Advanced Biotherapy Inc., of Woodland Hills, Calif., received U.S. Patent No. 6,863,890 for use of antibodies to tumor necrosis factor-alpha, interferon-gamma and interferon-alpha for the treatment of HIV infection and AIDS.

Biolex Inc., of Pittsboro, N.C., received U.S. Patent No. 6,852,319, titled, "Method of Use of Transgenic Plant Expressed Antibodies." The patent was issued to the Scripps Research Institute, where the technology was developed, and exclusively licensed to San Diego-based Epicyte Pharmaceutical Inc., which was acquired by Biolex in 2004.

Biophan Technologies Inc., of Rochester, N.Y., was issued two patents involving nanomagnetic coatings and advanced fiber-optics that add to MRI safety. The company also has been granted U.S. Patent No. 6,864,418, titled, "Nanomagnetically Shielded Substrate," to expand coverage over nanomagnetic materials licensed from Nanoset LLC. That patent applies to technology being developed to protect patients with implanted devices from harm due to magnetic resonance imaging.

Cardinal Health Inc., of Somerset, N.J., was granted U.S. Patent No. 6,852,510, titled," Host Cells Containing Multiple Integrating Vectors," for its gene product expression technology platform marketed as GPEx.

Crucell NV, of Leiden, Netherlands, was granted U.S. Patent No. 6,855,544 relating to the production of proteins using cell lines and production technology marketed under its PER.C6 platform.

Cyclacel Group plc, of Dundee, Scotland, received U.S. Patent No. 6,531,479 covering a series of pyrimidine small molecules shown to control the progress of cells through the cancer cycle.

DermaPlus Inc., of New York, said its CEO Burt Ensley, also chairman of MatrixDesign, was granted U.S. Patent No. 6,872,552, "A Method of Reconstituting Nucleic Acid Molecules," relating to methods for recovering and reconstituting genes from "degraded" DNA samples, which could allow scientists to reassemble everything from prehistoric, extinct animals to unsolved crime scenes.

EDC Biosystems Inc., of San Jose, Calif., was granted U.S. Patent No. 6,863,362 for claims relating to "Acoustically mediated liquid transfer method for generating chemical libraries." The technology uses an acoustic wave to transfer micro-droplets of fluids from sources to targets.