Astellas Pharma Inc., of Tokyo, named Percival Barretto-Ko president, Americas operations, for Astellas US, with responsibility for the company's operations in North and South America. Barretto-Ko joined Astellas in 2005 to lead Astellas Pharma Europe's corporate strategy organization. In 2011, he was appointed senior vice president, corporate strategy and government affairs for Astellas US, where he was responsible for business development, corporate strategy, corporate planning, alliance management, and government affairs. In 2015, he was appointed senior vice president, International Operations, responsible for the company's operations outside of the United States. The company also made three senior-level changes in its global Legal and Human Resources organizations, naming Roderick Christmon executive director, medical and development, Matt Silversten vice president, legal head of litigation and investigations, and Brian Taylor vice president, legal head of business development/alliance management.