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Killing the Housekeeper

Inhibiting Housekeeping Enzyme Wakes P53, in Cancer Cells Only

By Anette Breindl
Science Editor

Monday, July 16, 2012

Researchers from the Australian Peter MacCallum Cancer Centre and colleagues, including some from Cylene Pharmaceuticals Inc., have reported that by inhibiting RNA Polymerase I with their preclinical compound CX-5461, they were able to activate p53 specifically in cancer cells – a feat that researchers have been trying to achieve "for many years," Cylene CEO William Rice told BioWorld Today.

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