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No Effector, Better Effects

Unexpected Toxicity has Lessons for Making Bispecific Antibodies

By Anette Breindl
Science Editor

Monday, May 6, 2013

By taking a detailed look at toxicities of a bispecific antibody that targets the transferrin receptor to cross the blood-brain-barrier, researchers at Genentech Inc. have gained new insights into both "important safety concerns and potential mitigation strategies" for the therapeutic development of such antibodies.

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