Company*
(Country;
Symbol)		 Company*
(Country;
Symbol)		 Type/Product Area Terms/Details (Date)
Avexa Ltd.
(Australia;
ASX:AVX)		 Novasep* (France) Manufacturing agreement for the production of apricitabine, Avexa's nucleoside reverse trans-criptase inhibitor for HIV Terms cover the continued production, process optimization and further scale-up of ATC's active pharmaceutical ingredient (2/15)
Bioenvision Inc.
(BIVN)		 Foster Corp.* Agreement for exclusive rights to manufacture, market and distribute Oligon, technology based on the antimicrobial properties of silver ions Bioenvision will have a revenue-sharing arrangement on future sublicenses and a royalty on all sales by Foster (2/1)
Biotest AG
(Germany; FSE:BIO)		 CMC Biopharmaceuticals A/S* (Denmark) A deal to manufacture the BT-062 antibody being developed for treating multiple myeloma Further terms were not disclosed (2/5)
Cytonet GmbH
& Co. KG*
(Germany)		 Vesta Therapeutics Inc.* Liver cell products for Cytonet's clinical trials Manufacturing agreement under which Vesta is to construct a production facility in accordance with European standards; financial terms were not disclosed (1/16)
Cytori
Therapeutics
Inc. (CYTX)		 MBA Grupo*
(Italy)		 Agreement to distribute the Celution System in Spain, Italy and Portugal starting in early 2008 for reconstructive surgery applications The Celution System is a medical device designed to remove a patient's own stem and regenerative cells from their fat tissue; financial terms were not disclosed (2/20)
Durect Corp.(DRRX) Corium
International Inc.*		 Long-term manufacturing and supply agreement to produce clinical and commercial supplies of Transdur-Bupivacaine, a transdermal pain patch in development for post-herpetic neuralgia The product is in Phase II trials in about 50 patients; Corium will provide Transdur-Bupivacaine on a worldwide basis (2/5)
Inspire
Pharmaceuticals
Inc. (ISPH)		 InSite
Vision Inc.
(AMEX:ISV)		 Collaboration giving Inspire exclusive rights in the U.S.and Canada to AzaSite for ocular infections InSite is getting $13M up front and another $19M upon FDA approval; it also would pay InSite sales royalties of 20% in the first two years of commercialization and 25% in subsequent years (2/19)
Ovation
Pharmaceuticals
Inc.*		 Enzon Pharmaceuticals Inc. (ENZN) Ovation will supply the active ingredient for Enzon's Oncaspar through 2006, under an extension to existing deal Oncospar is a pegylated form of L-asparaginase for treating acute lymphoblastic leukemia; Enzon also made a payment for a nonexclusive license to the cell line from which the material is sourced (12/4)#
Pro-Pharma-
ceuticals Inc.
(AMEX:PRW)		 Chemwerth Inc.* Collaboration to scale-up production of Davanat to 100 kg for initial marketing needs Davanat is a carbohydrate polymer composed of mannose and galactose; the company is seeking approval of Davanat to be used with 5-Fluorouracil for intravenous injection to treat cancer (2/20)
Uluru Inc.
(OTC BB:ULUR)		 BioProgress plc (UK; BPRG) Strategic partnership to market OraDisc B in the European Union, the Commonwealth of Independent States and Middle Eastern markets The product, developed from Uluru's adhesive film technology, incorporates 15 mg of benzocaine for treating oral pain; terms call for an up-front fee and future milestone payments to Uluru (2/8)
Valeant
Pharmaceuticals
International
(NYSE:VRX)		 Cambridge Laboratories Ltd.* (UK) Valeant acquired commercial rights to nabilone in the UK and other European markets for $14M Valeant markets nabilone in the U.S. and Canada under the brand name Cesamet; it is indicated for nausea and vomiting associated with cancer chemotherapy (2/19)
VaxGen Inc.
(PK:VXGN)		 Celltrion Inc.
(South Korea)		 VaxGen sold most of it of its remaining stake in Celltrion for $51.3M Nexol Co. Ltd. and affiliated companies in June paid $79M for VaxGen's 62% stake in the manufacturing facility (1/3)
ViaCell Inc.
(VIAC)		 Invitrogen Corp.
(IVGN)		 Agreement for Invitrogen to manufacture ViaCell's Viacyte media The media will be used in ViaCell's pivotal clinical trial to evaluate the cryop-reservation and thawing of human oocytes (2/12)
Notes:
* Private companies are indicated with an asterisk.
# Item occurred before the time frame of this chart but was not included in the previous chart.
Unless otherwise noted, stock symbols listed are on the Nasdaq market.
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