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Oh, You'll Do

ZFN Binding Sites Specific, But Not Perfect, in Practice

By Anette Breindl

Wednesday, August 10, 2011
Zinc finger nucleases – which edit genes by inducing double-stranded DNA breaks at specific sites in the genome, then repair those same breaks with template DNA provided by the zinc finger nuclease complex itself – are clearly more specific than vector-based gene therapy, which delivers its therapeutic payload into patients DNA at essentially random places.

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