November 22 (EP), November 16 (WO)
Alabama, Univ. of WO 00/67576
Cancer gene therapy
Birmingham, Ala.
Conditionally replicative adenovirus vectors with enhanced tumor infectivity and tumor selective replication.
AstraZeneca WO 00/68268
Human GABAB receptor 1 promoters
Sodertalje, Sweden
Human GABAB receptor 1 promoters; for use in developing modulator screens.
BASF WO 00/67790
TNF receptor modulation
Ludwigshafen, Germany
Modulators of cellular TNF receptor content; for treating TNF-induced diseases.
Becton Dickinson WO 00/68270
Plasmodium detection
Franklin Lakes, N.J.
Repeated peptides from Plasmodium vivax ESP-1 protein, antibodies; for diagnostics and therapeutics.
Bristol-Myers Squibb WO 00/68413
Nocathiacin antibiotics
Princeton, N.J.
Halo- or hydroxy-substituted nocathiacin antibiotics produced by fermentation in Nocardia strains.
Burnham Inst. WO 00/67771
Antiangiogenesis therapeutics
La Jolla, Calif.
Antiangiogenic endostatin peptides, endostatin variants, functional equivalents; for therapeutics.
California, Univ. of WO 00/68248
Self-assembling proteins
Oakland, Calif.
Fusion proteins that assemble into regular structures, encoding genes; for preparing nanostructures.
California, Univ. of WO 00/68265
Antimicrobial defensins
Oakland, Calif.
Antimicrobial cyclic peptide theta defensins, encoding gene sequences; for infection therapeutics.
California, Univ. of WO 00/68382
Prion disorder gene
Oakland, Calif.
Gene encoding Doppel protein, encoded protein, antibodies; for identifying individuals at risk for prion disorders.
CNRS (Natl. Ctr. Sci. Res.) WO 00/67697
Gene delivery vehicle
Paris
Nucleic acid-antibody conjugates; for gene delivery into target cells.
CNRS (Natl. Ctr. Sci. Res.) WO 00/67792
Renal cell carcinoma antibodies
Paris
Monoclonal antibodies directed against human renal cell carcinoma.
Children's Hosp. WO 00/68433
Autism diagnosis
Los Angeles
Detection of human aromatic L-amino acid decarboxylase gene mutations; for autism diagnosis.
Chugai WO 00/68371
Cell culture methods
Tokyo
Culture of parent cells with a transformed strain that constitutively produces a specific protein.
Connecticut, Univ. of WO 00/68432
Diagnosing congenital glaucoma
Farmington, Conn.
Measurement of human cytochrome P4501B1 gene mutations; for diagnosing primary congenital glaucoma.
Curie Inst. WO 00/68424
FGF receptor 3 mutations
Paris
Detection of mutations in the fibroblast growth factor receptor 3 gene; for detecting carcinomas.
Du Pont WO 00/68366
Processing protease ligand assays
Wilmington, Del.
D1 C-terminal processing protease crystals; for structural determination and ligand identification.
Eli Lilly WO 00/68266
Amyloid precursor protein protease
Indianapolis
Amyloid precursor protein protease, encoding gene sequences; for developing Alzheimer's therapeutics.
European Molec. Biol. Lab WO 00/68423
Gene expression assays
Heidelberg, Germany
Isolation of polysomal mRNA for subsequent expression analyses; for enhanced gene expression assays.
European Molec. Biol. Lab WO 00/68693
Hsp90 fragments
Heidelberg, Germany
Methods for finding fragments, derivatives, and analogs of Hsp90 that are altered in their subcellular localization.
Genentech WO 00/67796
Autoimmune disease therapy
S. San Francisco
Treatment of autoimmune diseases with antagonists that bind to B cell surface markers.
Genentech WO 00/68363
Elastase variants
S. San Francisco
Elastase variants, substrates; for developing diagnostics and therapeutics.
Genentech WO 00/68376
Chimpanzee EPO
S. San Francisco
Chimpanzee erythropoietin, encoding gene sequences, chimeras, antibodies, recombinant production methods.
Harvard Univ. WO 00/68185
Protein processivity factor modulators
Cambridge, Mass.
Structure-based methods to design peptidomimetics that inhibit the protein processivity factor.
Human Genome Sciences WO 00/67775
FGF-15
Rockville, Md.
Fibroblast growth factor 15, encoding genes, antibodies, production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 00/67793
Death domain containing receptor 4
Rockville, Md.
Death domain containing receptor 4, encoding gene, recombinant production methods; for modulator screens.
Human Genome Sciences WO 00/68247
Serine proteases
Rockville, Md.
Serine proteases, encoding genes, recombinant production methods; for diagnostics and therapeutics.
Illinois, Univ. of WO 00/68392
RSV vaccines from plants
Urbana, Ill.
Insertion of respiratory syncytial virus-based vectors that express viral antigens into plants; for making vaccines.
Immune Response WO 00/67787
HIV immunoresponse
Carlsbad, Calif.
HIV-derived antigens; for enhancing _-chemokine levels and inducing immunoresponses.
Immunex WO 00/68383
Immunoregulators
Seattle
Leukocyte immunoglobulin-like receptors, encoding gene sequences, antibodies; for use as immunoregulators.
Immunomedics WO 00/67795
B-cell cancer antibodies
Morris Plains, N.J.
Methods for using antibodies that bind to CD22 or CD19 antigen to treat B-cell malignancies.
Incyte Genomics WO 00/68380
Extracellular matrix proteins
Palo Alto, Calif.
Extracellular matrix and adhesion-associated proteins, encoding genes, antibodies, modulators; for therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/68429
Glaucoma diagnosis
Paris
Measurement of ApoE or ApoE promoter alleles; for diagnosing glaucoma.
Japan Sci. & Technol. EP 1 054 057
Point mutation generation
Kawaguchi, Japan
Introduction of point mutations into genomic DNA such that one strand has more such mutations.
JCR Pharma EP 1 054 058
Muscular dystrophy antisense
Hyogo, Japan
Antisense oligonucleotide against exon 19 of dystrophin pre-mRNA; for treating muscular dystrophy.
Leiv Eiriksson Nyfotek WO 00/68375
Antibiotic resistance assay
Trondheim, Norway
Modified TOL plasmid promoter; for cell insertion to study antibiotic resistance.
Life Technologies WO 00/68411
Enhanced DNA synthesis
Rockville, Md.
Polypeptides having specific affinity for double- and single-stranded nucleic acid molecules; for synthesis.
Lindahl, G. WO 00/68259
Staphylococcus vaccines
Lund, Sweden
Antigenic proteins from Staphylococcus pyogenes; for making group B Staphylococcus vaccines.
Ludwig Inst. Cancer Res.
Ocular disorder mutations
New York
Mutations in the gene encoding 11-cis retinal dehydrogenase, encoded protein; for ocular disorder diagnostics.
Maryland, Univ. of WO 00/67784
Bacterial infection vaccines
Baltimore, Md.
Bacteriophage from bacterial genomes, extrachromosomal elements; for producing antibodies and vaccines.
Mass. Gen. Hosp. WO 00/68361
Hair growth induction
Boston
Expression of versican in dermal papilla cells; for inducing and modulating hair growth.
Merck WO 00/68377
Platelet collagen receptor
Darmstadt, Germany
Recombinant platelet collagen receptor glycoprotein VI, encoding gene; for modulator assays.
Merck Frosst Canada WO 00/68414
Cathepsin K modulator assay
Kirkland, Que.
Whole cell assay system for measuring cathepsin K; for identifying modulators.
Microscience WO 00/68261
Attenuated Salmonella strains
Wokingham, U.K.
Salmonella strains with attenuating mutations disrupting gene expression from the Spl2 pathogenicity island.
Minnesota, Univ. of WO 00/68399
Transposon-mediated gene insertion
Minneapolis, Minn.
Non-integrating vectors containing a transposon and gene sequences encoding a transposase; for gene integration.
Mycota Biosciences WO 00/68420
Antifungal drug assays
Montreal
Identification of essential genes in Candida albicans; for antifungal drug development.
NABI WO 00/67785
Staphylococcus vaccines
Rockville, Md.
Staphylococcus hexosamine-containing antigen; for making strains having this antigen to use as whole cell vaccines.
Natl. Ctr. Retroviuses WO 00/68436
HIV-1 subtype detection
Zurich, Switzerland
Detection of various subtypes of HIV-1 using nucleic acid amplification methods.
NIH (Natl. Inst. Hlth.) WO 00/68379
Antiangiogenesis therapy
Bethesda, Md.
Antiangiogenic gene inserted into a viral vector; for treating various cancers.
Natl. Jewish Med. & Res. Ctr. WO 00/68378
B cell growth regulation
Denver
Monocyte- and macrophage-expressed TALL-1 gene, encoded protein; for regulating B cell proliferation.
Neugenesis WO 00/68372
Metabolic pathway assays
San Carlos, Calif.
Methods for screening combinatorial libraries of multimeric proteins; for studying metabolic pathways.
Neurochem WO 00/68263
Amyloid disorder therapy
Montreal
Steroselective anti-fibrillogenic peptides, peptidomimetics; for treating amyloidosis disorders.
Niseho EP 1 054 066
Osteoporosis-related polymorphisms
Osaka, Japan
Methods for analyzing genetic polymorphisms of the vitamin D receptor gene; for osteoporosis diagnosis.
Palsson, B.O. WO 00/68687
Drug candidate screens
La Jolla, Calif.
Using cells from normal and diseased tissues to measure differential effects of putative therapeutic agents.
Relag WO 00/67569
Cell reprogramming
Melbourne, Australia
Production of heterokaryons containing embryo nuclei; for cell reprogramming to form embryos.
Rhein Biotech WO 00/68400
Protein production methods
Dusseldorf, Germany
Identification of nucleic acid sequences that enhance protein secretion; for recombinant protein production.
Rhone-Poulenc WO 00/68401
Protein production methods
Antony, France
Recombinant strains of Penicillium funculosum; for production of heterologous proteins.
Ruprecht Karls Univ. WO 00/68435
Retrovirus detection
Heidelberg, Germany
Using reverse transcriptase PCR and reverse dot blot hybridization to detect retroviruses in samples.
Salk Inst. Biol. Studies WO 00/68269
Chimeric receptor proteins
La Jolla, Calif.
Chimeric proteins having receptor fragment and ligand domains; for identifying additional ligands.
SmithKline Beecham WO 00/67575 & 67783
Antibacterial screens
Philadelphia
Bacterial proteins, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/67580
Splicing modulators
Philadelphia
Methods for using splicing reactions to identify modulators of eukaryotic splicing.
SmithKline Beecham WO 00/67780
Antibacterial screens
Philadelphia
Bacterial FabH proteins, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/68140
Staphylococcus antibacterial screens
Philadelphia
Staphylococcus signal transduction response regulators, encoding gene; for antibacterial screens.
SmithKline Beecham WO 00/68240 & 68243
Antibacterial screens
Philadelphia
Bacterial aroA proteins, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/68244
7-transmembrane receptor modulation
Philadelphia
Mouse 7-transmembrane receptor, encoding gene, recombinant production methods; for modulator screens.
SmithKline Beecham WO 00/68250
7-transmembrane receptor modulation
Philadelphia
Rat 7-transmembrane receptor, encoding gene, recombinant production methods; for modulator screens.
SmithKline Beecham WO 00/68360
Staphylococcus antibacterial screens
Philadelphia
Staphylococcus aureus histidine kinase, encoding gene, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/68365
Staphylococcus antibacterial screens
Philadelphia
Staphylococcus pneumoniae tRNA methyltransferases, encoding gene, production methods; for antibacterial screens.
SmithKline Beecham WO 00/68425
Antibacterial screens
Philadelphia
Bacterial ysxC proteins, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/68426
Antibacterial screens
Philadelphia
Bacterial ups proteins, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/68427
Antibacterial screens
Philadelphia
Bacterial yphC proteins, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/68430
Staphylococcus antibacterial assays
Philadelphia
Staphylococcus aureus Rnase P, encoding gene, recombinant production methods; for antibacterial screens.
South Carolina, Med. Univ. of WO 00/68249
G-protein modulators
Charleston, S.C.
G-protein modulator proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Stem Cell WO 00/67568
Cell reprogramming
Elstemwick, Australia
Production of heterokaryons containing embryo nuclei; for cell reprogramming to form embryos.
Sterrenbeld Biotech WO 00/68253
Gene expression promoter
Wilmington, Del.
Promoter derived from Staphylococcus aureus phage that is active in Gram-positive and -negative bacteria.
Target Quest EP 1 054 018
Fab fragment libraries
Maastricht, Netherlands
Fab fragment libraries; for isolating polyclonal or monoclonal antibodies with high specificity.
Telethon Inst. Child Hlth. Res. WO 00/68373
Modulator assays
Subiaco, Australia
Identifying biological activity modulators using diverse gene fragment libraries.
Texas A&M Univ. WO 00/68242
Bacterial collagen-binding proteins
College Stn., Texas
Collagen-binding proteins from enterococcal bacteria; for treating and preventing infections.
Toyo Kohan EP 1 054 056
Genome comparison assay
Tokyo
Apparatus for immobilizing DNA libraries in isolated sections; for genome comparisons.
Tularik WO 00/68686
Mitochondrial membrane potential modulators
S. San Francisco
High-throughput screening assays for identifying modulators of mitochondrial membrane potential uncoupling proteins.
U.S. Army Med. Res. Command WO 00/67700
Botulism vaccine
Ft. Detrick, Md.
Synthetic genes encoding protective epitopes from botulinum neurotoxin, encoded proteins; for making a vaccine.
Utah, Univ. of WO 00/68359
Neuroepithelial stem cells
Salt Lake City
Lineage-restricted precursor cells isolated from mouse neural tube and embryonic stem cells, isolation methods.
Vermicon WO 00/68421
Microorganisms detection
Munich, Germany
Detection of microorgansims in samples using probes for hybridization assays.
Vessel Res. Lab EP 1 053 677
Myosin transgenics
Tokyo
Cells transfected with genes for expressing smooth muscle myosin heavy chain; for making transgenics.
Visible Genetics WO 00/68410
Nucleic acid sequencing
Toronto
Nucleic acid sequencing with simultaneous quantitation using a single set of reagents.
Vlaams Inst. Biotech EP 1 054 059
Catenin-binding protein genes
Zwijnaarde, Belgium
Catenin-binding protein genes, encoded proteins; for modulating transcription and gene regulation.
Wake Forest Univ. WO 00/67761
Eliciting immunoresponses
Winston-Salem, N.C.
Transfection with gene constructs encoding antigens; for presentation to T cells to elicit an immune response.
Xencor WO 00/68384
Altered p53 proteins
Pasadena, Calif.
p53 proteins with altered tetramerization domains, encoding gene sequences; for cancer therapeutics.
Xencor WO 00/68385
Proteins with GH activity
Pasadena, Calif.
Proteins having growth hormone activity, encoding gene sequences; for treating growth hormone-related disease.
Xencor WO 00/68387
Proteins with IFN-_ activity
Pasadena, Calif.
Proteins having interferon-_, encoding gene sequences; for treating IFN-_ related disease.
Yale Univ. WO 00/68434
Multiple tag analysis
New Haven, Conn.
Detection of multiple analytes using decodable tags for marking the analytes; for diagnostics development.
Zeneca WO 00/68362
Erythroid stem cells
London
Undifferentiated erythroid cells transfected with heterologous genes controlled by globin promoters.
ZymoGenetics WO 00/68381
Cytokine receptor
Seattle
Mouse cytokine receptor, encoding gene, antibodies, production methods; for stimulating hematopoiesis.
ZymoGenetics WO 00/68386
Autotaxin variants
Seattle
Autotaxin variants, functional fragments, encoding gene sequences; for treating diabetes and obesity.