Company (Symbol)^#

Date Filed

Date Comm.

Shares/ Units (M)

Price

Shares Out

Lead, Other Underwriters

Gross (US$M)

Post- Offering Market Cap (M)^%

Addex Pharmaceuticals SA (Switzerland; SWX:ADXN)¹

5/16/07**

5/23/07

1.875S

CHF73

5.86S

N/A

CHF136.9 ($111.3)

CHF428 ($348)

Amicus Therapeutics Inc. (FOLD)²

3/30/07

5/31/07

5S

$15

22.2

Morgan Stanley, Merrill Lynch (co-lead), J.P. Morgan Securities Inc., Lazard Capital Markets LLC, Pacific Growth Equities

$75

$333

Biodel Inc. (BIOD)³

2/7/07

5/11/07

5.75S

$15

20.15

Banc of America Sec., Morgan Stanley (co-lead), Leerink Swann & Co., Natexis Bleichroeder

$86.25

$302.25

Eurand International SpA (Italy; EURX)⁴

5/1/07

5/17/07

7S

$16

43.86

Deutsche Bank Sec., Lehman Brothers (co-lead), Banc of America Securities, Lazard Capital Markets, Thomas Weisel Partners

$112

$701.76

A$0.50

Helicos BioSciences Corp. (HLCS)⁵

3/1/07

5/24/07

5.4S

$9

20.5

UBS Investment Bank, JP Morgan (co-lead), Leerink Swann & Co., Pacific Growth Equities

$48.6

$184.5

NeurogesX Inc. (NGSX)⁶

2/8/07

5/2/07

4S

$11

12.5

Morgan Stanley, Pacific Growth Equities, Lazard Capital Markets, Susquehanna Financial

$44

$112.5

Sirtris Pharmaceuticals Inc. (SIRT)⁷

3/1/07

5/23/07

6.9S

$10

28.7

JP Morgan, CIBC World Markets, Piper Jaffray, JMP Securities, Rodman & Renshaw

$69

$287

Company (Symbol)^#

Date Filed

Date Comm.

Shares/ Units (M)

Price

Shares Out (M)^@

Lead, Other Underwriters

Gross (M)

Post- Offering Market Cap (M)^%

Advanced Magnetics Inc.

5/16/07

5/23/07

2.5S

$65.14

16.7

Morgan Stanley, Bear Stearns (co-lead), Deutsche Bank Sec., Jefferies & Co., ThinkEquity Partners

$162.9

$1,088

Array BioPharma Inc. (ARRY)⁹

4/24/07

5/2/07

7S

$13

47

J.P. Morgan Securities Inc., Banc of America (co-lead), Jefferies & Co. Inc., Piper Jaffray & Co.

$91

$611

BioMS Medical Corp. (Canada;

4/10/07

5/15/07

16.1U

C$2.75

N/A

Orion Securities, Desjardins Sec. (co-lead), Versant Partners Inc., Jefferies & Co. Inc., Janney Montgomery Scott

C$44.3 ($40.8)

N/A

Cypress Bioscience Inc. (CYPB)¹¹

5/30/07

5/30/07

4.7S

$15.50

37

UBS Investment Bank, CIBC World Markets (co-lead), Jefferies & Co. (co-lead)

$72.9

$573.5

Genomic Health Inc. (GHDX)¹²

5/15/07

5/22/07

3S

$15.50

27.6

J.P. Morgan Securities, Lehman Brothers (co-lead), Piper Jaffray & Co., JMP Securities LLC

$46.5

$427.8

Javelin Pharmaceuticals Inc. (AMEX:JAV)¹³

5/2/07

5/11/07

7.1S

$6

47.86

JP Morgan Securities, Pacific Growth Equities, Leerink Swann & Co., Allen & Co. LLC, Fortis Securities, Punk Ziegel & Co.

$42.6

$287.16

Pharmacopeia Inc. (PCOP)¹⁴

4/24/07

5/2/07

8S

$5

29.5

CIBC World Markets, Canaccord Adams, Merriman Curhan Ford

$40

$147.5

Pharmion Corp. (PHRM)¹⁵

5/3/07

5/11/07

4S

$30

36.15

Banc of America Sec., Cowen and Co. (co-lead),

$120

$1,084.5

Rigel Pharmaceuticals Inc. (RIGL)¹⁶

4/30/07

5/3/07

5S

$9.75

30.2

Credit Suisse Sec., Lehman Brothers (co-lead), Thomas Weisel Partners

$48.8

$294.45

Sunesis Pharmaceuticals Inc. (SNSS)

11/16/06

5/24/07

4.75S

$4.43

34.2

Lehman Brothers Inc., Cowen & Co. LLC, C.E. Unterberg Towbin

$21

$151.5

Genitope Corp. (GTOP)¹⁷

4/19/07

5/18/07

0.5S

$3.85

42.05

Punk, Ziegel & Co.,

$1.9

$161.9

Orexigen Therapeutics Inc. (OREX)¹⁸

12/16/06

5/2/07

1.05S

$12

26.95

Merrill Lynch & Co., JP Morgan Securities (co-lead),JMP Securities, Leerink Swann & Co.

$12.6

$323.4

Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

@ This column reflects the shares outstanding following the offering, when disclosed.

% Market capitalization is calculated based on the offering price.

Currency conversions are based on exchange rates at the time of the deal.

AMEX = American Stock Exchange; ASX = Australian Stock Exchange; SWX = Swiss Stock Exchange; TSX = Toronto Stock Exchange

1. Addex's overallotment option: 281,250 shares.

2. Amicus' overallotment option: 750,000 shares

3. Includes Biodel's overallotment option: 750,000 shares.

4. Eurand's overallotment option: 1.05M shares.

5. Helicos' overallotment option: 810,000 shares.

6. NeurogesX's overallotment option: 600,000 shares.

7. Includes Sirtris' overallotment option: 900,000 shares

8. Advanced Magnetics' overallotment option:375,000 shares.

9. Array's overallotment option: 1.05M shares.

10. Includes BioMS' overallotment option: 2.1M units. Each unit equals one-common share and one-half of one warrant, with each whole warrant entitling the holder to purchase one common share at C$4.

11. Cypress' overallotment option: 705,000 shares.

12. Genomic Health's overallotment option: 450,000 shares.

13. Javelin's overallotment option: 1.1M shares.

14. Pharmacopeia's offering includes 1.05M-share overallotment option.

15. Pharmion's overallotment option: 600,000 shares.

16. Overallotment option: 750,000 shares

17. Genitope's total offering was 6M shares for $23.1M.

18. Orexigen's underwriters exercised in full their overallotment option, bringing the total shares offered to 8.05M and the gross amount raised to $96.6.

Company (Symbol/
Proposed Symbol)^#*

Date Filed

Shares/ Units (M)

Price Range

Shares Out (M)^@

Lead, Other Underwriters

Value (M)

Aegerion Pharmaceuticals Inc. (AEGR)¹

3/21/07

5S

$12-$14

18.6

Lehman Brothers, CIBC World Markets,

$65

Bioheart Inc. (BHRT)

2/13/07

N/A

N/A

21.5

BMO Capital Markets Corp., Janney Montgomery Scott (co-lead),

$35

EndoCeutics Inc. (Canada; ENCX)

2/27/07

5.75S

$7-$9

N/A

First Albany Capital, Oppenheimer & Co., Stifel Nicolaus

$46

ImaRx Therapeutics
Inc. (IMRX)²

5/4/07

3S

$6.50- $7.50

9.1

Maxim Group LLC

$21

Jazz Pharmaceuticals
Inc. (JAZZ)³

3/9/07

6S

$20-$21

24.55

Morgan Stanley, Credit Suisse,

$123

Light Sciences Oncology Inc.
(LSON)

4/21/06

5.25S

$14-$16

18.5

Cowen & Co. Wachovia Securities (co-lead), Jefferies & Co. Thomas Weisel Partners

$78.75

Merrion Pharmaceuticals
Ltd. (MERR)⁴

4/3/07

N/A

N/A

N/A

Punk, Ziegel & Co. Goodbody Stockbrokers, Stanford Group Co.

$46

MonoSol Rx Inc. (MSRX)

5/14/07

N/A

N/A

N/A

Cowen and Co. CIBC World Markets Susquehanna Financial

$86.25

NovaBay Pharmaceuticals
Inc. (AMEX:NBY; TSX:NBY)⁵

2/15/07

N/A

N/A

31.8

N/A

$23

NovaCardia Inc. (NCAR)

3/30/07

N/A

N/A

88.1

J.P. Morgan Securities Inc., Credit Suisse Securities (co-lead), Pacific Growth Equities LLC, Albany Capital Inc.

$86.3

Quark Biotech Inc. (QURK)

3/30/07

N/A

N/A

37.5

JPMorgan, CIBC World Markets, Banc of America Securities, C.E. Unterberg, Towbin

$86.3

Sucampo Pharmaceuticals
Inc. (SCMP)

6/19/06

N/A

N/A

N/A

Banc of America Securities, Deutsche Bank Securities (co-lead), Leerink Swann & Co.

$86.25

Targanta Therapeutics
Corp. (TARG)

5/14/07

N/A

N/A

N/A

Credit Suisse Securities, Cowen and Co., Lazard Capital Markets, Leerink Swann and Co.

$86.25

A.P. Pharma Inc. (APPA)

4/6/07

N/A

N/A

N/A

Merriman Curhan Ford

$28.8

Chemokine Therapeutics
Corp. (Canada; TSX:CTI; OTC BB: CHKT)

5/30/07

N/A

N/A

N/A

GMP Securities

$25

Neurochem Inc. (NRMX)

1/18/07

N/A

N/A

N/A

N/A

$102

Company (Symbol/
Proposed Symbol)^#*

Date Filed/
Date Pulled

Shares/ Units (M)

Price Range

Shares Out (M)^@

Lead, Other Underwriters

Value (M)

Perlegen Sciences Inc. (PERL)⁶

4/10/06 5/1/07

N/A

N/A

N/A

Lehman Brothers, Deutsche Bank Securities (co-lead), Piper Jaffray & Co., Allen & Co.

$115