Oh, You'll Do
ZFN Binding Sites Specific, But Not Perfect, in Practice
By Anette Breindl
Wednesday, August 10, 2011
Zinc finger nucleases which edit genes by inducing double-stranded DNA breaks at specific sites in the genome, then repair those same breaks with template DNA provided by the zinc finger nuclease complex itself are clearly more specific than vector-based gene therapy, which delivers its therapeutic payload into patients DNA at essentially random places.
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