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Transflammation Critical to Transformation

Vector-Triggered Innate Immune Activity Is Necessary for iPSCs

By Anette Breindl
Science Editor

Wednesday, October 31, 2012
Researchers reported last week that the retroviral vector that is used for gene delivery in the generation of induced pluripotent stem cells, or iPSCs, does more than just ferry its cargo into cells. It activates the innate immune system – and that activation is critical for efficient reprogramming.

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