequence of E3 esterase from organophosphateresistant microorganism, encoded protein; forbioremediation.
Cornell Univ.Marek's disease WO 95/18860
Ithaca, N.Y.viral protein
Coding sequence of a protein from Marek's disease virus(MDV); for vaccination and control of MDV infection.
CytogamGender selectionEPO 664 298
Chandler, Ariz.
Sperm cell sorting using antibodies to sex-associatedmembrane proteins; for controlling offspring gender.
Gene ShearsRibozymes against WO 95/18854
St. Leonards, AustraliaRNA viruses
Ribozymes directed against the packaging sequence ofRNA viruses; for treating infection by these viruses.
GenentechThrombopoietinWO 95/18858
South San Francisco
Coding sequence of thrombopoietin, encoded proteins;for treatment of thrombocytopenia.
Genetic TherapyRetroviral vector WO95/19427
Gaithersburg, Md.purification
Purification of retroviral vector particles; for increasedrecovery of particles useful in gene therapy.
Ghent, State Univ. ofViral neuraminidase WO95/18861
Ghent, Belgiumvaccine
Coding sequence of flu virus neuraminidase; forrecombinant protein production and vaccine manufacture.
Harvard CollegeVibrio motility WO95/18633
Cambridge, Mass.genes
Coding sequence of Vibrio cholerae motility genes, agarpenetration mutants, methods for making mutant strains.
Harvard CollegeHerpes virus WO 95/18852
Cambridge, Mass.vaccine
Replication-defective herpes virus; for use as a vaccine inimmunoregulatory diseases.
Harvard CollegeHedgehog-related WO95/18856
Cambridge, Mass.genes
Coding sequences for hedgehog-related genes, encodedproteins; for modulating tissue development.
Illinois, Univ. ofKinesin and WO 95/18857
Urbana, Ill.cancer drugs
Genetic suppressor elements for chemotherapeutic drugresistance, including human heavy chain kinesin gene.
ImmunexFas ligandWO 95/18819
Seattle
Coding sequence of Fas ligand (Fas-L), expressionvectors producing Fas-L, immunoreactive antibodies.
INSERM (Natl. Inst.Hematopoietic WO95/19432
Hlth. Med. Res.) stem cells
Paris
Bipotent immature mammalian hematopoietic precursorcells, pure stem cell culture, maturation factors.
Jockey ClubNon-invasive WO 95/19447
New YorkDNA sampling
Non-invasive sampling method for obtaining nucleic acidsamples for analysis.
Johns Hopkins Univ.Histologic tissue WO95/19448
Baltimoremutations
Detection of nucleic acid mutations in histologic tissuesections; for cancer treatment targeting.
Julich Res. Ctr.Deregulated WO 95/19442
Julich, Germanyrecombinant isoleucine
Threonine dehydratase mutated in its allosteric domains;for deregulated recombinant production of isoleucine.
La Jolla CancerCell death WO 95/19367
Res. Fdn. gene regulation
La Jolla, Calif.
Regulatory sequences linked to cell death genes; forscreening agents that modulate expression of these genes.
Leeds, Univ. ofCellulase regulatory WO95/19441
Leeds, U.K.sequences
Mold cellulase gene regulatory sequences; for use inexpression vectors.
Manitoba, Univ. ofCross-reactive WO95/19437
Winnipeg, Manitobapollen allergen
Highly cross-reactive allergen from Kentucky Bluegrass;for wide-spectrum pollen allergy treatment.
MitotixUbiquitin-conjugating WO95/18974
Cambridge, Mass.enzymes
Ubiquitin-conjugating enzymes and inhibition ofubiquitin-mediated degradation of cell-cycle regulatoryproteins.
NIH (Natl. Inst. Hlth.)Protein tyrosine WO95/19439
Bethesda, Md.kinase
Coding sequence of a protein tyrosine kinase, encodedprotein; for immunodiagnostics and therapy.
Novo NordiskFactor VIII WO 95/18827, 828, 829
Bagsvaerd, Denmarkderivatives
Factor VIII derivatives and subunit combinations; forgreater yield and extended coagulant activity.
Oswaldo Cruz-Protection from GB 2 285626
Fiocruz Fdn. helminths
Rio de Janeiro, Brazil
Amino acid sequence of antigenic protein fromSchistosoma, encoded protein; for treatment of helminthinfections.
Pasteur Inst.MHC minus cellsEPO 664 337
Paris
Cell lacking human MHC class II antigens; for detectingand producing antibodies to selected microorganisms.
Pennsylvania, Univ. ofAntisense WO95/19175
PhiladelphiaSTK-1 oligos
Antisense oligos against STK-1 mRNA; for treatingcancer and purging bone marrow of cancerous cells.
Pioneer Hi-BredSynthetic WO 95/18855
Des Moines, Iowa antimicrobial peptides
Synthetic polypeptides with amphipathic -helices; for cellexpression of antimicrobial activity.
Pittsburgh, Univ. ofHematopoietic WO95/18631
Pittsburghfacilitatory cells
Monoclonal antibodies to hematopoietic facilitatory cells;for isolation from bone marrow.
PromegaMutant luciferasesWO 95/18853
Madison, Wis.
Coding sequences of mutant beetle luciferases, encodedproteins; for use in biosensing applications.
Rhone-Poulenc RorerLipopolyamine WO95/18863
Antony, FranceDNA delivery
Lipopolyamine carriers for nucleic acids; for genetransfer and therapy.
Ribozyme PharmaHepatitis C WO 95/19429
Boulder, Colo.ribozyme
An enzymatic RNA molecule that specifically cleaveshepatitis C virus; for inhibiting replication.
Rogosin Inst.Secretory cell WO 95/19430
New Yorkencapsulation
Encapsulation of secretory cells in hydrophilic gels; forcell preservation and therapeutic use.
Salk Inst.Developing brain WO 95/18822
La Jolla, Calif.factors
Coding sequence of developing brain factors (DBFs),encoded proteins, antibodies; for DBF detection.
ScheringCTLA-8 antigenWO 95/18826
Kenilworth, N.J.
Coding sequence of primate CTLA-8 antigen, encodedprotein, antibodies; for diagnostic kits.
Scripps Res. Inst.Herpes simplex WO95/18634
La Jolla, Calif.antibodies
Monoclonal antibodies to herpes simplex virus; fordiagnosis and immunotherapy.
Scripps Res. Inst.Zinc finger WO 95/19431
La Jolla, Calif.proteins
Zinc finger-nucleotide binding polypeptides, assays foridentifying such molecules; for modulating expression.
Singapore, Natl.DNA repair WO 95/19445
Univ. of enzyme assay
Singapore
Assay for distinguishing wild-type and alkylated DNArepair enzymes using V8 protease.
Sloan-Kettering Inst.p27 and WO 95/18824
New Yorkhyperproliferation
Coding sequence of p27; for inhibiting E-Cdk2 complexand treating hyperproliferative disorders.
T Cell SciencesT cell antigen WO 95/19435
Needham, Mass.receptor
Full length T cell antigen receptor V region protein; fordiagnosing immune-related disorders.
TargetechHepatitis WO 95/19433
Meriden, Conn.B antisense
Antisense oligos against hepatitis B virus; for detectionand treatment of viral infection.
Thomas Jefferson Univ.Targeted gene WO95/19426
Philadelphiainsertion
Nucleotide sequence that directs integration of genes; fortargeted DNA insertion.
Union CampPlant selectable WO 95/18862
Wayne, N.J.markers
Transformation of plants with tfdA gene; for productionof transgenic plants with selectable markers.
Univ. Technol. & Cephalosporin EPO 663445
Sci. Res. Ministry production
Rome
7a-(4-carboxybutanamido)-cephalosporanic acid acylaseisolation; for low-cost production of cephalosporins.
Vanderbilt Univ.Early breast WO 95/19369
Nashville, Tenn.cancer detection
Identification of differentially expressed genes in pre-invasive breast cancer tissue; for early detection.
Vermont, Univ. ofMutator phenotype WO95/19444
Burlington, Vt.lymphocytes
Lymphocytes with different alleles near a selectablemarker gene; for identifying mutator phenotypes.
Virta et al.Metal level assayWO 95/19446
Vaha-Hameenkatu, Finland
Plasmid whose copy number is controlled by metal-regulatable promoter; for determining metal levels insamples.
WakunagaVariant PCR EPO 664 339
Osaka, Japandetection
PCR amplification and solid-phase binding of nucleicacids; for detecting variants.
Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.