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Rube Goldberg SNP

Two-Hit Theory of Damage May Apply to Heart Failure as Well

By Anette Breindl

Wednesday, January 19, 2011
Researchers reported new insights this week into an SNP that shows its carriers are at increased risk of developing heart failure. The protein that contains the SNP within its sequence does not affect the risk of heart failure – and the nearby, linked protein that does affect heart failure risk is not expressed in the heart. Instead, it codes for a chloride channel that is expressed in the kidneys.

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