Shares in Cell Therapeutics Inc., of Seattle, (NASDAQ:CTIC) gained 40.2 percent Friday on news a day earlier that the company had a final pivotal trial design for pixantrone in diffuse large B-cell lymphoma, following discussions with the FDA. The stock gained 9 cents to close at 30 cents. The study, designated PIX 306, will compare a combination of pixantrone plus Rituxan (rituximab, Genentech Inc./Roche AG and Biogen Idec Inc.) to a combination of gemcitabine plus rituximab in patients with relapsed or refractory disease who have received one to three prior lines of therapy.